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Electro-and photochemical studies of gold (Ⅲ) bromide towards a novel laser-based method of gold patterning

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International Journal of Extreme Manufacturing 2022年第3期4卷 105-111页

作者： Cecily Rosenbaum Matthew Murphy Paul T Lawrence Curtis Sirkoch Stella Rose Schneeberg Kyle Zigner Sarah morris Ethan Richman Chibuzo Anyanwu eric Will Clare Wheeler eric Reed Christopher N LaFratta Department of Chemistry and Biochemistry Bard CollegeAnnandale-on-HudsonNYUnited States of America

In this report, we demonstrate a novel technique for the microscopic patterning of gold by combining the photoreduction of Au^(Ⅲ)Br_(2)^(-)to Au^(Ⅰ)Br_(2)^(-)and the electrochemical reduction of Au^(Ⅰ)Br_(2)^(-)to elemental gold in a single step within solution. While mask-based methods have been the norm for electroplating, the adoption of direct laser writing for flexible, real-time patterning has not been widespread. Through irradiation using a 405 nm laser and applying a voltage corresponding to a selective potential window specific to Au^(Ⅰ)Br_(2)^(-), we have shown that we can locally deposit elemental gold at the focal point of the laser. In addition to demonstrating the feasibility of the technique, we have collected data on the kinetics of the photoreduction reaction in ethanol and have deduced its rate law. We have confirmed the selective deposition of Au^(Ⅰ)Br_(2)^(-) within a potential window through controlled potential electrolysis experiments and through direct measurement on a quartz crystal microbalance. Finally, we have verified local deposition through scanning electron microscopy.

关键词： photolithography direct laser writing electrodeposition gold(Ⅲ)bromide photoreduction

Vitamin D, Testosterone, Epigenetics and Pain an Evolving Concept of Neurosignaling, Neuroplasticity and Homeostasis

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World Journal of Neuroscience 2018年第2期8卷 203-253页

作者： Joseph Thomas Pierre morris eric Seigel Wayne State University/Ascension Crittenton Detroit USA

The thought of exploring a possible relationship between the broad systems of steroid hormone physiology (specifically vitamin D and testosterone) and nocioception was prompted by an unexpectedly frequent personal clinical observation. Patients with chronic pain syndromes or chronic musculoskeletal pain often have low serum levels of vitamin D and testos-terone. Mining for relevant information in Pub Med, Medline and Cochrane Systems Review, three concepts repeatedly emerge that provide a common context for understanding the mechanics of these diverse sys-tems—epigenetic, homeostasis and neuroplasticity. Viewing homeostasis within the framework of epigenetics allows reasoned speculation as to how various human systems interact to maintain integrity and function, while simultaneously responding in a plastic manner to external stimuli. Cell signaling supports normal function by regulating synaptic activity, but can also effect plastic change in the central and peripheral nervous system. This is most commonly achieved by post-translational remodeling of chromatin. There is thus persistent epigenetic change in protein synthesis with all the related downstream effects but without disruption of normal DNA se-quencing. In itself, this may be considered an example of genomic homeo-stasis. Epigenetic mechanisms in nociception and analgesia are active in the paleospinothalamic and neospinothalamic tracts at all levels. Physiologic response to a nociceptive insult, whether mechanical, inflammatory or ischemic, is provided by cell signaling that is significantly enhanced through epigenetic mechanisms at work in nociceptors, Gamma-Aminobutyric Acid (GABA) and glutamate receptors, voltage gated receptors, higher order neurons in the various dorsal horn laminae and proximal nociceptive pro-cessing centers in the brainstem and cortex. The mediators of these direct or epigenetic effects are various ligands also active in signaling, such as free radicals, substance P, a variety of cy

关键词： Gamma-Aminobutyric Acid (GABA) Jumonji (Jmjd3) Homer Gene Cholecalciferol Calcitriol Neurosteroids Glutamate 5-HT

Incidence and risk of herpes zoster in patients with ulcerative colitis and Crohn’s disease in the USA

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Gastroenterology Report 2023年第1期11卷 271-281页

