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ANTI-TUMOR RESPONSES INDUCED BY LASER IRRADIATION AND IMMUNOLOGICAL STIMULATION USING A MOUSE MAMMARY TUMOR MODEL

Journal of Innovative Optical Health Sciences 2013年第4期6卷 49-55页

作者： FEIFAN ZHOU XIAOSONG LI SHENG SONG JOSEPH T.ACQUAVIVA III ROMAN F.wOLF eric w.howard wEI R.CHEN MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal University Guangzhou P.R.China Department of Oncology The First A±liated Hospital of Chinese PLA General Hospital Beijing 100048 P.R.China Department of Engineering and Physics University of Central Oklahoma Edmond OklahomaUSA Department of Comparative Medicine College of Medicine University of Oklahoma Health Sciences Center 940 S.L.Young Blvd.Oklahoma City OklahomaUSA Department of Cell Biology University of Oklahoma Health Sciences Center 940 S.L.Young Blvd. Oklahoma City OklahomaUSA

Anti-tunor immunological response induced by local intervention is ideal for treatment of metastatic *** immunot herapy was developed to synergize photot hermal interaction with immunological stimulation for cancer *** an infrared laser,indocyanine green(ICG,as a light abeorbing agent),and glycated chitosan(GC,as an immunostimulant),.laser imm unot herapy has resulted in tumor suppression and anti-tumor responses in pre-clinical as well as clinical *** further understand the mechanism of laser immunotherapy,the efects of laser and GC treatment without specifc enhancement of laser absorption were *** adoptive immunity transfer was perfomed using splenocytes as immune *** cells harvested from tumor-bearing mice treated by laser+GC provided 60%immunity in naive ***,cytotoxicity and TNF-ar secretion by splenocytes from treated mice also indicated that laser+GC induced immunity was *** high level of infiltrating T cells in tumors after laser+GC treatment furt her confirned a specific anti-tumor immune ***,laser+GC could prove to be a promisi ng selective local trea tment modality that induces a systemic anti-tumor response,with appropriate laser parameters and GC doses.

关键词： Laser immunotherapy glycated chitosan anti-tumor immunity metastatic cancers

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Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

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Journal of Innovative Optical Health Sciences 2015年第4期8卷 97-104页

作者： Joseph T.Acquaviva III Cody F.Bahavar Feifan Zhou Xiaosong Li eric w.howard Liz C.Bullen Ricardo P.Silvy wei R.Chen Biophotonics Research Laboratory Center for Interdisciplinary Biomedical Education and Research University of Central Oklahoma EdmondOklahoma 73034USA South west Nano Technologies NormanOklahoma 73071USA Department of Oncology The First Affiliated Hospital of Chinese PLA General Hospital Fucheng Road 51 BeijingP.R.China University of Oklahoma Health Sciences Center 940 Stanton.L.Young Blvd. BMSB Rm.513 Oklahoma City Oklahoma 73104USA

The ideal treatment modality for metastatic cancer would be a local treatment that can destroy primary tumors while inducing an effective systemic anti-tumor *** this end,we de-veloped laser immunotherapy,combining photothermal laser application with an immunoadju-vant for the treatment of metastatic ***,to enhance the selective photothermal effect,we integrated light-absorbing nanomaterials into this innovative ***,we developed an immunologically modified carbon nanotube combining single-walled carbon nanotubes(SwNTs)with the immunoadjuvant glycated chitosan(GC).To determine the ef-fectiveness of laser iradiation,a series of experiments were performed using two different irra-diation durations-5 and 10 *** were inoculated with DMBA-4 cancer cells,a metastatic cancer cell *** treatment group of rats receiving laser irradiation for 10 min had a 50%long-term survival rate without residual primary or metastatic *** treatment group of rats receiving laser irradiation for 5 min had no long-term survivors;all rats died with multiple metastases at several distant ***,Laser+SwNT-GC treatment with 10 min of laser irradiation proved to be efective at reducing tumor size and inducing long-term anti-tumor immunity.

