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奈妥匹坦帕洛诺司琼预防化疗引起的恶心呕吐:从临床试验到日常临床实践

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中国实用医药 2024年第1期19卷 159-174页

作者： Matti Aapro Karin Jordan Florian scotté Luigi Celio Meinolf Karthaus eric.Roeland Genolier Cancer Centre Clinique de GenolierGenolierSwitzerland Department Haematology Oncology and Palliative CareErnst von Bergmann Klinikum PotsdamPotsdamGermany Department of Medicine V HematologyOncology and RheumatologyUniversity Hospital HeidelbergHeidelbergGermany Interdisciplinary Cancer Course Department Gustave Roussy Cancer InstituteVillejuifFrance Medical Oncology Unit ASST del GardaDesenzano del Garda(BS)Italy Department of Hematology Oncology and Palliative CareKlinikum NeuperlachMunichGermany Department of Hematology Oncology and Palliative CareKlinikum HarlachingMunichGermany Oregon Health and sciences University Knight Cancer InstitutePortlandORUSA

化疗引起的恶心呕吐(CINV)是众多抗癌药物治疗中常见的不良事件,不仅会对患者生活质量带来负面影响,还有可能影响化疗效果。目前,指南建议的止吐方案可以预防大部分癌症患者的CINV。但临床医师并不能始终遵循指南建议,患者也常常难以坚... 详细信息

化疗引起的恶心呕吐(CINV)是众多抗癌药物治疗中常见的不良事件,不仅会对患者生活质量带来负面影响,还有可能影响化疗效果。目前,指南建议的止吐方案可以预防大部分癌症患者的CINV。但临床医师并不能始终遵循指南建议,患者也常常难以坚持医师处方的治疗。因此需要采取一些提高指南依从性的方法。奈妥匹坦帕洛诺司琼(NEPA)是首个也是唯一一个固定剂量复方止吐药,由奈妥匹坦(口服)/福奈妥匹坦(静脉给药)与帕洛诺司琼(PALO)组成。NEPA可以联合地塞米松组成三联止吐方案,这是用于高致吐性化疗(HEC)患者和部分中致吐性化疗(MEC)患者预防CINV的推荐方案。因此,NEPA止吐治疗操作简单便捷,可能有助于提高指南依从性。本综述对CINV进行了概括,评价了在临床试验和真实实践中积累的NEPA止吐效果及安全性方面的证据,同时也评价了在关键临床试验之外的环境下,即日常临床环境中使用NEPA进行止吐的初步证据。此外,本文还评述了化疗期间使用NEPA控制恶心症状和提高患者生活质量,这是癌症患者管理中面临的两个大挑战。

关键词：奈妥匹坦帕洛诺司琼化疗引起的恶心呕吐 NK1受体拮抗剂 5-羟色胺-3受体拮抗剂生活质量止吐方案

systems for Hazards Identification in High Mountain Areas: An Example from the Kullu District, Western Himalaya

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Journal of Mountain science 2004年第2期1卷 115-127页

作者： James s. Gardner eric.saczuk Department of Environment and Geography and Natural Resources Institute University of Manitoba Winnipeg ManitobaCanada .R3T 2N2Department of Environment and Geography and Natural Resources Institute University of Manitoba Winnipeg ManitobaCanada .R3T 2N2

Methods and techniques for the identification, monitoring and management of natural hazards in high mountain areas are enumerated and described. A case study from the western Himalayan Kullu District in Himachal Pradesh, India is used to illustrate some of the methods. Research on the general topic has been conducted over three decades and that in the Kullu District has been carried out since 1994. Early methods of hazards identification in high mountain areas involved intensive and lengthy fieldwork and mapping with primary reliance on interpretation of landforms, sediments and vegetation thought to be indicative of slope failures, rock falls, debris flows, floods and accelerated soil surface erosion. Augmented by the use of airphotos and ad hoc observations of specific events over time, these methods resulted in the gradual accumulation of information on hazardous sites and the beginnings of a chronology of occurrences in an area. The use of historical methods applied to written and photographic material, often held in archives and libraries, further improved the resolution of hazards information. In the past two decades, both the need for, and the ability to, accurately identify potential hazards have increased. The need for accurate information and monitoring comes about as a result of rapid growth in population, settlements, transportation infrastructure and intensified land uses and, therefore, risk and vulnerability in mountain areas. Ability has improved as the traditional methods of gathering and manipulating data have been supplemented by the use of remote sensing, automated terrain modeling, global positioning systems and geographical information systems. This paper focuses on the development and application of the latter methods and techniques to characterize and monitor hazards in high mountain areas.

关键词： Hazards mapping GIs Himalaya

Klingsor syndrome: An Observation in a Patient with schizophrenia

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Effects of sARs-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

Open Journal of Urology（泌尿学期刊） 2024年第5期 346页

作者： Mbuya Musapudi eric.Ouake Hadidjatou Michel Agounkpe Yevi Dodji Magloire Inès Hodonou Fred Martin Avakoudjo Josué Georges Dejinnin

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew shing Hin Chung Xue Li Francisco Tsz Tsun Lai eric.Yuk Fai Wan Celine sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina state Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina school of Nursing The University of Hong KongHong KongChina school of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston school of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)*** To determine the effects of sARs-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed sARs-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of sARs-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,Pst-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,Pst-acute:IRR:1.24,95%CI:1.14-1.36,Pse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,Pst-acute:IRR:1.24,95%CI:1.13-1.35,Ps with sARs-CoV-2 infection were not associated with increased risk of HCC,they

关键词： sARs-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

Next-Generation Tools to study Autonomic Regulation In Vivo

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Neuroscience Bulletin 2019年第1期35卷 113-123页

作者： snigdha Mukerjee eric.Lazartigues Department of Pharmacology and Experimental Therapeutics Louisiana State University Health Sciences Center Neuroscience and Cardiovascular Centers of Excellence Louisiana State University Health Sciences Center southeast Louisiana Veterans Health Care system

The recent development of tools to decipher the intricacies of neural networks has improved our understanding of brain function. Optogenetics allows one to assess the direct outcome of activating a geneticallydistinct population of neurons. Neurons are tagged with light-sensitive channels followed by photo-activation with an appropriate wavelength of light to functionally activate or silence them, resulting in quantifiable changes in the periphery. Capturing and manipulating activated neuron ensembles, is a recently-designed technique to permanently label activated neurons responsible for a physiological function and manipulate them. On the other hand, neurons can be transfected with genetically-encoded Ca2^+ indicators to capture the interplay between them that modulates autonomic end-points or somatic behavior. These techniques work with millisecond temporal precision. In addition, neurons can be manipulated chronically to simulate physiological aberrations by transfecting designer G-protein-coupled receptors exclusively activated by designer drugs. In this review, we elaborate on the fundamental concepts and applications of these techniques in research.

关键词： Autonomic regulation Optogenetics Calcium sensors DREADD

Biologically Inspired Node Generation Algorithm for Path Planning of Hyper-redundant Manipulators Using Probabilistic Roadmap

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International Journal of Automation and computing 2014年第2期11卷 153-161页

作者： eric.Lanteigne Amor Jnifene Department of Mechanical Engineering University of Ottawa Department of Mechanical and Aerospace Engineering Royal Military College of Canada

This article describes a biologically inspired node generator for the path planning of serially connected hyper-redundant manipulators using probabilistic roadmap planners. The generator searches the configuration space surrounding existing nodes in the roadmap and uses a combination of random and deterministic search methods that emulate the behaviour of octopus limbs. The strategy consists of randomly mutating the states of the links near the end-effector, and mutating the states of the links near the base of the robot toward the states of the goal configuration. When combined with the small tree probabilistic roadmap planner, the method was successfully used to solve the narrow passage motion planning problem of a 17 degree-of-freedom manipulator.

关键词： Path planning hyper-redundant manipulators probabilistic road map(PRM) quasi-deterministic node generation bi-directional search algorithm.