作者： David Singer Philippe Thompson-Leduc Deepshekhar Gupta Wendy Y.Cheng Sara Poston Siyu Ma John E.Pawlowski Mei Sheng Duh eric D.morris Francesca Devine Francis A.Farraye US Health Outcomes and Epidemiology—Vaccines GSKPhiladelphiaPAUSA Health Economics and Outcomes Research Analysis GroupInc.MontrealQuebecCanada Health Economics and Outcomes Research Analysis GroupInc.Menlo ParkCAUSA Health Economics and Outcomes Research Analysis GroupInc.BostonMAUSA Tufts Medical Center BostonMAUSA Medical Affairs GSKPhiladelphiaPAUSA Health Economics and Outcomes Research Analysis GroupInc.New YorkNYUSA Division of Gastroenterology and Hepatology Mayo ClinicJacksonvilleFLUSA

Background:Patients with inflammatory bowel disease(IBD)are at increased risk of herpes zoster(HZ).We evaluated the incidence of HZ in ulcerative colitis(UC)and Crohn’s disease(CD)patients and compared this with HZ incidence in a non-IBD ***:We conducted a retrospective cohort study(GSK study identifier:VEO-000043)of adults aged18 years with UC and CD and without IBD who were identified from claims recorded in a US healthcare database between October 2015 and February *** HZ incidence rates/1,000 person-years(PY)were calculated,and comparisons of HZ incidence rates between UC or CD and non-IBD cohorts were made using adjusted generalized linear ***:The study population comprised a total of 29,928 UC,25,959 CD,and 11,839,329 non-IBD *** overall HZ incidence rates were 13.64/1,000 PY(UC),15.94/1,000 PY(CD),and 7.95/1,000 PY(non-IBD).UC and CD patients had increased HZ incidence rates,with adjusted incidence rate ratios of 1.35(95%confidence interval[CI],1.26–1.44)and 1.66(95%CI,1.56–1.77),respectively,compared with non-IBD *** analysis indicated increased relative rates of HZ in progressively younger age strata in the UC and CD patients compared with non-IBD *** incidence rates were higher in UC and CD patients who had previously received thiopurines or methotrexate,TNF-inhibitors,or corticosteroids than in UC and CD patients who did not take those ***:UC and CD patients had increased HZ incidence rates compared with patients without IBD,demonstrating the importance of HZ prevention in IBD patients.

关键词： ulcerative colitis Crohn’s disease herpes zoster

Genetic Linkage Map and Comparative Genome Analysis for the Atlantic Killifish (Fundulus heteroclitus)

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Open Journal of Genetics 2016年第1期6卷 28-38页

作者： eric R. Waits John Martinson Brian Rinner Stephen morris Dina Proestou Denise Champlin Diane Nacci Office of Research and Development US Environmental Protection Agency Cincinnati USA Agricultural Research Service US Department of Agriculture Kingston USA Office of Research and Development US Environmental Protection Agency Narragansett USA

Genetic linkage maps are valuable tools in evolutionary biology;however, their availability for wild populations is extremely limited. Fundulus heteroclitus (Atlantic killifish) is a non-migratory estuarine fish that exhibits high allelic and phenotypic diversity partitioned among subpopulations that reside in disparate environmental conditions. An ideal candidate model organism for studying gene-environment interactions, the molecular toolbox for F. heteroclitus is limited. We identified hundreds of novel microsatellites which, when combined with existing microsatellites and single nucleotide polymorphisms (SNPs), were used to construct the first genetic linkage map for this species. By integrating independent linkage maps from three genetic crosses, we developed a consensus map containing 24 linkage groups, consistent with the number of chromosomes reported for this species. These linkage groups span 2300 centimorgans (cM) of recombinant genomic space, intermediate in size relative to the current linkage maps for the teleosts, medaka and zebrafish. Comparisons between fish genomes support a high degree of synteny between the consensus F. heteroclitus linkage map and the medaka and (to a lesser extent) zebrafish physical genome assemblies.

关键词： Fundulus heteroclitus Genetic Linkage Map Synteny Analysis Microsatellite Single Nucleotide Polymorphism (SNP)

William morris Davis: Father of Geomorphology or Father of Geology’s Unrecognized Paradigm Problem

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Open Journal of Geology 2023年第6期13卷 579-597页

