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hypothalamic circuits and aging:keeping the circadian clock updated

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Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa Vázquez-Lizarraga Lucia Mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-Montoya erick Carreño-Vázquez Ricardo orozco-Solis Instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

Numerical Investigation of Thermal Behavior of CNC Machine Tool and Its Effects on Dimensional Accuracy of Machined parts

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Journal of Software Engineering and Applications 2024年第8期17卷 617-637页

作者： erick Matezo-Ngoma Abderrazak El ouafi Ahmed chebak Computer Science and Engineering Department University of Quebec Rimouski Canada GTI Mohammed VI Polytechnic University Ben Guerir Morocco

The dimensional accuracy of machined parts is strongly influenced by the thermal behavior of machine tools (MT). Minimizing this influence represents a key objective for any modern manufacturing industry. Thermally induced positioning error compensation remains the most effective and practical method in this context. however, the efficiency of the compensation process depends on the quality of the model used to predict the thermal errors. The model should consistently reflect the relationships between temperature distribution in the MT structure and thermally induced positioning errors. A judicious choice of the number and location of temperature sensitive points to represent heat distribution is a key factor for robust thermal error modeling. Therefore, in this paper, the temperature sensitive points are selected following a structured thermomechanical analysis carried out to evaluate the effects of various temperature gradients on MT structure deformation intensity. The MT thermal behavior is first modeled using finite element method and validated by various experimentally measured temperature fields using temperature sensors and thermal imaging. MT Thermal behavior validation shows a maximum error of less than 10% when comparing the numerical estimations with the experimental results even under changing operation conditions. The numerical model is used through several series of simulations carried out using varied working condition to explore possible relationships between temperature distribution and thermal deformation characteristics to select the most appropriate temperature sensitive points that will be considered for building an empirical prediction model for thermal errors as function of MT thermal state. Validation tests achieved using an artificial neural network based simplified model confirmed the efficiency of the proposed temperature sensitive points allowing the prediction of the thermally induced errors with an accuracy greater than 90%.

关键词： CNC Machine Tool Dimensional Accuracy Thermal Errors Error Modelling Numerical Simulation Finite Element Method Artificial Neural Network Error Compensation

A Meta-Analysis of the prognostic and Clinicopathological Significance of circZFR in human Gastrointestinal Cancers

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International Journal of Clinical Medicine 2024年第3期15卷 134-144页

作者： christian Cedric Bongolo erick Thokerunga Yu Zhang Jian-cheng Tu Wuhan Life origin Biotech Joint Stock Co Ltd. Wuhan China College of Life Sciences and Technology Huazhong Agricultural University Wuhan China Department & program of Clinical Laboratory Medicine and Center for Gene Diagnosis Zhongnan Hospital of Wuhan University Wuhan China

Background: Studies of gastrointestinal (GIT) cancers have shown that circZFR could be involved in the development and progression of various GIT cancers. however, small sample sizes limit the clinical significance of these studies. here, a meta-analysis was conducted to ascertain the actual involvement of circZFR in the development and prognosis of GIT cancers. Methods: pubMed, Embase, Web of Science, and the Cochrane Library were searched up to December 31, 2023. hazard ratios (hRs) or odds ratios (oRs) with 95% confidence intervals (CIs) were pooled to evaluate the association between circZFR expression and overall survival (oS). publication bias was measured using the funnel plot and Egger’s test. Results: 10 studies having 659 participants were enrolled for meta-analysis. high circZFR expression was associated with poor oS (hR = 1.4, 95% CI: 1.20, 1.70). high circZFR expression also predicted larger tumor size (oR = 4.38, 95% CI 2.65, 7.25), advanced clinical stage (oR = 5.33, 95% CI 3.10, 9.16), and tendency for distant metastasis (oR = 2.89, 95% CI: 1.62, 5.11), but was not related to age, gender, and histological grade. Conclusions: In summary, high circZFR expression was associated with poor oS, larger tumor size, advanced stage cancer and tendency for distant metastasis. These findings suggested that circZFR could be a prognostic marker for GIT cancers.

