检索结果-南通市图书馆

作者： (美)里克·皮蒂诺(Rick Pitino) (美)埃里克·克劳福德(eric crawford)

暂无评论

CGH-based microarray detection of cryptic and novel copy number alterations and balanced translocations in cytogenetically abnormal cases of b-cell all

引用

Health 2013年第5期5卷 23-40页

作者： Roger A. Schultz Karen Tsuchiya Aubry Furrow Marilyn L. Slovak Lisa D. McDaniel Meaghan Wall eric crawford Yi Ning Reza Saleki Min Fang Victoria Cawich Caitlin E. Johnson Sara L. Minier Nicholas J. Neill S. Annie Morton Steve Byerly Urvashi Surti Theresa C. Brown Blake C. Ballif Lisa G. Shaffer Department of Molecular and Human Genetics Baylor College of Medicine Houston USA Empire Genomics Buffalo USA Fred Hutchinson Cancer Research Center Seattle USA Genetics Associates Inc. Nashville USA Johns Hopkins University School of Medicine Baltimore USA Magee-Womens Hospital University of Pittsburgh Medical Center Pittsburgh USA Pathology Associates Medical Laboratories (PAML) Spokane USA Paw Print Genetics Genetic Veterinary Sciences Inc. Spokane USA Seattle Children’s Hospital Seattle USA Signature Genomic Laboratories PerkinElmer Inc. Spokane USA Signature Genomic Laboratories PerkinElmer Inc. Spokane USA Sonora Quest Laboratories Tempe USA Victorian Cancer Cytogenetics Service St. Vincent’s Hospital Melbourne Fitzroy Australia

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, with the majority of cases being of precursor B-cell phenoltype. Conventional cytogenetic analysis plays an important role in the diagnosis of B-cell ALL, identifying characteristic chromosomal abnormalities associated with a given prognosis therein facilitating optimized treatment. The more recent introduction of microarray technology to the analysis of B-cell ALL has afforded both higher resolution for the detection of known abnormalities and an ability to identify novel copy number abnormalities (CNAs) with potential clinical relevance. In the current study, microarray analysis was performed on 20 cytogenetically abnormal B-cell ALL cases (10 pediatric and 10 adult), while a novel microarray-based balanced-translocation detection methodology (translocation CGH or tCGH) was applied to that subset of cases with a known or suspected recurrent balanced translocation. Standard microarray analysis identified that CNAs was not detected by previous conventional cytogenetics in 75% (15/20) cases. tCGH identified 9/9 (100%) balanced translocations defining BCR/ABL1 (x4), ETV6/RUNX1 (x3), and MLL/AFF1 (x2) breakpoints with high resolution. The results illustrate the improved molecular detail afforded by these technologies and a comparison of translocation breakpoints, CNAs and patient age offers new insights into tumor biology with potential prognostic significance.

关键词： Acute Lymphoblastic Leukemia B-Cell ALL Microarray Balanced Translocation Translocation CGH Hematologic Malignancies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An update to monocanalicular stent surgery

引用

International Journal of Ophthalmology(English edition) 2016年第5期9卷 797-798页

作者： Bruno eric Fayet William R Katowitz Emmanuel Racy Jean-Marc Ruban James A Katowitz Hotel de Ophthalmology Place Du Parvis Natre DameParis 75004France Department of Ophthalmology 34th and Civic Center Boulevard the Children's Hospital of PhiladelphiaPennsylvania 19104USA Clinique Saint-Jean-de-Dieu-ENT 19 Rue OudinotParis 75007France Edouard Herriot Hospital Place D'arsonval Lyon 69003France

Dear Sir,I n their article, ＂A comparison between monocanalicular and pushed monocanalicular silicone intubation in the treatment of congenital nasolacrimal duct obstruction＂, Andalib et al present the results of a prospective study on congenital nasolacrimal duct obstruction treated either with a Monoka stent （using a crawford hook for nasal retrieval） or a Masterka pushed technique for insertion of the Masterka stent. The success rates were respectively 90% and 50%.

关键词： An update to monocanalicular stent surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low-to middle-income countries

引用

Infectious Diseases of Poverty 2017年第1期6卷 1449-1461页

作者： Richard M.Gibson Gabrielle Nickel Michael crawford Fred Kyeyune Colin Venner Immaculate Nankya Eva Nabulime Emmanuel Ndashimye Art F.Y.Poon Robert A.Salata Cissy Kityo Peter Mugyenyi Miguel E.Quinones-Mateu eric J.Arts Department of Microbiology and Immunology University of Western Ontario1151 Richmond St.Dental Sciences Bldg.Rm 3014LondonOntario N6A 5C1Canada Division of Infectious Diseases Department of MedicineCase Western Reserve UniversityClevelandOHUSA Department of Molecular Biology and Microbiology Case Western Reserve UniversityClevelandOHUSA Department of Pathology Case Western Reserve UniversityClevelandOHUSA Center for AIDS Research Uganda Laboratories Joint Clinical Research CentreKampalaUganda Department of Pathology and Laboratory Medicine University of Western OntarioKampalaUganda TREAT Joint Clinical Research CentreKampalaUganda

Background:Thymidine analogs,namely AZT(Zidovudine or Retrovir^(TM))and d4T(Stavudine or Zerit^(TM))are antiretroviral drugs still employed in over 75%of first line combination antiretroviral therapy(cART)in Kampala,Uganda despite aversion to prescribing these drugs for cART in high income countries due in part to adverse *** this study,we explored how the continued use of these thymidine analogs in cART could impact emergence of drug resistance and impact on future treatment success in Uganda,a low-income ***:We examined the drug resistance genotypes by Sanger sequencing of 262 HIV-infected patients failing a first line combined antiretroviral treatment containing either AZT or d4T,which represents approximately 5%of the patients at the Joint Clinical Research Center receiving a AZT or d4T containing *** generation sequencing(DEEPGEN^(TM)HIV)and multiplex oligonucleotide ligation assays(AfriPOLA)were then performed on a subset of patient samples to detect low frequency drug resistant ***4 cell counts,viral RNA loads,and treatment changes were analyzed in a cohort of treatment success and ***:Over 80%of patients failing first line AZT/d4T-containing cART had predicted drug resistance to 3TC(Lamivudine)and non-nucleoside RT inhibitors(NNRTIs)in the treatment regimen but only 45%had resistance AZT/d4T associated resistance mutations(TAMs).TAMs were however detected at low frequency within the patients HIV quasispecies(1-20%)in 21 of 34 individuals who were failing first-line AZT-containing cART and lacked TAMs by *** to lack of TAMs by Sanger,AZT was typically maintained in second-line therapies and these patients had a low frequency of subsequent virologic ***:Our findings suggest that continued use of AZT and d4T in first-line treatment in low-to-middle income countries may lead to misdiagnosis of HIV-1 drug resistance and possibly enhance a succession of second-and third-line treatment failu

关键词： Antiretroviral treatment Drug resistance Uganda

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2019年全球、地区和国家5岁以下儿童呼吸道合胞病毒引发急性下呼吸道感染疾病负担研究的系统分析

引用

中国病毒病杂志 2023年第2期13卷 81-95页

作者： You Li Xin Wang Dianna M.Blau Mauricio T.Caballero Daniel R.Feikin Christopher J.Gill Shabir A.Madhi Saad B.Omer eric A.F Simoes Harry Campbell Ana Bermejo Pariente Darmaa Bardach Quique Bassat Jean-Sebastien Casalegno Giorgi Chakhunashvili Nigel crawford Daria Danilenko Lien Anh Ha Do Marcela Echavarria Angela Gentile Aubree Gordon Terho Heikkinen QSue Huang Sophie Jullien Anand Krishnan Eduardo Luis Lopez Josko Markic Ainara Mira-Iglesias Hannah CMoore Jocelyn Moyes Lawrence Mwananyanda DJames Nokes Faseeha Noordeen Evangeline Obodai Nandhini Palani Candice Romero Vahid Salimi Ashish Satav Euri Seo Zakhar Shchomak Rosalyn Singleton Kirill Stolyarov Sonia K Stoszek Anne von Gottberg Danielle Wurzel Lay-Myint Yoshida Chee Fu Yung Heather J Zar Harish Nair 张甜甜从兵兵邓舒予不详南京医科大学公共卫生学院江苏南京211166

