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New language outcome measures for Mandarin speaking children with hearing loss

Journal of Otology 2016年第1期11卷 24-32页

作者： Xueman Liu Jill de Villiers Wendy lee Chunyan Ning eric Rolfhus Teresa Hutchings Fan Jiang Yiwen Zhang University of Texas at Dallas Communication Sciences and Disorders Bethel Hearing and Speaking Training Center Research and Development Smith College Psychology and Philosophy Bethel Hearing and Speaking Training Center Research and Development Tianjin Normal University Institute of Linguistics Bethel Hearing and Speaking Training Center Research and Development Bethel Hearing and Speaking Training Center Research and Development Shanghai Children's Medical Center Department of Developmental and Behavioral Pediatrics

Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language. Methods: Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages. The Diagnostic Receptive and Expressive Assessment of Mandarin (DREAM) was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland. Results:This paper summarizes the evidence-based item design process and validity and reliability results of DREAM. A pilot study reported here shows that DREAM provided detailed information about hearing impaired children's language abilities and can be used to aid intervention planning to maximize progress. Conclusion: DREAM represents an example of translational science, transferring methods from empirical studies of language acquisition in research environments into applied domains such as assessment and intervention. Research on outcomes in China will advance significantly with the availability of evidence-based comprehensive language tests that measure a sufficient age range of skills, are normed on Mandarin speaking children in China's Mainland, and are designed to capture features central to Mandarin language acquisition.

关键词： Standardized language test Language development Outcome assessment Mandarin DREAM

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Speed vernalization to accelerate generation advance in winter cereal crops

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Molecular Plant 2022年第8期15卷 1300-1309页

作者： Jin-Kyung Cha Kathryn O'Connor Samir Alahmad Jong-Hee lee eric Dinglasan Hyeonjin Park So-Myeong lee Dominique Hirsz Soon-Wook Kwon Youngho Kwon Kyeong-Min Kim Jong-Min Ko lee T.Hickey Dongjin Shin Laura E.Dixon National Institute of Crop Science RDAMiryang 50424Korea School of Biology Faculty of Biological SciencesUniversity of LeedsLeeds LS29JTUK Queensland Alliance for Agriculture and Food Innovation The University of QueenslandSt.LuciaQLDAustralia Department of Plant Bioscience Pusan National UniversityMiryang 60463Korea

There are many challenges facing the development of high-yielding,nutritious crops for future *** limiting factor is generation time,which prolongs research and plant breeding *** advances in speed breeding protocols have dramatically reduced generation time for many short-day and long-day species by optimizing lightand temperature conditions during plant ***,winter crops with a vernalization requirement stillrequire upto 6-10weeks in low-temperature conditions before thetransition to ***,we tested a suite of environmental conditions and protocols to investigate whether the vernalization process can be *** identified a vernalization method consisting of exposing seeds at the soil surface to an extended photoperiod of 22 h day:2 h night at 10°C with transfer to speed breeding conditions that dramatically reduces generation time in both winter wheat(Triticum aestivum)and winter barley(Hordeum vulgare).Implementation of the speedvernalization protocolfollowed byspeedbreedingallowed the completion ofuptofivegenerations per yearforwinter wheat or barley,whereas only two generations can be typically completed under standard vernalization and plant growth *** speed vernalization protocol developed in this study has great potential to accelerate biological research and breeding outcomes for winter crops.

关键词： speed breeding photoperiod temperature wheat barley breeding

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Gravitational wave astrophysics, data analysis and multimessenger astronomy

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Science China(Physics,Mechanics & Astronomy) 2015年第12期58卷 44-64页

作者： lee Hyung Mok LE BIGOT eric-Olivier DU ZhiHui LIN ZhangXi GUO XiangYu WEN LinQing PHUKON Khun Sang PANDEY Vihan BOSE Sukanta FAN Xi-Long HENDRY Martin Department of Physics and Astronomy Seoul National University Research Institute of Information Technology Tsinghua National Laboratory for Information Science and TechnologyTsinghua University Laboratoire Astro Particule et Cosmologie (APC) Universit Paris Diderot-Paris 7 Bc/timent Condorcet Case 7020 75205 Paris Cedex 13 France Tsinghua National Laboratory for Information Science and Technology Department of Computer Science and TechnologyTsinghua University School of Physics The University of Western Australia Department of Physics IIT Kanpur Inter-University Centre for Astronomy and Astrophysics Department of Physics & Astronomy Washington State University School of Physics and Electronics Information Hubei University of Education SUPA School of Physics and Astronomy University of Glasgow

This paper reviews gravitational wave sources and their detection. One of the most exciting potential sources of gravitational waves are coalescing binary black hole systems. They can occur on all mass scales and be formed in numerous ways, many of which are not understood. They are generally invisible in electromagnetic waves, and they provide opportunities for deep investigation of Einstein's general theory of relativity. Sect. 1 of this paper considers ways that binary black holes can be created in the universe, and includes the prediction that binary black hole coalescence events are likely to be the first gravitational wave sources to be detected. The next parts of this paper address the detection of chirp waveforms from coalescence events in noisy *** analysis is computationally intensive. Sect. 2 reviews a new and powerful method of signal detection based on the GPUimplemented summed parallel infinite impulse response filters. Such filters are intrinsically real time alorithms, that can be used to rapidly detect and localise signals. Sect. 3 of the paper reviews the use of GPU processors for rapid searching for gravitational wave bursts that can arise from black hole births and coalescences. In sect. 4 the use of GPU processors to enable fast efficient statistical significance testing of gravitational wave event candidates is reviewed. Sect. 5 of this paper addresses the method of multimessenger astronomy where the discovery of electromagnetic counterparts of gravitational wave events can be used to identify sources, understand their nature and obtain much greater science outcomes from each identified event.

关键词： gravitational waves data analysis multimessenger

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VOWEL DISPERSION AND VARIABILITY—DATA FROM THREE CHINESE DIALECTS

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中国语音学报 2013年第1期 143-152页

作者： lee Wai-Sum ZEE eric Department of Chinese Translation and LinguisticsCity University of Hong Kong

The study^1 investigates dispersion and variability of the vowels of three Chinese dialects,namely Yongding,Cantonese,and Wenling with the three-,seven-,and eleven-vowel systems,*** of formant frequencies were obtained through spectral analysis of speech data from ten male and ten female speakers of each dialect Results show that a larger vowel inventory correlates a more expanded acoustical vowel space for the three Chinese dialects,which supports the prediction of the vowel dispersion theory that the larger the vowel inventory is,the more expanded vowel space will ***,the difference in vowel space is not linearly related to the difference in vowel inventory ***,the vowel dispersion theory’s prediction that variability in vowel formant frequencies is inversely related to vowel inventory size is not supported by the vowel formant data from the three Chinese dialects.

关键词： Vowel dispersion and variability Formant frequencies Acoustical vowel space Vowel inventory size Chinese dialects

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Tetracycline-Based Binary Ti Vectors pLSU with Efficient Cloning by the Gateway Technology for <i>Agrobacterium tumefaciens</i>-Mediated Transformation of Higher Plants

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American Journal of Plant Sciences 2013年第7期4卷 1418-1426页

作者： Seokhyun lee Guiying Su eric Lasserre Norimoto Murai Department of Plant Pathology and Crop Physiology Louisiana State University and LSU AgCenter Baton Rouge USA

