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Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2009年第20期15卷 2520-2525页

作者： Eiji Oki Yan Zhao Rintaro Yoshida Takanobu Masuda Koji Ando Masahiiko Sugiyama eriko tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Department of Gastroenterology National Kyushu Cancer Center 3-1-1 Notame Minarni-ku Fukuoka 811-1395 Japan

AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric ***:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c *** microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct ***:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological *** found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation ***:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of ***, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis.

关键词： Checkpoint with forkhead-associated and ring finger Methylation Microsatellite instability Gastric cancer p53

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Predictors of LGBT Recognition by Health Sciences University Students in Japan

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Open Journal of Nursing 2019年第5期9卷 481-493页

作者： Kyoko Asazawa Ai Inamoto Misaki Suzuki Yukari Ashino Yurina Ishihara Yumu Oba Maki Endo Ayumi Iwata Miki Kishioka Arisa tokunaga Miharu Sumino Natsuko Kojima eriko Shinohara Division of Nursing Faculty of Nursing Tokyo Healthcare University Tokyo Japan

Background: This study aimed to identify the predictors of LGBT recognition by health sciences university students in Japan. Methods: This is a cross-sectional study that used quantitative data collected from 481 returned self-report questionnaires distributed to 866 health sciences undergraduate and graduate students. The following survey item and scales were used for measuring the main outcomes: Thoughts about sexual identity, Empathy scale, Objectivity scale, and LGBT recognition scale. Data were analyzed using descriptive statistics, two-sample t-test, one-way analysis of variance, and multiple regression analyses. SPSS ver. 23.0 (SPSS, Chicago, IL, USA) was used for data analysis at a 5% significance level. Results: The number of returned questionnaires was 481 (55.5%). There was no significant difference in the LGBT recognition and the participant’s characteristics (e.g., age and medical history). The 5 significant predictors of LGBT recognition were: 1) Empathy (β = 0.19, p LGBT learning experience (β = 0.18, p Objectivity (β = 0.15, p Sexual problem with a close person (β = 0.13, p Suffering from gender identity (β = 0.09, p Conclusions: The predictive factors of LGBT recognition were Empathy, LGBT learning experience, Objectivity, Sexual problem with a close person, and Suffering from gender identity. Careful development and implementation of LGBT educational programs are needed to better understand the situations and ideas of LGBT parties to enhance their recognition.

关键词： Sexual and Gender Minorities Recognition Students Health Occupations Cross-Sectional Studies

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