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Profile of People Living with HIV after 24 Weeks of Treatment with Dolutegravir in Kinshasa

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Advances in Infectious Diseases 2023年第4期13卷 660-674页

作者： Berry I. Bongenya Benoit O. Kabengele Marie-Thérèse A. S. Sombo Guy M. M. Bumoko Hippolyte N. T. Situakibanza Fridolin K. K. Kodondi Gauthier K. Mesia Mariano M. Lusakibanza Jean Marie N. Kayembe Baudouin B. Buassa Richard L. Kalala erick N. Kamangu Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo Focus HIV/AIDS Research Group Kinshasa Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Biochemistry Laboratory Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Clinical Pharmacology Unit Department of Pharmacology Faculty of Medicine and Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Introduction: The sixth month appointment (M6) is crucial because at the start of the ART course, it is an indicator of the prognosis of the evolution of care and decision-making on the continuity of treatment. Objective: The objective of this study is therefore to present the profile of People Living with HIV under treatment with Dolutegravir 6 months after starting ART in Kinshasa. Methods: The present study is a cross-sectional view at M6 of a prospective cohort to determine the profile of People Living with HIV (PLHIV) after 6 months of ARV Treatment (ART) in Kinshasa, DRC. During the M6 appointment, from April to August 2022, a sample of 5 ml of blood was taken for the various analyzes from all HIV patients included. The collection of sociodemographic data as well as biological and clinical data was carried out under the same conditions as at inclusion. The parameters recorded during M6 were: age, sex, and religion, level of study, marital status, profession, socio-economic level, height, weight, Body Mass Index (BMI), clinical profile, opportunistic infections as well as biochemical and molecular assessment. Results: In M6, 62 patients were registered including 38 women (61.3%), thus giving a sex ratio of 1.58 in favor of women. Fifty-seven (57) patients did not respond to the appointment, representing a loss rate of 47.89%. The most common age group is between 36 and 45 years old with 16 patients (26.7%). The mean age was 42.4 ± 13.3 years. The mean weight was 60.5 ± 15.4 kg with a mean BMI of 22.6 ± 5.8 kg/m2. Thirty-four (34) patients (61.82%) were in Clinical Stage 3. Thirty-six (36) patients (67.92%) had a normal clinical condition. The most common opportunistic infections among patients in M6 were: skin pruritus (25.8%), dermatitis (22.6%) and rash (21%). The mean values of biochemical parameters of patients in M6 were within normal ranges. The median VL value was 2.92 log10 RNA copies/ml with 17.75% of patients experiencing major failure of f

关键词： Profile PLHIV 6 Months of ART Dolutegravir Kinshasa

Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in the Dolutegravir Era in Kinshasa, Democratic Republic of Congo

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World Journal of AIDS 2023年第3期13卷 95-115页

作者： Berry I. Bongenya Benoit O. Kabengele Marie-Thérèse A. S. Sombo Guy M. M. Bumoko Hippolyte N. T. Situakibanza Fridolin K. K. Kodondi Gauthier K. Mesia Mariano M. Lusakibanza Jean Marie N. Kayembe Georges L. Mvumbi Baudouin B. Buassa Richard L. Kalala erick N. Kamangu Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo “HIV/AIDS Focus” Research Group Kinshasa Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Laboratory of Biochemistry Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Clinical Pharmacology Unit Department of Pharmacology Faculty of Medicine and Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Background: For several decades, the introduction of AntiRetrovirals (ARVs) has improved the symptomatology of People Living with HIV (PLHIV), a spectacular reduction in morbidity and mortality, an improvement in life expectancy and quality of life of PLHIV. Objective: The objective of this study was to determine the profile of PLHIV initiating AntiRetroViral Treatment (ART) in the era of Dolutegravir in Kinshasa. Methods: Cross-section of a prospective cohort to determine the profile of PLHIV initiating ART in Kinshasa. The inclusions were from October 04, 2021 to February 15, 2022. Confirmation of the diagnosis was carried out by Nested PCR. The inclusion criteria were: being at least 18 years old, confirmed HIV positive, naïve to ART, consenting and having signed an informed consent. The parameters of interest followed for the present study were: age, sex, religion, level of study, marital status, occupation, height, weight, body mass index (BMI), the clinical profile, the opportunistic infections as well as the para-clinical assessment (biochemistry and molecular biology). Results: 67 (56.3%) women and 52 (43.7%) men were included, thus 119 patients, all confirmed positive for HIV by Nested PCR on the gag, pol and env regions. The average age of the patients included is 39.87 ± 12.36 years and the most represented age group is that of 36 to 45 years with 37 patients (31.9%). The average height was 1.66 ± 0.08 meters, with an average weight of 56.41 ± 13.30 kg, giving an average Body Mass Index (BMI) of 21.54 ± 5.17 kg/m2. The majority of patients were married (46.1%), of Protestant religion (70.7%), with secondary education (66.7%), and working in the informal sector (29.4%). 49 patients (41.5%) were in clinical stage 3 and 55 patients (47.0%) had a normal clinical status. Malaria (45.4%) and tuberculosis (29.4%) were the most common Opportunistic Infections. The mean values of the patients’ assessed biochemical parameters were within the ranges. The

