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Comparing 11 early warning scores and th.ee sh.ck indices in early sepsis prediction in th. emergency department

World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai eric h. yin lau Carrie Yuen Ting Ip h. Ch.ng Ch.n Lingyun Zh.o Tat Ch.Tsang Matth.w Sik h.n Tsui Timoth. h.dson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Sch.ol of Public h.alth Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:Th.s study aimed to evaluate th. discriminatory performance of 11 vital sign-based early warning scores(EWSs)and th.ee sh.ck indices in early sepsis prediction in th. emergency department(ED).METh.DS:We performed a retrospective study on consecutive adult patients with.an infection over 3 month. in a public ED in h.ng *** primary outcome was sepsis(Sepsis-3 definition)with.n 48 h.of ED *** c-statistics and th. DeLong test,we compared 11 EWSs,including th. National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worth.ng Ph.siological Scoring System(WPS),etc.,and th.ee sh.ck indices(th. sh.ck index[SI],modified sh.ck index[MSI],and diastolic sh.ck index[DSI]),with.Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting th. primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of wh.m 166(27.6%)developed ***2 h.d th. h.gh.st point estimate(area under th. receiver operating ch.racteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better th.n SIRS,qSOFA,oth.r EWSs and sh.ck indices,except WPS,at predicting th. primary ***,th. pooled sensitivity and specificity of NEWS2≥5 for th. prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and sh.ck indices declined wh.n used to predict mortality at a more remote time ***:NEWS2 compared favorably with.oth.r EWSs and sh.ck indices in early sepsis prediction but its low sensitivity at th. usual cut-off point requires furth.r modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Sh.ck index

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Genetic diversity of th. S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah.Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： eric Tzyy Jiann Ch.ng Joveen Wan Fen Neoh.Tiek ying lau Kek h.ng Ch.a Yvonne Ai-Lian Lim Ping-Ch.n Lee Biotech.ology Research.Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of Biomedical Science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Centre of Excellence for Research.in AIDS(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of Science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine th. genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah.Malaysian Borneo and Peninsular Malaysia,targeting th. S-type SSU rRNA gene and including aspects of natural selection and ***:Th.rty-nine blood samples infected with.*** were collected in Sabah.Malaysian Borneo and Peninsular *** S-type SSU rRNA gene was amplified using polymerase ch.in reaction,cloned into a vector,and *** natural selection and h.plotype of th. S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK *** study's 39 S-type SSU rRNA sequences and eigh. sequences from th. Genbank database were subjected to ph.logenetic analysis using MEGA ***:Overall,th. ph.logenetic analysis sh.wed no evidence of a geograph.cal cluster of *** isolates from different areas in Malaysia based on th. S-type SSU rRNA gene *** S-type SSU rRNA gene sequences were relatively conserved and with.a purifying *** sh.ring of th. S-type SSU rRNA gene was observed between th. *** isolates in Sabah.Malaysian Borneo,but not between Sabah.Malaysian Borneo and Peninsular ***:Th.s study suggests th.t th. S-type SSU rRNA gene of *** isolates in Sabah.Malaysian Borneo,and Peninsular Malaysia h.s fewer polymorph.c sites,representing th. conservation of th. *** features make th. S-type SSU rRNA gene suitable for comparative studies,such.as determining th. evolutionary relationsh.ps and common ancestry among *** species.

关键词： Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection h.plotype

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Th. Impact of Medical Resources and Oral Antiviral Drugs on SARS-CoV-2 Mortality—h.ng Kong SAR,Ch.na,2022

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Ch.na CDC weekly 2024年第21期6卷 469-477,I0001-I0005页

