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World Journal of Pediatrics 2022年第7期18卷 498-504页

作者： Janaina Fortes Lino Llian Martins Oliveira Diniz Debora Marques de Miranda daniela Valadao Freitas Rosa Nathalia Gualberto Souza e silva Eduardo de Souza Nicolau Larissa Goncalves Rezende Lais silva Carvalho Marianna Fischer de Paula Lopes Luisa Petri Correa Gabriela Mafra de Oliveira Flavia Miranda da silva Alves Lorena Batista Pascoal Erika lima Dolabella Teixeira da Costal Leni Marcia Anchieta Roberta Maia de Castro Romaneli Odete Valadares Maternity Hospital Belo HorizonteBrazil Pediatrics Department.Faculy of Medice of Federal University of Minas Gerais Belo Horizonte.Brazil Molecular Laboratory of the INCT-MM.Faculy of Medicine.Federal University of Minas Gerais-UFMG.Belo Horizonte Brazil Faculty of Medicine.Federal University of Minas Gerais-UFMG Belo Horizonte.Brazil Risoleta Tolentino.Neves University Hospital's Maternity Belo HorizonteBrazil Sofia Feldman Maternity Hospital Belo HorizonteBrazil Hospital das Clinicas Maternity-Federal University of Minas Gerais.Belo Horizonte Brazil Pediatrics Department of Federal University of Minas Gerais School Medicine.Minas Gerais.Av Professor Alfredo Balena 190.Belo Horizonte 30130-100Brazil

Cytomegalovirus is the most frequent agent of congenital viral infections,affecting approximately 0.2%-2.4%of live births in different countries[1-7].Universal screening for congenital cytomegalovirus infection in newborns is not a standard practice considering cost-benefit issues and viabil-ity of diagnostic ***,most newborns are asympto-matic and there is no effective treatment for this population[2-5].

关键词： weight birth characteristics

Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

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Journal of Pharmaceutical Analysis 2022年第3期12卷 424-435页

作者： Ihatanderson A.silva Ana Luiza lima Tais Gratieri Guilherme M.Gelfuso Livia L.Sa-Barreto Marcilio Cunha-Filho Laboratory of Food Drugand Cosmetics(LTMAC)School of Health SciencesUniversity of Brasilia70910-900BrasíliaDFBrazil Faculty of Ceilandia University of Brasilia(UnB)72220-900BrasíliaDFBrazil

One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high *** work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,tested regarding their morphology and thermal,crystallographic,and spectroscopic ***,despite the strong drug-polymer interactions observed,the chemical stability of the model drugs was preserved under such *** fact,in the metoprolol and Soluplus®composition,the drug's solubilization in the polymer produced a delay in the drug decomposition,suggesting a protective effect of the *** and polyvinyl alcohol mixture,in turn,showed unmistakable signs of thermal instability and chemical decomposition,in addition to physical *** the presented context,establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.

关键词： Three-dimensional printing Preformulation Hot-melt extrusion Thermal analysis Drug-polymer compatibility

Assessing physical habitat structure and biological condition in eastern Amazonia stream sites

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Water Biology and Security 2023年第2期2卷 23-31页

作者： Jady Vivia Almeida da silva Santos Myllena lima Josinete Sampaio Monteles daiany Larissa Ribeiro Carrera Ana Paula Justino de Faria Leandro Schlemmer Brasil Leandro Juen Faculdades de Ciencias Biologicas Instituto de Ciencias BiologicasUniversidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Laboratorio de Ecologia e Conservacao Universidade Federal do Para/Rua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-graduacao em Zoologia Universidade Federal do Para/Museu Paraense Emílio GoeldiRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-graduacao em Ecologia Universidade Federal do Para e Embrapa Amazonia OrientalRua Augusto CorreiaNº1Bairro GuamaCEP66075-110BelemParaBrazil Programa de Pos-Graduacao em Agricultura e Ambiente Laboratorio de Ciencias Ambientais e BiodiversidadeUniversidade Estadual do MaranhaoSao LuísBrazil Instituto de Ciencias Biologicas e Saúde Universidade Federal do Mato GrossoCampus AraguaiaPontal do AraguaiaMato GrossoBrazil

The advance of agricultural frontiers and industrialization in Amazonia has increased natural resource deterioration,resulting in degraded physical habitat structure and reduced local aquatic *** evaluated the relative sensitivities of the Biological Monitoring Working Party(BMWP)and Average Score Per Taxon(ASPT)biotic indexes based on EPT(Ephemeroptera,Plecoptera,Trichoptera)versus EPT taxa richness,EPT abundance,and Shannon-Wiener EPT diversity for evaluating anthropogenic impacts on Amazonian *** expected that EPT-BMWP and EPT-ASPT would be more sensitive in detecting environmental changes on stream biota than the other *** sampled 32 stream sites in eastern Amazonia distributed along an environmental gradient resulting from different land use *** the biological metrics except EPT-ASPT were significantly responsive to anthropogenic pressures;however,EPT taxa richness was slightly more responsive.

