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Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals

hLife 2023年第1期1卷 26-34页

作者： Chee Wah Tan Feng Zhu Wan Ni Chia #Barnaby EYoung Aileen Ying Yan Yeoh Thomas Althaus Chee Fu Yung Wee Chee Yap Beng lee Lim Mark I-C Chen Jinyan Zhang Yun Yan Mah eric Voiglio Alex Sigal Jianxin Huo Shengli Xu Yee Joo Tan Kong-Peng Lam David Lye Lin-Fa Wang Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore National Center of Infectious Diseases Singapore Tan Tock Seng Hospital Singapore lee Kong Chian School of Medicine Nanyang Technology UniversitySingapore Centre Scientifique de Monaco Monaco Direction de I’Action Sanitaire de Monaco Monaco Infectious Disease Service Department of PediatricsKK Women’s and Children’s HospitalSingapore Duke-NUS Medical School Singapore African Health Research Institute DurbanSouth Africa Singapore Immunology Network Agency for ScienceTechnology and ResearchSingapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Infectious Diseases Translational Research Programme National University of SingaporeSingapore 14School of Biological SciencesNanyang Technological UniversitySingapore Singhealth Duke-NUS Global Health Institute Singapore

Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this *** key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their preceding *** raises the question of whether Omicron should be regarded as a separate serotype from viruses serologically clustered with the ancestral severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)***,we present cross-neutralization data based on a pseudovirus neutralization test using convalescent sera from naïve individuals who had recovered from primary infection by SARS-CoV-1 and SARS-CoV-2 strains/variants including the ancestral virus and variants Beta,Delta,Omicron BA.1,Omicron BA.2 and Omicron *** results revealed no significant cross-neutralization in any of the three-way testing for SARS-CoV-1,ancestral SARS-CoV-2 and SARS-CoV-2 Omicron *** data argue for the assignment of three distinct serotypes for the currently known human-infecting SARS-related coronaviruses.

关键词： SARS-CoV-2 SARS-CoV-1 serotype Omicron primary infection convalescent sera

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SEASONAL TROPICAL CYCLONE FORECASTING

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Tropical Cyclone Research and Review 2019年第3期8卷 134-149页

作者： Philip Klotzbach eric Blake Joanne Camp Louis-Philippe Caron Johnny C.L.Chan Nam-Young Kang Yuri Kuleshov Sai-Ming lee Hiroyuki Murakami Mark Saunders Yuhei Takaya Frederic Vitart Ruifen Zhan Colorado State University Fort CollinsUSA NOAA/National Hurricane Center MiamiUSA Met Office ExeterUK Barcelona Supercomputing Centre BarcelonaSpain Guy Carpenter Asia-Pacific Climate Impact Centre School of Energy and EnvironmentCity University of Hong KongHong KongChina National Typhoon Center/Korea Meteorological Administration SeoulRepublic of Korea Bureau of Meteorology MelbourneAustralia Hong Kong Observatory Hong KongChina Geophysical Fluid Dynamics Laboratory Princeton University/University Corporation for Atmospheric ResearchUSA University College London SurreyUK Meteorological Research Institute Japan Meteorological AgencyTokyoJapan European Centre for Medium-Range Weather Forecasts ReadingUK Shanghai Typhoon Institute of China Meteorological Administration ShanghaiChina

This paper summarizes the forecast methods,outputs and skill offered by twelve agencies for seasonal tropical cyclone(TC)activity around the *** agencies use a variety of techniques ranging from statistical models to dynamical models to predict basinwide activity and regional *** addition,several dynamical and hybrid statistical/dynamical models now predict TC track density as well as landfall *** Atlantic seasonal hurricane forecasts have shown low skill in April modest skill in June and good skill in August at predicting basinwide TC activity when evaluated over ***-time western North Pacific seasonal TC forecasts have shown good skill by July for basinwide intense typhoon numbers and the ACE index when evaluated for *** hindcasts and real-time forecasts have shown skill for other TC basins.A summary of recent research into forecasting TC activity beyond seasonal(e.g.,multi-year)timescales is *** for future areas of research are also discussed.

