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Neonatal Intestinal Obstruction in Acute renal Failure in Premature Infant: A Case report

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Open Journal of Pediatrics 2024年第2期14卷 338-343页

作者： Ondima Lucienne Irène Patricia Okiemy Niendet Cardinale Princilia Gandzali-Ngabe Pierre Eric Caryne Mboutol-Mandavo Bosseba Missengui rhodia hélène Akobande Nuptia erica Department of Paediatric Surgery CHU Brazzaville Brazzaville Congo Faculty of health Sciences Marien Ngouabi University Brazzaville Congo Department of Nephrology and Dialysis Brazzaville University Hospital Brazzaville Congo

Introduction: Intestinal obstruction is a common cause of abdominal surgery in the neonate. Diagnosis is straightforward using standard radiology, and surgical technique depends on the underlying anatomical lesion. Peritoneal dialysis (PD) is an effective, albeit invasive, therapy for neonatal renal failure. We report a case of neonatal obstruction with severe renal failure treated by PD to highlight our hospital practice and possible remedies in a context of limited resources. Case Presentation: This was a female neonate of moderate prematurity admitted on day 4 of life for management of a flat neonatal obstruction. radiological diagnosis suggested small bowel atresia. Biological tests revealed severe renal failure with creatinine levels of 416 micromoles per liter and blood urea of 27.1 micromoles per liter. Management consisted of preoperative peritoneal dialysis for 48 hours followed by laparotomy. The intraoperative diagnosis was GrOSFELD type IIIa digestive atresia. The postoperative course was favourable, transit was resumed on day 5 and the patient returned home on day 12. Progress at 3 months was satisfactory. Conclusion: Neonatal intestinal obstruction with renal failure in premature infants is associated with a poor prognosis, even more so if there is a delay in treatment. Peritoneal dialysis seems to be a suitable alternative for this management in our working conditions with limited resources.

关键词： Neonate Occlusion Peritoneal Dialysis Case report

Traumatic Diaphragmatic hernia in Children: A Case report

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Surgical Science 2024年第3期15卷 111-117页

作者： Lucienne Irène Patricia Ondima rhodia hélène Bosseba Missengue Nuptia erica Akobande Cardinale Princilia Okiemy Niendet Jean-Claude Mieret Caryne Mboutol-Mandavo Department of Pediatric Surgery Marien Ngouabi University Brazzaville Congo Department of Paediatric Surgery Hospital and University Centre (HUC) Brazzaville Congo

Introduction: Traumatic diaphragmatic hernia is a rare condition in children complicating closed or penetrating trauma to the abdomen and thorax. We report the case of an 11-year-old girl with a traumatic diaphragmatic hernia. Case Presentation: An 11-year-old girl was seen in the paediatric surgery department for a thoracolumbar spine deformity and intermittent chest pain. These symptoms occurred after a domestic accident involving a fall from a low wall onto the thoracolumbar spine 5 months previously. The diagnosis was suggested by the presence of a left hemithoracic hydroaera and confirmed by a thoraco-abdominal CT scan. Surgical exploration revealed a linear rupture of the entire left hemi-diaphragm with herniation of the stomach, small intestine, cecum, transverse colon and omentum. We performed a double-layer suture of the diaphragmatic rupture with a non-absorbable suture without edge rejuvenation after the reduction of the hernia. The outcome was favourable with normal postoperative radiographs at one year follow-up. Conclusion: Traumatic diaphragmatic hernia, although uncommon and difficult to diagnose, is a condition that is relatively easy to manage surgically, even if it is discovered late. In all cases of trauma to the thoracolumbar spine, regular follow-up and repeat X-rays are necessary if pain persists.

关键词： hernia Diaphragm Trauma Child Case report

Large Conventional Osteosarcoma of the Proximal humerus in a 13-Year-Old Child: Case report

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Open Journal of Pediatrics 2024年第2期14卷 297-304页

作者： Lucienne Irène Patricia Ondima rhodia hélène Bosseba Missengue Cardinale Princilia Okiemy Niendet Nuptia erica Akobande Jean Claude Mieret Caryne Mboutol-Mandavo redy Atipo Galloye Judith Nsondé Malanda Jennifer Mave Sirimé Ngandzo Fabien Mouamba Faculty of health Sciences Marien Ngouabi University Brazzaville Congo Paediatric Surgery Department Brazzaville University Hospital Centre Brazzaville Congo Department of General Surgery Brazzaville University Hospital Centre Brazzaville Congo Carcinology Department Brazzaville University Hospital Centre Brazzaville Congo Anatomo-Pathology Laboratory Brazzaville University Hospital Centre Brazzaville Congo

Introduction: Osteosarcoma is the most common primary malignant bone tumor in children. It is highly aggressive and has a poor prognosis. A late presentation modifies and makes difficult the management affecting the survival of children. We report the case of a large conventional osteosarcoma in a 13-year-old girl. Case Presentation: Adolescent girl admitted for painful swelling of the left shoulder with absolute functional impotence of the thoracic limb and severe anemia. The painful swelling was thought to have been caused by a minor trauma that had occurred six months previously. The patient’s general condition was poor, and she presented with a large, shiny, painful mass over the shoulder and upper 2/3 of the left arm, measuring 28 cm long by 28 cm wide and 57 cm in circumference, and a large fistulous axillary adenopathy. CT scan showed a tumour lesion of the left humerus with liver and lung metastases, raising suspicion of osteogenic osteosarcoma. The tumor was classified according to TNM staging: T2N1M1(a + b). Management was modified when uncontrolled bleeding developed. It consisted of an extended amputation of the left thoracic limb. Pathological analysis showed a high-grade conventional osteosarcoma. Quality improvement was obtained for thirty days, followed by the onset of dyspnea. The evolution was towards death at forty days post-operatively. Conclusion: Osteosarcoma is a highly aggressive cancer. Delayed treatment leads to a fatal outcome. Early diagnosis is one of the challenges to be met in order to improve survival.

