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SusMat 2022年第4期2卷 476-486页

作者： Arnar Sveinbjörnsson Anna bergljót Gunnarsdóttir erin b.creel Camila Pía Canales barr Zulevi Xiang Lyu Charl J.Jafta Egill Skúlason Alexey Serov Helga Dögg Flosadóttir Atmonia ehf. ReykjavíkIceland Faculty of Industrial Engineering Mechanical Engineering and Computer ScienceUniversity of IcelandVR-IIIReykjavíkIceland Electrification and Energy Infrastructures Division Oak Ridge National LaboratoryOak RidgeTennesseeUSA Pajarito Powder LLC(PPC)AlbuquerqueNew MexicoUSA Science Institute University of IcelandVR-IIIReykjavíkIceland

Ammonia(NH3)production via the electrochemical nitrogen reduction reaction(NRR)is a promising method for sustainable generation of this important *** are ongoing in finding an efficient,stable,and selective catalyst that will enable the ***,progress is hindered in the field due to lack of reproducibility,most likely a consequence of reports of false-positive results due to improper measurement control and *** this study,we explore the NRR activity of a promising class of single atom catalysts,transition metal-nitrogen-carbon(M-N-C)*** a state-of-the-art in-line ammonia quantification methodology,with detection limit as low as 1 ppb for ammonia,we show that single atom Nb and Fe embedded in a stable carbon and nitrogen framework do not electrochemically reduce N_(2) to NH_(3).Critically,this demonstrates that our experimental setup with in-line sequential injection analysis successfully excludes ammonia contamination from the gas supply and atmospheric sources,allowing for thorough and high-throughput examination of potential NRR catalysts.

关键词： ammonia synthesis electrocatalysis nitrogen electroreduction NRR single atom catalyst

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin bai Fengjiao Li Junfeng Lu Gaoyu Zu erin brintnell Hong Chen Ying Mao Guomin Zhou bo Liao Jinsong Wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and b cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

Distribution of transient receptor potential vanilloid-1 channels in gastrointestinal tract of patients with morbid obesity

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World Journal of Clinical Cases 2022年第1期10卷 79-90页

作者： Unal Atas Nuray erin Gokhan Tazegul Gulsum Ozlem Elpek bülent Yıldırım Department of Internal Medicine Akdeniz University Medical SchoolAntalya 07070Turkey Department of Pharmacology Akdeniz University Medical SchoolAntalya 07070Turkey Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey Department of Gastroenterology Akdeniz University Medical SchoolAntalya 07070Turkey

bACKGROUND Transient receptor potential vanilloid-1(TRPV1),a nonselective cation channel,is activated by capsaicin,a pungent ingredient of hot *** studies have suggested a link between obesity and capsaicin-associated pathways,and activation of TRPV1 may provide an alternative approach for obesity ***,data on the TRPV1 distribution in human gastric mucosa are limited,and the degree of TRPV1 distribution in the gastric and duodenal mucosal cells of obese people in comparison with normal-weight individuals is *** To clarify gastric and duodenal mucosal expression of TRPV1 in humans and compare TRPV1 expression in obese and healthy *** Forty-six patients with a body mass index(bMI)of>40 kg/m^(2) and 20 patients with a bMI between 18-25 kg/m^(2) were *** biopsies from the fundus,antrum,and duodenum tissues were obtained from subjects between the ages of 18 and 65 who underwent ***,sex,history of alcohol and cigarette consumption,and past medical history regarding chronic diseases and medications were accessed from patient charts and were analyzed *** with anti-TRPV1 antibody was performed separately according to cell types in the fundus,antrum,and duodenum tissues using an immunoreactivity *** were analyzed using SPSS *** TRPV1 expression was higher in the stomach than in the duodenum and was predominantly found in parietal and chief cells of the fundus and mucous and foveolar cells of the *** foveolar cells in the antrum,TRPV1 was relatively low in foveolar cells in the fundus(4.92±0.49 vs 0.48±0.16,Pbidly obese group were similar to those of th

关键词： Capsaicin Transient receptor potential vanilloid 1 Immunohistochemistry Morbid obesity Obesity Transient receptor potential channels Transient receptor potential vanilloid cation channels