NONLINEAR DYNAMICs OF A CRACKED ROTOR IN A MANEUVERING AIRCRAFT

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Applied Mathematics and Mechanics(English Edition) 2004年第10期25卷 1139-1150页

作者：林富生孟光 eric.Hahn state Key Laboratory of Vibration shock and Noise shanghai Jiaotong University school of Mechanical and Manufacturing Engineering The University of New south Wales

The nonlinear dynamics of a cracked rotor system in an aircraft maneuvering with constant velocity or acceleration was investigated. The influence of the aircraft climbing angle on the cracked rotor system response is of particular interest and the results show that the climbing angle can markedly affect the parameter range for bifurcation, for quasi-periodic response and for chaotic response as well as for system stability. Aircraft acceleration is also shown to significantly affect the nonlinear behavior of the cracked rotor system, illustrating the possibility for on-line rotor crack fault diagnosis.

关键词： cracked rotor maneuvering aircraft nonlinear response fault diagnosis

A higher-dimensional model of the nucleon-nucleon central potential

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Frontiers of physics 2014年第2期9卷 234-239页

作者： eric.R. Hedin Department of Physics & Astronomy Ball State University Muncie IN 47306 USA

Based on a theory of extra dimensional confinement of quantum particles [E. R. Hedin, Physics Essays, 2012, 25（2）： 177], a simple model of a nucleon nucleon （NN） central potential is derived which quantitatively reproduces tile radial profile of other models, without adjusting any free pa- rameters. It is postulated that a higher-dimensional simple harmonic oscillator confining potential localizes particles into three-dimensional （3D） space, but allows for an ewmescent penetration of the particles into two higtmr spatial dimensions. Producing an effect identical with the relativistic quan- tum phenolnenon of zitterbewegung, the higher-dimensional oscillations of amplitude h（mc） call be alternatively viewed as a localized curvature of 3D space back and forth into the higher dimensions. The overall spatial curvature is proportional to the particle＇s extra-dimensional ground state wave function in tile higher-dimensional harmonic confining potential well. Minimizing the overlapping curvature （proportional to the energy） of two particles in proximity to each other, subject to the constraint that for the two particles to occupy the same spatial location one of them must be excited into the 1st excited state of the harmonic potential well, gives the desired NN potential. specifying only the imcleon masses, the resulting potential well and repulsive core reproduces the radial profile of several published NN central potential models. In addition, the predicted height of the repulsive core, when used to estimate the maximum neutron star mass, matches well with the best estimates from relativistic theory incorporating standard nuclear matter equations of state. Nucleon spin, Coulomb interactions, and internal nucleon structure are not considered in the theory as presented in this article.

关键词： nucleon-nucleon potential higher-dimensional theory neutron star mass limit

A review of regenerative therapies as penile rehabilitation in men following primary prostate cancer treatment:Evidence for erectile restoration and cavernous nerve regeneration

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Asian Journal of Urology 2022年第3期9卷 287-293页

作者： eric.Chung AndroUrology Centre BrisbaneQLDAustralia University of Queensland Princess Alexandra HospitalBrisbaneQLDAustralia Macquarie University Hospital SydneyNSWAustralia

Objective:The following article explores our evolving understandings of the role of regenerative technology as an effective penile rehabilitation tool in men with erectile dysfunction(ED)in the setting of prostate cancer(PCa)treatment and PCa ***:This narrative clinical review paper summarizes what is currently known about various modalities of regenerative therapy in restoring spontaneous erectile function(EF)in men following PCa treatment with an emphasis on penile rehabilitation ***:Conventional medical therapy often does not reverse underlying endothelial dysfunction or promote neuro-vasculogenesis to preserve penile health in men with *** the past decade,there has been considerable interest in the role of regenerative therapy to restore endothelial dysfunction and ED without future dependency on medical *** therapy can be classified into cellular-based(immunomodulators,stem cells,and platelet-rich plasma),biomaterials(nerve graft transfer),and device-related technology(low-intensity shockwave).Although published literature shows early promise in the role of regenerative technology for ED,there is a paucity of high-quality clinical trials in the setting of penile rehabilitation and PCa survivorship to support their use as standard care and be adopted in clinical guidelines.

关键词： Regenerative therapy Low-intensity shockwave therapy stem cell therapy Platelet-rich plasma Immunomodulator Nerve transfer Erectile dysfunction Penile rehabilitation