关键词： Anti-tumor immune response laser immunotherapy single-walled carbon nanotubes glycated chitosan laser irradiation

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Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic ***

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Journal of Animal Science and Biotechnology 2024年第2期15卷 749-764页

作者： Kwangwook Kim Cynthia Jinno Xunde Li David Bravo eric Cox Peng Ji Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA Department of Animal Science Michigan State UniversityEast LansingMI 48824USA Cedars-Sinai Medical Center Los AngelesCA 90084USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma|ADM 1180 RolleSwitzerland Nutreco Exploration NutrecoThe Netherlands Department of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium Department of Nutrition University of CaliforniaDavisCA 95616USA

Background Our previous study has reported that supplementation of oligosaccharide-based polymer enhances gut health and disease resistance of pigs infected with enterotoxigenic ***(ETEC)F18 in a manner similar to *** objective of this study was to investigate the impacts of oligosaccharide-based polymer or antibiotic on the host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC *** Multivariate analysis highlighted the differences in the metabolic profiles of serum and colon digesta which were predominantly found between pigs supplemented with oligosaccharide-based polymer and *** relative abundance of metabolic markers of immune responses and nutrient metabolisms,such as amino acids and carbohydrates,were significantly differentiated between the oligosaccharide-based polymer and antibiotic groups(q2.0).In addition,pigs in antibiotic had a reduced(Pwhereas had greater(Pwith d 5 *** The impact of oligosaccharide-based polymer on the metabolic and microbial profiles of pigs is not fully understood,and further exploration is ***,current research suggest that various mechanisms are involved in the enhanced disease resistance and performance in ETEC-challenged pigs by supplementing this polymer.

关键词： Carbadox Colon microbiota Enterotoxigenic E.coli F18 Metabolomics Oligosaccharide-based polymer weaned pigs

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Foam rolling and stretching do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第4期13卷 509-520页

作者： Konstantin warneke Gerit Plöschberger Lars H.Lohmann eric Lichtenstein Daniel Jochum Stanislav D.Siegel Astrid Zech David G.Behm Institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria Department of Human Motion Science and Exercise Physiology Friedrich Schiller UniversityJena 07749Germany Department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Department of Health Sciences and Technology ETH ZurichZurich 8092Switzerland School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is a widely reported effect of stretching and foam rolling,which is commonly explained by changes in pain threshold and/or musculotendinous ***,these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle ***,we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching or foam rolling that promote an increase in muscle ***:After a systematic search in PubMed,web of Science,and SPORTDiscus databases,38 studies comparing the effects of stretching and foam rolling with several other interventions on ROM and passive properties were *** studies had 1134 participants in total,and the data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using robust variance estimation model with ***:Study quality of the included studies was classified as fair(PEDro score=4.58)with low to moderate certainty of *** showed no significant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching or foam rolling and the other identified *** plots revealed no publication ***:Based on current literature,our results challenge the established view on stretching and foam rolling as a recommended component of warm-up *** lack of significant difference between interventions suggests there is no need to emphasize stretching or foam rolling to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Range of motion Passive properties Muscletendon unit Muscle tissue

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Storylines of family medicine Ⅲ:core principles—primary care,systems and family

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Family Medicine and Community Health 2024年第S3期12卷 23-32页

作者： william B Ventres Leslie A Stone Timothy A Joslin John w Saultz Sommer Aldulaimi Paul R Gordon John C Lane eric R Lee Jacob Prunuske Limor Gildenblatt Michael H Friedman Colleen T Fogarty Susan H McDaniel Tessa Rohrberg Amy Odom Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine Oregon Health&Science UniversityPortlandOregonUSA Family and Community Medicine University of Arizona Medical Center–South CampusTucsonArizonaUSA Family and Community Medicine University of Arizona Medical Center–University CampusTucsonArizonaUSA UAMS west Regional Campus Family Medicine Residency Program Fort SmithArkansasUSA Medical College of wisconsin–Central wisconsin Campus WausauWisconsinUSA Family and Community Medicine Medical College of Wisconsin–Central Wisconsin CampusWausauWisconsinUSA Family Medicine Advocate Illinois Masonic Medical CenterChicagoIllinoisUSA Family Medicine Presence Saints Mary and Elizabeth Medical CenterChicagoIllinoisUSA Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Psychiatry and Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Family and Community Medicine University of Kansas School of Medicine-WichitaWichitaKansasUSA Sparrow/Michigan State University Family Medicine Residency Program LansingMichiganUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅲ:core principles—primary care,systems,and family’,authors address the following themes:‘Continuity of care—building therapeutic relationships over time’,‘Comprehensiveness—combining breadth and depth of scope’,‘Coordination of care—managing multiple realities’,‘Access to care—intersectional,systemic,and personal’,‘Systems theory—a core value in patient-centered care’,‘Family-oriented practice—supporting patients’health and well-being’,‘Family physician as family member’and‘Family in the exam room’.May readers develop new understandings from these essays.

