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L-Arginine Supplementation and Nitric Oxide Production:No Additional Effect When Associated to Exercise

Food and Nutrition Sciences 2013年第8期4卷 779-784页

作者： Diego dos Santos Baiao Carlos Adam Conte jr Joab Trajano silva Vânia Margaret Flosi Paschoalin Thiago Silveira Alvares Department of Biochemistry Chemistry InstituteFederal University of Rio de JaneiroRio de JaneiroBrazil Department of Food Technology Fluminense Federal UniversityNiteróiBrazil Department of Basic Nutrition&Dietetics Federal University of Rio de JaneiroRio de JaneiroBrazil

L-arginine is an amino acid semiessencial considered a precursor of nitric oxide, a gas mainly produced in endothelial cells. Nutritional supplements based on the amino acid L-arginine have been broadly marketed in order to increase vasodilation and the blood supply to muscle in order to optimize metabolic responses induced by exercise. The main objective of this study was to evaluate the effect of L-arginine supplementation on nitric oxide production in response to exercise. Furthermore, the biochemical parameters of muscle fatigue were assessed. Fourteen trained runners were divided in two groups, supplemented with L-arginine (ARG) and placebo (PLA). Blood samples were collected before supplementation (T0), immediately after the first exercise session (T1), immediately after the second exercise session (T2), and after 20 minutes of rest (T3). Plasma cyclic guanosine monophosphate was assessed as a marker of nitric oxide production. The biochemical parameters of muscle fatigue analyzed were plasma lactate and ammonia. There was significant increase in plasma cyclic guanosine monophosphate in both groups in response to exercise: ARG (T0: 3.6 ± 1.4;T1: 17.9 ± 5.8;T2: 15.9 ± 5.3;T3: 7.3 ± 2.5 pmol/mL) and PLA (T0: 4.1 ± 1.1;T1: 18.8 ± 9.9;T2: 16.1 ± 3.5;T3: 9.3 ± 3.7 pmol/mL). A significant reduction in plasma lactate and ammonia were observed in the recovery period after exercise (T3). However, no significant difference was observed between groups in the variables studied. Therefore, L-arginine supplementation was unable to increase the effects of exercise on nitric oxide production and did not improve the metabolic responses to exercise in runners.

关键词： Nutritional Supplements L-Arginine Nitric Oxide Exercise Cyclic Guanosine Monophosphate

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Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2:In silico and in vivo evaluation in a colitis model

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World Journal of Gastroenterology 2023年第17期29卷 2628-2641页

作者： Gabrielle Caroline Peiter Thayene Kamyli Moesch Queiroz Edson Luiz Michalkiewicz jr Raphael Henrique Chappuis Jennefer Sousa Luz Luiz Henrique Casagrande Piovezani Cleison Ferreira silva Matheus Nozomi Tsutumi Augusto Fernandes Chaves Rafael Messias Luiz Cinthia Façanha Wendel Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Programa Multicêntrico de Pós-graduação em Biquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa de Pós-graduação em Biotecnologia-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil

BACKGROUND Inflammatory bowel diseases(IBD)are a worldwide health problem and mainly affect young people,consequently affecting the *** treatments are often associated with side effects,and new therapeutic options are *** centuries,plants have represented important substrates in the field of drug *** pacari(***)is a plant whose pharmaceutical potential has been described,and may have biological activity relevant to the treatment of IBD *** To investigate the activity of keto-alcoholic extracts of *** with respect to ameliorating the inflammatory and nociceptive symptoms of acute experimental colitis in *** Keto-alcoholic extracts of *** leaves and bark were administered to male andfemale Swiss mice weighing 25 g to 30 g(n=8 male mice and n=8 female mice).The effect of these extracts was observed in an acetic acid-induced acute experimental model of colitis with regard to antinociception/analgesia and inflammatory tissue *** macroscopic indices included the Wallace score and the colon weight obtained using a precision *** hyperalgesia was determined using an electronic *** related to overt pain was determined by quantifying the number of writhing instances within 20 min of administration of acetic *** docking was performed using human and murine cyclooxygenase-2(COX-2)with 3 flavonoids(ellagic acid,kaempferol,and quercetin)on the AutoDock Vina *** of variance followed by Tukey’s posttest was used with P<0.05 indicating *** In this murine model of colitis,administration of extracts from *** ameliorated acetic acidinduced writhing and colitis-associated inflammatory *** improvements may be attributable to the reduction in edema,inflammation(e.g.,ulcers,hyperemia,and bowel wall damage),and the intensity of abdominal *** keto-alcoholic extracts of *** leaves and bark administered at a