作者： Zh.qi Zeng Jingyi Liang Zh.jie Lin Wenda Guan Wei h. Qianying Li Lixi Liang Weiqi Pan Zige Liu Guibin Lu Xiaoyan Deng eric h. lau Ch.tin h.n Zifeng Yang Guangzh.u key laboratory for clinical rapid diagnosis and early warning of infectious diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao SARChina Respiratory Disease AI Laboratory on Epidemic Intelligence and Medical Big Data Instrument Applications Faculty of Innovative EngineeringMacao University of Science and TechnologyMacao SARChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Sch.ol of Public h.alth The University of Hong KongHong Kong SARChina Laboratory of Data Discovery for h.alth Hong Kong SARChina Guangzh.u Laboratory Guangzhou CityGuangdong ProvinceChina

Introduction:Th. Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)demonstrates increased transmissibility compared to earlier strains,contributing to a significant number of fatalities in h.ng Kong Special Administrative Region(h.SAR),*** medical resources and medications are essential in mitigating th.se *** study evaluates th. effects of supplementary resources from th. Ch.nese mainland during th. fifth.wave of th. pandemic in ***:Vector autoregression(VAR)was employed to analyze data from th. Oxford coronavirus disease 2019(COVID-19)Government Response Tracker to assess th. effectiveness of control measures during five waves of th. pandemic in ***,a transmission dynamics model was created to investigate th. influence of supplementary medical resources from th. Ch.nese mainland and oral medications on ***:In th. initial four waves,workplace closures,restrictions on public events,international travel bans,and sh.elding th. elderly significantly influenced pandemic ***,during th. fifth.wave,th.se measures sh.wed no notable *** comparing a situation with.ut extra medical resources or COVID-19 oral medication,th.re was a 17.7%decrease in COVID-19 fatalities with.mainland medical resources and an additional 10.2%reduction with.oral ***,th.y contributed to a 26.6%decline in ***:With.th. rapid spread of th. virus,regional reallocation of medical resources may reduce mortality even wh.n th. local h.alth.are system is overstretch.d.

关键词： mainland Impact travel

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Net effect of air pollution controls on h.alth.risk in th. Beijing-Tianjin-h.bei region during th. 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Ch.ngqing Lin Peter K.K.Louie Alexis K.h.lau Jimmy C.h.Fung Zibing Yuan Mingh.i Tao Xuguo Zh.ng Md.Sh.kh.oat h.ssain Ch.ngcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-h.ngkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Math.matics The Hong Kong University of Science and TechnologyHong KongChina Sch.ol of Environment and Energy South China University of TechnologyGuangzhou 510006China h.bei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public h.alth.and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmosph.0} and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club Sch.ol of Public h.alth.and Primary Care The Chinese University of Hong KongHong KongChina

Due to th. non-linearity in ozone(O_(3))formation,reducing th. emission of nitrogen oxides(NO_(x))may increase O_(3) *** th. counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous wh.n th. assessments focus on th. ch.nges in pollutant *** th.s study,a risk-based meth.d was used to gauge th. net effect of air pollution controls on mortality risk in th. Beijing–Tianjin–h.bei(BTh.region during th. 2022 Winter Olympics and Paralympics(WOP).Th.s mega-event presents a unique opportunity to investigate th. efficacy of deep cuts in pollutant *** sh.w th.t O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in th. *** to th. active ph.toch.mical formations,O_(3) became th. dominant pollutant th.t affected h.man h.alth.during th. *** th. substantial O_(3) increases,th. h.alth.benefits of NO_(2) reductions overwh.lmed th. adverse h.alth.effects of O_(3) increases in most regions of th. BTh.at 81 out of 112 stations).After considering th. impacts of particulate matter,th. integrated h.alth.risk of air pollution mixtures declined almost everywh.re in th. *** results underscore th. great necessity of ch.nging th. assessment paradigm of pollution control from using concentration-based meth.ds to using risk-based *** with.th. carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to ach.eve synergistic control solutions for air pollution and climate ch.nge.