关键词： Profile PLHIV Starting of ART Dolutegravir Kinshasa

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在电脑中开辟“空间”

个人电脑 1995年第9期1卷 6-6页

作者： Linda erick Von Schweber 伍颖文

虚拟现实正在World-Wide Web上张贴声明,它许诺让今天的图形用户界面象命令行一样成为过去。想象一下象通常那样登录至Web上的某个主页。在Travel中揿击Adven-ture,过去所见的图形和文本已被旅行机构办公室的3D场景取代。巡访控件让你... 详细信息

虚拟现实正在World-Wide Web上张贴声明,它许诺让今天的图形用户界面象命令行一样成为过去。想象一下象通常那样登录至Web上的某个主页。在Travel中揿击Adven-ture,过去所见的图形和文本已被旅行机构办公室的3D场景取代。巡访控件让你前、后、左、右、上、下游走。当你走近观看某个名胜的招贴广告时,你发现自己已被带到相应的目的地,那里泉水淙淙,棕榈摇曳。这就是3D Web。这类感受幕后的技术是这样工作的:你的Web浏览器(假定是NetscapeNavigator)被设置成在某个条件下触发一个帮助程序。

关键词：虚拟现实 Web浏览器图形质量招贴广告交互性虚拟世界图形用户电脑描述文件服务器

Navigation Model for a Lego Robot Using a Backpropagation Neural Network

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通讯和计算机（中英文版） 2015年第4期12卷 212-218页

作者： erick Cervantes Chirinos Jose Antonio Castan Rocha Salvador Ibarra Martinez Julio Laria Menchaca Javier Guzman Obando Mayra Trevino Berrones Emilio Castan Rocha Autonomous University of Tamaulipas Computer Science Tampico Tamaulipas Mexico CP. 89440

Managament Wound Healing: The Importance of a Wound Clinic in Hospital Centers

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Modern Plastic Surgery 2023年第4期13卷 118-125页

作者： Alfredo Chama Naranjo Cuahutémoc Márquez Espriella Alberto Ignacio Cahuana Quispe Barbosa Villarreal Fernando Ana Priscila Campollo López Mauricio Gutiérrez Álvarez Carlos Emiliano García Córdova Jesús Ricardo García Corral Cuervo Vergara Marco Antonio Jorge Luis Rosales Becerra Dávila Díaz Rodrigo Edgar Alan Guillen Martínez Marín Canto Miguel Eduardo Luis Arturo Herrera Lozano Ochoa Contreras erick Cesar Martinez Villalobos Claudia Nallely Cruz Soto Randall Camacho Rodriguez Hayah Ricardo Alberto Pulido López Edwing Michel Jaimes Durán Department of Plastic and Restrictive Surgery Hospital Central Sur de Alta Especialidad Pemex Mexico City Mexico

Background: In clinical practice, acute and chronic wounds continue to be a challenge. Unfortunately, wound care is often inadequate or inappropriate. The implementation of wound clinics involving an interdisciplinary team for wound care and treatment yields favorable clinical outcomes as well as a reduction in economic expenses due to a higher rate of healing, a decrease in hospital stays, and a reduction in the number of readmissions. The establishment of wound clinics enhances the utilization of diagnostic, preventive, and therapeutic resources, improving the quality of life of patients and facilitating their reintegration into their normal lives. The objective is solely to describe the importance of wound clinics in the medical profession. Methods: A retrospective literature search was conducted to include articles no more than 10 years old that reported measures or results of the study in order to perform a literature review and describe the importance of wound clinics in medical practice. Results: A total of 7 articles were obtained with the inclusion criteria, the most recent being from the year 2023 and the oldest from 2013. Conclusion: An important area for improvement in the healthcare industry is the management and treatment of complex wounds. The establishment of wound clinics offers comprehensive and specialized care for both acute and chronic complex wounds with the goal of enhancing secondary illness patients’ prevention, treatment, and rehabilitation.

