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Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

第十届全国疑难及重症肝病大会

作者： K.Rajender REDDY Ira M.jacobson Armand Abergel Barbara A.Leggett Charles S.Landis Robert Hyland Frances Chen Liyun Ni Anu O.Osinusi Diana Brainard jose Luis Calleja eric j.lawitz Andrew joseph Muir Alessandra Mangia UniversityofPennsylvania QIMRBerghoferMedicalResearchInstitute UniversityofWashington CentroDeInvestigacionBiomedicaEnRedDeEnfermedadesHepaticasyDigestivas(CIBERehd) Irccs-OspedaleCasaSollievoDellaSofferenza CHUClermontFerrand GileadSciencesInc. DukeClinicalResearchInstitute NewYorkUniversity GileadSciences Inc. TexasLiverInstitute UniversityofTexasHealthSanAntonio

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一...

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一项汇总分析,评估了吉利德SVR和肝硬化登记处的患者中的新发HCC的

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World journal of Diabetes 2024年第7期15卷 1448-1460页

作者： eric D Tenda joshua Henrina jin H Cha Muhammad R Triono Ersananda A Putri Dahliana j Aristy Dicky L Tahapary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia Head of Research Group Artificial Intelligence and Digital Health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

Quantifying foliar trait variation and covariation in sun and shade leaves using leaf spectroscopy in eastern North America

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Forest Ecosystems 2024年第5期11卷 728-742页

作者： Zhihui Wang Philip A.Townsend eric L.Kruger Anna K.Schweiger Guangdong Provincial Key Laboratory of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and ApplicationGuangzhou Institute of GeographyGuangdong Academy of SciencesGuangzhou510070China Department of Forest and Wildlife Ecology University of Wisconsin-Madison1630 Linden DriveMadisonWI53706USA Department of Land Resources and Environmental Sciences Montana State University334 Leon Johnson HallBozemanMT59717USA

Characterizing foliar trait variation in sun and shade leaves can provide insights into inter-and intra-species resource use strategies and plant response to environmental ***,datasets with records of multiple foliar traits from the same individual and including shade leaves are sparse,which limits our ability to investigate trait-trait,trait-environment relationships and trait coordination in both sun and shade *** presented a comprehensive dataset of 15 foliar traits from sun and shade leaves sampled with leaf spectroscopy,including 424 individuals of 110 plant species from 19 sites across eastern North *** investigated trait variation,covariation,scaling relationships with leaf mass,and the effects of environment,canopy position,and taxonomy on trait ***,sun leaves had higher leaf mass per area,nonstructural carbohydrates and total phenolics,lower mass-based chlorophyll a+b,carotenoids,phosphorus,and potassium,but exhibited species-specific *** between sun and shade leaf traits,and trait-environment relationships were overall consistent across *** main dimensions of foliar trait variation in seed plants were revealed including leaf economics traits,photosynthetic pigments,defense,and structural *** and canopy position collectively explained most of the foliar trait *** study highlights the importance of including intra-individual and intra-specific trait variation to improve our understanding of ecosystem *** findings have implications for efficient field sampling,and trait mapping with remote sensing.

关键词： Foliar traits Leaf trait variation Trait-environment covariation Shade leaves NEON Leaf spectroscopy

Bilateral nephrolithiasis and upper tract transitional cell carcinoma in horseshoe kidney

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Current Urology 2024年第3期18卷 247-249页

作者： jacob M.Gaines eric j.Macdonald Arun Rai David Hoenig Arthur Smith Zeph Okeke Tareq Aro The Smith Institute for Urology Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellLake SuccessNYUSA

Nephroureterectomy is currently the criterion-standard treatment for high-grade upper tract urothelial carcinoma(UTUC).Current guidelines and expert opinions propose some exceptions to this approach based on patient characteristics,disease status,and function of the contralateral *** present a rare case of a patient with horseshoe kidney,bilateral large nephrolithiasis,high-grade UTUC in one moiety,and relative parenchymal thinning of the contralateral *** patient was treated with a percutaneous,minimally invasive,nephron sparing *** patient also had intracollecting system instillations of gemcitabine and *** invasive percutaneous resection of high-grade UTUC is a safe procedure in select *** guidelines may not apply to all patients;unique scenarios with UTUC may require personalized decision-making and treatment at specialized centers.