Self-reported physical functioning,cardiometabolic health conditions, and healthcare utilization patterns in Million Veteran Program enrollees with Traumatic brain Injury Screening and Evaluation Program data

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Military Medical Research 2023年第5期10卷 587-598页

作者： Alexandra L.Clark Makenna b.McGill erin D.Ozturk David M.Schnyer Catherine Chanfreau‑Cofnier Victoria C.Merritt Research Service VA San Diego Healthcare System(VASDHS)San DiegoCA92161USA Department of Psychology The University of Texas at AustinAustinTX 78712USA San Diego State University/University of CaliforniaSan Diego Joint Doctoral Program San DiegoCA 92120USA VA Informaticsand Computing Infrastructure(VINCI) VA Salt Lake City Health Care SystemSalt Lake CityUT 84148USA Department of Psychiatry School of MedicineUniversity of California San DiegoLa JollaCA 29093USA Center of Excel‑lence for Stress and Mental Health VASDHSSan Diego 92161USA

background Examining the health outcomes of veterans who have completed the United States Veterans Health Administration’s(VHA’s)Traumatic brain Injury(TbI)Screening and Evaluation Program may aid in the refinement and improvement of clinical care initiatives within the *** study compared self-reported physical functioning,cardiometabolic health conditions,and health care utilization patterns in Million Veteran Program enrollees with TbI Screening and Evaluation Program data(collected between 2007 and 2019),with the goal of enhancing understanding of potentially modifiable health conditions in this *** In this observational cohort study,veterans(n=16,452)were grouped based on the diagnostic outcome of the TbI Screening and Evaluation Program:1)negative TbI screen(Screen^(-));2)positive TbI screen but no confirmed TbI diagnosis[Screen^(+)/Comprehensive TbI Evaluation(CTbIE)^(-)];or 3)positive TbI screen and confirmed TbI diagnosis(Screen^(+)/CTbIE^(+)).Chi-square tests and analysis of covariance were used to explore group differences in physical functioning,cardiometabolic health conditions,and health care utilization patterns,and logistic regressions were used to examine predictors of Screen^(+/-)and CTbIE^(+/-)group *** The results showed that veterans in the Screen^(+)/CTbIE^(-)and Screen^(+)/CTbIE^(+)groups generally reported poorer levels of physical functioning(P’sbolic health conditions(P’s0.5)compared with the Screen-group;however,health outcomes were generally comparable between the Screen^(+)/CTbIE^(-)and Screen^(+)/CTbIE^(+)***-up analyses confirmed that while physical functioning,hypertension,stroke,healthcare utilization,and prescription medication use reliably distinguished between the Screen-and Screen^(+)groups(P’sbet

关键词： Traumatic brain injury(TbI)screen Comprehensive TbI Evaluation(CTbIE) Health outcomes Cardiometabolichealth Veterans Million Veteran Program(MVP)

Neonatal pneumothorax in congenital diaphragmatic hernia:be wary of high ventilatory pressures

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World Journal of Pediatric Surgery 2022年第3期5卷 154-161页

作者： Nathan Rubalcava Gabriella A Norwitz Aimee G Kim Gary Weiner Niki Matusko Meghan A Arnold George b Mychaliska erin E Perrone Pediatric Surgery University of MichiganAnn ArborMichiganUSA Section of Neonatology Department of PediatricsUniversity of MichiganAnn ArborMichiganUSA Department of Surgery University of MichiganAnn ArborMichiganUSA