关键词： CircZFR Gastrointestinal prognostic Significance Meta-Analysis

Impact of data balancing a multiclass dataset before the creation of association rules to study bacterial vaginosis

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Intelligent Medicine 2024年第3期4卷 188-199页

作者： Freddy de la Cruz-Ruiz Juana Canul-Reich Rafael Rivera-López erick de la Cruz-hernández Academic Division of Science and Technology of the Information Juárez Autonomous University of TabascoLa Esmeralda DistrictTabascoMexico Department of Systems National Technological Institute of MexicoTechnological Institute of VeracruzVeracruzMexico Multidisciplinary Academic Division of Comalcalco Juárez Autonomous University of TabascoTabascoMexico

Background Bacterial vaginosis is a polymicrobial syndrome in which the homeostasis exerted by the Latobacillus species that protect the vaginal mucosa has been *** study explored the data balancing process with the intention of improving the quality of association *** article aimed to balance the unbalanced multiclass dataset to improve association rule *** A dataset with 201 observations and 58 variables was analyzed.A preconstructed dataset was *** authors collected the data between August 2016 and october 2018 in Tabasco,*** study population comprised sexually active women ages 18 to 50 who underwent gynecological inspection at the infectious and metabolic diseases research laboratory at the Universidad Juarez Autonoma de *** determine the best κ-value,the random-forest algorithm was used and the balancing was performed with the synthetic minority over-sampling technique(SMoTE),random over-sampling examples(RoSE),and adaptive syntetic sampling approach for imbalanced learning(ADASYN)*** Apriori algorithm created the rules and to select rules with statistical significance,the ***(),***(),and ***()functions and quality metric Fisher’s exact tes were *** biological validation was carried out by the expert(bacteriologist).Results The ADASYN algorithm at K=9 the out of the bag(ooB)error was zero,this was the best𝐾-*** the balancing process the ADASYN algorithm show best the *** the dataset balanced with ADASYN,the apriori algorithm created the association rules and the selection with the quality metric Fisher’s exact test,and the biological validation reported 13 ***-bacteria Atopobium vaginae,Gardnerella vaginalis,Megasphaera filotipo 1,Mycoplasma hominis and Ureaplasma parvum were detected by the apriori algorithm from the balanced *** Balancing may improve the creation of association rules to efficiently model the bacteria that cause bac

关键词： Bacterial vaginosis Data balancing Random forest Synthetic minority over-sampling technique

Evaluation of human Impacts on Bartlett pond Ecosystem, Laredo, Southern Texas, USA, through Empirical Modeling

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Journal of Environmental protection 2024年第4期15卷 497-526页

作者： Maya p. Bhatt Amede Rubio Ganesh B. Malla Cristobal Lopez Virginia Morales erick Vazquez Cano David Marquez orlando Berumen Alvarez Alfred Addo-Mensah Department of Biology and chemistry Texas A&M International University Laredo USA Department of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of Bartlett pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (bass and tilapia) were also sampled to see the trace element accumulation in different parts of their body. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb > pb > As ≫Co > Tl > Cr > Cd within Bartlett pond. overall, the water quality of the pond is unacceptable for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, pb, Fe, Sb and Tl) are exceedingly higher (several fold) than the Who and US EpA guidelines. predictive and correlation analysis shows that most trace elements exhibit a strong positive correlation among them indicating the same anthropogenic sources and biogeochemical processes regulate these trace elements within the pond. Distributions of the trace elements in water exhibit different shapes mostly as positively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for pb and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the Bass than Tilapia fish. The concentrations of As, Tl, Co, and Sb appeared significantly higher in different parts of the body of both Bass and Tilapia than the maximum SRM certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohibited. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the Bartlett pond and waters of this pond to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to improve understanding about these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements Bartlett pond Laredo Southern Texas Wetlands Ecosystem Ecology

A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.Munley erick E.pons Kolenkode B.Kannan Elizabeth M.Whitley Letitia E.Bible philip A.Efron Alicia M.Mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA pathogenesis LLCGainesvilleFloridaUSA

Background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LchS),multicompartmental polytrauma(pT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuespolytrauma resulted in markedly more profound inhibition of weight gain compared to LchS(p=0.0002)along with elevated plasma TLR4(power hemoglobin(ppleen to body weight ratios(p=0.004).Both LchS and pT demonstrated suppression of CFU-E and BFU-E growth compared to naive(ppplasma G-CSF was elevated in pT compared to both na?ve and LchS(pp=0.02).LchS and pT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

Unusual presentations of eosinophilic gastroenteritis:Case series and review of literature

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World Journal of Gastroenterology 2009年第17期15卷 2156-2161页

作者： Rafiq A Sheikh Thomas p prindiville R erick pecha Boris h Ruebner Department of Gastroenterology Kaiser Permanente Medical Center 6600 Bruceville Road SacramentoCA 95823 United States Department of Gastroenterology University of California Davis 4150 V Street Sacramento CA95917 United States Department of Gastroenterology Marshall Medical Center 1100 Marshall Way Placerville CA 95667 United States Department of pathology University of California Davis 4150 V Street Sacramento CA 95917 United States

Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy.

