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三种林果枝干腐烂病发病皮层真菌群落比较

西南农业学报 2024年第3期37卷 589-596页

作者：郝海婷王庆朋李猛闫成才代先兴祖丽胡玛尔·麦提喀迪尔塔里木大学农学院/南疆农业有害生物综合治理兵团重点实验室新疆阿拉尔843300

【目的】探究新疆核桃树、苹果树以及杨树枝干发生腐烂病后对枝干皮层真菌群落的影响,为微生物防治腐烂病提供参考依据。【方法】基于高通量ITS扩增子测序方法,以新疆核桃树、苹果树以及杨树3种林果健康枝干作为对照,分别分析3种林果发... 详细信息

【目的】探究新疆核桃树、苹果树以及杨树枝干发生腐烂病后对枝干皮层真菌群落的影响,为微生物防治腐烂病提供参考依据。【方法】基于高通量ITS扩增子测序方法,以新疆核桃树、苹果树以及杨树3种林果健康枝干作为对照,分别分析3种林果发生腐烂病后枝干皮层中真菌群落结构的变化,解析腐烂病与微生物群落的关系。【结果】新疆核桃树、苹果树以及杨树3种林果健康枝干的真菌群落多样性和丰富度都大于发病枝干,表明腐烂病对枝干皮层真菌群落产生了影响。门水平,核桃树、苹果树和杨树健康枝干与感病枝干皮层优势菌门均为子囊菌门(Ascomycota)。属水平,核桃树健康枝干皮层(WH)的优势属为链格孢属(Alternaria),发病枝干皮层(WD)的优势属为隐球壳属(Cryptosphaeria);杨树健康枝干皮层(PH)的优势属为球腔菌属(Mycosphaerella),发病枝干皮层(PD)的优势属为黑腐皮壳属(Valsa);苹果树健康枝干皮层(AH)的优势属为亚隔孢壳属(Didymella),发病枝干皮层(AD)的优势属为层孔菌属(Fomes)和黑腐皮壳属(Valsa)。【结论】发生腐烂病后,新疆核桃树、苹果树以及杨树3种林果枝干皮层真菌群落结构发生改变。该研究可为基于微生物群落的变化防治植物病害提供一定的理论依据。

关键词：扩增子测序真菌多样性核桃树苹果树杨树

Optimal Design of Splitters Attached to Turbo Blower Impeller by RSM

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Journal of Thermal Science 2012年第3期21卷 215-222页

作者： Choon-Man Jang ka-Ram Choi Environmental Engineering Research Division Korea Institute of Construction Technology

This paper describes the optimization of the impeller having splitters for a turbo *** design variables,chord of splitter and pitch of splitter,are introduced to enhance the blower *** pressure and ef-ficiency are selected as an object function,and the optimization of the blower impeller is performed by a response surface method (RSM).Three-dimensional Navier-Stokes equations are introduced to analyze the internal flow of the blower and to find the value of the object function for each *** the shape optimization of the splitters attached to the impeller in the turbo blower,pressure and efficiency at the design flow condition are suc-cessively increased by 5.9 percent and 17.9 percent respectively based on the reference *** higher blower efficiency obtained by optimization of impeller having splitters is mainly caused by reducing the number of im-peller blades and optimal design of splitters in the blade passage while pressure increase keeps almost the same with the reference *** the object function of pressure,pressure increase is obtained at the design and off-design conditions while efficiency keeps higher compared to the reference *** enhancement of blow-er performance is due to the reduction of reverse and circulation flows in the blade passage.

关键词： Turbo Blower Splitter Numerical Simulation Optimal Design Pressure Response Surface Method

Relationship between microorganisms in coronary atheromatous plaques and periodontal pathogenic bacteria

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Chinese Medical Journal 2008年第16期121卷 1595-1597页

作者： ZHANG Yuan-ming ZHONG liang-jun lIANG Ping lIU Hua MU la-ti AI Si-ka-er Centre of Cardiology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Stomatology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China

Inflammation plays an important role in the pathogenesis .of atherosclerosis, and low-grade chronic systemicinflammation is thought to be related to adverse cardiovascular outcomes,In the past decade, epidemiological studies have repeatedly shown an association between coronary heart disease and periodontal disease. Observational studies have shown that periodontitis is associated with an increased risk of myocardial infarction and stroke, although a causal link has not yet been proven.

关键词： cardiovascular diseases periodontitis polymerase chain reaction DNA sequencing

Role of chromosomal instability and clonal heterogeneity in the therapy response of breast cancer cell lines

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Cancer Biology & Medicine 2020年第4期17卷 970-985页

作者： Natalia Vargas-Rondon erika Perez-Mora Victoria E.Villegas Milena Rondon-lagos School of Biological Sciences Universidad Pedagogica y Tecnologica de ColombiaTunja 150003Colombia Biology Program Faculty of Natural SciencesUniversidad del RosarioBogota 111221Colombia

Objective:Chromosomal instability(CIN)is a hallmark of cancer characterized by cell-to-cell variability in the number or structure of chromosomes,frequently observed in cancer cell populations and is associated with poor prognosis,metastasis,and therapeutic *** cancer(BC)is characterized by unstable karyotypes and recent reports have indicated that CIN may influence the response of BC to chemotherapy ***,paradoxical associations between extreme CIN and improved outcome have been ***:This study aimed to 1)evaluate CIN levels and clonal heterogeneity(CH)in MCF7,ZR-751,MDA-MB468,BT474,and KPl4 BC cells treated with low doses of tamoxifen(TAM),docetaxel(DOC),doxorubicin(DOX),Herceptin(HT),and combined treatments(TAM/DOC,TAM/DOX,TAM/HT,HT/DOC,and HT/DOX)by using fluorescence in situ hybridization(FISH),and 2)examine the association with response to treatments by comparing FISH results with cell ***:Intermediate CIN was linked to drug sensitivity according to three characteristics:estrogen receptorα(erα)and Her2 status,pre-existing CIN level in cancer cells,and the CIN induced by the ***α+/Her2-cells with intermediate CIN were sensitive to treatment with taxanes(DOC)and anthracyclines(DOX),while erα-/Her2-,erα+/Her2+,and erα-/Her2+cells with intermediate CIN were resistant to these ***:A greater understanding of CIN and CH in BC could assist in the optimization of existing therapeutic regimens and/or in supporting new strategies to improve cancer outcomes.

关键词： Breast cancer chromosomal instability therapy resistance FISH clonal heterogeneity

Physisorption of Hydrogen in A, X and ZSM-5 Types of Zeolites at Moderately High Pressures

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Chinese Journal of Chemical Physics 2006年第5期19卷 457-462页

作者： Xiao-ming Du er-dong Wu Shenyang National laboratory for Materials Sciences Institute of Metal Research Chinese Academy of Science Shenyang 110016 China

The hydrogen adsorption properties and uptake capacities of the A, X and ZSM-5 types of zeolites were investigated at temperatures of 77, 195 and 293 K and pressures up to 7 MPa, using a conventional volumetric adsorption apparatus. All hydrogen adsorption isotherms were basically type Ⅰ, but the maximum in isotherm, a unique feature of supereritical adsorption, was observed at high pressures of 2-5 MPa at 77 K. The isosteric heats of adsorption were determined from the isotherms and the factors that influence their variations were discussed. Different types of zeolites exhibited remarkably different hydrogen uptake, based on both the framework structure and the nature of the cations present. The highest gravimetrie storage capacity of 2.55wt% was obtained for NaX-type zeolite at 4 MPa and 77 K. In CaA, NaX and ZSM-5 types of zeolites, hydrogen uptakes were proportional to the specific surface areas, which were associated with the available void volumes of the zeolites. A threshold in hydrogen adsorption observed in NaA and ka was attributed to a pore blocking effect by large cations in ka. A ratio of the kinetic diameter of adsorbate to the effective opening diameter of zeolite was used to judge the blocking effect for physisorption.

关键词： Zeolite Hydrogen storage Hydrogen adsorption Adsorption isotherm

Effects of supplementation of green tea extract on the milk performance of peripartal dairy cows and the expression of stress response genes in the liver

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Journal of Animal Science and Biotechnology 2020年第4期11卷 1163-1174页

作者： Denise K.Gessner Corinna Brock lena M.Hof erika Most Christian Koch Klaus Eder Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany Educational and Research Centre for Animal Husbandry Hofgut Neumühle67728 Münchweiler an der AlsenzGermany.

Background: We hypothesised that supplementation of green tea extract(GTE) in dairy cows during the transition period can attenuate proinflammatory conditions and prevent endoplasmic reticulum(er) stress in the liver of these cows. Thirty Holstein cows with an average parity of 3.06(± 1.31, SD) were divided into a control group and a group that received a daily amount of 10 g of GTE from d 7 before the calving day and a daily amount of 20 g of GTE from the day of calving until d 7 of ***: Cows supplemented with GTE did not show differences in energy intake or milk yield in weeks 2–7 of lactation. However, these cows had a lower milk fat concentration and a lower energy corrected milk yield than the control cows and showed a trend of improved energy balance. The relative m RNA concentrations of proinflammatory genes, genes involved in the acute phase reaction and antioxidant genes in the liver in weeks 1, 4 and 7 of lactation were not different between the two groups of cows. The concentrations of α-tocopherol and the Trolox equivalent antioxidant capacity in plasma were not different between the two groups. However, the group supplemented with GTE showed significant reductions of some genes of the unfolded protein response(UPR) in week 1 and a trend of lower liver triacylglycerol(TAG) concentrations in the liver compared to the control ***: This study shows that supplementation of GTE in dairy cows lowers the fat concentration in the milk but overall has no effect on the expression of inflammatory genes and the antioxidative status in dairy cows during early lactation. The finding of reduced m RNA levels of genes involved in the UPR at week 1, however, supports other results showing that supplementation of polyphenols could prevent the development of er stress in the liver of cows during early lactation. The finding of a tendency towards a reduced TAG concentration in the liver of cows supplemented with GTE might be due to an improved ene

