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Infrared chemical imaging through non-degenerate two-photon absorption in silicon-based cameras

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Light(Science & Applications) 2020年第1期9卷 813-822页

作者： David Knez Adam M.Hanninen Richard c.Prince eric O.Potma Dmitry A.Fishman Department of chemistry University of CaliforniaIrvineCA 92697USA Department of Biomedical Engineering University of CaliforniaIrvineCA 92697USA

chemical imaging based on mid-infrared(MIR)spectroscopic contrast is an important technique with a myriad of applications,including biomedical imaging and environmental *** MIR cameras,however,lack performance and are much less affordable than mature Si-based devices,which operate in the visible and nearinfrared ***,we demonstrate fast MIR chemical imaging through non-degenerate two-photon absorption(NTA)in a standard Si-based charge-coupled device(ccD).We show that wide-field MIR images can be obtained at 100 ms exposure times using picosecond pulse energies of only a few femtojoules per pixel through NTA directly on the ccD *** this on-chip approach does not rely on phase matching,it is alignment-free and does not necessitate complex postprocessing of the *** emphasize the utility of this technique through chemically selective MIR imaging of polymers and biological samples,including MIR videos of moving targets,physical processes and live nematodes.

关键词： absorption Infrared chemical

A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings

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chinese Science Bulletin 2011年第32期56卷 3394-3397页

作者： LUI Simon S Y SHAM Pak cHAN Raymond c K cHEUNG eric F c Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Graduate University of chinese Academy of Sciences castle Peak Hospital Department of Psychiatry the University of Hong Kong

The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in china as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in china. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.

关键词：精神病患者稳定家庭早期原理预计香港面部表情识别

changes in ankle work,foot work,and tibialis anterior activation throughout a long run

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Journal of Sport and Health Science 2022年第3期11卷 330-338页

作者： eric.c.Honert Florian Ostermair Vinzenzvon Tscharner Benno M.Nigg Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgaryAlberta T2N 1N4Canada Institute of Sports and Sports Science Karlsruhe Institute of TechnologyKarlsruhe 76131Germany Department of Sports Science and Sports Friedrich Alexander University Erlangen-NurembergErlangen 91058Germany

Background The ankle and foot together contribute to over half of the positive and negative work performed by the lower limbs during ***,little is known about how foot kinetics change throughout a *** amount of negative foot work may decrease as tibialis anterior(TA)electromyography(EMG)changes throughout longer-duration ***,we examined ankle and foot work as well as TA EMG changes throughout a changing-speed *** Fourteen heel-striking subjects ran on a treadmill for 58 *** collected ground reaction forces,motion capture,and *** ran at 110%,100%,and 90%of their 10-km running speed and 2.8 m/s multiple times throughout the *** work was evaluated using the distal rearfoot work,which provides a net estimate of all work contributors within the *** Positive foot work increased and positive ankle work decreased throughout the run at all *** the 110%10-km running speed,negative foot work decreased and TA EMG frequency shifted lower throughout the *** increase in positive foot work may be attributed to increased foot joint work performed by intrinsic foot *** in negative foot work and TA EMG frequency may indicate that the TA plays a role in negative foot work in the early stance of a *** This study is the first to examine how the kinetic contributions of the foot change throughout a *** studies should investigate how increases in foot work affect running performance.

关键词： Electromyography Footwear Running performance

Semantic Segmentation of Sorghum Using Hyperspectral Data Identifies Genetic Associations

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Plant Phenomics 2020年第1期2卷 14-24页

作者： chenyong Miao Alejandro Pages Zheng Xu eric Rodene Jinliang Yang James c.Schnable center for Plant Science Innovation University of Nebraska-LincolnLincolnNEUSA Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNEUSA Quantitative Life Sciences Initiative University of Nebraska-LincolnLincolnNEUSA Department of Mathematics and Statistics Wright State UniversityDaytonOHUSA

This study describes the evaluation of a range of approaches to semantic segmentation of hyperspectral images of sorghum plants,classifying each pixel as either nonplant or belonging to one of the three organ types(leaf,stalk,panicle).While many current methods for segmentation focus on separating plant pixels from background,organ-specific segmentation makes it feasible to measure a wider range of plant *** scored training data for a set of hyperspectral images collected from a sorghum association population was used to train and evaluate a set of supervised classification *** algorithms show acceptable accuracy for this classification *** trained on sorghum data are able to accurately classify maize leaves and stalks,but fail to accurately classify maize reproductive organs which are not directly equivalent to sorghum *** measurements extracted from semantic segmentation of sorghum organs can be used to identify both genes known to be controlling variation in a previously measured phenotypes(e.g.,panicle size and plant height)as well as identify signals for genes controlling traits not previously quantified in this population(e.g.,stalk/leaf ratio).Organ level semantic segmentation provides opportunities to identify genes controlling variation in a wide range of morphological phenotypes in sorghum,maize,and other related grain crops.

关键词： Sorghum classify organs

Yeast knockout library allows for efficient testing of genomic mutations for cell-free protein synthesis

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Synthetic and Systems Biotechnology 2016年第1期1卷 2-6页

作者： Jennifer *** Lauren G.clark Alaksh choudhury c.eric Hodgman Michael c.Jewett Department of chemical and Biological Engineering Northwestern University2145 Sheridan RoadEvanstonIL 60208-3120USA chemistry of Life Processes Institute 2170 Campus DriveEvanstonIL 60208-3120USA Masters in Biotechnology Program Northwestern University2145 Sheridan RoadEvanstonIL 60208-3120USA Robert H.Lurie comprehensive cancer center Northwestern University676 N.St Clair StSuite 1200ChicagoIL 60611-3068USA Simpson Querrey Institute Northwestern University303 E.Superior StSuite 11-131ChicagoIL 60611-2875USA

cell-free protein synthesis(cFPS)systems from crude lysates have benefitted from modifications to their enzyme *** example,functionally deleting enzymes in the source strain that are deleterious to cFPS can improve protein synthesis ***,making such modifications can take substantial *** a proof-of-concept to accelerate prototyping capabilities,we assessed the feasibility of using the yeast knockout collection to identify negative effectors in a Saccharomyces cerevisiae cFPS *** analyzed extracts made from six deletion strains that targeted the single deletion of potentially negative effectors(e.g.,nucleases).We found a statistically significant increase in luciferase yields upon loss of function of GcN3,PEP4,PPT1,NGL3,and XRN1 with a maximum increase of over 6-fold as compared to the wild *** work has implications for yeast cFPS and for rapidly prototyping strains to enable cell-free synthetic biology applications.

关键词： cell-free protein synthesis Saccharomyces cerevisiae Synthetic biology In vitro translation cell-free biology Protein expression

Is chronic hepatitis c virus infection a risk factor for breast cancer?

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World Journal of Gastroenterology 2010年第29期16卷 3687-3691页

作者： Dominique Larrey Marie-cécile Bozonnat Ihab kain Georges-Philippe Pageaux eric Assenat Liver Unit and INSERM Unit 632 Saint-Eloi HospitalMontpellier University Department of Biostatistics Intitut Universitaire de Recherche CliniqueMontpellier University Liver Unit Saint-Eloi HospitalMontpellier University Medical Oncology Unit Saint-Eloi HospitalMontpellier University

AIM:To evaluate the prevalence of breast tumors in adult females with chronic hepatitis c virus(HcV) ***:Prospective,single-center study,based on female outpatients consulting in a liver unit,for 1 *** study group included females with present and/or past history of chronic infection by *** with spontaneous recovery were *** hepatitis had been proved by liver biopsy in the majority of cases and/or biological markers of inflammation and *** control group included female patients with other well documented chronic liver diseases:chronic hepatitis B,alcoholic liver disease,autoimmune hepatitis,hemochromatosis,non alcoholic liver disease,chronic *** patients were prospectively questioned during consultation about past breast history and follow-up by ***:Breast carcinoma was recorded in 17/294 patients with HcV infection(5.8%,95% cI:3.1-8.4) vs 5/107 control patients(4.7%,95% cI:0.67-8.67).Benign tumors of the breast(mastosis,nodules,cysts) were recorded in 75/294 patients with HcV infection(25.5%,95% cI:20.5-30.5) vs 21/107(19.6%,95% cI:12.1-27.1) in the control *** lesion was noted in 202 patients with HcV(68.7%,95% cI:63.4-74) vs 81 control patients(75.7%,95% cI:67.6-83.8).Despite a trend to an increased prevalence in the group with HcV infection,the difference was not significant compared to the control group(P=NS).In patients over 40 years,the results were,respectively,as follows:breast cancer associated with HcV:17/266 patients(6.3%,95% cI:3.4-9.3) vs 5/95 patients(5.2%,95% cI:0.7-9.7) in the control group;benign breast tumors:72/266 patients with HcV infection(27%,95% cI:21.7-32.4) vs 18/95 patients(18.9%,95% cI:11-26.8) in the control group;no breast lesion 177/266(66.5%,95% cI:60.9-72.2) in patients with HcV infection vs 72/95(75.7%,95% cI:67.1-84.4) in the control *** differences were not significant(P=NS).cONcLUSION:These results suggest that chronic HcV infectio

关键词： Breast tumors Breast cancer Hepatitis c virus infection Risk factor

Facile design of Au@Pt core-shell nanostructures： Formation of Pt submonolayers with tunable coverage and their applications in electrocatalysis

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Nano Research 2014年第3期7卷 410-417页

作者： Fulin Zheng Wing-Tak Wong ka-Fu Yung Department of Applied Biology and chemical Technology The Hong Kong Polytechnic University Hung Hom Hong Kong SAR China

A facile design of Pt nanostructures from submonolayer to monolayer has been realized by ion adsorption-in situ electrochemical reduction on Au nanoparticles supported on multiwall carbon nanotubes （cNTs）. The as prepared Au@Pt/cNTs catalysts display coverage-specific electrocatalysis. Au@Pt/cNTs with low Pt coverage is inactive towards methanol oxidation whereas it oxidizes formic acid effectively through a direct pathway with mass specific activity 90 times that of a commercial Pt/c catalyst. Due to its inertness to methanol, it shows high performance in the oxygen reduction reaction （ORR） with high methanol tolerance. In contrast, simply increasing the Pt coverage to above 40% switches the formic acid oxidation process to both direct and indirect catalytic pathways, and also results in high methanol oxidation activity.

关键词： electrocatalysis platinum submonolayer fuel cell

Loco-regional intervention for hepatocellular carcinoma

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Journal of Interventional Medicine 2019年第2期2卷 43-46页

作者： Wan Yee Lau eric.c.H.Lai Faculty of Medicine The Chinese University of Hong KongNew TerritoriesHong KongChina

Anatomic location/size and number of lesions,inadequate volume of future liver remnant,or poor coexisting premorbid conditions preclude surgery in the majority of patients with hepatocellular carcinoma(Hcc).Liver transplantation can cure some patients with poor liver function,but few patients are eligible because of scarcity of *** specific anti-cancer treatment,the prognosis of Hcc is *** locoregional therapies are used to treat patients who are not candidates for surgery,and have emerged as tools for palliation,tumor downstaging,and bridging therapy prior to liver ***,local ablative therapy even competes with partial hepatectomy and liver transplantation as a primary treatment for small *** is well suited to treatment with loco-regional therapy because it has a tendency to stay within the liver,with distant metastasis generally occurring late in the course of *** suggests that an effective local-regional therapy can have a great impact on Hcc patients who are not candidates for surgical ***-regional therapy can further be justified because patients with Hcc usually die of liver failure consequent to intrahepatic growth resulting in liver tissue destruction,rather than extrahepatic metastases.

关键词： Hepatocellular carcinoma Hepatectomy Loco-regional therapy TAcE Local ablation

Effects of low-oxygen conditions on embryo growth in the painted turtle,chrysemys picta

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Integrative Zoology 2017年第2期12卷 148-156页

作者： Gerardo A.cORDERO Matthew L.kaRNATZ Jon c.SVENDSEN eric J.GANGLOFF Department of Ecology Evolutionand Organismal BiologyIowa State UniversityAmesIowaUSA Technical University of Denmark National Institute of Aquatic ResourcesFreshwater FisheriesSilkeborgDenmark Interdisciplinary centre of Marine and Environmental Research University of PortoPortoPortugal

Low-oxygen conditions(hypoxia;<21%O_(2))are considered unfavorable for growth;yet,embryos of many vertebrate taxa develop successfully in hypoxic subterranean *** enhanced tolerance to hypoxia has been demonstrated in... 详细信息

Low-oxygen conditions(hypoxia;considered unfavorable for growth;yet,embryos of many vertebrate taxa develop successfully in hypoxic subterranean *** enhanced tolerance to hypoxia has been demonstrated in adult reptiles,such as in the painted turtle(chrysemys picta),its effects on sensitive embryo life stages warrant *** tested the hypothesis that short-term hypoxia negatively affects growth during day 40 of development in ***,when O_(2) demands are highest in embryos.A brief,but severe,hypoxic event(5%O_(2) for 0.5 h)moderately affected embryo growth,causing a 13%reduction in mass(relative to a normoxic control).The same condition had no effect during day 27;instead,a nearly anoxic event(1%O_(2) for 72 h)caused a 5%mass *** embryos survived the egg incubation *** study supports the assumption that reptilian embryos are resilient to intermittently low O_(2) in subterranean *** work is needed to ascertain responses to suboptimal O_(2) levels while undergoing dynamic changes in developmental physiology.

关键词： embryo metabolism embryo respiration growth rate nest environment oxygen consumption rate