关键词： Land use Aquatic insects Biotic index Environmental monitoring

Giant squamous cell carcinoma of the gallbladder: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2787-2793页

作者： Marcelo AF Ribeiro Junior Murillo de lima Favaro Stephanie Santin Cintia Magalhaes silva Ana Paula Marconi Iamarino Department of Acute Care and Trauma Surgery Hospital MoriahSao Paulo 04081000Brazil Department of Surgery University of Santo AmaroSao Paulo 04829- 300Brazil Department of Surgery Hospital MoriahUniversity of Santo AmaroSao Paulo 04829-300Brazil Medical Student University of Santo AmaroSao Paulo 04829-300Brazil Department of Surgery Hospital MoriahHospital MoriahSao Paulo 04829-300Brazil

BACKGROUND Gallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy. CASE SUMMARY A 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery. CONCLUSION Squamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor.

关键词： Squamous cell Carcinoma Gallbladder neoplasm Treatment Case report

Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation:A Systematic Review

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Chinese Journal of Integrative Medicine 2023年第3期29卷 268-279页

作者： Guilherme Vinicio de Sousa silva Ana Luiza Vieira Ferreira Guimaraes Lopes Isis Carolina Viali Lucas Zannini Medeiros lima Matheus Ribeiro Bizuti Fabiana Brum Haag Débora Tavares de Resende e silva Department of Medicine Federal University of Fronteira SulChapecóSanta CatarinaBrazil Department of Nursing Federal University of Fronteira SulChapecóSanta CatarinaBrazil Department of Graduate Studies in Biomedical Sciences Federal University of Fronteira SulChapecóSanta CatarinaBrazil

Cancers have high morbidity and mortality rates *** anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of *** is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant ***,drugs aimed at autophagy can function as antitumor *** are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in *** this review,the systematic search strategy was used,which included the search for descriptors"flavonoids"AND"mTOR pathway"AND"cancer"AND"autophagy",in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January *** current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor *** demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration ***42021243071 at PROSPERO)

关键词： anti-cancer effects apoptosis cell proliferation cell survival flavonoids

Impacts of land use and land cover changes on hydrological processes and sediment yield determined using the SWAT model

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International Journal of Sediment Research 2022年第1期37卷 54-69页

作者： Edivaldo Afonso de Oliveira Serr?o Madson Tavares silva Thomás Rocha Ferreira Lorena Concei??o Paiva de Ataide Cleber Assis dos Santos Aline Maria Meiguins de lima Vicente de Paulo Rodrigues da silva Francisco de Assis Salviano de Sousa Denis José Cardoso Gomes Academic Unit of Atmospheric Sciences Federal University of Campina Grande Department of Physics Center for Natural and Exact Sciences Federal University of Santa Maria Institute of Technology Civil Engineering Graduate Program Federal University of Pará Earth System Science Center National Institute of Space Research Institute of Geosciences Federal University of Pará

Land use and land cover (LULC) changes strongly affect local hydrology and sediment *** current study focused on a basin in the Brazilian Amazon and had the following three objectives:(1) to perform an effective diagnosis of flow and sediment yield,(2) to evaluate the impacts of LULC changes over the last 40 years on the hydro-sedimentological variables,and (3) to investigate the impacts of the possible trends or breaking points in the flow,surface runoff,and sediment yield *** Soil and Water Assessment Tool (SWAT) model validation showed that the simulated results were consistent with the data measured in the dynamic reproduction of flow ***,changes in LULC altered surface runoff,sediment yield,and flow according to the Mann-Kendall and Pettitt non-parametric *** was also observed that the sub-basins in which pastureland is predominant are more susceptible to increased surface runoff and sediment *** to trend and homogeneity tests,these sub-basins had break points in the time series of these *** the other hand,in the sub-basins whose land cover is predominantly forest,the time series is homogeneous and *** current study highlighted the impacts that 40 years of LULC changes in an Amazonian basin had on hydro-sedimentological variables,which,in turn,can play an important role in changing the hydrological cycle,consequently these changes can also impact diverse human activities in the region,such as agribusiness,livestock,energy production,food security,and public water ***,it is concluded that the SWAT model is a good estimator of hydro-sedimentological processes in Amazonian basins and can be used by decision makers in the management of water and environmental resources.

