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Influence of mixed organosilane coatings with variable rGD surface densities on the adhesion and proliferation of human osteosarcoma Saos-2 cells to magnesium alloy AZ31

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Bioactive Materials 2017年第1期2卷 35-43页

作者： Xiaoxi Yang Afrah Al Hegy eric r.gauthier Joy Gray-Munro Dept.of Chemistry and Biochemistry Laurentian UniversitySudburyOntarioP3E 2C6Canada

In the last decade,the use of magnesium and its alloys as biodegradable implant materials has become increasingly ***,surface modification of these materials to control the degradation rate in the early stages of healing and improve their biocompatibility is crucial to the successful implementation of magnesium alloy implants in *** adhesion and proliferation at the implant surface is a vital factor for successful integration of a biomaterial within the *** accomplish this task by binding to ligands such as the arginine-glycine-aspartic acid peptide sequence(rGD)commonly found on adhesive proteins present in the extracellular *** this paper,we report a biomimetic surface modification strategy involving deposition of a mixed organosilane layer on Mg AZ31 followed by covalent immobilization of rGD peptides through a heterobifunctional cross-linker *** results indicate that with optimized deposition conditions uniform organosilane coatings were successfully deposited on the Mg AZ31 ***,we have demonstrated that the surface density of immobilized rGD can be varied by depositing organosilane layers from solutions containing two different organosilanes in specified *** in cell adhesion and cell proliferation were observed on the surface modified substrates.

关键词： Magnesium alloys Biodegradable Biomimetic rGD peptide Surface modification Cell adhesion Organosilane

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Investigation of a cyanine dye assay for the evaluation of the biocompatibility of magnesium alloys by direct and indirect methods

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Bioactive Materials 2020年第1期5卷 26-33页

作者： Afrah Al Hegy ryan Smith eric r.gauthier Joy E.Gray-Munro Dept.of Chemistry and Biochemistry Laurentian UniversitySudburyOntarioP3E 2C6Canada

Magnesium and its alloys are promising candidates for a new generation of biodegradable metals in orthopaedic applications due to their excellent biocompatibility,biodegradability,and mechanical properties that are similar to natural ***,direct in vitro assessment of these materials in the presence of cells is complicated by degradation products from the alloy that lead to a false positive for the most commonly used cell adhesion and cell proliferation *** this paper,a cyanine dye was used to quantitatively evaluate the in vitro biocompatibility of a Mg AZ31 alloy by both direct and indirect *** cytotoxicity of the corrosion products was evaluated via an indirect method;a 25%decrease in cell viability compared to control samples was ***,direct assessment of cell adhesion and proliferation showed a statistically significant increase in cell number at the surface after 72 *** addition,the degradation rate and surface characteristics of the Mg AZ31 alloy were evaluated for both direct and indirect *** degradation rate was unaffected by the presence of cells while evidence of an increase in calcium phosphate deposition on the magnesium alloy surface in the presence of cells was *** study demonstrates that a cyanine dye based assay provides a more accurate assessment of the overall in vitro biocompatibility of biodegradable metals than the more commonly used assays reported in the literature to date.

关键词： Magnesium alloys Biocompatibility Direct method Indirect method Cyanine dye Cell adhesion Cell proliferation Cytotoxicity

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Le Fresnoy国立当代艺术工作室

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城市环境设计 2016年第1期 78-85页

作者： Bernard Tschumi Francois Gillet Mark Haukos Tom Kowalski robert Young Jim Sullivan Yannis Aesopos Douglas gauthier eric Liftin robert Moric Sheri Olsen Jordan Parnass Tsuto Sakamoto Henning Ehrhardt Jean-Francois Erhel Véronique Descharrèires Vincent Tehvenon Paul H.Huchard Louis Choulet

法国Le Fresnoy国立当代艺术工作室的竞赛目标是创造一个能为电影、录像和电子传媒等艺术提供展出、表演和制作场地的跨领域设施。将不同门类的艺术置于同一个项目中是教学层面的一次大胆尝试,目的是在不同领域的交叉地带催生实验与创... 详细信息

法国Le Fresnoy国立当代艺术工作室的竞赛目标是创造一个能为电影、录像和电子传媒等艺术提供展出、表演和制作场地的跨领域设施。将不同门类的艺术置于同一个项目中是教学层面的一次大胆尝试,目的是在不同领域的交叉地带催生实验与创新。该项目位于法国北部的老工业城市图尔昆,基地选在市内一处建于20世纪20年代的废弃建筑,这里曾集

关键词：当代艺术工作室 Le Fresnoy

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