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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu erin Brintnell Hong Chen Ying Mao Guomin Zhou Bo Liao Jinsong Wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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Cognitive function among military veterans with STEM occupations

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Military Medical Research 2024年第2期11卷 308-310页

作者： Justin T.McDaniel Kevin N.Hascup erin R.Hascup Ugochukwu G.Ezigbo Amanda M.Weidhuner Harvey Henson David L.Albright Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technology,engineering,and mathematics(STEM)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(STEM) Animal fluency test Dementia

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保费上涨成为年轻一代新烦恼

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商业周刊（中文版） 2024年第2期 23-24页

作者： erin Lowry 逸思(译) 不详

成年人常常觉得自己面临着没完没了的待办事项,还不得不在知之甚少或毫无经验的情况下做出重大决策——很有可能导致可怕后果。这听上去或许有些夸张,但从买房到选择医疗保险,再到正确填写W-4税表,如果出现失误,都会带来严重经济后果。... 详细信息

成年人常常觉得自己面临着没完没了的待办事项,还不得不在知之甚少或毫无经验的情况下做出重大决策——很有可能导致可怕后果。这听上去或许有些夸张,但从买房到选择医疗保险,再到正确填写W-4税表,如果出现失误,都会带来严重经济后果。也许,决策方面的疲劳感正是许多人。

关键词：疲劳感医疗保险年轻一代成年人

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Elite,transformable haploid inducers in maize

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The Crop Journal 2024年第1期12卷 314-319页

作者： Brent Delzer Dawei Liang David Szwerdszarf Isadora Rodriguez Gonzalo Mardones Sivamani Elumalai Francine Johnson Samson Nalapalli Rachel Egger erin Burch Kerry Meier Juan Wei Xiujuan Zhang Huaping Gui Huaibing Jin Huan Guo Kun Yu Yubo Liu Becky Breitinger Ana Poets Jason Nichols Wan Shi David Skibbe Qiudeng Que Timothy Kelliher Seeds Development Syngenta SeedsJanesvilleWI 53546USA Seeds Research Syngenta Biotechnology China Co.Ltd.Beijing 102206China Centro de Investigación de Cultivos Arica Syngenta R&DArica 1000000Chile Syngenta S.A. Proyecto la SoledadGraneros 2880000Chile Seeds Research Syngenta Crop Protection LLCRTPNC 27709USA Seeds Development Syngenta SeedsSlaterIA 50244USA

The introduction of alleles into commercial crop breeding pipelines is both time consuming and *** technologies that are disrupting traditional breeding processes are doubled haploid(DH)breeding and genome editing(GE).Recently,these techniques were combined into a GE trait delivery system called HI-Edit(Haploid Inducer-Edit).In HI-Edit,the pollen of a haploid inducer line is reprogrammed to deliver GE traits to any variety,obviating recurrent *** HI-Edit to operate at scale,an efficient transformable HI line is needed,but most maize varieties are recalcitrant to transformation,and haploid inducers are especially difficult to transform given their aberrant reproductive *** marker assisted selection and a three-tiered testing scheme,we report the development of new Iodent and Stiff Stalk maize germplasm that are transformable,have high haploid induction rates,and exhibit a robust,genetically-dominant anthocyanin native trait that may be used for rapid haploid *** show that transformation of these elite‘‘HI-Edit”lines is enhanced using the BABYBOOM and WUSCHEL morphogenetic ***,we evaluate the HI-Edit performance of one of the lines against both Stiff Stalk and non-Stiff Stalk *** strategy and results of this study should facilitate the development of commercially scalable HI-Edit systems in diverse crops.

关键词： Zea mays L Doubled haploids Transformation Genome editing QTL

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Engineering of Materials for Respiratory Protection:Salt-Coated Antimicrobial Fabrics for Their Application in Respiratory Devices

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Accounts of Materials Research 2022年第3期3卷 297-308页

作者： Sumin Han Euna Oh erin Keltie Jong Sung Kim Hyo-Jick Choi Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada Health and Environments Research Centre(HERC) Department of Community Health and EpidemiologyFaculty of MedicineDalhousie UniversityHalifaxNS B3H 4R2Canada

CONSPECTUS:The development of a highly effective,low-cost method for protection against direct transmission through infectious media associated with respiratory diseases has been considered to be a major challenge in the management of the pandemic ***,filtration in respirators and masks depends on the mesh size,raising safety concerns about direct contact with the virus-laden layers of masks and respirators during use and ***,conventional medical face masks and respirators are recommended for single use only because long-term use and reuse of masks increase the risk of contact transmission of *** a result,mask reusability has gained much attention in addressing the global problem of respirator and mask shortages during the COVID-19 ***,coinfection by influenza,SARSCoV-2,and bacteria has been an ongoing issue in the current COVID-19 *** our response to the increasing demand for more convenient forms of disease control,our group has investigated antimicrobial technologies for respiratory devices against pandemic/epidemic diseases and developed two universal antimicrobial coating technologies:(1)nonwashable,reusable salt-coated fabrics and(2)washable,photopolymerizable polymer-coated fabrics which efficiently inactivate infectious viruses by contact with the *** is an opportune time to assess research efforts toward antimicrobial face mask technology for its expected impact on society and the economy.