关键词： Osteosarcoma Child Conventional Case report

Exploring expressive and functional capacities of knitted textiles exposed to wind influence

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Frontiers of Architectural research 2021年第3期10卷 669-691页

作者： erica hörteborn Malgorzata A.Zboinska Department of Architecture and Civil Engineering Chalmers University of TechnologyGöteborgSE-41296Sweden

This study explores the design possibilities with knitted architectural textiles subjected to *** purpose is to investigate how such textiles could be applied to alter the usual static expression of exterior architectural and urban elements,such as facades and *** design investigations were made on a manual knitting machine and on a CNC(computer numerically controlled)flat knitting *** knitting techniques-tuck stitch,hanging stitches,false lace,and drop stitch-were explored based on their ability to create a three-dimensional effect on the surface level as well as on an architectural *** textile samples produced using those four techniques were subjected to controlled action of *** experiments were also conducted,to probe the possibilities of digitally simulating textile behaviours in *** results indicate that especially the drop stitch technique exhibits interesting *** variations in the drop stitch pattern generate both an aesthetic effect of volumetric expression of the textile architectural surface and seem beneficial in terms of wind speed ***,these types of knitted textiles could be applied to design architecture that are efficient in terms of improving the aesthetic user experience and comfort in windy urban areas.

关键词： Textile architecture Knitted textiles Kinetic architecture Wind Aesthetic qualities Digital textile simulation

Neonatal Intestinal Obstruction in Acute renal Failure in Premature Infant: A Case report

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Traumatic Diaphragmatic hernia in Children: A Case report

Open Journal of Pediatrics（儿科学期刊） 2024年第2期 338页

作者： Ondima Lucienne Irène Patricia Okiemy Niendet Cardinale Princilia Gandzali-Ngabe Pierre Eric Caryne Mboutol-Mandavo Bosseba Missengui rhodia hélène Akobande Nuptia erica

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Calyculin A induces prematurely condensed chromosomes without histone h1 phosphorylation in mammalian G1-phase cells

Surgical Science（外科学） 2024年第3期 111页

作者： Lucienne Irène Patricia Ondima rhodia hélène Bosseba Missengue Nuptia erica Akobande Cardinale Princilia Okiemy Niendet Jean-Claude Mieret Caryne Mboutol-Mandavo1

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Advances in Biological Chemistry 2013年第3期3卷 36-43页

作者： James r. Paulson erica r. Vander Mause Department of Chemistry University of Wisconsin-Oshkosh Oshkosh USA

It is shown here that one can induce prematurely condensed chromosomes (PCCs) in G1-phase human (heLa) and mouse (FT210) cells by treating them with the protein phosphatase inhibitor calyculin A. however, histone h1 is not phosphorylated in these G1-PCCs. It has previously been proposed that histone h1 phosphorylation is responsible for mitotic chromosome condensation, but our results suggest that this is not the case. They indicate instead that phosphorylation of histone h1 is not required for chromosome condensation. It is known that the Cdk1 protein kinase, which triggers mitosis and also phosphorylates histone h1, cannot be activated in G1-phase because mitotic cyclins are not present. Since calyculin A induces PCCs in G1-phase in the absence of active Cdk1, our results suggest that inactivation of protein phosphatases may be just as important for the onset of chromosome condensation and other mitotic events as the activation of protein kinases.

关键词： Mitosis Chromosome Condensation histones Protein Phosphatases

Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism

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Cancer Communications 2023年第4期43卷 508-512页

作者： Georgios Makris Semih Kayhan Marvin Kreuzer Véronique rüfenacht erica Faccin Jarl Underhaug Carmen Diez-Fernandez Philip A.Knobel Martin Poms Nadine Gougeard Vicente rubio Aurora Martinez Martin Pruschy Johannes häberle Division of Metabolism and Children’s research Center University Children’s Hospital ZurichUniversity of ZurichZurichSwitzerland Center for Integrative human Physiology University of ZurichZurichSwitzerland Department of radiation Oncology Laboratory for Applied RadiobiologyUniversity Hospital ZurichUniversity of ZurichZurichSwitzerland Department of Biomedicine University of BergenBergenNorway Department of Chemistry University of BergenBergenNorway NUVISAN Gmbh Neu-UlmBavariaGermany CDr Life Inc. SchlierenZurichSwitzerland Division of Clinical Chemistry and Biochemistry University Children’s Hospital ZurichUniversity of ZurichZurichSwitzerland Instituto de Biomedicina de Valencia(IBV-CSIC) CIBER de Enfermedades Raras(CIBERER-ISCIII)ValenciaSpain

Dear Editor,Metabolically induced cancer heterogeneity creates a large source of novel potential targets towards an enhanced therapeutic window alone and in combination with classic chemo-and radiotherapy[1,2].This is of particular interest for non-small cell lung cancer(NSCLC),which accounts for more than 80%of all lung tumor types characterized by limited responses to current treatment options[3–5].

关键词： metabolism lung cancer

Large Conventional Osteosarcoma of the Proximal humerus in a 13-Year-Old Child:Case report

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