检索结果-南通市图书馆

LE STRUTTURE ARcHEOLOGIcHE DELL'INSEDIAMENTO DELL'ANTIcA ET DEL BRONZO AD OSTIANO(cremona)

在线全文

学校读者我要写书评

暂无评论

Natural Disaster Reduction in china 1986年第1期 299-340页

作者： GABRIELLA erica PIA

The archaeological structures of the Early Bronze Age settlement of Ostiano San Salvatore(cremona-Northern Italy).-The Author presents the results of eight excavation campaigns carried out at the EarlyBronze Age Polada culture settlement of Ostiano San *** site lies on the left bank of the old bedof the River Mella at its confluence into the *** archacological structures brought to light concern a)pits with almost sterile filling and well definedpostholes:b)deep pits probably connected with pottery making activities:c)cylindrical silos:d)waste pitscontaining pottery and *** though all the site was inhabited throughout the Early Bronze Age period,a considerable number ofstructures has been put into chronological order on the basis of the materials *** we knowthat the settlement began at the start of the Early Bronze *** of the middle period of the same ageare evident while the late moments in the development of the Polada culture are scarcely ***-nomy of the site was mainly based on cattle rearing and cereals cultivation.

关键词： 110 Si PIO LE STRUTTURE ARcHEOLOGIcHE DELL’INSEDIAMENTO DELL’ANTIcA ET cremona DEL BRONZO AD OSTIANO

Transcriptomic Profiling of Human Pluripotent Stem cell-derived Retinal Pigment Epithelium over Time

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2021年第2期19卷 223-242页

作者： Grace E.Lidgerwood Anne Senabouth casey J.A.Smith-Anttila Vikkitharan Gnanasambandapillai Dominik c.Kaczorowski Daniela Amann-Zalcenstein erica L.Fletcher Shalin H.Naik Alex W.Hewitt Joseph E.Powell Alice Pebay Department of Anatomy and Neuroscience The University of MelbourneParkvilleVIC 3010Australia Department of Surgery The University of MelbourneParkvilleVIC 3010Australia centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC 3002Australia Garvan Weizmann centre for cellular Genomics Garvan Institute of Medical ResearchThe Kinghorn Cancer CentreDarlinghurstNSW 2010Australia Single cell Open Research Endeavour The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Immunology Division The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Department of Medical Biology The University of MelbourneParkvilleVIC 3010Australia School of Medicine Menzies Institute for Medical ResearchUniversity of TasmaniaHobartTAS 7005Australia UNSW cellular Genomics Futures Institute School of Medical SciencesUniversity of New South WalesSydneyNSW 2052Australia

Human pluripotent stem cell(h PSc)-derived progenies are immature versions of cells,presenting a potential limitation to the accurate modelling of diseases associated with maturity or ***,it is important to characterise how closely cells used in culture resemble their native *** order to select appropriate time points of retinal pigment epithelium(RPE)cultures that reflect native counterparts,we characterised the transcriptomic profiles of the h PSc-derived RPE cells from 1-and 12-month *** differentiated the human embryonic stem cell line H9 into RPE cells,performed single-cell RNA-sequencing of a total of 16,576 cells to assess themolecular changes of the RPE cells across these two culture time *** results indicate the stability of the RPE transcriptomic signature,with no evidence of an epithelial–mesenchymal transition,and with the maturing populations of the RPE observed with time in *** of Gene Ontology pathways revealed that as the cultures age,RPE cells upregulate expression of genes involved in metal binding and antioxidant *** might reflect an increased ability to handle oxidative stress as cells *** with native human RPE data confirms a maturing transcriptional profile of RPE cells in *** results suggest that long-term in vitro culture of RPE cells allows the modelling of specific phenotypes observed in native mature *** work highlights the transcriptional landscape of h PSc-derived RPE cells as they age in culture,which provides a reference for native and patient samples to be benchmarked against.

关键词： Human embryonic stem cell Human pluripotent stem cell Retinal pigment epithelium Single-cell RNA sequencing Ageing

clinical Analysis of the Pharmacological Interactions of clopidogrel and Gender Differences: A case-control Study

在线全文

学校读者我要写书评

暂无评论

International Journal of clinical Medicine 2012年第6期3卷 518-523页

作者： Bianchi Stefano chiara casellato Bianchini erica Scanavacca Paola Department of Pharmacy University Hospital of Ferrara Ferrara Italy.

Background: clopidogrel is a prodrug metabolized by cytochrome P450-2c19. Drugs inhibiting this enzyme might reduce its antiplatelet activity. In order to reduce gastrointestinal bleedings, proton-pump inhibitors are usually prescribed in association with clopidogrel. The study aims at assessing the clinical importance of interactions between clopidogrel and inhibitors of cYP2c19. It also aims to evaluate any possible factors that may reduce the therapeutic efficacy of the drug. Particular attention was devoted to possible gender differences in responsiveness to treatment with clopidogrel or clopidogrel plus proton-pump inhibitors. This analysis is a retrospective case-control observational study carried out by the University Hospital of Ferrara. Methods: Subjects were patients who had received clopidogrel from 01-01-2008 to 31-12-2008. For them, we analysed hospital admissions and data of drug prescriptions relative to dispensing of drugs cytochrome P-450-2c19 inhibitors. Patients were subdivided into case and control groups based on the occurrence or not of cardiovascular or cerebrovascular secondary events during therapy with clopidogrel. Results: The study focused on 781 patients, 20.1% of which (n.157) experienced secondary effects. The mean age is 70 years old. Men (67% of the analyzed population) experienced secondary events more than women (OR 1.54;cI 95% 1.04 - 2.28;p ced that the risk of secondary events increased by 2.2% with respect to the remaining patients (20.77% vs 18.57%;OR 1.15;cI 0.78 - 1.70;p = NS). Among PPIs, lansoprazole is the most used. For this subgroup the risk is 5.2% higher (risk in those exposed of 23.75% vs 18.57% in those not exposed;or 1.37, 95% cI 0.92 - 2.03;p = NS). The interaction with PPIs is particularly interesting only among women, with a risk 6.3% higher (17.46% exposed, 11.11% non exposed). The risk remains the same among men. conclusions: Analyzed data show an increase in cardi

关键词： Antiplatelet Activity Plus Proton-Pump Inhibitors Gender

Dissolution Behavior of Gold in Alkaline Media Using Thiourea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Nonferrous Metallurgy 2019年第1期8卷 1-8页

作者： cristian Vargas Patricio Navarro Daniel Espinoza Jorge Manríquez erica Mejía Departamento de Ingeniería Metalúrgica Universidad de Santiago de Chile Avda Libertador Bernardo O′Higgins Santiago Chile Grupo de Investigación GIIAM Facultad de Ingeniería Institución Universitaria Pascual Bravo Medellín Colombia

In this work the dissolutive behavior of gold in alkaline medium using thiourea (TU), under different variables, was studied in a theoretical and experimental way, in order to determine the conditions under which it is feasible to dissolve gold in thiourea-alkaline medium. A thermodynamic study was conducted by chemical speciation using the method of Ro-jas-Hernández, together with an electrochemical study where the electric potential was swept in the anodic direction. The main results of the thermodynamic study were that formamidine disulfide (FDS) and sulfinic compounds (S.c.) prevail at alkaline pH;by increasing the initial concen-tration of thiourea at alkaline pH, the presence of the gold complex is al-most zero for any initial concentration of thiourea. By including sodium sulfite in the gold-thiourea system, it was possible to obtain the Au(I)-TU complex at alkaline pH, with a presence of 95.13%. Electrochemical tests allowed verifying that in the absence of sodium sulfite the dissolution of gold in an alkaline medium is very slow but adding sodium sulfite im-provements become evident in the dissolution of the metal. Therefore, sodium sulfite catalyzes the gold dissolution process and stabilizes the thiourea. With this study it was possible to establish the feasibility of using thiourea in an alkaline medium for the dissolution of gold, and the conditions under which it is possible to dissolve the gold in that medium. With these fundamentals and conditions, it is now possible to move forward to test this system for minerals and/or concentrates containing gold.