作者： eric Clausen Independent Investigator Jenkintown Pennsylvania USA

An often unrecognized problem is the geology and glacial history paradigm’s inability to explain topographic map drainage system and erosional landform evidence, which means geology research studies rarely address that type of topographic map evidence. The problem originated in the late 19th century with William morris Davis who is sometimes called the father of geomorphology and was one of the first geologists to interpret what in the late 19th century were newly available topographic maps. An 1889 Davis paper describes selected drainage system evidence observed on an advance copy of the 1890 Doylestown (Pennsylvania) topographic map and an 1892 Ward paper written after discussions with Davis describes additional selected drainage system evidence seen on the same map. Both papers fail to mention the majority of the Doylestown map’s drainage system features including most barbed tributaries, asymmetric drainage divides, and through (dry) valleys crossing major drainage divides. Had Davis used all of the map’s drainage system and erosional landform evidence he should have recognized the map evidence shows headward erosion of an east-oriented Neshaminy Creek valley captured southwest-oriented streams which headward erosion of the south-oriented Delaware River valley and its east-oriented tributary Tohickon Creek valley had beheaded. Consciously or unconsciously, Davis chose not to alert future investigators that Doylestown topographic map evidence did not support his yet-to-be-published Pennsylvania and New Jersey erosion history interpretations and instead Davis proceeded to develop and promote erosion history interpretations which the map evidence did not support.

关键词： Doylestown Topographic Map Drainage Systems Geology Paradigm History of Geology Robert DeCourcy Ward Topographic Map Interpretation

Structural and functional analysis of two new positive allosteric modulators of GluR2 desensitization and deactivation

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Structural and functional analysis of two new positive allos...

The 4th ISGO International Conference on Structural Genomics

作者： Autumn M.Weeks David E.Timm morris J.Benveniste eric S.Nisenbaum Kathryn M.Partin Colorado State University Fort Collins CO80523U.S.A. Lilly Research Labs Lilly Corporate Center IndianapolisIN46285USA Colorado State University Fort Collins CO80523U.S.A. Lilly Research Labs Lilly Corporate Center Indianapolis IN46285 USA Colorado State University Fort Collins CO 80523 U.S.A.

＜正＞Recent crystallographic and functional analyses of AMPA receptors have identified a common binding pocket for two classes of positive allosteric AMPA receptor modulators. From those studies, a working model of channel desensitization and deactivation has been established. Here we present structural and functional data on two new positive allosteric modulators of AMPA receptors. These compounds

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论燕海扇和异海扇(英文)

古生物学报 1999年第2期38卷 17-24页

作者：方宗杰,ＮｏｅｌＪ．Ｍｏrｒｉｓ中国科学院南京地质古生物研究所英国自然历史博物馆古生物部

燕海扇（Ａｖｉｃｕｌｏｐｅｃｔｅｎ）由ＭｃＣｏｙ（１８５１）创立，是燕海扇科和燕海扇超科的模式属，故地位十分重要。它是石炭二叠纪海扇类中最为常见的属名之一。由于它的模式种Ａｖｉｃｕｌｏｐｅｃｔｅｎｐｌａｎｏｒａｄｉ... 详细信息

燕海扇（Ａｖｉｃｕｌｏｐｅｃｔｅｎ）由ＭｃＣｏｙ（１８５１）创立，是燕海扇科和燕海扇超科的模式属，故地位十分重要。它是石炭二叠纪海扇类中最为常见的属名之一。由于它的模式种ＡｖｉｃｕｌｏｐｅｃｔｅｎｐｌａｎｏｒａｄｉａｔｕｓＭｃＣｏｙ只有左壳，而右壳和铰部构造的特征不明，在实际应用中，其含义被不适当地扩大，从而导致在燕海扇类研究中的混乱。１９８６年，笔者在大英博物馆发现４块燕海扇模式种Ａｖｉｃｕｌｏｐｅｃｔｅｎｐｌａｎｏｒａｄｉａｔｕｓ的右壳标本，其中包括一块双壳铰合在一起的标本，另有２块标本显示了铰合构造。这些标本的发现为系统修订燕海扇属的属征创造了条件。最近，Ｎｅｗｅｌ和Ｂｏｙｄ（１９９５）根据Ｐｅｃｔｅｎｆｌｅｘｕｏｓｕｓ（ＭｃＣｏｙ，１８４４，ｐ．９３，ｐｌ．１８，ｆｉｇ．１）和ＡｖｉｃｕｌｏｐｅｃｔｅｎａｍｅｒｉｃａｎｕｓＮｅｗｅｌｅｔＢｏｙｄ（１９９５，ｐ．６０，Ｆｉｇ．４４）的特征，推测燕海扇属的特征为两壳相等或几乎相等，这一推测显然与燕海扇模式种的特征不符，因此，他们对燕海扇和燕海扇科所作的定义不能成立。我们认为，对任何属征的修订都应基于对模式标本进行充分研究的基础之上，应避免建立在假设基