关键词： hurricane typhoon tropical cyclone seasonal forecasting forecast skill

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Adjuvant chemotherapy for intrahepatic cholangiocarcinoma: approaching clinical practice consensus?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 577-586,I0001页

作者： Ariella M.Altman Scott Kizy Schelomo Marmor Jane Y.C.Hui Todd M.Tuttle eric H.Jensen Jason W.Denbo Department of Surgery University of MinnesotaMinneapolisMNUSA Department of Gastrointestinal Oncology H.Lee Moffitt Cancer CenterTampaFLUSA

Background:Intrahepatic cholangiocarcinoma(ICC)is rare with limited evidence-based *** retrospective study evaluates the use of chemotherapy in patients with resected ***:The Surveillance Epidemiology and End Results(SEER)program database was used to identify patients with resected *** were stratified by date of diagnosis(2000-2004,2005-2009,2010-2014),T,and N *** logistic regression models identified predictors of chemotherapy ***-Meier and Cox proportional hazard models were used to identify survival ***:One thousand and two hundred twenty-three patients met inclusion *** utilization increased over time(33%to 41%,P≤0.05).Chemotherapy use increased in lymph node(LN)positive patients[32%to 60%in 2010-2014;(P≤0.05)and T3/T4 disease(40%to 60%in 2010-2014;P≤0.01)],but not in patients with LN negative or T1/T2 *** positivity was associated with utilization of chemotherapy in 2005-2009 and *** survival increased from 32 to 41 months(P≤0.05).In LN positive patients,chemotherapy was associated with a decreased hazard ratio of death(P≤0.05)and T3/T4 disease was associated with an increased hazard ratio of death(P≤0.05).Conclusions:Adjuvant chemotherapy use in ICC has *** LN positive or patients with T3/T4 tumors are receiving chemotherapy,which may explain the improvement in overall survival.

关键词： Cholangiocarcinoma adjuvant chemotherapy survival lymph node(LN) surgical procedures

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用于亚65纳米光刻的双层抗蚀剂

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集成电路应用 2006年第3期23卷 22-25页

作者： Daisuke Kawana Kazufumi Sato Sanlin Hu.J.K.lee eric S.Moyer Tokyo ohka Kogyo co.Ltd. Dow Corning Corp.

采用含硅量较高(23wt％)的新型光致抗蚀剂实现了55nm的各种特性,获得了较高的耐腐蚀性能,并降低了线条边缘粗糙度。结果还表明。

关键词：光致抗蚀剂纳米光刻耐腐蚀性能光刻工艺含硅量粗糙度一致性浸没式

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TURMeric-COULD IT BE A MULTI-TARGETED HERB FOR COLORECTAL CANCER ADJUVANT THERAPY?

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 74-75页

作者： Grace GL Yue Hin-Fai Kwok Julia KM lee Lei Jiang Si Gao Carmen KM Chan eric CW Wong Kwok-Pui Fung Ping-Chung Leung Zhong Zuo Clara BS Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) School of Biomedical Sciences School of Pharmacy The Chinese University of Hong Kong

Turmeric is a medicinal herb in Asia and as dietary supplement in western *** major active component,*** good reputation for chemopreventive effects in different ***,poor oral bioavailability of curcumin hinders the w... 详细信息

关键词： TURMeric-COULD IT BE A MULTI-TARGETED HERB FOR COLORECTAL CANCER ADJUVANT THERAPY

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Temporally resolving premixed turbulent flame structures using self-supervised adversarial reconstruction of CH-PLIF

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能源与人工智能(英文) 2023年第1期11卷 51-62页

作者： Ji-Hun Oh Aaron W.Skiba Stephen D.Hammack Constandinos M.Mitsingas Campbell D.Carter Tonghun lee Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignIL61801United States U.S.Air Force Research Laboratory Wright-Patterson Air Force BaseOH45433United States Army Research Lab Aberdeen Proving GroundMD21005United States