关键词： Upper tract urothelial cancer Percutaneous resection Horseshoe kidney Nephrolithiasis

Association of initial assessment variables and mortality in severe pediatric traumatic brain injury

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World journal of Pediatric Surgery 2024年第2期7卷 125-133页

作者： Katherine C Bergus Kelli N Patterson Lindsey Asti josh Bricker Tariku j Beyene Lauren N Schulz Dana M Schwartz Rajan K Thakkar eric A Sribnick Pediatric Surgery Nationwide Children's HospitalColumbusOhioUSA CenterforSurgical Outcomes Research Nationwide Children's HospitalColumbusOhioUSA Neurologic Surgery The Ohio State UniversityColumbusOhioUSA Neurologic Surgery Nationwide Children's HospitalColumbusOhioUSA

Background Predictive scales have been used to prognosticate long-term outcomes of traumatic brain injury(TBI),but gaps remain in predicting mortality using initial trauma resuscitation *** sought to evaluate the association of clinical variables collected during the initial resuscitation of intubated pediatric severe patients with TBI with in-hospital *** Intubated pediatric trauma patientsjanuary 2011 to December 2020 were *** between initial trauma resuscitation variables(temperature,pulse,mean arterial blood pressure,GCS score,hemoglobin,international normalized ratio(INR),platelet count,oxygen saturation,end tidal carbon dioxide,blood glucose and pupillary response)and mortality were evaluated with multivariable logistic *** Among 314 patients,median age was 5.5 years(interquartile range(IQR):2.2-12.8),GCS score was 3(IQR:3-6),Head Abbreviated Injury Score(hAIS)was 4(IQR:3-5),and most had a severe(25-49)Injury Severity Score(ISS)(48.7%,153/314).Overall mortality was 26.8%.GCS score,hAIS,ISS,INR,platelet count,and blood glucose were associated with in-hospital mortality(all p<0.05).As age and GCS score increased,the odds of mortality *** 1-point increase in GCS score was associated with a 35%decrease in odds of *** hAIS,INR,and blood glucose increased,the odds of mortality *** each 1.0 unit increase in INR,the odds of mortality increased by 1427%.Conclusions Pediatric patients with severe TBI are at substantial risk for in-hospital *** are needed to examine whether earlier interventions targeting specific parameters of INR and blood glucose impact mortality.

关键词： mortality pediatric traumatic

Physiological phenotypes differ among color morphs in introduced common wall lizards(Podarcis muralis)

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Integrative Zoology 2024年第3期19卷 505-523页

作者： Ali AMER Sierra SPEARS Princeton L.VAUGHN Cece COLWELL Ethan H.LIVINGSTON Wyatt MCQUEEN Anna SCHILL Dustin G.REICHARD eric j.GANGLOFF Kinsey M.BROCK Department of Biological Sciences Ohio Wesleyan UniversityDelawareOhioUSA Department of Ecology and Evolutionary Biology Princeton UniversityPrincetonNew JerseyUSA Department of Biology Idaho State UniversityPocatelloIdahoUSA Department of Environmental Science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA Museum of Vertebrate Zoology University of CaliforniaBerkeleyUSA

Many species exhibit color polymorphisms which have distinct physiological and behavioral ***,the consistency of morph trait covariation patterns across species,time,and ecological contexts remains *** trait covariation is especially relevant in the context of invasion biology and urban ***,physiological traits pertaining to energy maintenance are crucial to fitness,given their immediate ties to individual reproduction,growth,and population *** investigated the physiological traits of Podarcis muralis,a versatile color polymorphic species that thrives in urban environments(including invasive populations in Ohio,USA).We measured five physiological traits(plasma corticosterone and triglycerides,hematocrit,body condition,and field body temperature),which compose an integrated multivariate *** then tested variation among co-occurring color morphs in the context of establishment in an urban *** found that the traits describing physiological status and strategy shifted across the active season in a morph-dependent manner—the white and yellow morphs exhibited clearly different multivariate physiological phenotypes,characterized primarily by differences in plasma *** suggests that morphs have different strategies in physiological regulation,the flexibility of which is crucial to urban *** white-yellow morph exhibited an intermediate phenotype,suggesting an intermediary energy maintenance *** morphs also exhibited distinct phenotypes,but the low prevalence of this morph in our study populations precludes clear *** work provides insight into how differences among stable polymorphisms exist across axes of the phenotype and how this variation may aid in establishment within novel environments.

