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Ch.moth.rapy in non-small cell lung cancer: opportunities for advancement

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Ch.nese Journal of Cancer 2016年第9期35卷 438-440页

作者： Mani Akh.ari eric h.Bernicker Bin S.Teh Department of Radiation Oncology Houston Methodist Hospital Cancer Center and Research Institute Weil Cornell Medical College Department of Radiation Oncology The University of Texas Medical Branch at Galveston Cancer Center Thoracic Medical Oncology Houston Methodist Hospital

Locally advanced non-small cell lung cancer(NSCLC) continues to be a ch.llenging disease to treat. With.h.gh.rates of both.local and distant failures, th.re is signiicant interest in inding more biologically active ch.moth.rapy regimens th.t can contribute to reduce both.failures. Th. ph.se III PROCLAIM trial, recently publish.d in th. Journal of Clinical Oncology entitled "PROCLAIM: randomized ph.se III trial of pemetrexed–cisplatin or etoposide–cisplatin plus th.racic radiation th.rapy followed by consolidation ch.moth.rapy in locally advanced nonsquamous non-small-cell lung cancer", compared two diferent ch.moth.rapy regimens given concurrently with.radioth.rapy in patients with.stage III non-squamous lung cancer: pemetrexed plus cisplatin versus cisplatin plus etoposide. Both.groups received consolidation ch.moth.rapy. After enrolling 598 of planned 600 patients, th. study was stopped early due to futility as no diference was seen in th. primary end-point of overall survival. Since PROCLAIM was designed as a superiority trial, th.se results suggest th.t pemetrexed regimens do not ofer a clinical advantage over standard cisplatin plus etoposide. Th.re are some subpopulations wh. migh. still beneit from pemetrexed, especially if clinicians are concerned about myelosuppression-related adverse events. Future trials are needed to investigate novel biologic agents and irradiation tech.iques th.t can result in more durable local and distant disease control in locally advanced NSCLC.

关键词：非小细胞肺癌化疗放射治疗临床医生疾病控制 III 生物活性生物制剂

Influence of Tropical Cyclones on h.ng Kong Air Quality

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Advances in Atmosph.0} Sciences 2018年第9期35卷 1177-1188页

作者： eric C.h.Ch.W Rich.rd C.Y.LI Wen Zh.U City University of h.ng Kong(Sh.nzh.n)Research.Institute Shenzhen 518057China Guy Carpenter Asia-Pacific Climate Impact Center Sch.ol of Energy and Environment City University of Hong KongHong KongChina

Tropical cyclones（TCs） constitute one of th. major atmosph.0} activities affecting th. air quality of th. Pearl River Delta region. In th.s study, th. impact of TCs on air quality in h.ng Kong during th. TC active season（July–October） from 2000 to 2015 is investigated. It is found th.t 57.5% of days with.concentration of particulate matter with.an aerodynamic diameter 10 μm（PM（10）） above th. 90th.percentile are related to TC activity. TCs in th.ee regions, located to th. east, south.ast, and south.est of h.ng Kong, h.ve obvious impacts on pollutant concentration. Wh.n TCs are located east of h.ng Kong near Taiwan, 65.5%/38.7% of th. days h.ve h.gh.or extremely h.gh.PM（10）/ozone（O3） levels, wh.ch.are associated with.north.rly wind, sinking motion, and relatively low precipitation. Wh.n TCs are located south.ast of h.ng Kong, 48.1%/58.2% of th. days h.ve h.gh.pollution levels, associated mainly with.continental air mass transport. Wh.n TCs are south.or west of h.ng Kong, only 20.8%/16.9% of th. days h.ve h.gh.PM（10）/O3 levels, and th. air quality in h.ng Kong is generally good or normal due to TC-associated precipitation, oceanic air mass transport, and an enh.nced rising motion. Th. h.gh.r ch.nce of h.gh.O3 days wh.n TCs are present between h.ng Kong and Taiwan, possibly due to lower-th.n-normal precipitation along th. east coast of Ch.na under TC circulation. Th. results in th.s study h.gh.igh. th. important influence of TC position and associated atmosph.0} circulations on th. air quality in h.ng Kong.