关键词： Antinociceptive activity Anti-inflammatory activity Cyclooxygenase-2 Flavonoids Inflammatory bowel disease Lafoensia pacari

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Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old Mongolian gerbils

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Asian Journal of Andrology 2017年第2期19卷 160-167页

作者： Manoel F Biancardi Ana PS Perez Cassia RS Caires Luiz R Falleiros jr Rejane M Goes Patricia SL Vilamaior Diogenes R Freitas jr Fernanda CA Santos Sebastiao R Taboga Department of Structural and Functional State University of Campinas Av. Bertrand Russel s/n Campinas Sao Paulo 13084864 Brazil 2Department of Histology Embryology and Cell BiologyFederal University of Goias Samambaia II Goiania Goias 74001970 Brazil University Estadual Paulista - UNESP Department of Biology Laboratory of Microscopy and Microanalysis Rua Cristovao Colombo 2265 Sao Jose do Rio Preto Sao Paulo 15054000 Brazil Medical School Federal University of Goias Colemar Natal e Silva Goiania Goias 74001970 Brazil

The prostate is an accessory sex gland that develops under precise androgenic control. It is known that hormonal imbalance may disrupt its development predisposing this gland to develop diseases during aging. Although the hypothesis regarding earlier origins of prostate diseases was proposed many years ago, the mechanisms underlying this complex phenomenon are poorly understood. Therefore, the aim of this study was to evaluate the prostates of old male gerbils exposed to testosterone during intrauterine and postnatal life using morphological, biometrical, stereological, Kariometric, immunohistochemical, and immunofluorescence analyses. Our findings demonstrate that prenatal and pubertal exposure to testosterone increases the susceptibility to the development of prostate diseases during aging. The presence of a more proliferative gland associated with foci of adenomatous hyperplasia in animals exposed to testosterone during the prenatal and pubertal phase show that the utero life and the pubertal period are important phases for prostatic morphophysiology establishment, which is a determinant for the health of the gland during aging. Therefore, these findings reinforce the idea that prostate disease may result from hormonal disruptions in early events during prostate development, which imprint permanently on the gland predisposing it to develop lesions in later stages of life.

关键词： adenomatous hyperplasia endocrine-disrupting chemicals gerbil prostate development testosterone

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Environmental Forensic Investigation in the Residential Neighborhood Volta Grande IV,Volta Redonda,RJ,Brazil,Using TPH and PAHs Analyses in Soil Samples

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Journal of Environmental Protection 2019年第7期10卷 972-991页

作者： Jose C.R.Gouvea jr. Fernando Simao e silva Reginaldo A.Bertolo Tiago R.Moura Stephen Emsbo-Mattingly CEPAS—Groundwater Research Center University of Sao PauloIGc-USPSao PauloBrazil NewFields Rio de JaneiroBrazil NewFields RocklandMassachusettsUSA

This article presents the results of a forensic investigation concerning the origin of hydrocarbons detected in the subsurface soil of the residential neighborhood Volta Grande IV, Volta Redonda, RJ, Brazil. Previous investigations identified several areas with concentrations of volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) above the Brazilian regulatory standards of CONAMA 420/2009 within the study area. Concern was raised that these hydrocarbons might be derived from local steel mill wastes. This forensic investigation determined that the VOCs in the residential soil are associated with gasoline and possibly diesel fuel oil releases into the subsurface soils that are not associated with the steel mill waste. The PAHs in residential subsurface soil generally fell below background concentrations and are likely associated with regional soot. The PAHs in the three samples with concentrations above background (out of a total of thirty-six samples) exhibit compositional features similar to coal byproducts, such as tar and coke, possibly attributable to the steel mill operation. This work discusses the geoforensic data and chemical signatures that support these findings.