关键词： individual Storyline principles

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The Impact of Medical Resources and Oral Antiviral Drugs on SARS-CoV-2 Mortality—Hong Kong SAR,China,2022

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China CDC weekly 2024年第21期6卷 469-477,I0001-I0005页

作者： Zhiqi Zeng Jingyi Liang Zhijie Lin wenda Guan wei He Qianying Li Lixi Liang weiqi Pan Zige Liu Guibin Lu Xiaoyan Deng eric HY Lau Chitin Hon Zifeng Yang Guangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao SARChina Respiratory Disease AI Laboratory on Epidemic Intelligence and Medical Big Data Instrument Applications Faculty of Innovative EngineeringMacao University of Science and TechnologyMacao SARChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina School of Public Health The University of Hong KongHong Kong SARChina Laboratory of Data Discovery for Health Hong Kong SARChina Guangzhou Laboratory Guangzhou CityGuangdong ProvinceChina

Introduction:The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)demonstrates increased transmissibility compared to earlier strains,contributing to a significant number of fatalities in Hong Kong Special Administrative Region(HKSAR),*** medical resources and medications are essential in mitigating these *** study evaluates the effects of supplementary resources from the Chinese mainland during the fifth wave of the pandemic in ***:Vector autoregression(VAR)was employed to analyze data from the Oxford coronavirus disease 2019(COVID-19)Government Response Tracker to assess the effectiveness of control measures during five waves of the pandemic in ***,a transmission dynamics model was created to investigate the influence of supplementary medical resources from the Chinese mainland and oral medications on ***:In the initial four waves,workplace closures,restrictions on public events,international travel bans,and shielding the elderly significantly influenced pandemic ***,during the fifth wave,these measures showed no notable *** comparing a situation without extra medical resources or COVID-19 oral medication,there was a 17.7%decrease in COVID-19 fatalities with mainland medical resources and an additional 10.2%reduction with oral ***,they contributed to a 26.6%decline in ***:with the rapid spread of the virus,regional reallocation of medical resources may reduce mortality even when the local healthcare system is overstretched.

关键词： mainland Impact travel

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Data-Driven Viewpoint for Developing Next-Generation Mg-Ion Solid-State Electrolytes

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电化学（中英文） 2024年第7期30卷 38-49页

作者： Fang-Ling Yang Ryuhei Sato eric Jianfeng Cheng Kazuaki Kisu Qian wang Xue Jia Shin-ichi Orimo Hao Li Advanced Institute for Materials Research(wPI-AIMR) Tohoku UniversitySendai980-8577Japan College of Physics Sichuan UniversityChengdu610065China Institute for Materials Research(IMR) Tohoku UniversitySendai980-8577Japan College of Materials Science and Engineering Sichuan UniversityChengdu610064China

Magnesium(Mg)is a promising alternative to lithium(Li)as an anode material in solid-state batteries due to its abundance and high theoretical volumetric ***,the sluggish Mg-ion conduction in the lattice of solidstate electrolytes(SSEs)is one of the key challenges that hamper the development of Mg-ion solid-state *** various Mg-ion SSEs have been reported in recent years,key insights are hard to be derived from a single literature ***,the structure-performance relationships of Mg-ion SSEs need to be further unraveled to provide a more precise design guideline for *** this viewpoint article,we analyze the structural characteristics of the Mg-based SSEs with high ionic conductivity reported in the last four decades based upon data mining-we provide big-data-derived insights into the challenges and opportunities in developing next-generation Mg-ion SSEs.