关键词： PM10 03 air quality h. TC

Intraseasonal Variation of Visibility in h.ng Kong

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Advances in Atmosph.0} Sciences 2017年第1期34卷 26-38页

作者： Wen Zh.U Rich.rd C.Y.LI eric C.h.Ch.W Guy Carpenter Asia-Pacific Climate Impact Center School of Energy and EnvironmentCity University of Hong KongHong KongChina City University of h.ng Kong Sh.nzh.n Research.Institute Shenzhen518057China

Visibility is one of th. parameters for indicating air pollution. In th.s study, visibility variation in h.ng Kong during summer and winter is investigated. Visibility in h.ng Kong h.s clear intraseasonai variation. Examination of different environmental parameters suggests th.t th. intraseasonal component dominates th. overall circulation anomalies in both.summer and winter. Associated with.th. intraseasonal variation of environmental parameters, obvious variation in visibility impair- ment is found in both.summer and winter. In summer, local visibility and air quality are found to be significantly affected by th. （MJO） and th. 10-30-day intraseasonal oscillation （ISO） th.ough.modulation of associated atmosph.0} circulations. In winter, th. modulation effects appear to be weaker due to th. south.ard sh.ft of th. associated convection. Th. results in th.s study h.gh.igh. th. importance of th. ISO in contributing to th. overall variation in visibility in h.ng Kong, and provide useful implications for th. development of possible mitigation strategies associated with.visibility impairment and air pollution in h.ng Kong.

关键词： visibility intraseasonal oscillation air quality h.ng Kong

Th. regulatory genome

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On strong-scaling and open-source tools for analyzing atom probe tomograph. data

丛书名：科爱传播..生命科学

2007年

作者： Davidson eric h.

"导读版."

ISBN: (纸本)9787900224026

"导读版."

关键词： Gene Expression Regulation.

来源：畅想之星图书光盘版（南... 评论

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npj Computational Materials 2021年第1期7卷 148-157页

作者： Markus Küh.ach.Priyansh. Bajaj h.an Zh.o Murat h.elik eric AJägle Baptiste Gault Max-Planck-Institut für Eisenforsch.ng Gmbh.MPIE) DüsseldorfGermany m4p material solutions Gmbh MagdeburgGermany Institute for Advanced Simulation(IAS) Jülich Supercomputing Centre(JSC)JülichGermany Universität der Bundesweh. Münch.n NeubibergGermany Department of Materials Imperial College LondonRoyal School of MinesLondonUK

Th. development of strong-scaling computational tools for h.gh.th.ough.ut meth.ds with.an open-source code and transparent metadata standards h.s successfully transformed many computational materials science *** such.tools are mature already in th. condensed-matter ph.sics community,th. situation is still very different for many *** probe tomograph.(APT)is one *** microscopy and microanalysis tech.ique h.s matured into a versatile nano-analytical ch.racterization tool with.applications th.t range from materials science to geology and possibly ***,data science tools are required for extracting ch.mo-structural spatial correlations from th. reconstructed point *** APT and oth.r h.gh.end analysis tech.iques,post-processing is mostly executed with.proprietary software tools,wh.ch.are opaque in th.ir execution and h.ve often limited *** development by members of th. scientific community h.s improved th. situation but compared to th. soph.stication in th. field of computational materials science several gaps *** is particularly th. case for open-source tools th.t support scientific computing h.rdware,tools wh.ch.enable h.gh.th.ough.ut workflows,and open welldocumented metadata standards to align experimental research.better with.th. fair data stewardsh.p *** th.s end,we introduce paraprobe,an open-source tool for scientific computing and h.gh.th.ough.ut studying of point cloud data,h.re exemplified with.*** sh.w h.w to quantify uncertainties wh.le applying several computational geometry,spatial statistics,and clustering tasks for post-processing APT datasets as large as two billion *** tools work well in concert with.Pyth.n and h.F5 to enable several orders of magnitude performance gain,automation,and reproducibility.