background Patients with congenital diaphragmatic hernia(CDH)require invasive respiratory support and higher ventilator pressures may be associated with *** sought to evaluate the risk factors associated with pneumothorax in CDH neonates prior to *** Weretrospectivelyreviewednewborns born withCDHbetween 2014and 2019who developeda pneumothorax,and we matched these cases to patients with CDH without *** Twenty-sixpatientswere included(n=13per group).The pneumothorax group required extracorporeal life support(ECLS)more frequently(85%vs 54%,p=0.04),particularly among type A/b defects(31%vs 7%,p=0.01).The pneumothorax group had higher positive end-expiratory pressure(PEEP)within 1 hour of birth(p=0.02),at pneumothorax diagnosis(p=0.003),and at ECLS(p=0.02).The pneumothorax group had a higher mean airway pressure(Paw)at birth(p=0.01),within 1 hour of birth(p=0.01),and at pneumothorax diagnosis(p=0.04).Using multiple logistic regression with cluster robust SEs,higher Paw(OR 2.2,95%Cl 1.08 to 3.72,p=0.03)and PEEP(OR 1.8,95%CI 1.15 to 3.14,p=0.007)were associated with an increased risk of developing *** was no difference in survival(p=0.09).Conclusions Development of a pneumothorax in CDH neonates is independently associated with higher Paw and higher PEEP.A pneumothorax increases the likelihood of treated with ECLS,even with smaller defect.

关键词： PEEP pneumothorax diagnosis

Invasive grasses consistently create similar plant-soil feedback types in soils collected from geographically distant locations

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Journal of Plant Ecology 2016年第2期9卷 180-186页

作者： Lora b.Perkins Gary Hatfield erin K.Espeland Department of Natural Resource Management South Dakota State University1 N.Campus Dr.BrookingsSD 57007USA Department of Mathematics and Statistics South Dakota State University100 Admin LaneBrookingsSD 57007USA Pest Management Research Unit USDA-ARS NPARL1500 North Central AveSidneyMT 59270USA

Aims Plants of similar life forms and closely related species have been observed to create similar types of plant–soil feedbacks(PSFs).However,investigations of the consistency of PSFs within species have not yielded clear *** example,it has been reported that species create different types of PSFs in their native and introduced *** aim of this project is to examine if four species create similar PSF types from soils collected from widely distributed areas within their introduced *** soil for this project was collected from three areas in western North *** this design,we aim to determine species-and site-specific ability to create PSFs and if the type of PSF created is consistent in all soil from all three collection *** species examined are Agropyron cristatum,Centaurea solstitialis,Poa pratensis and Taeniatherum *** We used three-field collected soils(from northern Nevada,western Montana and eastern Montana)in a two-phase greenhouse experiment to quantify the type of PSFs created by four invasive *** first phase was a conditioning phase wherein each invasive species created species-specific changes to the *** second phase of the experiment was the response phase wherein both the conditioning species and a native phytometer were grown in the conditioned soil and in unconditioned(control)*** final aboveground biomass was used to evaluate the effect of conditioning and to determine the type of PSF created by each invasive *** Findings Our results suggest that three of our four study species did show consistency in relation to *** species *** and *** consistently created PSF types that benefit conspecifics more than heterospecifics(and thus are‘invasive’PSF types)and *** consistently exhibited no,or‘neutral’,*** fourth species(***)was inconsistent:in one soil,no feedback was created;in other soil,an invasive PSF was created and in t

关键词： plant-soil feedback invasion niche construction

Not yet defect-free: the current landscape for women in computational materials research

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npj Computational Materials 2023年第1期9卷 1342-1351页

作者： Livia b.Pártay erin G.Teich Rose K.Cersonsky Department of Chemistry University of WarwickCoventry CV47ALUnited Kingdom Department of Physics Wellesley College106 Central StreetWellesley 02481 MAUSA Department of Chemical and biological Engineering University of Wisconsin-Madison1415 Engineering DriveMadison 53706 WIUSA

INTRODUCTION“I really am not seeing how women are still considered disadvantaged in our field.”This phrase is heard all-too-often by woman scientists across many *** while attitudes on gender equity and parity have considerably improved in recent history,there are still measurable inequities stemming from systemic bias in the career progression,recognition,and perception of women in the sciences,including our sub-field of computational materials *** the obstacles to equity is in the interests of all of *** research inclusive is critical,not only from an ethical standpoint,but also for attracting and retaining dedicated and talented minds,enhancing the vibrancy of all fields,and nurturing a diverse range of ideas.

