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Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer

World Journal of Gastrointestinal Oncology 2021年第12期13卷 1997-2012页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Hernan Araya erik morales Milibeth Gómez Nelson Urdaneta Paulina Araya Miguel Angel morales Biomedical Research Lab. Medicine FacultyCatholic University of MauleTalca 34600000Chile Department of Clinical Sciences Medicine FacultyCatholic University of MauleTalca 34600000Chile Servicio de Oncología Hospital Regional de TalcaTalca 34600000Chile Servicio de Anatomía Patologica Hospital Regional de TalcaTalca 34600000Chile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus(DM)as a risk factor associated with increased cancer incidence and mortality in many human neoplasms,including gastric cancer(GC).DM is considered a systemic inflammatory disease and therefore,this inflammatory status may have profound effects on the tumor microenvironment(TME),particularly by driving many molecular mechanisms to generate a more aggressive *** is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix(ECM),leading to an increased ECM ***,DM can alter many cellular signaling mechanisms and thus favoring tumor growth,invasion,and metastatic potential,as well as key elements in regulating cellular functions and cross-talks,such as the microRNAs network,the production,and cargo of exosomes,the metabolism of cell stroma and resistance to *** the present review,we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC.

关键词： Diabetes mellitus Gastric cancer Tumor microenvironment Hyperglycemia Chronic inflammation

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Diabetes and cancer:Looking at the multiligand/RAGE axis

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World Journal of Diabetes 2011年第7期2卷 108-113页

作者： Armando Rojas Ileana González erik morales Ramón Pérez-Castro Jacqueline Romero Héctor Figueroa Biomedical Research Labs. Medicine FacultyCatholic University of Maule

The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many *** the association is not fully understood,current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms,including hyperinsulinemia,hyperglycemia and chronic *** this context,the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor *** high-light how RAGE,once activated,as it manifests itself in conditions such as diabetes or hyperglycemia,is able to continuously bring about an inflammatory milieu,thus supporting the contribution of chronic inflammation to the development of malignancies.

关键词： Diabetes Cancer Inflammation Receptor for advanced glycation end-products Malignant transformation

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Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González Cristian Lindner Ivan Schneider erik Diaz Miguel Angel morales Armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

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