We constructed small high-yielding binary Ti vectors with a bacterial tetracycline resistance gene to facilitate efficient cloning afforded by the Gateway Technology (Invitrogen) for Agrobacterium tumefaciens-mediated transformation of higher plants. The Gateway Technology vectors are kanamycin-based, thus tetracycline-based destination and expression vectors are easily selected for the antibiotic resistance in the Escherichia coli media. We reduced the size of the tetracycline resistance gene TetC from pBR322 to 1468 bp containing 1191 bp of the coding region, 93 bp of 5’-upstream, and 184 bp 3’-downstream region. The final size of binary Ti vector skeleton pLSU11 is 5034 bp. pLSU12 and 13 have the kanamycin resistance NPTII gene as a plant-selectable marker. pLSU13?and 15 contain the hygromycin resistance HPH gene as a selection marker. pLSU13 and 15 also have the β-glucuronidase (GUS) reporter gene in addition to the plant selection marker. We also constructed a mobilizable version of tetracycline-based binary Ti vector pLSU16 in which the mob function of ColE1 replicon was maintained for mobilization of the binary vector from E. coli to A. tumefaciens by tri-parental mating. The final size of binary Ti vector skeleton pLSU16 is 5580 bp. New tetracycline- based binary Ti vectors pLSU12 were found as effective as kanamycin-based vector pLSU2 in promoting a 10-fold increase in fresh weight yield of kanamycin-resistant calli after A. tumefaciens-mediated transformation of tobacco leaf discs. Using the Gateway Technology we introduced the plant-expressible GUSgene to the T-DNA of binary Ti vector pLSU12. Expression of the β-glucuronidase enzyme activity was demonstrated by histochemical staining of the GUS activity in transformed tobacco leaf discs.

关键词： Agrobacterium tumefaciens Binary Ti Vectors Gateway Technology pLSU Tobacco Leaf Disk Transformation Tetracycline Resistance

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Genetic regulation of programmed cell death in Drosophila

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Cell Research 2000年第3期10卷 193-204页

作者： lee CHENG-YU, eric H BAEHRECKE (l Center for Agricultural Biotechnology, University of Maryland Biotechnology institute, College Park, Maryland 20742,USA Department of Biology, University of Maryland, College Park, Maryland 20742, USA) Center for Agricultural Biotechnology University of Maryland Biotechnology Institute College Park USA Department of Biology University of Maryland College Park USA

Programmed cell death plays an important role in maintaining homeostasis during animal development, and has been conserved in animals as different as nematodes and humans. Recent studies of Drosophila have provided valuable information toward our understanding of genetic regulation of death. Different signals trigger the novel death regulators rpr, hid, and grim, that utilize the evolutionarily conserved iap and ark genes to modulate caspase function. Subsequent removal of dying cells also appears to be accomplished by conserved mechanisms. The similarity between Drosophila and human in cell death signaling pathways illustrate the promise of fruit mes as a model system to elucidate the mechanisms underlying regulation of programmed cell death.

关键词： Apoptosis autophagy phagocytosis development.

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Clinical management of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes

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Cancer Biology & Medicine 2016年第3期13卷 360-372页

作者： Joseph A.Clara David A.Sallman eric Padron Department of Internal Medicine University of South Florida Morsani College of Medicine Malignant Hematology Program H.Lee Moffitt Cancer Center and Research Institute

The myelodysplastic/myeloproliferative neoplasms(MDS/MPNs) are a unique group of hematologic malignancies characterized by concomitant myelodysplastic and myeloproliferative features. According to the 2008 WHO classification, the category includes atypical chronic myeloid leukemia(a CML), chronic myelomonocytic leukemia(CMML), juvenile myelomonocytic leukemia(JMML), MDS/MPN-unclassifiable(MDS/MPN-U), and the provisional entity refractory anemia with ring sideroblasts and thrombocytosis(RARS-T). Although diagnosis currently remains based on clinicopathologic features, the incorporation of nextgeneration platforms has allowed for the recent molecular characterization of these diseases which has revealed unique and complex mutational profiles that support their distinct biology and is anticipated to soon play an integral role in diagnosis,prognostication, and treatment. Future goals of research should include the development of disease-modifying therapies, and further genetic understanding of the category will likely form the foundation of these efforts.

关键词： Myelodysplastic syndromes myeloproliferative neoplasms next-generation sequencing CMML aCML IMML MDS/MPN-U

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Is Tetranychus urticae suitable prey for development and reproduction of nafve Coleomegilla maculata？

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Insect Science 2014年第1期21卷 83-92页

作者： eric W. Riddick Zhixin Wu M~ Guadalupe Rojas National Biological Control Laboratory Agricultural Research Service USDA 59 Lee Road Stoneville MS 38776 USA