关键词： Data mining Magnesium-ion solid-state electrolytes All-solid-state batteries Magnesium-ion conductivity

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The past 800 ka viewed through Antarctic ice cores

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Episodes 2008年第2期31卷 219-221页

作者： eric w wolff British Antarctic Survey High Cross Madingley Road Cambridge CB3 0ET UK.

The later parts of the Quaternary are of particular importance for assessing our ability to understand the future operation of the Earth because the main boundary conditions are similar to those of today, and because we have a density of data that allows hypotheses to be tested rigorously. An important source of such data is Antarctic ice cores, now extending back 800 ka, and containing signals both of climate, and of climate forcing factors. The Antarctic ice core deuterium record, representing Antarctic temperature, is one of the iconic Quaternary records.

关键词：第四纪地质时代南极冰川地球

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Design of on-demand wireless capsule endoscope

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仪器仪表学报 2008年第1期29卷 11-15页

作者： Yang Li eric w Able Peng Chenglin College of Bioengineering Chongqing University Chongqing 400044 China School of Engineering and Physical Sciences University of Dundee Dundee DD1 4HN UK

An on-demand wireless capsule endoscope with fulldigital and bidirectional communication is presented,aiming at fulfilling the requirements of micromation and micropower consumption of modern wireless *** proposed multifunctional operation and unique radio transmission system cuts down the power consumption efficiently and on-demand bidirectional communication in vitro improves the detection rate of ***,gray dilatation is introduced in a bit plane that optimizes the distortion rate in the process of image recording and transmission.

关键词：随机无线内窥镜全数字式双向通信灰度级扩张术设计

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Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease

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world Journal of Gastroenterology 2018年第18期24卷 2036-2046页

作者： Neera Gupta Robert H Lustig Cewin Chao eric Vittinghoff howard Andrews Cheng-Shiun Leu Division of Gastroenterology and Nutrition Department of Pediatrics Weill Cornell Medicine Division of Endocrinology Department of Pediatrics University of CaliforniaSan Francisco Department of Nutrition and Food Services University of CaliforniaSan Francisco Department of Epidemiology and Biostatistics University of CaliforniaSan Francisco Department of Biostatistics Mailman School of Public Health Columbia University Department of Biostatistics Columbia University Medical Center

AIM To determine the distribution of anthropometric parameter(AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn's disease(CD).METHODS CD patients [were enrolled in a cross-sectional study. Descriptive statistics were generated for participants' demographic characteristics and key variables of interest. Paired t-tests were used to compare AP-z-scores calculated based on CA(CA z-scores) and bone age(BA)(BA z-scores) for interpretation of AP's. Linear regression was utilized to examine associations between medications and serum biomarkers with AP-z-scores calculated based on CA(n = 82) and BA(n = 49). we reported regression coefficients as well as their corresponding p-values and 95% confidence *** Mean CA at the time of the study visit was 15.3 ± 3.5(SD; range = 4.8-20.7) years. Mean triceps skinfold(P = 0.039), subscapular skinfold(P = 0.002) and midarm circumference(MAC)(P = 0.001) BA z-scores were higher than corresponding CA z-scores. Medications were positively associated with subscapular skinfold [adalimumab(P = 0.018) and methotrexate(P = 0.027)] and BMI CA z-scores [adalimumab(P = 0.029)]. Azathioprine/6-mercaptopurine were negatively associated with MAC(P = 0.045), subscapular skinfold(P = 0.014), weight(P = 0.002) and BMI(P = 0.013) CA z-scores. ESR, CRP, and wBC count were negatively associated, while albumin and IGF-1 BA z-scores were positively associated, with specific AP z-scores(P were higher in females, not males, treated with infliximab(P = 0.038). Hemoglobin(P = 0.018) was positively associated, while platelets(P = 0.005), ESR(P = 0.003) and CRP(P = 0.039) were negatively associated with height CA z-scores in males, not females. CONCLUSION Our results suggest poor efficacy of thiopurines and a possible sex difference in statural growth response to infliximab in pediatric CD. Prospective longitudinal studie

关键词： Inflammatory bowel disease Azathioprine/6-mercaptopurine Biologics Nutrition

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