关键词： Hydrological modeling Sediment yield Amazon basin SWAT model

Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives

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World Journal of Clinical Pediatrics 2022年第2期11卷 105-119页

作者： Maria Luísa Cordeiro Santos Ronaldo Teixeira da silva Júnior Breno Bittencourt de Brito Filipe Antônio França da silva Hanna Santos Marques Vinícius lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use.

关键词： Functional abdominal pain disorder Pediatrics Rome IV Behavioral intervention Nonpharmacological treatment Complementary medicine

Motor speed estimation and failure detection of a small UAV using density of maxima

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Frontiers of Information Technology & Electronic Engineering 2021年第7期22卷 1002-1009页

作者： Jefferson S.SOUZA Moises C.BEZERRIL Mateus A.silva Frank C.VERAS Abel lima-FILHO Jorge Gabriel RAMOS Alisson V.BRITO Laboratory of System Engineering and Robotics Federal University of ParaibaJoao PessoaBrazil Department of Information Systems Federal University of PiauiPicosBrazil Department of Mechanical Engineering Federal University of ParaibaJoao PessoaBrazil Department of Physics Federal University of ParaibaJoao PessoaBrazil

This work presents the application of the technique named signal analysis based on chaos using density of maxima to analyze brushless direct current *** uses a correlation coefficient estimated from the density of maxima of the current *** study demonstrates in experiments the speed estimation of a brushless motor on a testbench and failure detection in a small flying *** experimental results demonstrate that it is possible to estimate the speed in 97.8%of the cases and to detect failure in 82.75%of the analyzed cases.

关键词： Unmanned aerial vehicle(UAV) Speed identification Failure detection Chaos

Bulk Density in Jack Bean’s Development Grown in Cerrado Oxisol

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American Journal of Plant Sciences 2015年第9期6卷 1349-1360页

作者： Edna Maria Bonfim-silva Juliana Terezinha Sasso Paludo Tonny José Araújo da silva Salomao lima Guimaraes Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and TechnologyFederal University of Mato GrossoRondonópolisBrazil

The use of cover plants promotes the recycling of nutrients and the increase in organic mass, and minimizes the effects of erosion. The objective was to evaluate the effect of bulk density in the development of jack bean (Canavalia ensiformis) in Cerrado Oxisol. The experiment was conducted in a greenhouse at the Federal University of Mato Grosso, Rondonópolis-MT, in the period from June to September 2013. Oxisol was used from a Cerrado reserve area, collected at 0 - 0.20 m depth. The experimental design was completely randomized, corresponding to bulk density levels (1.0, 1.2, 1.4, 1.6 and 1.8 Mg·m-3), and five replications. The experimental plot consisted of three PVC rings (polyvinyl chloride) with 150 mm internal diameter, 300 mm total height, where the upper and lower rings of pots were filled with 1.0 Mg·m-3 density soil and intermediaries according to bulk density treatments. The results were submitted to variance analysis and, when significant, to regression analysis, both with a 5% probability, using SISVAR software. At 60 days after germination, number of leaves, stem diameter, plant height, dry mass of leaves, stem dry mass, dry mass of roots, dry mass of nodules, number of nodules and chlorophyll index (SPAD index) were evaluated. The increase in bulk density negatively influences the development of jack bean, showing little efficiency as a decompacting plant in Cerrado Oxisol.

关键词： Canavalia ensiformis Bulk Density Cover Crops

Therapeutic and biological activities of Calotropis procera(Ait.) ***.

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 332-336页

作者： Marcia Calheiros Chaves silva Antonio Batista da silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda lima Oliveira Angela Nadyla Martins Holonda silvania Maria Mendes de Vasconcelos Enfermeira Mestre em Farmacologia/Universidade Federal do Ceara/UFC Farmaceutico Mestre em Patologia Tropical/Universidade Federal do Amazonas/UFAM Biologo Mestre em Bioquimica/Universidade Federal do Ceara/UFC Farmaceutico Mestre em Ciencias Farmaceutica/Universidade Federal do Ceara/UFC Biologa Mestre em Producao Animal/Universidade Estadual do Ceara/UECE Biologo Mestre em Fisiologia da Universidade Estadual do Ceara/UECE Enfermeiro Mestrando em Farmacologia da Universidade Federal do Ceara/UFC Aluna de Farmacia da Universidade Federal do Ceara/UFC Enfermeira Professora Adjunto do Depto.de Fisiologia e Farmacologia da Universidade Federal do Ceara/UFC

Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being *** Calotropis procera(***) is a plant original from Africa,commonly found in northeastern *** is well known for their pharmacological properties,since it produces large amounts of *** important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera.

关键词： Calotropis procera Pharmacological activity Medicinal plants