关键词：石炭-二叠纪海扇类,燕海扇,异海扇

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驻点流中的颗粒动力学

驻点流中的颗粒动力学

马来西亚航空公司MH370次航班：客机坠海分析

第十一届全国流体力学学术会议

作者：李青 Micheline Abbas Jeffrey morris eric Climent Jacques Magnaudet 中国空气动力研究与发展中心法国图卢兹大学化学工程系美国纽约城市大学城市学院

携带颗粒的驻点流在工业和航空航天中有着广泛应用。驻点流是全场非均匀减速流,压力在驻点最大,边界层厚度是常数。局部雷诺数随着远离驻点的距离增大,不像常规的槽道流,平板等标准模型,有一个固定的特征雷诺数。被携带相的颗粒由于具... 详细信息

携带颗粒的驻点流在工业和航空航天中有着广泛应用。驻点流是全场非均匀减速流,压力在驻点最大,边界层厚度是常数。局部雷诺数随着远离驻点的距离增大,不像常规的槽道流,平板等标准模型,有一个固定的特征雷诺数。被携带相的颗粒由于具体问题不同,密度比,特征惯性参数斯托克斯数可以相差好几个量级。弥散颗粒相与流体相互作用的动力学机理是建立欧拉两相流预测模型的关键。问题的复杂性驱动我们用颗粒解析的直接数值模拟,关注一个最基本的问题:一个和一对中性颗粒在驻点流的对称轴上的动力学过程是什么?选取中性颗粒模型的好处在于,颗粒惯性完全由颗粒的有限大小提供。我们可以关注颗粒有限大小带来的惯性效应,与密度比带来的惯性效应分开。我们发现:远离驻点流壁面,上举的无粘压力主导颗粒动力学,惯性颗粒就像示踪粒子一样,变得没有了惯性;靠近壁面,颗粒惯性效应导致了颗粒动力学两种截然不同的现象,我们也找到了相关的归一化关系。当颗粒静止在驻点的时候,无论颗粒有限大小,都会受到一个向下挤压的,40左右的无量纲力;一些列Moffatteddies在颗粒与驻点壁面处形成,相关特征与理论预测吻合。上举的无粘压力还会使得低位颗粒在高位颗粒的庇护下不接触壁面反弹,这是高位颗粒替低位颗粒抵挡了驻点流的向下挤压作用,使得上举无粘压力可以托起低位颗粒。此外,我们开发了能自适应颗粒惯性和物理材料属性的颗粒碰撞模型,与湿润碰撞的经典实验结果吻合很好。总结,驻点流中的有限大小中性惯性颗粒动力学完全由惯性主导。

关键词：粘性润滑力无粘压力惯性颗粒近壁动力学惯性自适应的碰撞模型驻点流向下挤压作用

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数学译林 2016年第1期35卷 1-16页

作者： Goong Chen Cong Gu Philip J. morris eric G. Paterson Alexey Sergeev Yi-Ching Wang Tomasz Wierzbicki 叶其孝吴庆宝

2014年3月8日马来西亚航空公司从吉隆坡至北京的MH370航班起飞后一个小时就失联了．波音777—200ER飞机共有12名机组人员和227名乘客．3月24日，马来西亚总理宣布，“因此，怀着深深的悲哀和遗憾，我必须告诉你们…MH370航班的飞行在南... 详细信息

2014年3月8日马来西亚航空公司从吉隆坡至北京的MH370航班起飞后一个小时就失联了．波音777—200ER飞机共有12名机组人员和227名乘客．3月24日，马来西亚总理宣布，“因此，怀着深深的悲哀和遗憾，我必须告诉你们…MH370航班的飞行在南印度洋终结了．”虽然MH370航班的确切下落仍然不明，但是现有的证据表明，飞机坠入了海洋．然而，令人不安的是因为并非被称为“迫降海上”的所有的应急水上降落，当他们得到控制时都会以悲剧告终．在2009年1月15日“哈德森河上的迫降奇迹”中，机长ChelseyB．“Sully”Sullenberger。）及其机组人员把从拉瓜迪亚机场起飞，由于飞鸟击中飞机而导致断电后的美国航空公司1549航班的飞机——空客A320—200——成功地迫降在哈得逊河上．没有造成人员伤亡．

关键词：航空公司马来西亚航班客机机组人员波音777 南印度洋人员伤亡