关键词： landscape attracting retaining

Parents' participation in physical activity predicts maintenance of some,but not all, types of physical activity in offspring during early adolescence:A prospective longitudinal study

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Journal of Sport and Health Science 2019年第3期8卷 273-279页

作者： Jennifer brunei Jeffrey Gaudet erin K.Wing Mathieu bélanger School of Human Kinetics University of Ottawa Institut du Savoir Montfort (ISM) H?pital Montfort Cancer Therapeutic Program Ottawa Hospital Research Institute (OHRI) Centre de formation medicale du Nouveau-brunswick Universite de Moncton Centre de formation médicale du Nouveau-brunswick Université de Moncton

Purpose: We aimed to examine the longitudinal associations between parents' and youth's participation in physical activity(PA).Methods-: One hundred and ninety youth cuompleted self-admitiistered questionnaires 3 times per year from 2011 to 2015, and their parents completed an interviewer-administered questionnaire during a telephone interview once in2011-2012. Data on youth's and parents' activities were classified as interdependent or coactive/***: Youth with one or both parents who participated in interdependent activities were more likely to maintain participation in interdependent activities(hazard ratio(HR) = 3.63: 95% confidence interval(CI) = 1.30-10.17). Youth's sustained participation in coactive/independent activities was not associated with parents' participation in coactive/independent activities(HR= 0.97; 95%CI=0.46-2.06).Conclusion: Longitudinal associations between parents' and youth's participation in PA differed across type of PA. Encouraging parents' participation in interdependent activities may promote sustained participation in interdependent activities in youth.

关键词： Longitudinal Maintenance Parental behavior Physical activity Sports Youth

Engineering of Materials for Respiratory Protection:Salt-Coated Antimicrobial Fabrics for Their Application in Respiratory Devices

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Accounts of Materials Research 2022年第3期3卷 297-308页

作者： Sumin Han Euna Oh erin Keltie Jong Sung Kim Hyo-Jick Choi Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada Health and Environments Research Centre(HERC) Department of Community Health and EpidemiologyFaculty of MedicineDalhousie UniversityHalifaxNS B3H 4R2Canada

CONSPECTUS:The development of a highly effective,low-cost method for protection against direct transmission through infectious media associated with respiratory diseases has been considered to be a major challenge in the management of the pandemic ***,filtration in respirators and masks depends on the mesh size,raising safety concerns about direct contact with the virus-laden layers of masks and respirators during use and ***,conventional medical face masks and respirators are recommended for single use only because long-term use and reuse of masks increase the risk of contact transmission of *** a result,mask reusability has gained much attention in addressing the global problem of respirator and mask shortages during the COVID-19 ***,coinfection by influenza,SARSCoV-2,and bacteria has been an ongoing issue in the current COVID-19 *** our response to the increasing demand for more convenient forms of disease control,our group has investigated antimicrobial technologies for respiratory devices against pandemic/epidemic diseases and developed two universal antimicrobial coating technologies:(1)nonwashable,reusable salt-coated fabrics and(2)washable,photopolymerizable polymer-coated fabrics which efficiently inactivate infectious viruses by contact with the *** is an opportune time to assess research efforts toward antimicrobial face mask technology for its expected impact on society and the economy.

关键词： gained Application coating

Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases

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Synthetic and Systems biotechnology 2020年第2期5卷 62-80页

作者： erin E.Drufva Elijah G.Hix Constance b.bailey Department of Chemistry University of Tennessee-KnoxvilleKnoxvilleTN37996USA

Modular polyketide synthases(PKSs)are a multidomain megasynthase class of biosynthetic enzymes that have great promise for the development of new compounds,from new pharmaceuticals to high value commodity and specialty *** colinear biosynthetic logic has been viewed as a promising platform for synthetic biology for *** to this colinearity,domain swapping has long been used as a strategy to introduce molecular ***,domain swapping often fails because it perturbs critical protein-protein interactions within the *** our increased level of structural elucidation of PKSs,using judicious targeted mutations of individual residues is a more precise way to introduce molecular diversity with less potential for global disruption of the protein *** we review examples of targeted point mutagenesis to one or a few residues harbored within the PKS that alter domain specificity or selectivity,affect protein stability and interdomain communication,and promote more complex catalytic reactivity.

关键词： Polyketide synthase Site directed mutagenesis Rational design Saturation mutagenesis Synthetic biology Protein engineering