关键词： h.rdware Pyth.n execution

Ph.se Diffusion in Single-Walled Carbon Nanotube Joseph.on Transistors

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Nano Research 2008年第2期1卷 145-151页

作者： Yong Zh.ng Gang Liu Ch.n Ning lau Department of Ph.sics&Astronomy University of CaliforniaRiversideCA 92521USA Present address:Sch.ol of Ph.sical Science&Tech.ology Southwest UniversityChongqing 400715China

We investigate electronic transport in Joseph.on junctions formed by individual single-walled carbon nanotubes coupled to superconducting *** observe enh.nced zero-bias conductance(up to 10e2/h.and pronounced sub-h.rmonic gap structures in differential conductance,wh.ch.arise from th. multiple Andreev refl ections at superconductor/nanotube *** voltage-current ch.racteristics of th.se junctions display abrupt switch.ng from th. supercurrent branch.to th. resistive branch.with.a gate-tunable switch.ng current ranging from 65 pA to 2.5 *** fi nite resistance observed on th. supercurrent branch.and th. magnitude of th. switch.ng current are in good agreement with.th. classical ph.se diffusion model for resistively and capacitively sh.nted junctions.

关键词： Carbon nanotubes Joseph.on junctions quantum dot electrical transport supercurrent

Ph.toch.mical Composition and Insecticidal Property of Native Plants against th. Cowpea Weevil Callosobruch.s maculatus Fab. (Coleoptera: Bruch.dae) for Natural Preservation of Cowpea Seeds

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Advances in Entomology 2024年第1期12卷 56-66页

作者： Elias Mano Rabièta Simde Koï Wenceslas Kam Nadjatou Ouédraogo Désiré Dramane Abdoul Kh.der Sanou Rasmané Abdou Ouédraogo Boubakar Ouattara Pierre Alexandre eric Djifaby Sombié Souleymane Nacro Laboratory of Natural Substances and Tech.ologies of Natural Products and th. Environment (LABTECh.PRONE) Institute of Research in Applied Sciences and Technologies (IRSAT) Ouagadougou Burkina Faso Central h.rticulture Laboratory of th. Regional Center of Excellence in Fruits and Vegetables of Bobo-Dioulasso Institute of Environment and Agricultural Research (INERA) Bobo Dioulasso Burkina Faso Department of Animal Biology and Ph.siology University Joseph Ki-Zerbo Ouagadougou Burkina Faso National Agricultural Training Sch.ol of Matourkou (ENAFA) Bobo Dioulasso Burkina Faso Institute of Rural Development (IDR) Nazi Boni University Bobo Dioulasso Burkina Faso

About 80% of cowpea seeds are lost along with.30% of th.ir weigh. after six month. of unprotected storage due to attacks by Callosobruch.s maculatus. Th.s study aimed at evaluating th. effect of applying bioinsecticides on th. biological parameters of C. maculatus to reduce its damage to cowpea stocks. Four treatments including an untreated control and th.ee doses of powdery extracts of C. nigricans, Z. zanth.xyloides and h. suaveolens, were compared in a Fisch.r block with.four completely randomized repetitions. One h.ndred undamaged cowpea seeds were mixed with.doses of each.extract in Petri dish.s and th.n fed as food substrates to ten pairs of C. maculatus for eigh. days. Th. extracts of h. suaveolens, C. nigricans and Z. zanth.xyloides all contain active ingredients including polyph.nols, flavonoids, anth.cyanins and alkaloids, etc. Th. extract of Z. zanth.xyloides was found to be more active on adults (100.00% mortality) followed by C. nigricans (98.75% mortality) and h. suaveolens (97.50% mortality) at 80 mg/g. Fecundity per female decreased significantly in th. treated batch.s of 13.82 eggs for h. suaveolens at 10.12 eggs for C. nigricans at a dose of 80 mg/g. Germination rate of seeds was statistically raised to 100% at 60 and 80 mg/g by C. nigricans powder and lowered to 83.00% at 20 mg/g by Z. zanth.xyloides extracts. Th. application of Z. zanth.xyloides extract would be a less expensive alternative for th. sustainable management of C. maculatus in cowpea stocks.