关键词： gained Application coating

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Structure-aware fusion network for 3D scene understanding

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Chinese Journal of Aeronautics 2022年第5期35卷 194-203页

作者： Haibin YAN Yating LV Venice erin LIONG School of Automation Beijing University of Posts and TelecommunicationsBeijing 100876China Interdisciplinary Graduate School Nanyang Technological UniversitySingapore 639798Singapore

In this paper,we propose a Structure-Aware Fusion Network(SAFNet)for 3D scene *** 2D images present more detailed information while 3D point clouds convey more geometric information,fusing the two complementary data can improve the discriminative ability of the *** is a very challenging task since 2D and 3D data are essentially different and show different *** existing methods first extract 2D multi-view image features and then aggregate them into sparse 3D point clouds and achieve superior ***,the existing methods ignore the structural relations between pixels and point clouds and directly fuse the two modals of data without *** address this,we propose a structural deep metric learning method on pixels and points to explore the relations and further utilize them to adaptively map the images and point clouds into a common canonical space for *** experiments on the widely used ScanNetV2 and S3DIS datasets verify the performance of the proposed SAFNet.

关键词： 3D point clouds Data fusion Structure-aware 3D scene understanding Deep metric learning

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Metabolic reprogramming of glial cells as a new target for central nervous system axon regeneration

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Neural Regeneration Research 2022年第5期17卷 997-998页

作者： erin L.Walden Shuxin Li Shriners Hospitals Pediatric Research Center Department of Neural SciencesLewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

After central nervous system(CNS)injury,severed axons fail to regenerate and their disconnections to the original targets result in permanent functional deficits in patients(Mahar and Cavalli,2018).Both the diminished intrinsic regenerative capacity of mature neurons and the inhibitory CNS milieu contribute to the regenerative failure following CNS injury.

关键词： programming system permanent

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Inhaled volatile anesthetics in the intensive care unit

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World Journal of Critical Care Medicine 2024年第1期13卷 28-39页

作者： erin D Wieruszewski Mariam ElSaban Patrick M Wieruszewski Nathan J Smischney Department of Pharmacy Mayo ClinicRochesterMN 55905United States Anesthesiology and Perioperative Medicine Mayo ClinicRochesterMN 55905United States Department of Anesthesiology&Perioperative Medicine Mayo ClinicRochesterMN 55905United States

The discovery and utilization of volatile anesthetics has significantly transformed surgical practices since their inception in the mid-19th ***,a paradigm shift is observed as volatile anesthetics extend beyond traditional confines of the operating theatres,finding diverse applications in intensive care *** the dynamic landscape of intensive care,volatile anesthetics emerge as a promising avenue for addressing complex sedation requirements,managing refractory lung pathologies including acute respiratory distress syndrome and status asthmaticus,conditions of high sedative requirements including burns,high opioid or alcohol use and neurological conditions such as status *** anesthetics can be administered through either inhaled route via anesthetic machines/devices or through extracorporeal membrane oxygenation circuitry,providing intensivists with multiple options to tailor ***,their unique pharmacokinetic profiles render them titratable and empower clinicians to individualize management with heightened accuracy,mitigating risks associated with conventional sedation *** the amounting enthusiasm for the use of these therapies,barriers to widespread utilization include expanding equipment availability,staff familiarity and training of safe *** article delves into the realm of applying inhaled volatile anesthetics in the intensive care unit through discussing their pharmacology,administration considerations in intensive care settings,complication considerations,and listing indications and evidence of the use of volatile anesthetics in the critically ill patient population.

关键词： Anesthesia Critical care Mechanical ventilation Sedation Volatile anesthetics Sedative

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Exploring the anti-cancer effects of Panax notoginseng through network pharmacology and molecular modeling

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Genes & Diseases 2023年第6期10卷 2229-2232页

作者： erin M.Thorpe Michael Kalafatis Yan Xu Department of Chemistry Science and Research CenterCleveland State University2121 Euclid AvenueClevelandOH 44115USA

The second leading cause of death worldwide is *** is a general term that refers to a highly diverse and complex set of over 200 diseases where abnormal cells grow uncontrollably and avoid death.1 These diseases can start almost anywhere within the body and may develop the ability to invade nearby tissues and *** cancer is the byproduct of a unique combination of various genetic and environmental factors.1 Even within the same individual,different cells may possess distinct cancerous mutations which can mutate further over time.

关键词： diseases cancer Cancer

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Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第2期11卷 184-193页

作者： Benjamin Singh Eva M.Zopf erin J Howden Gallipoli Medical Research Foundation Greenslopes Private HospitalGreenslopesQLD 4120Australia Mary MacKillop Institute for Health Research Australian Catholic UniversityMelbourneVIC 3000Australia Baker Heart and Diabetes Institute MelbourneVIC 3004Australia

Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer ***:CINAHL,Cochrane,Ebscohost,MEDLINE,Pubmed,ProQuest Health and Medical Complete,ProQuest Nursing and Allied Health Source,ScienceDirect,and SPORTDiscus databases were searched for randomized controlled trials published before September 1,2020,that evaluated interventions involving wearable devices in cancer *** mean differences(SMDs)were calculated to assess effects on physical activity and health-related *** analyses were conducted to assess whether the effects differed by interventions and cancer *** of bias was assessed using the Cochrane risk of bias ***:Thirty-five trials were included(breast cancer,n=15,43%).Intervention durations ranged between 4 weeks and 1 *** trials(n=25,71%)involved pedometer-based physical activity ***(20%)involved Fitbit-based interventions,and 3(9%)involved other wearable physical activity trackers(e.g.,Polar,Garmin).Compared to usual care,wearable devices had moderate-to-large effects(SMD range 0.54-0.87,p<0.001)on moderate-intensity physical activity,moderate-to-vigorous-intensity physical activity,total physical activity,and daily *** to usual care,those in the intervention had higher quality of life,aerobic fitness,physical function,and reduced fatigue(SMD range=0.18-0.66,all p<0.05).Conclusion:Wearable physical activity trackers and pedometers are effective tools that increase physical activity and improve health-related outcomes in individuals with *** how these devices can be implemented for longer-term use with other intervention components remains an area for future research.

关键词： Activity tracker Cancer Exercise Physical activity Wearable

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