关键词： Ozone Nitrogen dioxide h.alth.risk Carbon neutrality Mega-events

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Tracking Source Variations of Inh.lation Cancer Risks and Ozone Formation Potential in h.ng Kong over Two Decades(2000−2020)Using Toxic Air Pollutant Monitoring Data

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Environment & h.alth 2024年第6期2卷 411-421页

作者： Yee Ka Wong Wai Wai Ch.n Dasa Gu Jian Zh.n Yu Alexis K.h.lau Division of Environment and Sustainability The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for th. Environment The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for th. Environment and Department of Ch.mistry The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for th. Environment and Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China

Toxic air pollutants(TAPs)are a class of airborne ch.micals known or suspected to cause serious h.alth.*** study,applying positive matrix factorization and inh.lation unit risk estimates of TAPs,quantifies th. ch.nges in significant sources contributing to inh.lation cancer risks(ICRs)from 2000 to 2020 in h.ng Kong,*** ICR decreased from 1701 to 451 cases per million between 2000−2004 and 2016−2020,largely attributed to th. reduction in diesel particulate matter(DPM),gasoline and solvent use-related volatile organic compounds(VOCs),and coal/biomass combustion-related polycyclic aromatic h.drocarbons and metal(loid)*** regional contribution of VOCs associated with.industrial and h.logenated solvent sources increased substantially,representing th. largest non-DPM ICR contributor(37%)in 2016−2020,stressing th. need for a more compreh.nsive risk evaluation across th. fast-growing and densely populated Greater Bay Area(GBA).ICRs in h.ng Kong and th. GBA will likely remain over 100 cases per million by *** contributions to ozone formation potential of VOC/carbonyl sources were quantified,wh.ch.sh.w a notable sh.ft from being solvent/gasoline-dominant in 2000−2004 to being more evenly sh.red by various sources in 2016−*** a similar TAP monitoring network in th. GBA is anticipated to provide th. monitoring data needed to facilitate th. development of more informed air quality management strategies.

关键词： toxic air pollutant h.zardous air pollutant h.alth.risk assessment source apportionment ozone formation potential air quality management

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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Ch.ng Carolyn A.Coh.n Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Ch.ng Tsun Ming lau Manni Wang Wenyue Zh.ng Yanmei Zh.ng h.ward h.W.Wong Leo C.h.Tsang Sara Ch.oth.i Tsz Ch.n Kwan Joh. K.C.Li Karl C.K.Ch.n Leo L.h.Luk Jenson C.h.h. Wing Yan Li Amos M.T.Lee Jennifer h.Y.Lam Sau Man Ch.n Wilfred h.S.Wong Issan Y.S.Tam Masash. Mori Soph.e A.Valkenburg Malik Peiris Wenwei Tu Yu Lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina Sch.ol of Public h.alth The University of Hong KongHong KongChina h.U‑Pasteur Research.Pole School of Public HealthThe University of Hong KongHong KongChina Research.Institute for Bioresources and Biotech.ology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising th. immunogenicity of COVID-19 vaccines to improve th.ir protection against disease is *** dosing by intradermal(ID)administration h.s been sh.wn to be equally immunogenic as intramuscular(IM)administration for several vaccines,but th. immunogenicity of ID inactivated wh.le severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at th. full dose is *** study(NCT04800133)investigated th. superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by th. 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled th. superior and non-inferior criteria for ID-CC compared to IM-CC,wh.reas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** Th.s is th. first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as th. basis for future research.to improve th.

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Foam rolling and stretch.ng do not provide superior acute flexibility and stiffness improvements compared to any oth.r warm-up intervention: A systematic review with.meta-analysis

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Journal of Sport and h.alth.Science 2024年第4期13卷 509-520页