The lady beetle Coleomegilla maculata De Geer is an omnivorous predator that could help suppress aphid and spider mite populations on plants in greenhouses, plantscapes or interiorscapes. We are assessing the nutritional requirements and feeding behavior of C. maculata on target prey （spider mites） and factitious （unnatural） food. Our ultimate goal is to develop an efficacious diet to mass produce C. maculata. In this study, we tested the hypothesis that Tetranychus urticae Koch （two-spotted spider mite） is not suitable prey for development and reproduction of naive C. maculata （i.e., with no prior exposure to T. urticae）. Our objectives were to （i） provide baseline data on the effects of consuming T. urticae on C. maculata life history, （ii） to compare the effects of consuming all stages of T. urticae versus eggs ofMusca domestica L. （common housefly）, and （iii） to determine if the consumption of plant products was beneficial. We used C. maculata from a colony reared only on Ephestia kuehniella Zeller （Mediterranean flour moth） eggs. In experiments, C. maculata larvae were reared from the first instar to adult stage with prey/food in replicated arenas; adult females were paired with a single male with prey/food. The results showed that naive C. maculata readily attacked and consumed T. urticae. Nevertheless, T. urticae was less suitable than M. domestica eggs for C. maculata development and reproduction. Applying a synthetic pollen-Chlorella alga powder （SPCA） in arenas containing T. urticae appeared to boost C. maculata female development and reproduction.

关键词： behavior biocontrol CoccineUidae nutrition rearing

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Anesthesia for ABO incompatible living Donor liver transplant

Anesthesia for ABO incompatible living Donor liver transplan...

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2008年中华医学会全国麻醉学术年会

作者： Chih-Chung Lin eric Chang Wei-chen lee Department of Anesthesiology Chang Gung Memorial Hospital

Introduction: The long waiting time for liver transplant makes it necessary to expand the donor pool for those can not found living liver donor with the same blood type for acute liver failure,ABO incompatible was con...

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Evaluation of spatial and temporal patterns of insect damage and aflatoxin level in the pre-harvest corn fields to improve management tactics

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Insect Science 2014年第5期21卷 572-583页

作者： Xinzhi Ni Jeffrey P. Wilson Michael D. Toews G. David Buntin R. Dewey lee Xin Li Zhongren Lei Kanglai He Wenwei Xu Xianchun Li Alisa Huffaker eric A. Schmelz USDA-ARS Crop Genetics and Breeding Research Unit Department of Entomology University of Georgia Tifton Department of Entomology University of Georgia Griffin Department of Crop and Soil Sciences University of Georgia Tifton Georgia USA Collegeof Plant Protection Northwest A&F University Yangling Shaanxi State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China Texas A&M University Texas AgriLife LubbockTexas Department of Entomology University of Arizona Tucson Arizona USDA-ARS Center for Medical Agricultural and Veterinary Entomology Gainesviile Florida USA

Spatial and temporal patterns of insect damage in relation to aflatoxin contamination in a corn field with plants of uniform genetic background are not well understood. After previous examination of spatial patterns of insect damage and aflatoxin in pre-harvest corn fields, we further examined both spatial and temporal patterns of cob- and kernel- feeding insect damage, and aflatoxin level with two samplings at pre-harvest in 2008 and 2009. The feeding damage by each of the ear/kernel-feeding insects （i.e., corn earworm/fall armyworm damage on the silk/cob, and discoloration of corn kernels by stink bugs） and maize weevil population were assessed at each grid point with five ears. Sampling data showed a field edge effect in both insect damage and aflatoxin contamination in both years. Maize weevils tended toward an aggregated distribution more frequently than either corn earworm or stink bug damage in both years. The frequency of detecting aggregated distribution for aflatoxin level was less than any of the insect damage assessments. Stink bug damage and maize weevil number were more closely associated with aflatoxin level than was corn earworm damage. In addition, the indices of spatial-temporal association （χ） demonstrated that the number of maize weevils was associated between the first （4 weeks pre-harvest） and second （1 week pre-harvest） samplings in both years on all fields. In contrast, corn earworm damage between the first and second samplings from the field on the Belflower Farm, and aflatoxin level and corn earworm damage from the field on the Lang Farm were dissociated in 2009.

关键词： aflatoxin level corn earworm damage maize weevil population SADIE analysis spatial pattern spatio-temporal association stink bug damage

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