Understanding the turbulence-flame interaction is crucial to model the low-emission combustors developed for energy and propulsion applications. To this end, a novel frame interpolation (FI) method is proposed to better resolve the spatiotemporal evolution of premixed turbulent flame structures. The framework is completely selfsupervised, agnostic to optical flow, and driven by leveraging transferrable feature knowledge at lower speeds and adversarial learning to statistically map the flame dynamics across frames. The method is successfully applied on a 10 kHz CH planar laser-induced fluorescence (PLIF) dataset of highly wrinkled premixed flames with turbulent Reynolds numbers (ReT ) of 1100, 1400, and 7900, by down-sampling the image sequence to 5 kHz and restoring the sequence back to 10 kHz via FI. All reconstructions recovered important flame events and displayed excellent resemblance of the corrugated CH-layer geometries to that of the ground truths, with average intersection over union (IoU) and structural similarity index (SSIM) scores of 0.49 and 0.82, which are above the high-similarity baselines of 0.36 and 0.75, respectively. The wrinkling parameters (WP) of the flames also matched the ground truths, wherein R2 was roughly 0.95 for ReT = 1100 and 1400 and 0.85 for ReT = 7900 (lower due to the turbulence-induced uncertainties). The FI is further iteratively repeated to 40 kHz on the ReT = 7900 flames to facilitate pocket analysis by confidently linking their origin of formation, thus, enabling distinction from 3D tunnels, and improving statistical characterization of their consumption speeds. Given that the object features do not exhibit highly turbulent motions with regard to the initial time step, the proposed FI method is shown to be highly accurate and useful to analyzing finite-resolution experimental image sets including, but not restricted to, CH-PLIF.

关键词： Self-supervised frame interpolation Premixed turbulent flames Planar laser-induced fluorescence Generative adversarial networks Pocket behavior

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Large Vessel Vasculitis in a Patient with Systemic Lupus Erythematosus Presenting as Takayasu’s Pulseless Arteritis

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International Journal of Clinical Medicine 2021年第10期12卷 415-423页

作者： Cathy-lee Jagdeo Stephanie Battersby Azad Esack Department of Neurology The Eric Williams Medical Sciences Complex Mt. Hope Trinidad and Tobago

Systemic lupus erythematosus (SLE) with an associated aortoarteritis presenting as an ischemic stroke is a rarity in the medical literature. We report the case of an 11-year-old male presenting with an acute ischemic stroke meeting the criteria for the diagnosis of SLE and findings consistent with an aortitis on imaging but mimicking the diagnosis of Takayasu’s pulseless arteritis. Blood and imaging investigations revealed the finding of SLE aortitis following an acute stroke presentation. Thus, it is imperative to note that even though it is infrequent, SLE can be associated with a large vessel vasculitis.

关键词： Systemic Lupus Erythematosus Aortoarteritis Takayasu’s Pulseless Arteritis

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微软豪赌——一场446亿美元的互联网“地震”

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微型计算机 2008年第7期28卷 90-91页

作者： Silver_lee

曾先后担任过Sun技术总监和Novell首席执行官的eric Schmidt可以说是一个职业的反微软斗士，他曾总结出这样一句话：“任何戏弄微软的竞争对手都是愚蠢的，这只会激发微软的愤怒。”现在，他又见识到了微软可怕的一面，而且是作为Googl... 详细信息

曾先后担任过Sun技术总监和Novell首席执行官的eric Schmidt可以说是一个职业的反微软斗士，他曾总结出这样一句话：“任何戏弄微软的竞争对手都是愚蠢的，这只会激发微软的愤怒。”现在，他又见识到了微软可怕的一面，而且是作为Google公司的首席执行官。

关键词：微软互联网 Google公司 Schmidt 首席执行官地震美元 Novell

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COVID-19 among African Americans and Hispanics:Does gastrointestinal symptoms impact the outcome?

