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Development of non-nucleoside reverse transcriptase inhibitors(nnRTIs):our past twenty years

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Acta Pharmaceutica Sinica B 2020年第6期10卷 961-978页

作者： Chunlin Zhuang Christophe Pannecouque erik De Clercq Fener Chen Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China Rega Institute for Medical Research KU LeuvenLeuven B-3000Belgium

Human immunodeficiency virus(HIV)is the primary infectious agent of acquired immunodeficiency syndrome(AIDS),and non-nucleoside reverse transcriptase inhibitors(nnRTIs)are the cornerstone of HIV *** the last 20 years,our medicinal chemistry group has made great strides in developing several distinct novel nnRTIs,including 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine(HEPT),thio-dihydro-alkoxy-benzyl-oxopyrimidine(S-DABO),diaryltriazine(DATA),diarylpyrimidine(DAPY)analogues,and their hybrid *** of integrated modern medicinal strategies,including structure-based drug design,fragment-based optimization,scaffold/fragment hopping,molecular/fragment hybridization,and bioisosterism,led to the development of several highly potent analogues for further *** this paper,we review the development of nnRTIs in the last two decades using the above optimization strategies,including their structure-activity relationships,molecular modeling,and their binding modes with HIV-1 reverse transcriptase(RT).Future directions and perspectives on the design and associated challenges are also discussed.

关键词： HIV-1 nnRTIs HEnTs S-DABOs DATAs DAPYs Structure-based optimization Fragment-based drug design Molecular hybridization Bioisosterism

Comparative Literature:Issues and Prospect——An Interview with Professor Svend erik Larsen

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Comparative Literature:East & West 2016年第1期 141-146页

作者： Cha ZHAnG Svend erik LARSEn Sichuan normal University Aarhus University

本文是对奥尔胡斯大学比较文学教授斯文德·埃里克·拉森就比较文学的若干问题所作的专题访谈。拉森教授在此访谈中大致回顾了比较文学学科发展的历史演变情况,指出了当今比较文学研究中存在的相关问题。他在肯定中国学者出版的比较文... 详细信息

本文是对奥尔胡斯大学比较文学教授斯文德·埃里克·拉森就比较文学的若干问题所作的专题访谈。拉森教授在此访谈中大致回顾了比较文学学科发展的历史演变情况,指出了当今比较文学研究中存在的相关问题。他在肯定中国学者出版的比较文学理论专著《比较文学变异学理论》的学术价值的同时,反思了比较文学中国学派的建立问题,提出了比较文学研究者应该具备的基本素养并表达了对中国比较文学研究者,特别是中国年轻一代比较文学研究者的深切期望。

关键词：拉森演变情况中国学派理论专著文学研究者专题访谈 Larsen scholar 埃里克 discipline

Review:Protein folding pathology in domestic animals

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2004年第10期 60-72页

作者： GRUYS erik Department of Pathobiology The netherlands Faculty of Veterinary Medicine Utrecht University Section of Domestic Animal Pathology Utrecht

Fibrillar proteins form structural elements of cells and the extracellular matrix. Pathological lesions of fibrillar microanatomical structures, or secondary fibrillar changes in globular proteins are well known. A special group concerns histologically amorphous deposits, amyloid. The major characteristics of amyloid are: apple green birefringence after Congo red staining of histological sections, and non-branching 7-10 nm thick fibrils on electron microscopy revealing a high content of cross beta pleated sheets. About 25 different types of amyloid have been characterised. In animals, AA-amyloid is the most frequent type. Other types of amyloid in animals represent: AIAPP (in cats), AApoAI, AApoAII, localised AL-amyloid, amyloid in odontogenic or mammary tumors and amyloid in the brain. In old dogs Ap and in sheep APrPsc-amyloid can be encountered. AA-amyloidosis is a systemic disorder with a precursor in blood, acute phase serum amyloid A (SAA). In chronic inflammatory processes AA-amyloid can be depos

关键词： Extracellular fibrils Amyloid Amyloid enhancing factor Prion PrP Spongiform encephalopathy Alzheimer’s disease

S-Adenosyl-L-methionine towards hepatitis C virus expression: need to consider S-Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics

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World Journal of Gastroenterology 2017年第40期23卷 7343-7346页

作者： Dimitrios Tsikas erik Hanff Alexander Bollenbach Core Unit Proteomics Hannover Medical School

S-Adenosyl-L-methionine(SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated.

关键词： S-Adenosyl-L-methionine Bioavailability Concentration Liver

VIGE:virus-induced genome editing for improving abiotic and biotic stress traits in plants

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Stress Biology 2022年第1期2卷 675-684页

作者： Irene n.Gentzel erik W.Ohlson Margaret G.Redinbaugh Guo-Liang Wang Department of Plant Pathology The Ohio State UniversityColumbusOH 43210USA USDA Agricultural Research ServiceCornSoybean and Wheat Quality Research UnitWoosterOH 44691USA

Agricultural production is hampered by disease,pests,and environmental *** minimize yield loss,it is important to develop crop cultivars with resistance or tolerance to their respective biotic and abiotic *** techniques are not optimized for many species and desirable cultivars may not be amenable to genetic transformation,necessitating inferior cultivar usage and time-consuming introgression through backcrossing to the preferred *** these limitations will greatly facilitate the development of disease,insect,and abiotic stress tolerant *** such avenue for rapid crop improvement is the development of viral systems to deliver CRISPR/Cas-based genome editing technology to plants to generate targeted beneficial *** delivery of genomic editing constructs can theoretically be applied to span the entire host range of the virus utilized,circumventing the challenges associated with traditional transformation and breeding *** we explore the types of viruses that have been optimized for CRISPR/Cas9 delivery,the phenotypic outcomes achieved in recent studies,and discuss the future potential of this rapidly advancing technology.