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RS... 详细信息

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RSV相关社区死亡的更精确估计。本文旨在更新2019年全球、地区和国家层面60月龄以下儿童RSV相关急性下呼吸道感染的发病率和死亡率,重点关注总体死亡率和在研RSV免疫制剂针对的更窄的婴儿年龄组。方法检索获得MEDLINE、Embase、Global Health、CINAHL、Web of Science、LILACS、OpenGrey、中国知网、万方和维普数据库2017—2020年发表文献中的新数据,并纳入RSV GEN合作者提供的未发表数据,以扩展全球RSV疾病负担数据集。纳入的研究符合以下条件:报告了社区中或需要住院治疗的60月龄以下儿童RSV原发性急性下呼吸道感染的数据;报告了至少连续12个月的数据,但院内病死率或RSV季节性定义明确的地区除外;报告了RSV相关急性下呼吸道感染的发病率、住院率、院内病死率或急性下呼吸道感染住院的RSV阳性比例。如果病例定义不明或应用不一致、RSV感染未经实验室确认或仅基于血清学检测、报告的急性下呼吸道感染病例少于50例,则排除该研究。本研究应用广义线性混合效应模型(generalized linear mixed-effects model,GLMM)估计了2019年全球和地区(按国家发展状况和世界银行收入分类)RSV相关急性下呼吸道感染的发病率、住院率和院内病死率;通过基于危险因素的模型估计了国家层面RSV相关急性下呼吸道感染的发病率;通过GLMM开发了新模型,纳入最新的RSV社区死亡率数据,用于估计RSV的总体死亡率。本综述已在PROSPERO注册(CRD42021252400)。结果除了先前综述中纳入的317项研究外,还纳入了113项符合条件的新研究以及51项未发表的研究,共计481项研究。据估计,2019年全球60月龄以下儿童中,共发生3 300万(置信区间为2 540万~4 460万)次RSV相关急性下呼吸道感染,导致360万(290万~460万)例住院、26 300(15 100~49 100)例院内死亡以及101 400(84 500~125 200)例可归因于RSV的总死亡数。在0~6个月的婴儿中,共发生660万(460万~970万)次RSV相关急性下呼吸道感染,导致140万(100万~200万)例住院、13 300(6 800~28 100)例院内死亡以及45 700(38 400~55 900)例可归因于RSV的总死亡数。60月龄以下和28 d~6月龄儿童的死亡中分别有2.0%(置信区间为1.6%~2.4%)和3.6%(3.0%~4.4%)归因于RSV。在各年龄组中,95%以上的RSV相关急性下呼吸道感染事件和97%以上的可归因于RSV的死亡事件都发生在中低收入国家。结论 RSV显著增加了全球60月龄以下儿童的发病和死亡负担,尤其是在出生后前6个月和中低收入国家。本研究强调了全球RSV疾病的总体死亡率负担,60月龄以下儿童中,每50例死亡就有1例可归因于RSV;28 d至6个月大的婴儿中,每28例死亡就有1例可归因于RSV。每1例RSV相关急性下呼吸道感染院内死亡,对应社区中约3例可归因于RSV的死亡。对6月龄内婴儿提供保护的RSV被动免疫计划有望对减轻RSV疾病负担,但实施计划时,仍需要更多数据来了解RSV疾病负担高峰可能向大龄转移的影响。

关键词：呼吸道合胞病毒下呼吸道感染儿童疾病负担住院发病率死亡率病死率模型估计系统分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：