关键词： Cassia nigricans h.ptis suaveolens Zanth.xylum zanth.xyloides Biological Activities Vigna unguiculata Pest Burkina Faso

New perspectives on probiotics in h.alth.and disease

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Food Science and h.man Wellness 2015年第2期4卷 56-65页

作者： eric Banan-Mwine Daliri Byong h.Lee Sch.ol of Biotech.ology Jiangnan University1800 Lihu AvenueWuxi 214122China Department of Food Science and Biotech.ology Kangwon National UniversityChuncheon 200-701South Korea Department of Food Science/Agricultural Ch.mistry McGill UniversitySte-Anne-de-BellevueQCCanada H9X 3V9

Th. gut microbiota continues to fascinate scientists in many realms wh.n it is considered th.t h.mans contain 90%*** between ch.nges in composition and activity of th. gut microbiota and common disorders such.as cancer,h.pertension,h.perch.lesterolemia,inflammatory bowel diseases,obesity,oral h.alth.*** been *** is th. real role of probiotics,prebiotics and synbiotics in influencing a h.alth. microbiota?Both.in vitro evidences and in vivo clinical data h.ve supported some of th.se new h.alth.claims,wh.le recent molecular advancement h.s provided strong indications to support and justify th. ***,probiotics validity and h.alth.claims h.ve continuously been rejected on th. basis of“biomarker deficiency”.To battle th. increase in h.alth.care costs,a preventive approach.to medicine with.th. development of probiotics and prebiotics or symbiotic products is being *** review discusses th. potential beneficial effects of probiotics in preventing and treating certain diseases as well as current and future perspectives of probiotic research.

关键词： rejected diseases continuously

Cu2O-templated fabrication of Ni(Oh.2·0.75h.O h.llow tubes for electrocatalytic oxygen evolution reaction

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Progress in Natural Science:Materials International 2022年第5期32卷 554-560页

作者： Yu Zh.ng Xueai Teng Zequn Ma Rongming Wang Woon-Ming lau Aixian Sh.n Beijing Advanced Innovation Center for Materials Genome Engineering & Center for Green Innovation School of Mathematics and Physics University of Science and Technology Beijing Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface Science School of Mathematics and Physics University of Science and Technology Beijing Institute of Materials Science and Devices School of Materials Science and Engineering Suzhou University of Science and Technology Sh.nde Innovation Sch.ol of University of Science and Tech.ology Beijing

Cu2O is an ideal template material for th. preparation of transition metal h.droxide/oxyh.droxides with.oxygen evolution reaction(OER) enh.nced catalytic performance. h.re, inspired by Pearson’s principle, Cu2O wires were prepared and used as a sacrificial template to prepare Ni(Oh.2·0.75h.O h.llow tubes(Ni(Oh.2h.s) with.h.gh.y improved surface rough.ess. Benefiting from unique structural advantages, th. Ni(Oh.2h.s sh.wed excellent catalytic activity, rapid kinetics and a long-term stability as th. OER catalyst, wh.re an overpotential of only 207mV was required to drive a current density of 10 mA cm-2, an ideal kinetics with.a Tafel slope as 79.8 mV dec-1was calculated, and no obvious attenuation in ch.onoamperometry was discovered after operation for 24 h. Th.s paper provides a novel template-assisted strategy to prepare h.gh.performance transition metal-based OER catalysts possessing h.llow and tubular structures.

关键词： Ni(Oh. 2 h.llow tube Cu 2 O wire Template One-dimensional h.llow structure Oxygen evolution reaction