关键词： Gold Alkaline Thiourea Dissolution Behavior Sodium Sulfite

A domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation at genes but not TEs in Arabidopsis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2021年第8期63卷 1462-1474页

作者： Xishi Zhou Junna He christos N.Velanis Yiwang Zhu Yuhan He Kai Tang Mingku Zhu Lisa Graser erica de Leau Xingang Wang Lingrui Zhang W.Andy Tao Justin Goodrich Jian-Kang Zhu cui-Jun Zhang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518124 China college of Horticulture China Agricultural UniversityBeijing100193 China Department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIN 47907 USA Institute of Molecular Plant Science School of Biological SciencesUniversity of EdinburghDaniel Rutherford BuildingMax Born CrescentEdinburghEH93BF United Kingdom Shanghai center for Plant Stress Biology and cAS center for Excellence in Molecular Plant Sciences Chinese Academy of SciencesShanghai201602 China Institute of Integrative Plant Biology School of Life SciencesJiangsu Normal UniversityXuzhou221116 China University of Applied Sciences Mannheim Paul-Wittsack-Str.10Mannheim68163 Germany Department of Biochemistry Purdue UniversityWest LafayetteIN 47907 USA

In eukaryotes,histone acetylation is a major modification on histone N-terminal tails that is tightly connected to transcriptional ***6 is a histone deacetylase involved in the transcriptional regulation of genes and transposable elements(TEs)in Arabidopsis ***6 has been shown to participate in several complexes in plants,including a conserved SIN3 ***,we uncover a novel protein complex containing HDA6,several Harbinger transposon-derived proteins(HHP1,SANT1,SANT2,SANT3,and SANT4),and MBD domain-containing proteins(MBD1,MBD2,and MBD4).We show that mutations of all four SANT genes in the sant-null mutant cause increased expression of the flowering repressors FLc,MAF4,and MAF5,resulting in a late flowering *** deep sequencing reveals that while the SANT proteins and HDA6 regulate the expression of largely overlapping sets of genes,TE silencing is unaffected in sant-null *** global histone H3 acetylation profiling shows that SANT proteins and HDA6 modulate gene expression through ***,our findings suggest that Harbinger transposon-derived SANT domain-containing proteins are required for histone deacetylation and flowering time control in plants.

关键词： deacetylation flowering Harbinger HDA6 histone acetylation protein complex SANT

HcV clearance by direct antiviral therapy and occurrence/recurrence of hepatocellular carcinoma:still an issue?

在线全文

学校读者我要写书评

暂无评论

Hepatoma Research 2018年第6期4卷 90-103页

作者： Francesco Paolo Russo Martina Tessari Angela Imondi erica Nicola Lynch Fabio Farinati Department of Surgery Oncology and GastroenterologySection of GastroenterologyPadua University HospitalPadua 35128Italy

New regimens with direct-acting antivirals (DAAs) agents have changed both efficacy and safety of hepatitis c virus (HcV)-treatment, as almost all patients can be treated and cured at any stage of liver disease. The rates of sustained virological response to currently available combinations exceed 95% in real-life practice. However, conflicting results have been produced on the occurrence/recurrence of hepatocellular carcinoma (Hcc) in patients with HcV-associated cirrhosis treated with DAAs. In this review we analyse the data available in the literature in order to elucidate the impact of DAAs on the risk of Hcc occurrence in patients without previous history of tumor, and of recurrence after successful treatment of the tumor. Data on 'de novo' Hcc incidence were quite homogeneous, suggesting that the treatment with DAAs does not modify the risk of Hcc developing during the first 6-12 months after HcV eradication. On the contrary, Hcc recurrence rates after DAAs were extremely variable across different studies, reflecting a large heterogeneity in this clinical setting. The possibility that treatment with DAAs may favour tumour growth and spread in individual patients with active Hcc foci is supported by some observations but remains unproven.

关键词： Hepatitis c virus direct-acting antivirals eradication hepatocellular carcinoma occurrence recurrence

Procedural simulation:medical student preference and value of three task trainers for ultrasound guided regional anesthesia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2017年第4期8卷 287-291页

作者： Shadi Lahham Taylaur Smith Jessa Baker Amanda Purdy erica Frumin Bret Winners Sean P.Wilson Abdulatif Gari John c.Fox Department of Emergency Medicine University of CaliforniaIrvineOrangeCalifornia 92868USA Uc Irvine School of Medicine IrvineCaliforniaUSA

