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High quality genome sequences of thirteen Hypoxylaceae(Ascomycota)strengthen the phylogenetic family backbone and enable the discovery of new taxa

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Fungal Diversity 2021年第1期106卷 7-28页

作者： Daniel Wibberg Marc Stadler Christopher lambert Boyke Bunk Cathrin Spröer Christian Rückert Jörn Kalinowski Russell JCox eric Kuhnert Center for Biotechnology(CeBiTec) Bielefeld UniversityUniversitätsstraße 2733615 BielefeldGermany Department Microbial Drugs Helmholtz Centre for Infection Research(HZI)and German Centre for Infection Research(DZIF)Partner Site Hannover-BraunschweigInhoffenstrasse 738124 BraunschweigGermany Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures Inhoffenstraße 7B38124 BraunschweigGermany Centre of Biomolecular Drug Research(BMWZ) Institute for Organic ChemistryLeibniz University HannoverSchneiderberg 3830167 HannoverGermany

The Hypoxylaceae(Xylariales,Ascomycota)is a diverse family of mainly saprotrophic fungi,which commonly occur in angiosperm-dominated forests around the *** their importance in forest and plant ecology as well as a prolific source of secondary metabolites and enzymes,genome sequences of related taxa are scarce and usually derived from envi-ronmental *** address this lack of knowledge thirteen taxonomically well-defined representatives of the family and one member of the closely related Xylariaceae were genome sequenced using combinations of Illumina and Oxford nanopore technologies or PacBio *** workflow leads to high quality draft genome sequences with an average N50 of 3.0 Mbp.A backbone phylogenomic tree was calculated based on the amino acid sequences of 4912 core genes reflecting the current accepted taxonomic concept of the Hypoxylaceae.A Percentage of Conserved Proteins(POCP)analysis revealed that 70%of the proteins are conserved within the family,a value with potential application for the definition of family boundaries within the order ***,Hypomontagnella spongiphila is proposed as a new marine derived lineage of *** based on in-depth genomic comparison and morphological differences of the *** results showed that both species share 95%of their genes corresponding to more than 700 strain-specific *** difference is not reflected by standard taxonomic assessments(morphology of sexual and asexual morph,chemotaxonomy,phylogeny),preventing species delimitation based on traditional *** changes are likely to be the result of environmental adaptations and selective pressure,the driving force of *** data provide an important starting point for the establishment of a stable phylogeny of the Xylariales;they enable studies on evolution,ecological behavior and biosynthesis of natural products;and they significantly advance the taxonomy of fungi.

关键词： AAI ANI Cazyme Oxford nanopore Phylogenomics POCP Xylariales

Lenormandins A—G,new azaphilones from Hypoxylon lenormandii and Hypoxylon jaklitschii ***.,recognised by chemotaxonomic data

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Fungal Diversity 2015年第2期71卷 165-184页

作者： eric Kuhnert Frank Surup Esteban B.Sir Christopher lambert Kevin D.Hyde Adriana I.Hladki Andrea I.Romero Marc Stadler Department of Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BraunschweigGermany German Centre for Infection Research(DZIF) partner site Hannover-Braunschweig38124 BraunschweigGermany Fundación Miguel Lillo Institute of MycologyMiguel Lillo 251San Miguel de Tucumán 4000TucumánArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Av.Rivadavia 1917Buenos Aires C1033AAJArgentina Institute of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Biodiversity and Experimental Biology University of Buenos AiresInt.Güiraldes 2620Buenos Aires C1428EHAArgentina

Seven new azaphilone pigments named lenormandins A–G were isolated from stromata(fruiting bodies)of the xylariaceous fungus,Hypoxylon lenormandii using preparative High Performance Liquid Chromatography(HPLC)and their structures were elucidated by NMR spectroscopy,high resolution mass spectrometry and other spectral *** occurrence in herbarium specimens(including various type materials collected in the 19th and early 20th century)and several fresh collections was studied by analytical HPLC with diode array and mass spectrometric detection(HPLC-DAD/MS),revealing that this group of pigments is specific for Hypoxylon lenormandii from various geographic regions and otherwise only occurs in closely related taxa,*** and an undescribed fungus from Sri Lanka,for which we propose the name *** status of the new species was established by using molecular phylogenetic data based on ITS and partial beta-tubulin sequences,and by detailed morphological studies.

关键词： Chemotaxonomy Hypoxylon Phylogeny Secondary metabolites Systematics Xylariaceae

Phylogenetic and chemotaxonomic resolution of the genus Annulohypoxylon(Xylariaceae)including four new species

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Fungal Diversity 2017年第4期85卷 1-43页

作者： eric Kuhnert Esteban B.Sir Christopher lambert Kevin D.Hyde Adriana I.Hladki Andrea I.Romero Manfred Rohde Marc Stadler Department of Microbial Drugs Helmholtz-Zentrum fur Infektionsforschung GmbHInhoffenstrasse 738124 BrunswickGermany German Centre for Infection Research(DZIF) partner site Hannover-Braunschweig38124 BrunswickGermany Fundacion Miguel Lillo CONICETInstitute of MycologyMiguel Lillo 251San Miguel de Tucuman 4000TucumanArgentina Fundacion Miguel Lillo Institute of MycologyMiguel Lillo 251San Miguel de Tucuman 4000TucumanArgentina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Instituto de Micologia y Botanica(INMIBO) UBACONICETDepto.Biodiversidad y Biologia ExperimentalFCENAv.Int.Guiraldes 2620C1428EHA Ciudad Autonoma de Buenos AiresArgentina Central Facility for Microscopy Helmholtz-Zentrum fur Infektionsforschung GmbHInhoffenstrasse 738124 BrunswickGermany