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World Journal of Clinical Cases 2021年第28期9卷 8374-8387页

作者： Hassan Ashktorab Adeleye Folake Antonio Pizuorno Gholamreza Oskrochi Philip Oppong-Twene NuriTamanna Maryam Mehdipour Dalivand Lisa N Umeh Esther S Moon Abdoul Madjid Kone Abigail Banson Cassandra Federman Edward Ramos Eyitope Ola Awoyemi Boubini Jones Wonni eric Otto Guttu Maskalo Alexandra Ogando Velez Sheldon Rankine Camelita Thrift Chiamaka Ekwunazu Derek Scholes LakshmiGayathri Chirumamilla Mohd Elmugtaba Ibrahim Brianna Mitchell Jillian Ross Julencia Curtis Rachel Kim Chandler Gilliard Joseph Mathew Adeyinka Laiyemo Angesum Kibreab Edward lee Zaki Sherif Babak Shokrani Farshad Aduli Hassan Brim Department of Medicine Gastroenterology Division and Cancer CenterHoward University College of MedicineWashingtonDC 20060United States Faculty of Medicine La Universidad del ZuliaMaracaibo 4002ZuliaVenezuela College of Engineering and Technology American University of Middle East KuwaitEgaila 54200Kuwait Department of Biochemistry and Molecular Biology Howard University College of MedicineWashingtonDC 20060United States Pathology and Cancer Center Department of Biochemistry and Molecular BiologyHoward University College of MedicineWashingtonDC 20060United States

BACKGROUND The coronavirus disease 2019(COVID-19)disproportionately affected African Americans(AA)and Hispanics(HSP).AIM To analyze the significant effectors of outcome in African American patient population and make special emphasis on gastrointestinal(GI)symptoms,laboratory values and comorbidities METHODS We retrospectively evaluated the medical records of 386 COVID-19 positive patients admitted at Howard University Hospital between March and May *** assessed the symptoms,including the GI manifestations,comorbidities,and mortality,using logistic regression *** Of these 386 COVID-19 positive patients,257(63.7%)were AAs,102(25.3%)HSP,and 26(6.45%)*** were 257(63.7%)AA,102(25.3%)HSP,26(6.45%)*** mean age was 55.6 years(SD=18.5).However,the mean age of HSP was the lowest(43.7 years vs 61.2 for Whites vs 60 for AAs).The mortality rate was highest among the AAs(20.6%)and lowest among HSP(6.9%).Patients with shortness of breath(SOB)(OR2=3.64,CI=1.73-7.65)and elevated AST(OR2=8.01,CI=3.79-16.9)elevated Procalcitonin(OR2=8.27,CI=3.95-17.3),AST(OR2=8.01,CI=3.79-16.9),ferritin(OR2=2.69,CI=1.24-5.82),and Lymphopenia(OR2=2.77,CI=1.41-5.45)had a high mortality *** and fever were common but unrelated to the *** and diabetes mellitus were the most common *** treatment was associated with higher mortality(OR2=5.40,CI=2.72-10.7).Diarrhea was prevalent(18.8%),and GI symptoms did not affect the *** African Americans in our study had the highest mortality as they consisted of an older population and *** is the most important factor along with SOB in determining the mortality ***,elevated liver enzymes,ferritin,procalcitonin and C-reactive protein were associated with poor *** symptoms did not affect the *** should be used judiciously,considering the poor outcomes associated with *** should also be paid to monitor liver function

关键词： COVID-19 Pandemic,Gastrointestinal manifestation Liver African Americans Hispanics

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加州六年级学生赢得2019年度NASA兰利艺术比赛

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中学生英语 2019年第25期 36-37页

作者： eric Gillard 侯怡(选译) 不详

我们可以用很多方法表达自己的灵感和想象力,尤其是在艺术的世界里。罗亚·李是一名来自加利福尼亚州的六年级学生,她探寻了自己对未来人类航天事业的想象并为此创作了一幅画作,在美国国家航空和宇宙航行局兰利研究中心举办的年度学生... 详细信息

我们可以用很多方法表达自己的灵感和想象力,尤其是在艺术的世界里。罗亚·李是一名来自加利福尼亚州的六年级学生,她探寻了自己对未来人类航天事业的想象并为此创作了一幅画作,在美国国家航空和宇宙航行局兰利研究中心举办的年度学生艺术比赛中获得特等奖。

关键词：六年级艺术 NASA 学生比赛加州加利福尼亚州航天事业

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