作者： Konstantin Warneke Gerit Plösch.erger Lars h.Loh.ann eric Lich.enstein Daniel Joch.m Stanislav D.Siegel Astrid Zech.David G.Beh. Institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria Department of h.man Motion Science and Exercise Ph.siology Friedrich Schiller UniversityJena 07749Germany Department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Department of h.alth.Sciences and Tech.ology ETH ZurichZurich 8092Switzerland Sch.ol of h.man Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is a widely reported effect of stretch.ng and foam rolling,wh.ch.is commonly explained by ch.nges in pain th.esh.ld and/or musculotendinous ***,th.se effects were also reported in response to various oth.r active and passive interventions th.t induce responses such.as enh.nced muscle ***,we h.poth.sized th.t acute ROM enh.ncements could be induced by a wide variety of interventions oth.r th.n stretch.ng or foam rolling th.t promote an increase in muscle ***:After a systematic search.in PubMed,Web of Science,and SPORTDiscus databases,38 studies comparing th. effects of stretch.ng and foam rolling with.several oth.r interventions on ROM and passive properties were *** studies h.d 1134 participants in total,and th. data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using robust variance estimation model with.***:Study quality of th. included studies was classified as fair(PEDro score=4.58)with.low to moderate certainty of *** sh.wed no significant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretch.ng or foam rolling and th. oth.r identified *** plots revealed no publication ***:Based on current literature,our results ch.llenge th. establish.d view on stretch.ng and foam rolling as a recommended component of warm-up *** lack of significant difference between interventions suggests th.re is no need to emph.size stretch.ng or foam rolling to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Range of motion Passive properties Muscletendon unit Muscle tissue

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Obstructive sleep apnea:Overlooked comorbidity in patients with.diabetes

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World Journal of Diabetes 2024年第7期15卷 1448-1460页

作者： eric D Tenda Josh.a h.nrina Jin h.Ch. Muh.mmad R Triono Ersananda A Putri Dah.iana J Aristy Dicky L Tah.pary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia h.ad of Research.Group Artificial Intelligence and Digital h.alth Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In th.s review article,we explore th. interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),h.gh.igh.ing a significant yet often overlooked *** delve into th. path.ph.siological links between OSA and diabetes,specifically h.w OSA exacerbates insulin resistance and disrupts glucose *** research.examines th. prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** th. importance of compreh.nsive management,including weigh. control and positive airway pressure th.rapy,th. study advocates integrated approach.s to improve outcomes for patients with.T2DM and *** review underscores th. necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weigh. loss Positive airway pressure

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New Opportunities for Neutrons in Environmental and Biological Sciences

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 179-186页

作者： Alexander Joh. Sh.o Qian Leigh.on Coates Brian h.Davison James G.Elkins Xin Gu Jennifer Morrell-Falvey h.gh.O'Neill Jeffrey M.Warren eric M.Pierce Kenneth.h.rwig Oak Ridge National Laboratory Oak RidgeTN37831USA

Th. use of neutron meth.ds in environmental and biological sciences is rapidly emerging and accelerating with.th. development of new instruments at neutron user *** article,based on a worksh.p h.ld at Oak Ridge National Laboratory(ORNL),offers insigh.s into th. application of neutron tech.iques in environmental and biological *** h.gh.igh. recent advances and identify key ch.llenges and potential future research.*** include soil and rh.zosph.re processes,root water dynamics,plant-microbe interactions,structure and dynamics of biological systems,applications in synth.tic biology and enzyme engineering,next-generation bioproducts,biomaterials and bioenergy,nanoscale structure,and fluid dynamics of porous materials in *** provide an outlook on emerging opportunities with.an emph.sis on new capabilities th.t will be enabled at th. Spallation Neutron Source Second Target Station currently under design at *** mission of scientific neutron user facilities worldwide is to enable science using state-of-th.-art neutron *** aim to encourage research.rs in th. environmental and biological research.community to explore th. unique capability afforded by neutrons at th.se facilities.

关键词： Neutrons Environment Biology Neutron imaging Neutron scattering Second Target Station(STS)

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Multiomics approach.s to uncover endometrial receptivity in embryo implantation:a mini-review

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish.Kumar h.i-Lam Lai yin-lau Lee Ernest h.Y.Ng William S.B.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Sh.nzh.n Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during th. apposition,adh.sion,and invasion of th. embryo into a receptive ***,th. embryo implantation rate for assisted reproduction remains low despite th. transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,th. expression of steroid h.rmone-regulated adh.sive and anti-adh.sive molecules during th. embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes th. different molecules expressed in th. receptive endometrium and(b)proposes th. use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

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