关键词： Animal nutrition Cow Green tea extract liver Metabolism Milk performance

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金诺S1500型扫路机特点分析

建筑机械 2006年第21期 112-113页

作者：义马尔·卡里新疆维吾尔自治区交通厅公路管理局哈密公路总段新疆哈密839000

目前,我国公路和市政部门使用的扫路机以国产机型为主,同时也有一定数量的进口扫路车,前者主要用于一般公路和市政部门,后者主要用于以高速公路为主的高等级公路及其它重要路段.

关键词：扫路机成本低扫路车 S1500 养护单位金诺

葡萄籽原花青素对氯化钴诱导的视网膜神经节细胞RGC-5缺氧损伤的保护作用

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浙江大学学报（医学版） 2015年第1期44卷 24-29页

作者：林卡娜林美丽魏尔清浙江大学医学院附属第二医院药剂科浙江杭州310009 浙江大学医学院药理学系浙江杭州310058

目的：探讨体外葡萄籽原花青素对氯化钴致视网膜神经节细胞RGC－5缺氧损伤模型的保护作用。方法：采用氯化钴（400μmol／l）诱导RGC－5细胞化学缺氧损伤，观察葡萄籽原花青素（40μg／ml ）对缺氧的抗损伤作用。以MTT法检测细胞存活率... 详细信息

目的：探讨体外葡萄籽原花青素对氯化钴致视网膜神经节细胞RGC－5缺氧损伤模型的保护作用。方法：采用氯化钴（400μmol／l）诱导RGC－5细胞化学缺氧损伤，观察葡萄籽原花青素（40μg／ml ）对缺氧的抗损伤作用。以MTT法检测细胞存活率；Hoechst 33342荧光染色法观察细胞凋亡情况；以H2 DCFDA荧光法检测细胞内活性氧的变化；实时定量PCR检测细胞Bcl－2、半胱酰胺天冬氨酸蛋白酶（ caspase ）9和caspase 3 mRNA水平。结果：与缺氧对照组比较，葡萄籽原花青素预处理可提高细胞存活率（ P＜0．001）、减少细胞凋亡（ P＜0．001），并减少细胞内的活性氧（ P ＜0．001）；葡萄籽原花青素还显著升高 Bcl－2基因的表达（ P ＜0．001），显著降低caspase 9和caspase 3基因的表达（ P＜0．001）。结论：葡萄籽原花青素对氯化钴诱导的视网膜神经节RGC－5细胞缺氧损伤起保护作用，其保护作用可能与细胞内活性氧减少、Bcl－2基因表达上调及casepase 9和casepase 3基因表达下调有关。

关键词：葡萄/化学原花青素类/药理学钴/药理学视网膜神经节细胞/药物作用缺氧/治疗

Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3108-3118页

作者： Xiang-Na Zhao Yue You Xiao-Ming Cui Hui-Xia Gao Guo-lin Wang Sheng-Bo Zhang lin Yao li-Jun Duan ka-li Zhu Yu-ling Wang li li Jian-Hua lu Hai-Bin Wang Jing-Fang Fan Huan-Wei Zheng er-Hei Dai lu-Yi Tian Mai-Juan Ma Center for Disease Control and Prevention of Chinese People's liberation Army BeijingChina The Walter and Eliza Hall Institute of Medical Research ParkvilleVicAustralia Department of Medical Biology The University of MelbourneParkvilleVicAustralia State Key laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina The Fifth Hospital of Shijiazhuang Hebei Medical UniversityShijiazhuangChina

While some individuals infected by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)present mild-to-severe disease,many SARS-CoV-2-infected individuals are *** sought to identify the distinction of immune response between asymptomatic and moderate *** performed single-cell transcriptome and T-cell/B-cell receptor(TCR/BCR)sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic,moderate,and severe patients with healthy *** patients displayed increased CD56^(bri)CD16^(-) natural killer(NK)cells and upregulation of interferon-gamma in effector CD4^(+) and CD8^(+) T cells and NK *** showed more robust TCR clonal expansion,especially in effector CD4^(+) T cells,but lack strong BCR clonal expansion compared to moderate ***,asymptomatic patients have lower interferon-stimulated genes(ISGs)expression in general but large interpatient variability,whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe *** data provide evidenee of different immune signatures to SARS-CoV-2 in asymptomatic infections.

关键词： patients asymptomatic interferon