关键词： Wound Clinic Pressure Ulcer Chronic Wound Wound Healing Quality of Life

Molecular Identification of Hammerhead Shark Trunks from the Southern Gulf of California using Multiplex PCR

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Journal of Fisheries Science 2020年第1期2卷 22-29页

作者： Thelma A.Aguilar-Rendón J.Juan Rendón-Herrera Virginia Osuna-González erick C.Oñate-Gónzalez Omar Domínguez-Domínguez Nancy C.Saavedra-Sotelo Laboratorio de Ecología Molecular Facultad de Ciencias del MarUniversidad Autónoma de Sinaloa.Paseo Claussen s/nMazatlánSinaloa.C.P.82000.México Laboratorio de Ictiología Facultad de Ciencias BiológicasUniversidad Autónoma de Nuevo LeónAv.Pedro de Alba y Manuel L.Barragans/nCd UniversitariaSan Nicolás de los GarzaNuevo León.C.P.66455.México Laboratorio de Biología Acuática Universidad Michoacana de San Nicolás de Hidalgo.Edificio RPlanta BajaCiudad UniversitariaMoreliaMichoacán.C.P.58030.México Cátedras-CONACyT Consejo Nacional de Ciencia y TecnologíaAv.Insurgentes Sur No.1582Del.Benito JuárezCDMX.C.P.03940.México

The demand for shark fins in Asiatic markets has resulted in excessive increases in shark catches,even for species that may be under protection or subject to *** such,it has been necessary to develop and promote monitoring efforts for exploited species and taxonomic groups in order to improve fishing management strategies for *** species from landings is one of many fishing management problems because landed organisms have usually already been processed and are therefore incomplete,which makes identification problematic,impedes the generation of proper species records,and leads to poor fishery *** that can correctly identify species,such as various molecular techniques,have become essential for accurate fishery *** this study,30 hammerhead trunks from artisanal fisheries from the southern portion of the Gulf of California were identified using multiplex PCR(17 Sphyrna lewini and 13 Sphyrna zygaena).The total fee to identify each trunk with this technique was~$3.80 and the procedure required 2 to 5 *** compared with other widely-used methods,such as PCR-RFLP or barcoding,multiplex PCR is fast,efficient,low-cost,and easy to implement in a laboratory.

关键词： Sphyrna ITS2 Molecular marker Ribosomal DNA Electrophoreses

Management of Complex Wounds with Dermal Substitute Assisted by a Negative Pressure System

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Modern Plastic Surgery 2023年第4期13卷 95-105页

作者： Cuahutémoc Márquez Espriella Ruiz Garza Jorge Gerardo Barbosa Villarreal Fernando Dávila Díaz Rodrigo Cuervo Vergara Marco Antonio Campollo López Ana Priscila Gutierrez Alvarez Mauricio Chama Naranjo Alfredo García Corral Jesús Ricardo Pérez Benítez Omar Alberto Pulido López Ricardo Alberto Jaimes Duran Edwing Michel Garibaldi Bernot Mauro Cortes Aguilar Carlos Manuel García Córdova Carlos Emiliano Camacho Rodriguez Hayah Camacho Rodriguez Hayah Martinez Villalobos Claudia Nallely Ochoa Contreras erick Cesar Randall Cruz Soto Herrera Lozano Luis Arturo Department of Plastic and Reconstructive Surgery Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Introduction: The standard treatment for complex wound care is autografting. The advent of dermal substitutes has provided a novel tool for the preparation of the bed to be grafted. However, most types of dermal matrices require the application of a skin graft a second time. Currently, other strategies have been developed to improve the vascularization process, such as negative pressure wound therapy (NPWT), which has been reported to reduce the time required for vascular growth and dermal matrix integration and thus achieve a shorter waiting period for autologous graft application. The present study aims to evaluate the effectiveness and safety of dermal matrix management associated with NPWT in the treatment of complex wounds. Methods: Seven patients with a diagnosis of complex wounds were enrolled in this study between July 1, 2015, and June 31, 2016. After debridement and having an adequate wound bed, patients who met the criteria for the application of combined therapy were treated with dermal substitutes and a negative pressure system. The percentage of graft integration into the wound bed, complications, length of hospital stay, and duration of therapy were analyzed. Results: The mean age was 42.5 ± 16 (39 - 54) years old;three women and four men were included in the study. The approximate size of skin loss was 120.7 ± 75 cm2 (25 - 250 cm2). The combined therapy of dermal matrix plus NPWT was instituted in all cases for a period of 14 days. There were no complications, with 100% graft integration in 6 of 7 cases. Patients were discharged after a mean hospital stay of 5.4 days. Conclusions: This study demonstrates that the utilization of combined dermal matrix plus NPWT therapy can be performed safely and effectively in patients with complex wounds with low complication rates and a short hospital stay.

关键词： Negative Pressure Wound Therapy Complex Wound Dermal Matrix Wound Therapy

EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression