检索结果-南通市图书馆

Navigating the currents of seascape genomics： how spatial analyses can augment population genomic studies

Current Zoology 2016年第6期62卷 581-601页

作者： Cynthia RIGINOS eric d. CRANdALL Libby LIGGINS Pim BONGAERTS eric A, TREML School of Biological Sciences The University of Queensland St Lucia QLD 4072 Australia division of Science and Environmental Policy California State University Seaside CA 93955 USA Institute of Natural and Mathematical Sciences Massey University Auckland 0745 New Zealand Global Change Institute The University of Queensland QLD 4072 St Lucia Australia School of BioSciences The University of Melbourne VIC 3010 Australia

Population genomic approaches are making rapid inroads in the study of non-model organisms, including marine taxa. To date, these marine studies have predominantly focused on rudimentary metrics describing the spatial and environmental context of their study region （e.g., geographical distance, average sea surface temperature, average salinity）. We contend that a more nuanced and considered approach to quantifying seascape dynamics and patterns can strengthen population genomic investigations and help identify spatial, temporal, and environmental factors associated with differing selective regimes or demographic histories. Nevertheless, approaches for quantifying marine landscapes are complicated. Characteristic features of the marine environment, including pelagic living in flowing water （experienced by most marine taxa at some point in their life cycle）, require a well-designed spatial-temporal sampling strategy and analysis. Many genetic summary statistics used to describe populations may be inappropriate for marine species with large population sizes, large species ranges, stochastic recruitment, and asymmetrical gene flow. Finally, statistical approaches for testing associations between seascapes and population genomic patterns are still maturing with no single approach able to capture all relevant considerations. None of these issues are completely unique to marine systems and therefore similar issues and solutions will be shared for many organisms regardless of habitat. Here, we outline goals and spatial approaches for land- scape genomics with an emphasis on marine systems and review the growing empirical literature on seascape genomics. We review established tools and approaches and highlight promising new strategies to overcome select issues including a strategy to spatially optimize sampling. despite the many challenges, we argue that marine systems may be especially well suited for identifying candidate genomic regions under environmentally mediated sele

关键词： adaptation genetic-environment association landscape oceanography population genomics remote sensing seascape genetics.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting and utilizing primary tumors as live vaccines:changing strategies

引用

Cellular & Molecular Immunology 2012年第1期9卷 20-26页

作者： Xuanming Yang eric d Mortenson Yang-Xin Fu department of Pathology and Committee on Immunology University of ChicagoChicagoILUSA

Tumor metastases and relapse are the major causes of morbidity and mortality in *** surgery,chemotherapy and/or radiation therapy can typically control primary tumor growth,metastatic and relapsing tumors are often inaccessible or resistant to these *** adaptive immune response can be generated during these conventional treatments of the primary tumor,and presumably both the primary tumor and secondary metastases share many of the same or similar antigenic characteristics recognized by the immune ***,when established,this response should be able to control metastatic growth and tumor *** review summarizes the mechanisms by which antitumor immune responses are generated,and recent findings supporting the hypothesis that many therapies targeting primary tumors can generate antitumor adaptive immune responses to prevent metastases and tumor relapse.

关键词： chemotherapy immunotherapy metastasis radiotherapy tumor vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Collaboration Exercises——The Lack of Collaborative Benefits

引用

International Journal of disaster Risk Science 2014年第3期5卷 192-205页

作者： Johan M.Berlin eric d.Carlstrom department of Social and Behavioral Studies University West46186 TrollhattanSweden Sahlgrenska Academy Institute of Health and Care SciencesUniversity of Gothenburg40530 GothenburgSweden

The purpose of this article is to analyze what professional emergency personnel learn during collaboration exercises and the benefits of what they have ***(n = 19) and semistructured interviews(n = 32) were carried out in conjunction with major exercises held in Sweden(2007–2012). The results show that exercises tend to be based on their own logic, which differs from actual events. Exercise participants believe that they mainly learn single-track, parallel, and pathdependent behavior. The exercises do not facilitate the use of cross-boundary activities. This means that learning, as well as benefits from the exercises for actual events, is limited. The exercises would be more appropriate if those participating had the opportunity to identify weaknesses,try alternative ways, and engage in comprehensive organizational analyses at the conclusion of the *** on the results of the study, alternative models for collaboration exercises are suggested, with elements that would better develop collaboration and contribute to learning.

关键词： Ambulance Collaboration exercises Emergency personnel Police Rescue services Sweden

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tuning periodicity of polymer-decorated carbon nanotubes

引用

Science China Chemistry 2012年第5期55卷 802-807页

作者： LAIRd eric d. LI Christopher Y. A. J. drexel Nanotechnology Institute and department of Materials Science and Engineering Drexel University Philadelphia Pennsylvania 19104 USA

Carbon nanotube (CNT) is one of the most extensively investigated nanomaterials. Patterning soft matter such as liquid crystals and polymers on CNTs could potentially enable various applications for CNTs. We have demonstrated that controlled polymer crystallization using CNTs as the 1d nucleation sites can lead to periodically functionalized CNTs. Here we show that selected crystalline block copolymers can be periodically decorated along CNTs. This facile technique opens a gateway to periodic patterning on 1-d nanomaterials.

关键词： polymer crystallization carbon nanotube block copolymers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical computation of hurricane effects on historic coastal hydrology in Southern Florida

引用

Ecological Processes 2015年第1期4卷 37-56页

作者： eric d Swain dennis Krohn Catherine A Langtimm U.S.Geological Survey Caribbean-Florida Water Science Center7500 SW 36th StreetDavieFL 33314USA U.S.Geological Survey St.Petersburg Coastal and Marine Science Center600 Fourth Street SouthSt.PetersburgFL 33701USA U.S.Geological Survey Southeast Ecological Science Center7920 NW 71st StreetGainesvilleFL 32653USA

Introduction:Numerical models are critical for assessing the effects of sea level rise(SLR),hurricanes,and storm surge on vegetation change in the Everglades National *** model must be capable of representing short-timescale hydrodynamics,salinity transport,and groundwater ***,there is also a strong need to adapt these numerical models to hindcast past conditions in order to examine long-term effects on the distribution of vegetation that cannot be determined using only the modern ***:Based on parameters developed for a numerical model developed for the recent 1996 to 2004 period,a hindcast model was developed to represent sea level and water management for the period of 1926 to 1932,constrained by the limited hydrology and meteorology data available from the historic *** hurricanewind and storm surge representations,required for the hindcast model,are based on information synthesized from modern storm data.A series of simulation scenarios with various hurricane representations inserted into both hindcast and recent numerical models were used to assess the utility of the storm representation in the model and compare the two ***:The comparison of the hindcast and recent models showed differences in the hydrology patterns that are consistent with known differences in water delivery systems and sea level rise.A 30×lower-resolution spatially variable wind grid for the hindcast produced similar results to the original high-resolution full wind grid representation of the recent *** effects on hydrologic patterns demonstrated with the simulations show hydrologic processes that could have a long-term effect on vegetation ***:The hindcast simulation estimated hydrologic processes for the 1926 to 1932 *** shows promise as a simulator in long-term ecological studies to test hypotheses based on theoretical or empirical-based studies at larger landscape scales.

关键词： Hindcast Numerical models Hurricanes Wind fields Storm surge Sea level rise Coastal hydrology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural health monitoring of bridges in the State of Connecticut

引用

Earthquake Engineering and Engineering Vibration 2008年第4期7卷 427-437页

作者： Chengyin Liu Joshua Olund Alan Cardini Paul d＇Attilio eric Feldblum John deWolf SP-SELLS Inc. Briarcliff Manor NY 10510 USA department of Civil and Environmental Engineering University of Connecticut 261 Glenbrook Rd Unit 2037 Storrs CT06269 USA dMJM Harris Boston MA 02110 USA Connecticut department of Transportation 280 West Street Rocky Hill CT 06067 USA

A joint effort between the Connecticut department of Transportation and the University of Connecticut has been underway for more than 20 years to utilize various structural monitoring approaches to assess different bridges in Connecticut. This has been done to determine the performance of existing bridges, refine techniques needed to evaluate different bridge components, and develop approaches that can be used to provide a continuous status of a bridge＇s structural integrity. This paper briefly introduces the background of these studies, with emphasis on recent research and the development of structural health monitoring concepts. This paper presents the results from three different bridge types： a post-tensioned curved concrete box girder bridge, a curved steel box-girder bridge, and a steel multi-girder bridge. The structural health monitoring approaches to be discussed have been successfully tested using field data collected during multi-year monitoring periods, and are based on vibrations, rotations and strains. The goal has been to develop cost-effective strategies to provide critical information needed to manage the State of Connecticut＇s bridge infrastructure.

关键词： structural integrity structural health monitoring field data vibrations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hospitalization for variceal hemorrhage in an era with more prevalent cirrhosis

引用

World Journal of Gastroenterology 2014年第32期20卷 11326-11332页

作者： Nicholas Lim Michael J desarno Steven d Lidofsky eric Ganguly division of Gastroenterology and Hepatology University of Vermont College of Medicine Burlington VT 05401 United States department of Biostatistics University of Vermont College of Medicine Burlington VT 05401 United States

AIM: To examine hospitalization rates for variceal hemorrhage and relation to cause of cirrhosis during an era of increased cirrhosis prevalence.

关键词： Varices Gastrointestinal bleeding Cirrhosis Hospitalization Portal hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancement of energy efficiency for mechanical production of fine and ultra-fine particles in comminution

引用

China Particuology 2007年第3期5卷 193-201页

作者： Yanmin Wang eric Forssberg College of Material Science & Engineering South China University of Technology Guangzhou 510640 China department of Chemical Engineering & Geosciences Lulea University of Technology S-97187 Lulea Sweden

This paper presents the energy requirements for mechanical production of fine and ultra-fine particles in comminution. Recent approaches for effective size reduction and energy saving in comminution are described, viz., （a） development and application of new mills/classifiers, （b） adjustment of the bead characterization in stirred bead mills, （c） hybrid comminution systems with roller-press and media mill, （d） assisted methods, and （e） simulation.2007 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V.

关键词： Comminution Mill Classifier Grinding aids Microwave Ultrasound Simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mode-synthesizing atomic force microscopy for 3d reconstruction of embedded low-density dielectric nanostructures

引用

Nano Research 2015年第7期8卷 2199-2205页

作者： Pauline Vitry eric BouriUot Cedric Plassard Yvon Lacroute eric Calkins Laurene Tetard eric Lesniewska Avenue Alain Savary UMR CNRS 6303 Physics Department University of Bourgogne 210786 Cedex France Nanoscience Technology Center University of Central Florida Orlando FL 32826 USA department of Physics University of Central Florida Orlando FL 32826 USA

Challenges in nanoscale characterization call for non-invasive, yet sensitive subsurface characterization of low-density materials such as polymers. In this work, we present new evidence that mode-synthesizing atomic force microscopy can be used to detect minute changes in low-density materials, such as those engendered in electro-sensitive polymers during electron beam lithography, surpassing all common nanoscale mechanical techniques. Moreover, we propose 3d reconstruction of the exposed polymer regions using successive high-resolution frames acquired at incremental depths inside the sample. In addition, the results clearly show the influence of increasing dwell time on the depth profile of the nano-sized exposed regions. Hence, the simple approach described here can be used for achieving sensitive nanoscale tomography of soft materials with promising applications in material sciences and biology.

关键词： na_noscale subsurface imaging tomic force microscopy,3d reconstruction, nanoscale tomography acoustic microscopy dielectic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatocellular carcinoma locoregional therapies:Outcomes and future horizons

引用

World Journal of Gastroenterology 2021年第43期27卷 7462-7479页

作者： Mina S Makary Stuart Ramsell eric Miller Eliza W Beal Joshua d dowell department of Radiology The Ohio State University Wexner Medical CenterColumbusOH 43210United States department of Radiation Oncology The Ohio State University Wexner Medical CenterColumbusOH 43210United States department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States department of Radiology Northwest RadiologySt.Vincent HealthIndianapolisIN 46260United States

Hepatocellular carcinoma(HCC)is the most common primary cancer of the liver and has an overall five-year survival rate of less than twenty *** patients with unresectable disease,evolving liver-directed locoregional therapies provide efficacious treatment across the spectrum of disease stages and via a variety of catheter-directed and percutaneous *** of locoregional therapies in HCC may include curative intent in early-stage disease,bridging or downstaging to surgical resection or transplantation for early or intermediate-stage disease,and local disease control and palliation in advanced-stage *** review explores the outcomes of chemoembolization,bland embolization,radioembolization,and percutaneous ablative *** is also given to prognostic factors related to each of the respective techniques,as well as future directions of locoregional therapies for HCC.

关键词： Hepatocellular carcinoma Bland embolization Chemoembolization Radioembolization Transarterial embolization Thermal ablation Locoregional therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：