This study deals with an extensive evaluation focusing on phylogenetic and chemotaxonomic infrageneric relationships of the genus Annulohypoxylon(Xylariaceae,Ascomycota),whose species are ubiquitously associated with seed plants as endophytes and saprotrophs in all forested areas of the *** evidence from phylogenetic,chemotaxonomic and morphological data,various varieties within the genus are raised to species level,leading to the new combinations for ***(:*** ***),***(:*** ***),and ***(:*** ***).Annulohypoxylon substygium *** applied for *** *** the four new tropical and subtropical species ***,***,*** and *** are ***,*** is excluded from the genus as its morphological characters disagree with the generic concept,the recently erected *** is synonymized with *** and *** has been reassigned to the genus *** addition,the key taxa *** and *** have been reinvestigated and epitypes have been *** the first time,a dichotomous key to the genus is provided.A phylogenetic b-tubulin tree in conjunction with stromatal HPLC profiles clearly shows that Annulohypoxylon comprises two distinct *** ***/multiforme group might eventually warrant segregation into a new genus as further molecular data become available.

关键词： β-Tubulin Biodiversity Chemotaxonomy Phylogeny Systematics Xylariales

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

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Cellular & Molecular Immunology 2019年第10期16卷 810-819页

作者： Mohamad Omar Ashi Nivine Srour Jean-Marie lambert Anne Marchalot Ophelie Martin Sandrine Le Noir eric Pinaud Maria Victoria Ayala Christophe Sirac Jerome Sauliere Jerome Moreaux Michel Cogne Laurent Delpy Unite Mixte de Recherche Centre National de la Recherche Scientifique 7276 INSERM U1262-Controle de la Reponse Immune B et LymphoproliferationsUniversitede LimogesLimogesFrance Institute of Human Genetics CNRS-UM UMR9002Department of Biological HaematologyCHU MontpellierUniversity of MontpellierUFR MedecineMontpellierFrance Institut Universitaire de France Universitede LimogesLimogesFrance Present address:Lady Davis Institute for Medical Research McGill University3755 Cote Ste-Catherine RoadMontrealQC H3T 1E2Canada

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)*** recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)***,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)*** questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell *** address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced *** found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC *** analysis further revealed that the skipped V exon turned into a ***,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders.

关键词： Immunoglobulin Exon skipping Plasma cells Antisense Oligonucleotides Nonsense-associated altered splicing

Impact of intragastric balloon on blood pressure reduction:A retrospective study in Eastern North Carolina

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World Journal of Gastrointestinal Endoscopy 2021年第5期13卷 115-124页

作者： Gbeminiyi Olanrewaju Samuel Karissa lambert Elijah Asagbra Glenn Harvin eric Ibegbu Division of Gastroenterology East Carolina UniversityGreenvilleNC 27834United States Department of Internal Medicine Brody School of MedicineEast Carolina UniversityGreenvilleNC 27834United States Department of Health Services and Information Management East Carolina UniversityCollege of Allied Health SciencesGreenvilleNC 27834United States

BACKGROUND Obesity has evolved into a global *** prevalence of obesity and hypertension in eastern North Carolina are comparable,if not higher,than the national *** the United States,an estimated 34%of adults have hypertension,the most modifiable risk factor for heart disease and *** and pharmacological interventions often do not provide sustained weight loss in obese *** surgery offers an effective weight reduction with short-and long-term health improvements;however,a higher body mass index is associated with higher surgical morbidity and mortality,longer hospitalization,and increasing rates of 30-day readmission due to *** balloon may bridge a critical gap in the treatment of *** objective of this paper is to showcase the impact of endoscopic bariatric therapy on blood pressure *** To investigate the impact of intragastric balloon on blood pressure *** A retrospective chart review was conducted from January 1,2016 to January 31,2019 of consecutive adults who received intragastric balloon therapy(IGBT)in a gastroenterology private practice in Eastern North *** balloon was introduced into the stomach under endoscopic guidance,and while in the region of the gastric body,inflation with saline was performed at increments of 50 mL until target volume between 500 to 650 mL of saline was attained depending on the patient's gastric *** procedural complications were noted during endoscopic placement and removal of the balloon.A cohort study design was used for data analysis.A total of 172 patients had the Orbera^(■)intragastric balloon *** the 172 patients who had IGBT at baseline,11 patients(6.4%)requested early balloon removal due to foreign body sensation(n=1),and/or intolerable gastrointestinal adverse events(n=10).The reported gastrointestinal adverse events were nausea,vomiting,abdominal pain,and ***,6-mo follow-up data were ava

关键词： Intragastric balloon Orbera^(■) Obesity Hypertension Systolic blood pressure Diastolic blood pressure