关键词： Gastroenteritis Eosinophilic Gastrointestinal obstruction Eosinophilic esophagitis Eosinophilic colitis Eosinophilic pancreatitis

Storylines of family medicine Ⅳ:perspectives on practice—lenses of appreciation

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Family Medicine and Community health 2024年第S3期12卷 33-42页

作者： William B Ventres Leslie A Stone Radeeb Akhtar Jeffrey M Ring Lucy M Candib erick Messias Ronald M Epstein Marc Tunzi Amy L Lee christopher p Morley Carina M Brown David Slawson Jill Konkin David G Campbell Ian Couper Susan Williams Robert Brooks Lucie Walters Family and preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine and Community health Icahn School of Medicine at Mount SinaiNew YorkNew YorkUSA Independent health psychologist Los AngelesCaliforniaUSA Family Medicine and Community health UMass Chan Medical SchoolWorcesterMassachusettsUSA psychiatry and Behavioral Neurosciences Saint Louis University School of MedicineSaint LouisMissouriUSA Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Family Medicine Residency program Natividad Medical CenterSalinasCaliforniaUSA Family Medicine Tufts University School of MedicineBostonMassachusettsUSA public health and preventive Medicine SUNY Upstate Medical UniversitySyracuseNew YorkUSA Cone health Family Medicine Residency The University of North Carolina School of MedicineGreensboroNorth CarolinaUSA Family Medicine Atrium HealthCharlotteNorth CarolinaUSA Family Medicine University of Alberta Faculty of Medicine&DentistryEdmontonAlbertaCanada Cunninghame Arm Medical Centre Australian College of Rural and Remote MedicineLakes EntranceQueenslandAustralia Ukwanda Centre for Rural health Stellenbosch University Faculty of Medicine and Health SciencesCape TownWestern CapeSouth Africa Adelaide Rural Clinical School The University of AdelaideAdelaideSouth AustraliaAustralia Department of Rural health Broken Hill UniversityBroken HillNew South WalesAustralia Adelaide Rural Clinical School The University of Adelaide Faculty of Health and Medical SciencesMount GambierSouth AustraliaAustralia

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅳ:perspectives on practice—lenses of appreciation’,authors address the following themes:‘Relational connections in the doctor–patient partnership’,‘Feminism and family medicine’,‘positive family medicine’,‘Mindful practice’,‘The new,old ethics of family medicine’,‘public health,prevention and populations’,‘Information mastery in family medicine’and‘Clinical courage.’May readers nurture their curiosity through these essays.

关键词： thematic illustration doctor

Water, Sanitation and hygiene in Lower-Level health Care Facilities of Dar es Salaam Region in Tanzania: Status towards Achieving the Sustainable Development Goals and Way Forward

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Advances in Infectious Diseases 2024年第1期14卷 279-295页

作者： Mariam Mahamudu hussein Mohamed Michael habtu Dennis Rweyemamu Anyitike Mwakitalima Amour Seleman erick Mgina Khalid Massa Grace Saguti Andre Arsene Bita Fouda Zabulon Yoti Ministry of health Dodoma Tanzania Department of Environmental and occupational health Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania Regional office for Africa World Health Organization Brazzaville Republic of the Congo National Institute for Medical Research Dar es Salaam Tanzania

Background: Improving Water, Sanitation and hygiene in health care settings is a critical prerequisite for achieving national health goals and Sustainable Development Goals (SDGs). The World health organization (Who) has set a target for each United Nations member state to reach by 2030. Each member state is required to reach by 2022, 2025 and 2030 at least 60%, 80% and 100%, respectively of basic level of service of the five elements which are water, sanitation, hygiene, waste management and environmental cleaning. Methods: This study aimed to evaluate and document the current state of basic water, sanitation, and hygiene services in all lower-level health care facilities in the Dar es Salaam region of Tanzania as of July 2022. A cross-sectional study was conducted in 99 public dispensaries in the Dar es Salaam region’s five councils: Ubungo, Kigamboni, Kinondoni and Temeke Municipalities, and Ilala City. The interviewee form and observational checklists were both digitalized using the Kobo tool software. The respondents were health care facility in-charges or nurse in-charges. Data were downloaded, validated, and imported to Stata version 15 for analysis. Results: The basic WASh level per JMp is far below the target in 2022. Each member state by 2022 is required to reach at least 60% of the basic level of service of each element. We found a low coverage of basic WASh in the 99 dispensaries included in this study. The basic WASh coverage was met in only 10 (10.1%) of the dispensaries, while the remaining 89 (89.9%) dispensaries fall on limited WASh services. Conclusion: This study revealed lower coverage of basic WASh services in dispensaries. An urgent need is required to improve the status of WASh in all the dispensaries and facilitate the provision of quality health care services, patient safety and reduce health care associated infections.

关键词： Dispensaries Low Level health Care Facilities Service Levels Basic WASh Dar es Salaam