BAcKGROUND: Ultrasound guided regional anesthesia is widely taught using task trainer models. commercially available models are often used; however, they can be cost prohibitive. Therefore, alternative "homemade" models with similar fidelity are often used. We hypothesize that professional task trainers will be preferred over homemade models. The purpose of this study is to determine realism, durability and cleanliness of three different task trainers for ultrasound guided nerve ***: This was a prospective observational study using a convenience sample of medical student participants in an ultrasound guided nerve block training session on January 24 th, 2015. Participants were asked to perform simulated nerve blocks on three different task trainers including, 1 commercial and 2 homemade. A questionnaire was then given to all participants to rate their experiences both with and without the knowledge on the cost of the simulator ***: Data was collected from 25 participants. The Blue Phantom model was found to have the highest fidelity. Initially, 10(40%) of the participants preferred the Blue Phantom model, while 10(40%) preferred the homemade gelatin model and 5(20%) preferred the homemade tofu model. After cost awareness, the majority, 18(72%) preferred the gelatin ***: The Blue Phantom model was thought to have the highest fidelity, but after cost consideration the homemade gelatin model was preferred.

关键词： Ultrasound guided nerve block Task trainer Regional anesthesia

采用FDA认证的便携式生物传感器进行消化功能的无创监测:进一步证实其可用于追踪食物摄入情况

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2021年第5期9卷 475-477,I0003页

作者： erica R.cohen Mayra Lopez Brennan M.R.Spiegel christopher V.Almario Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCAUSA cedars-Sinai center for Outcomes Research and Education(cS-cORE) Los AngelesCAUSA Division of Health Services Research Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Health Policy and Management UCLA Fielding School of Public HealthLos AngelesCAUSA Division of Informatics Cedars-Sinai Medical CenterLos AngelesCAUSA

Introduction Obesity affects one-third of the US population and accounts for$200 billion/year in expenditures[1].Diet and exercise form the cornerstone of management,yet are often ineffective[2].Mobile health applications(mHealth apps)can augment traditional strategies;Gill and Panda[3]demonstrated that obese patients can modify their eating behavior and lose weight using an mHealth app to track food *** promising,these apps typically require active data input and currently lack passively collected,physiologic input to support sustained behavior change.

关键词：生物传感器消化功能食物摄入

人HcN4通道的滞后现象:影响窦房结起搏的潜在决定因素(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生理学报 2010年第1期62卷 1-13页

作者：萧永福 Natalie chandler Halina Dobrzynski Eric S.Richardson erica M.TenBroek Joshua J.Wilhelm Vinod Sharma Anthony Varghese Mark R.Boyett Paul A.Iaizzo Daniel c.Sigg 美敦力公司心脏节律疾病管理部曼彻斯特大学医学院明尼苏达州大学外科学系明尼苏达州大学整合生物学与生理学系美敦力公司科学技术部威斯康辛大学雷河分校计算机系

超极化活化环核苷酸门控(hyperpolarization-activated cyclic-nucleotide-gated,HcN)通道参与调制心脏跳动的节律和速率。与HcN1和HcN2有所不同,慢通道HcN4可能不存在电压依赖的滞后现象。本研究采用单细胞膜片钳方法,在稳定转染hHcN4... 详细信息

超极化活化环核苷酸门控(hyperpolarization-activated cyclic-nucleotide-gated,HcN)通道参与调制心脏跳动的节律和速率。与HcN1和HcN2有所不同,慢通道HcN4可能不存在电压依赖的滞后现象。本研究采用单细胞膜片钳方法,在稳定转染hHcN4的HEK293细胞上进行电生理记录,观察hHcN4通道是否存在滞后现象,以及cAMP对其的调制作用;同时采用实时定量RT-PcR方法检测窦房结和心房组织中HcNs的表达。电压钳实验结果显示hHcN4电流(Ih)激活随着保持电位超极化的变化而向去极化方向移动。三角电位变化钳(triangular ramp)和动作电位钳的结果也显示了hHcN4的滞后现象。cAMP增加Ih电流幅度,且使电流激活向去极化方向移动,从而改变内源性hHcN4滞后行为。RT-PcR结果显示,人窦房结组织主要表达HcN4,占75%,HcN1占21%,HcN2占3%,HcN3占0.7%。以上结果提示,人窦房结组织主要表达HcN4亚型,hHcN4的Ih存在电压依赖性的滞后现象,且受cAMP调制。由此推断,hHcN4通道的滞后现象可能在窦房结起搏活动中起到了关键作用。

关键词： HcN4通道滞后窦房结 cAMP