关键词： Biotic stress Abiotic stress CRISPR/Cas9 Plants Virus Gene editing

Approximation of partially smooth functions

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Science China Mathematics 2008年第4期51卷 553-561页

作者： John erik FORn/ESS Erlend Fornaess WOLD Mathematics Department The University of Michigan Mathematisches Institut Universit■t Bern

In this paper we discuss approximation of partially smooth functions by smooth functions. This problem arises naturally in the study of laminated currents.

关键词： approximation currents test functions 57R30 32U40

Influence of oil viscosity on oil-water core-annular flow through a horizontal pipe

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Petroleum 2019年第2期5卷 199-205页

作者： erik van Duin Ruud Henkes Gijs Ooms m.burgerscentrum delft university of technologyfaculty of mechanicalmaritimeand materials engineering(3me)laboratory for aero-&hydrodynamicsmekelweg 22628 sc delftthe netherlands shell projects and technology po box 380001030 bn amsterdamthe netherlands

An experimental study has been made of oil-water core-annular flow in a horizontal pipe with special attention for the influence of the oil viscosity on the pressure *** that purpose a heating system has been installed and configured that is able to control the oil temperature,such that the oil viscosity could be varied between 3000 cSt at 20C and 400 cSt at 50*** oil flow rate was kept at a constant value of 0.35 l/s,whereas the watercut was varied between 9%and 25%.The measured pressure drop is scaled with the calculated pressure drop of only oil flowing at the same flow rate and *** main conclusion is that for a large oil viscosity the scaled pressure drop is almost independent of the watercut,whereas with decreasing viscosity the scaled pressure drop becomes strongly dependent on the *** of the oil-water interface shows a more irregular wave shape with smaller wave lengths when the viscosity is *** is very good agreement between the predictions of the model of Ullmann&Brauner for the scaled pressure drop and the measurements.

关键词： viscosity flow annular

Fecal microbiome of growing pigs fed a cereal based diet including chicory(Cichorium intybus L.) or ribwort(Plantago lanceolata L.) forage

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Journal of Animal Science and Biotechnology 2016年第2期7卷 167-175页

作者： Johan Dicksved Janet K.Jansson Jan erik Lindberg Department of Animal nutrition and Management Swedish University of Agricultural Sciences Department of Microbiology Swedish University of Agricultural Sciences Division of Biology Earth and Biological Sciences Pacific Northwest National Laboratories

Background： The purpose of this study was to investigate how inclusion of chicory forage or ribwort forage in a cereal-based diet influenced the fecal microbial community（microbiome） in newly weaned（35 days of age） *** piglets were fed a cereal-based diet without（B） and with inclusion（80 and 160 g/kg air-dry forage） of vegetative shoots of chicory（C） and leaves of ribwort（R） forage in a 35-day growth trial. Fecal samples were collected at the start（D0）, 17（D17） and 35（D35） days after weaning and profiles of the microbial consortia were generated using terminal restriction fragment length polymorphism（T-RFLP）. 454-FLX pyrosequencing of 16 S r RnA gene amplicons was used to analyze the microbial composition in a subset of the samples already analyzed with ***： The microbial clustering pattern was primarily dependent on age of the pigs, but diet effects could also be observed. Lactobacilli and enterobacteria were more abundant at D0, whereas the genera Streptococcus, Treponema,Clostridium, Clostridiaceae1 and Coprococcus were present in higher abundances at D35. Pigs fed ribwort had an increased abundance of sequences classified as Treponema and a reduction in lactobacilli. However, the abundance of Prevotellaceae increased with age in on both the chicory and the ribwort diet. Moreover, there were significant correlations between the abundance of Bacteroides and the digested amount of galactose, uronic acids and total non-starch polysaccharides, and between the abundance of Bacteroidales and the digested amount of ***： This study demonstrated that both chicory and ribwort inclusion in the diet of newly weaned pigs influenced the composition of the fecal microbiota and that digestion of specific dietary components was correlated with species composition of the microbiota. Moreover, this study showed that the gut will be exposed to a dramatic shift in the microbial community structure several weeks after weaning.

关键词： Amplicon sequencing Chicory Microbiome Ribwort Uronic acid Weaning 16S

Use of Standard Operating Procedures for Supporting Cross-Organizational Emergency Management: Challenges and Opportunities Identified from a Tabletop Exercise

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International Journal of Disaster Risk Science 2024年第05期15卷 673-687页

作者： Kristine Steen-Tveit Bj?rn erik Munkvold Kjetil Rustenberg Department of Information Systems Centre for Integrated Emergency ManagementUniversity of Agder

This study investigated the crucial role of formulating and applying standard operating procedures(SOPs) in the context of emergency planning and response. The effective application of SOPs during operations is essential in order to address challenges that surpass individual organizational capacities. A specific focus on fostering efficient information sharing and executing specified actions maximizes the prospect of success. To explore the collective functionality of SOPs across organizations, we conducted a comprehensive tabletop exercise involving 10 organizations spanning tactical, operational,and strategic levels. Our analysis identified six key challenges, primarily related to the structures for information sharing,communication pathways, and the complex integration and application of common SOPs within these diverse organizational contexts. This research contributes insights into the use of SOPs in large-scale, cross-organizational scenarios.

关键词： Cross-organizational emergency management Standard operating procedures Tabletop exercise Team situational awareness