关键词： Environmental Forensic Investigation Hydrocarbons Fingerprinting Polycyclic Aromatic Hydrocarbons

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The Biology of <i>Szelenyiopria talitae</i>(Hymenoptera: Diapriidae): Larval Parasitoid of the Leaf-Cutting Ant <i>Acromyrmex subterraneus</i>(Hymenoptera: Formicidae)

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Advances in Entomology 2021年第3期9卷 131-145页

作者： Thalles Cardoso Mattoso Denise Delores Oliveira Moreira Thais Berçot Pontes Teodoro Claudio Luiz Moreira de Souza Rita de Kássia Guarnier da silva Veronica de Morais Carlos Peres silva Milton Erthal jr. Richard Ian Samuels Laboratório de Entomologia e Fitopatologia Universidade Estadual do Norte Fluminense Darcy Ribeiro Campos dos Goytacazes Rio de Janeiro Brazil Universidade Candido Mendes Campos dos Goytacazes Rio de Janeiro Brazil Departamento de Bioquímica Universidade Federal de Santa Catarina Florianópolis Brazil Instituto Federal Fluminense Campos dos Goytacazes Rio de Janeiro Brazil

The biology of a koinobiont parasitoid of leaf-cutting ant larvae, Szelenyiopria talitae (Hymenoptera: Diapriidae), was studied from naturally infested Acromyrmex subterraneus (Hymenoptera: Formicidae) nests. Nests were collected in the field from the Atlantic rainforest biome in the state of Rio de Janeiro. A total of fifty-three nests were collected from 2015 to 2018. Parasitized nests were only found during the months of September and October. Approximately 22% of the nests collected over a four-year period were found to have been parasitized by S. talitae. The mean within-nest parasitism rate was 66.3%. This diapriid displayed both solitary (14%) and gregarious parasitism (86%), with up to a maximum of 12 parasitoids developing within a single host. Gregarious parasitism with two (29%) or three (21%) S. talitae per host was most frequently observed. There was a positive correlation between the number of parasitoids per host and host size (dry weight), indicating that S. talitae females oviposited a higher number of eggs in larger hosts. There was also a negative correlation between S. talitae<

关键词： Formicidae Leaf Cutting Ant Pest Koinobiont

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Potentially dangerous fish of the Paraiba Estuary: Identification and envenomation mechanisms

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Journal of Coastal Life Medicine 2017年第11期5卷 459-462页

作者： Anderson Kelvin Saraiva Macêdo Jicaury Roberta Pereira Da silva Samara Pereira De Oliveira Vidal Haddad jr Ana Lúcia Vendel Centro de Ciências Biológicas e Sociais Aplicadas Universidade Estadual da ParaíbaCampus VRua Horácio TrajanoCristo Redentor58070-450 Joao PessoaParaíbaBrasil Faculdade de Medicina de Botucatu Universidade Estadual PaulistaCaixa Postal 55719618-000 BotucatuSao PauloBrasil

Objective: To present venomous and poisonous fish species in the Paraiba Estuary, Paraiba State, Brazil, with a description of the envenomation mechanisms and characteristics of the toxins. Methods: Fishes were caught by beach seine in the dry and rainy season (November 2013 and June 2014) and bimonthly between May 2016 and March 2017. Results: Eight potentially dangerous species belonging to the families Batrachoididae, Ariidae and Tetraodontidae were identified. The representatives of the former two families, toadfish and catfish, respectively had specific venom inoculating apparatuses that could penetrate tissues, releasing toxins that caused injuries mainly to fishermen. The family Tetraodontidae had poisonous species, once the pufferfish could accumulate biotoxins (especially tetrodotoxin, which is a neurotoxin produced by bacteria). Despite being toxic for consumption, these fish were often consumed by fishermen and their families. Conclusions: The present study is the first record of venomous and poisonous species in the Paraiba Estuary and contributes to the knowledge of the identification of the species and the mechanisms that cause severe envenomation and even deaths in artisanal fishing communities. Such knowledge is fundamental to future campaigns aimed at the prevention of injuries involving fish in the region and in other estuarine environments, where such fishes are common.