关键词： color polymorphism physiological status seasonal variation thermoregulation urban habitat

Comparison of Two Recurrent Neural Networks for Rainfall-Runoff Modeling in the Zou River Basin at Atchérigbé (Bénin)

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journal of Geoscience and Environment Protection 2024年第9期12卷 167-181页

作者： Iboukoun Eliézer Biao Oscar Houessou Pierre jérôme Zohou Adéchina eric Alamou National School of Mathematical Engineering and Modeling National University of Sciences Technology Engineering and Mathematics Abomey Benin LaGEA National School of Public Works National University of Sciences Technology Engineering and Mathematics Abomey Benin International Chair of Mathematical Physics and Applications (ICMPA-UNESCO Chair) University of Abomey-Calavi Abomey-Calavi Bnin

Hydrological models are developed to simulate river flows over a watershed for many practical applications in the field of water resource management. The present paper compares the performance of two recurrent neural networks for rainfall-runoff modeling in the Zou River basin at Atchérigbé outlet. To this end, we used daily precipitation data over the period 1988-2010 as input of the models, such as the Long Short-Term Memory (LSTM) and Recurrent Gate Networks (GRU) to simulate river discharge in the study area. The investigated models give good results in calibration (R2 = 0.888, NSE = 0.886, and RMSE = 0.42 for LSTM;R2 = 0.9, NSE = 0.9 and RMSE = 0.397 for GRU) and in validation (R2 = 0.865, NSE = 0.851, and RMSE = 0.329 for LSTM;R2 = 0.9, NSE = 0.865 and RMSE = 0.301 for GRU). This good performance of LSTM and GRU models confirms the importance of models based on machine learning in modeling hydrological phenomena for better decision-making.

关键词： Supervised Learning Modeling Zou Basin Long and Short-Term Memory Gated Recurrent Unit Hyperparameters Optimization

Thermomechanical Modelling of Industrial Vessels that Contain Refractory Masonry Linings

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China's Refractories 2024年第3期33卷 1-8页

作者： Alain GASSER eric BLOND Thomas SAYET Univ.Orléans Univ.ToursINSA-CVLLaMé(EA 7494)Orléans 45072France

Some refractory linings that protect metallic vessels from the hot temperature of the products they contain are made of masonries with or without *** joints play an important role,reducing the stresses in the masonries during ***,the presence of these joints makes the behaviour of the masonry nonlinear and *** perform a thermomechanical simulation using a finite element method of an industrial vessel that contains hundreds or thousands of bricks and joints,microscopic models are not suitable due to the high computational time and the management of the behaviour of the joints(opening/closing)which affects the *** overcome these problems,it is proposed to replace the masonry by a homogeneous material that has a behaviour equivalent to the set of bricks and joints,using a periodic homogenization *** the joints can be closed or open,the equivalent material will have a different behaviour according to the joint ***,refractory materials have an elastic-viscoplastic behaviour at high ***,the equivalent material will have an orthotropic elastic-viscoplastic behaviour,requiring a nonlinear homogenisation *** overview of this approach developed at University of Orléans is presented with two industrial applications(blast-furnace and steel ladle).

关键词： thermomechanical simulation refractory masonry homogenization elastic-viscoplastic behaviour

Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G Dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 B from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： jia-Qi Wang Xiao-jun jiang jie Zheng Hanna Kellermann Arno Riffeser Liang Wang Karen A.Collins Allyson Bieryla Lars A.Buchhave Steve B.Howell Elise Furlan eric Girardin joao Gregorio eric jensen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-juan Wang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lijiang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(j),and a very low mass companion star with a mass of about 96.5±1.5 Mj,TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041Rj and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 B is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(j) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic