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Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity

Journal of Animal Science and Biotechnology 2021年第3期12卷 1125-1137页

作者： Xiangqi Fan Haiyan Hu Daiwen Chen Bing Yu Jun He Jie Yu Junqiu Luo erik eckhardt Yuheng Luo Jianping Wang Hui Yan Xiangbing Mao Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Key laboratory of Animal Disease-resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey laboratory of Animal Disease-resistant Nutrition of Sichuan ProvinceInstitute of Animal NutritionSichuan Agricultural UniversityNo.211Gongpinghuimin RoadWenjiang DistrictChengdu 611130Sichuan ProvincePeople’s Republic of China Adisseo SAS Center of Excellence and Research in Nutrition03600 MalicorneFrance

Background:Lentinan(LNT)may regulate many important physiological functions of human and *** study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus(RV)-challenged weaned ***:Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d(n=14).RV infection was executed on d *** extracting polysaccharides from LNT product,its major monosaccharides were ***,LNT polysaccharide was used to administrate RV-infected IPEC-J2 ***:Dietary LNT supplementation supported normal function of piglets even when infected with RV,as reflected by reduced growth performance loss and diarrhea prevalence,and maintained gut immunity(P<0.05).The polysaccharide was isolated from LNT product,which molecular weight was 5303 Da,and major monosaccharides included glucose,arabinose and *** RV-infected IPEC-J2 cells,this polysaccharide significantly increased cell viability(P<0.05),and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides(P<0.05).Conclusion:Those results suggest that LNT administration increases the piglets’resistance to RV-induced stress,likely by supporting intestinal immunity.

关键词： Gut immunity IPEC-J2 cells Lentinan Rotavirus Weaned pigs

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一场关于对比的讨论洛杉矶Departamento零售店

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室内设计与装修 2025年第1期 78-83页

作者：无 erik Stackpole Undehn(摄影) coco(编译) 22RE 不详

总部位于洛杉矶的多学科事务所22RE受豪华男装多品牌零售商Departamento邀请,为其在洛杉矶的最新店面进行设计。该店位于洛杉矶市中心的建筑零售飞地Signal内,是加州高档生活方式和设计品牌的聚集地。与现有的Departamento店面类似,顾... 详细信息

总部位于洛杉矶的多学科事务所22RE受豪华男装多品牌零售商Departamento邀请,为其在洛杉矶的最新店面进行设计。该店位于洛杉矶市中心的建筑零售飞地Signal内,是加州高档生活方式和设计品牌的聚集地。与现有的Departamento店面类似,顾客通过位于Concierge Coffee的隐蔽入口进入店面后,会发现自己置身于一个由镜面墙壁组成的入口。通过这种俏皮的方式将顾客带入店内。

关键词：洛杉矶设计品牌零售商店面事务所零售店

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Possible role of power-to-vehicle and vehicle-to-grid asstorages and flexible loads in the German 110 kV distributiongrid

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Frontiers in Energy 2017年第2期11卷 146-154页

作者： erik BLASIUS Department for Energy Distribution and High Voltage Engineering Brandenburg University of Technology Cottbus-Senflenberg 03046Cottbus Germany

The sectoral coupling of road traffic (in form of E-Mobility) and electrical energy supply (known as power-to-vehicle (P2V), vehicle-to-grid (V2G) is discussed as one of the possible development concepts for the flexible system integration of renewable energy sources (RES) and the support of the objectives of the German energy transition (aka. Energiewende). It is obvious that E-mobility, which shall produce as few emissions as possible, should be based on the exclusive use of renewable energies. At the same time, the E-mobility can help to reduce the negative effects of the grid integration of RES to the distribution grids. However, this assumes that the electric vehicles are smart integrated to the grids where they charge, meaning that they must be able to communicate and be controllable. Because per se unplanned and uncontrollable charging processes are harmful for the grid operation, especially if they occur frequently and unexpected in similar time periods, the effects can hardly be controlled and can lead to serious technical problems in practical grid operation. This paper provides an insight into the current development of E-mobility in Germany. The insight will be matched with the German development of the RES. By the combination of both sectors, the possible role of the E-mobility for the distribution grid will be depicted, which can have positive and negative aspects.

关键词： P2V V2G grid integration electric vehicles distribution grid

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Real-time performance of DAE and ODE based estimators evaluated on a diesel engine

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Science China(Information Sciences) 2018年第7期61卷 27-39页

作者： erik H?CKERDAL erik FRISK Lars erikSSON Scania CV AB Vehicular Systems Link?ping University

Computation and sampling time requirements for real-time implementation of observers is studied. A common procedure for state estimation and observer design is to have a system model in continuous time that is converted to sampled time with Euler forward method and then the observer is designed and implemented in sampled time in the real time system. When considering state estimation in real time control systems for production there are often limited computational resources. This becomes especially apparent when designing observers for stiff systems since the discretized implementation requires small step lengths to ensure stability. One way to reduce the computational burden, is to reduce the model stiffness by approximating the fast dynamics with instantaneous relations, transforming an ordinary differential equations(ODE)model into a differential algebraic equation(DAE) model. Performance and sampling frequency limitations for extended Kalman filter(EKF)'s based on both the original ODE model and the reduced DAE model are here analyzed and compared for an industrial system. Furthermore, the effect of using backward Euler instead of forward Euler when discretizing the continuous time model is also analyzed. The ideas are evaluated using measurement data from a diesel engine. The engine is equipped with throttle, exhaust gas recirculation(EGR), and variable geometry turbines(VGT) and the stiff model dynamics arise as a consequence of the throttle between two control volumes in the air intake system. The process of simplifying and modifying the stiff ODE model to a DAE model is also discussed. The analysis of the computational effort shows that even though the ODE, for each time-update, is less computationally demanding than the resulting DAE, an EKF based on the DAE model achieves better estimation performance than one based on the ODE with less computational effort. The main gain with the DAE based EKF is that it allows increased step lengths without degrading the

关键词： estimation learning DAE ODE EKF observability real-time

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Efficacy of anticoagulant-free alternative bait products against house mice(Mus musculus)and brown rats(Rattus norvegicus)

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Integrative Zoology 2010年第1期5卷 44-52页

作者： erik SCHMOLZ Federal Environmental Agency BerlinGermany

The attractiveness and efficacy of four anonymous anticoagulant-free alternative rodenticides(active ingredients cellulose or plaster)were tested on wild strain groups of house mice(Mus musculus Linnaeus)and brown rats(Rattus norvegicus Berkenhout)in laboratory choice and no-choice *** no-choice tests,the rodenticide product was offered ad libitum to the animals for 21 days(mice)and 10 days(rats),*** choice tests,the rodenticide product and non-poisoned food were offered for 28 days(mice)and 14 days(rats).Two products with cellulose(C1 and C2)as the active ingredient were tested against both mice and *** two no-choice tests with mice,all animals died within 14 days(C1)and 21 days(C2);in a third no-choice test,11%(2/18)of mice survived(C1:21 days).In all three tests,numerous incidents of cannibalism were *** attractiveness of cellulose baits was tested for one product(C1)in three trials against normal food *** all trials,bait consumption was low and all mice survived(15-34 days).Two no-choice trials with cellulose baits(C1)were conducted on groups of Rattus norvegicus;11 of 12 rats survived the bait feeding period and no cannibalism or sign of aggression between conspecifics was *** plaster-based(CaSO_(4)·0.5H_(2)O)products(P1 and P2)were tested against both mice and rats;in no-choice tests,only one mouse(n=20)and no rats(n=8)were killed,although the baits proved to be attractive for rats and mice in choice *** results of these experiments suggest that neither cellulose-based nor plaster-based rodenticides are suitable agents for the control of Mus musculus and Rattus norvegicus.

关键词： cellulose Mus musculus plaster Rattus norvegicus rodenticides

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Atomistic simulations of plasma catalytic processes

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 145-154页

作者： erik C. Neyts Research Group PLASMANT Department of Chemistry University of Antwerp Universiteitsplein 1 2610 Wilrijk-Antwerp Belgium

There is currently a growing interest in the realisation and optimization of hybrid plasma/catalyst systems for a multitude of applications, ranging from nanotechnology to environmental chemistry. In spite of this interest, there is, however, a lack in fundamental understanding of the underlying processes in such systems. While a lot of experimental research is already being carded out to gain this understanding, only recently the first simulations have appeared in the literature. In this contribution, an overview is presented on atomic scale simulations of plasma catalytic processes as carried out in our group. In particular, this contribution focusses on plasma-assisted catalyzed carbon nanostructure growth, and plasma catalysis for greenhouse gas conversion. Attention is paid to what can routinely be done, and where challenges persist.