关键词： Catfish Poisonous fish Pufferfish Toadfish Venomous fish

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Barefoot and High-Heeled Gait: Changes in Muscles Activation Patterns

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Health 2014年第16期6卷 2190-2196页

作者： Nathalya Ingrid Cardoso do Nascimento Thaís Sepêda Saraiva Alex Tadeu Viana da Cruz jr. Givago da silva Souza Bianca Callegari Institute of Health Sciences Federal University of Pará Belém Brazil Institute of Biological Sciences Federal University of Pará Belém Brazil Center for Tropical Medicine Federal University of Pará Belém Brazil

Most women like wearing high-heeled shoes for the benefit of sensuous attractiveness and self-esteem while musculoskeletal problems and gait patterns changes are often associated. The present study aimed to identify changes during the gait stance and swing phases in some lower limb muscles. In addition, abdominal muscle was included due to its importance in dynamic trunk stability, and lack of studies on the subject. Here, we found that the use of high-heeled shoes elicited not only the increasing of the electrical activity from the muscles involved in the gait cycle, but also altered the temporal sequence of their recruitment. As practical applications, these changes may be strategies to maintain stability and minimize risks of falling, but they are often associated to diseases. Women that use high-heeled shoes for prolonged time must apply specific muscle exercises to minimize its long-term effects.

关键词： Human Gait High-Heeled Shoes Lower Limb Muscles Temporal Activation Electromyography

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Unmanned Aerial Vehicles Flight Safety Improvement Using In-Flight Awareness

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Intelligent Information Management 2021年第2期13卷 97-123页

作者： André L. P. Mattei Engenharia S. A. Orbital Claudio F. M. Toledo Jesimar da silva Arantes Onofre Trindade jr. Sã o José dos Campos SP Brazil Department of Computer Systems Institute of Mathematics and Computer Sciences University of S&#227 o Paulo Sao Carlos SP Brazil

This paper presents a novel onboard system called In-Flight Awareness Augmentation System (IFA2S) to improve flight safety. IFA2S is designed to semi-automatically (with human supervision) avoid hazards and accidents due to either internal or external causal factors. The requirements were defined in an innovative way using Systems-Theoretic Process Analysis (STPA) method and applied next to model the system. IFA2S increases aircraft awareness regarding both itself and its environment and, at the same time, recognizes platform and operational constraints to act in accordance to predefined decision algorithms. Results are presented through simulations and flight tests using state machines designed to allow the adoption of appropriate actions for the identified hazards. The different decision algorithms are evaluated over as many as possible hazard situations by simulations conducted with software Labview and XPlane flight simulator. Flight tests are performed in a small fixed wing aircraft and make use of a limited version IFA2S, partially attending identified requirements. Results support the conclusion that IFA2S is capable of improving flight safety.

关键词： Unmanned Aerial Vehicles Air Safety Systems-Theoretic Process Analysis In-Flight Awareness

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A review of potential conservation and fisheries benefits of breaching four dams in the Lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.Schaller Charles E.Petrosky Robert L.Vadas jr. Benjamin J.Clemens Gary Sprague Norman Mercado-silva Brett Roper Michael J.Parsley Edward Bowles Robert M.Hughes Jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific Lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific Lamprey,and(10)Snake River Basin Pacific Lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

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利用磁共振诊断半月板损伤

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中国中医骨伤科杂志 1989年第6期5卷 59-61页

作者： Ismael silva,jr 赵文炼白鹤龙张德桂

磁共振在探查膝关节的特殊病理变化方面的作用,普遍认为对临床是很有帮助的。但这种方法的实用性,仍在被观察中。在本研究中,我们试图用磁共振检查所见与关节镜检查所见进行比较,以确定利用磁共振探查半月板损伤的准确程度。

关键词：关节镜检查磁共振检查平均时间间隔半月板撕裂半月板损伤

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