关键词： atomic scale simulation plasma-catalyst

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Inverse Ising techniques to infer underlying mechanisms from data

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Chinese Physics B 2020年第8期29卷 1-23页

作者： Hong-Li Zeng erik Aurell School of Science New Energy Technology Engineering Laboratory of Jiangsu ProvinceNanjing University of Posts and TelecommunicationsNanjing 210023China Nordita Royal Institute of Technologyand Stockholm UniversitySE-10691 StockholmSweden KTH-Royal Institute of Technology AlbaNova University CenterSE-10691 StockholmSweden Faculty of Physics Astronomy and Applied Computer ScienceJagiellonian University30-348 KrakowPoland

As a problem in data science the inverse Ising(or Potts)problem is to infer the parameters of a Gibbs-Boltzmann distributions of an Ising(or Potts)model from samples drawn from that *** algorithmic and computational interest stems from the fact that this inference task cannot be carried out efficiently by the maximum likelihood criterion,since the normalizing constant of the distribution(the partition function)cannot be calculated exactly and *** practical interest on the other hand flows from several outstanding applications,of which the most well known has been predicting spatial contacts in protein structures from tables of homologous protein *** applications to date have been to data that has been produced by a dynamical process which,as far as it is known,cannot be expected to satisfy detailed *** is therefore no a priori reason to expect the distribution to be of the Gibbs-Boltzmann type,and no a priori reason to expect that inverse Ising(or Potts)techniques should yield useful *** this review we discuss two types of problems where progress nevertheless can be *** find that depending on model parameters there are phases where,in fact,the distribution is close to Gibbs-Boltzmann distribution,a non-equilibrium nature of the under-lying dynamics *** also discuss the relation between inferred Ising model parameters and parameters of the underlying dynamics.

关键词： inverse Ising problem kinetic Ising model statistical genetics fitness reconstruction

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An Odyssey in antiviral drug development—50 years at the Rega Institute:1964–2014

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Acta Pharmaceutica Sinica B 2015年第6期5卷 520-543页

作者： erik De Clercq Rega Institute for Medical Research

*** it started I entered the Rega Institute for Medical Research in August 1964,as a medical student,to start working under the guidance of *** De Somer,then professor of microbiology at the Leuven School of *** I gra... 详细信息

关键词： erik De Clercq Antiviral drug Poly(I) poly(C) Polyacrylic acid Interferon Reverse transcriptase Suramin Valaciclovir Brivudin Stavudine Tenofovir disoproxil fumarate(TDF) Truvada~ Atripla~ Complera~/Eviplera~ Stribild~ FV-100 Mozobil~ Tenofovir alafenamide(TAF) Holy's legacy Sofosbuvir

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Two-Body Local-Momentum Approximation of Spinless Particles Scattered by a (1+1)-D Woods–Saxon Barrier Potential

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Communications in Theoretical Physics 2017年第6期67卷 619-625页

作者： Karl-erik Thylwe KTH-Mechanics Royal Institute of Technology

A local momentum(LM) approximation applicable to semi-relativistic two-body repulsive interactions is presented. It assumes negligible variations in the(vector-type) potential. A Woods–Saxon barrier with a rectangularlike shape is studied in some detail. The LM-approximation gives exact results within the semi-relativistic framework for rectangular barrier interactions in(1+1) dimensions. Further approximations of the local momentum approach leads to the two-body approximation of Ikhdair & Sever, known since the early 90's as the spinless Salpeter equation approximating the Bethe–Salpeter equation. LM-and GS-results indicate significant two-body effects. Results obtained from the(single-mass) Dirac equation are similar for certain two-body mass combinations.

关键词： two-body effects semi-relativistic barrier transmission

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A comparative genomic framework for the fish-tetrapod transition

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Science China(Life Sciences) 2021年第4期64卷 664-666页

作者： Per erik Ahlberg Department of Organismal Biology Uppsala University75236 UppsalaSweden

The evolution of tetrapods(land vertebrates)from lobe-finned fishes,nearly 400 million years ago,was a hugely important *** one thing,if these ancient fishes had not found a way to adapt to life out of the water,we humans would not *** investigate this event we can look at the fossil record,but that only tells us about changes in the skeleton.

关键词： skeleton record fish

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