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Frontiers of Structural and Civil Engineering 2019年第1期13卷 190-200页

作者： eric N.LANDIS Roman KRAVCHUK Dmitry LOSHKOV Department of Civil &Environmental Engineering University of MaineOronoME 04469USA

Split-cylinder fracture of fiber-reinforced ultra-high-performance concrete (UHPC)was examined using two complementary techniques:X-ray computed tomography (CT)and acoustic emission (AE).Fifty-mm-diameter specimens of two different fiber types were scanned both before and after load *** the CT images,fiber orientation was evaluated to establish optimum and pessimum specimen orientations,at which fibers would have maximum and minimum effect,*** expected,fiber orientation affected both the peak load and the toughness of the specimen,with the optimum toughness being between 20% and 30%higher than the *** AE energy was also affected *** CT scans of the specimens were used to measure internal damage. Damage was quantified in terms of internal energy dissipation due to both matrix cracking and fiber pullout by using calibration measurements for *** results showed that fiber pullout was the dominant energy dissipation mechanism;however,the sum of the internal energy dissipation measured amounted to only 60% of the total energy dissipated by the specimens as measured by the net work of *** is postulated that localized compaction of the UHPC matrix as well as internal friction between fractured fragments makes up the balance of internal energy dissipation.

关键词： ultra-high-performance concrete concrete fracture X-ray computed tomography acoustic emission

Inhibitory effects of nisin-coated multi-walled carbon nanotube sheet on biofilm formation from Bacillus anthracis spores

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Journal of Environmental Sciences 2014年第12期26卷 2526-2534页

作者： Xiuli Dong eric McCoy Mei Zhang Liju Yang Department of Pharmaceutical Sciences Biomanufacturing Research Institute and Technology Enterprise (BRITE) North Carolina Central UniversityDurham NC USA Department of Industrial & Manufacturing Engineering Florida State University Tallahassee FL USA

Multi-walled carbon nanotube（MWCNT） sheet was fabricated from a drawable MWCNT forest and then deposited on poly（methyl methacrylate） film. The film was further coated with a natural antimicrobial peptide nisin. We studied the effects of nisin coating on the attachment of Bacillus anthracis spores, the germination of attached spores, and the subsequent biofilm formation from attached spores. It was found that the strong adsorptivity and the super hydrophobicity of MWCNTs provided an ideal platform for nisin coating. Nisin coating on MWCNT sheets decreased surface hydrophobicity, reduced spore attachment, and reduced the germination of attached spores by 3.5 fold, and further inhibited the subsequent biofilm formation by 94.6% compared to that on uncoated MWCNT sheet. Nisin also changed the morphology of vegetative cells in the formed *** results of this study demonstrated that the anti-adhesion and antimicrobial effect of nisin in combination with the physical properties of carbon nanotubes had the potential in producing effective anti-biofilm formation surfaces.

关键词： Multi-walled carbon nanotubes (MWCNTs) Biofilm Bacillus anthracis Nisin

Optimization Potentials for the Waste Heat Recovery of a Gas-Steam Combined Cycle Power Plant Based on Absorption Heat Pump

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Journal of Thermal Science 2019年第2期28卷 283-293页

作者： ZHANG Hongsheng ZHAO Hongbin LI Zhenlin HU eric College of Machinery and Transportation Engineering China University of Petroleum School of Mechanical Engineering the University of Adelaide Beijing Key Laboratory of Process Fluid Filtration and Separation

A new waste heat recovery system is presented to recover exhausted steam waste heat from the steam turbine by absorption heat pump(AHP) in a gas-steam combined cycle(GSCC) power plant. The system can decrease energy consumption and further improve the energy utilization. The performance evaluation criteria are calculated, and exergy analysis for key components are implemented in terms of the energy and exergy analysis theory. Besides, the change of these criteria is also revealed before and after modification. The net power output approximately increases by 21738 kW, and equivalent coal consumption decreases by 5.58 g/kWh. A 1.81% and 1.92% increase in the thermal and exergy efficiency is respectively obtained in the new integrated system as the heating load is 401095 kJ at 100% condition. Meanwhile, the appropriate extraction parameters for heating have been also analyzed in the two systems. The proposed scheme can not only save energy consumption but also reduce emission and gain great economic benefit, which is proven to be a huge potential for practical application.

关键词： combined cycle power plant absorption heat pump waste heat recovery evaluation criteria exergy analysis

Cross-regulation between CDK and MAPK control cellular fate

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Quantitative Biology 2021年第3期9卷 341-359页

作者： eric Durandau Serge Peiet Department of Fundamental Microbiology University of LausanneCH-1015 LausanneSwitzerland

Background:Commitment to a new cell cycle is controlled by a number of cellular ***-activated protein kinase(MAPK)pathways,which transduce multiple extracellular cues,have been shown to be interconnected with the cell cycle and can modulate its ***:In budding yeast,we have introduced fluorescent biosensors that monitor in real time the signaling activity of the MAPKs Fus3 and Kssl and the cyclin-dependent kinase(CDK)in individual *** have quantified in hundreds of live single cells the interplay between the MAPKs regulating the mating response and the CDK controlling cell cycle ***:Different patterns of MAPK activity dynamics could be identified by clustering cells based on their CDK activity,denoting the tight relationship between these two cellular *** data suggest that beyond the already well-established mechanisms of regulation between the MAPK and the CDK,additional mechanisms remain to be ***:A tight interplay between MAPK pathways and the cell cycle is essential to control cellular proliferation and cell fate decisions.

关键词： MAPK signaling cell cycle yeast mating single cell analysis fluorescent biosensors

Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders

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Neuroscience Bulletin 2020年第11期36卷 1327-1343页

作者： Alexia Duveau Eleonore Bertin eric Boue-Grabot Universite de Bordeaux Institut des Maladies NeurodegenerativesUMR 529333000 BordeauxFrance CNRS Institut des Maladies NeurodegenerativesUMR 529333000 BordeauxFrance

The P2X4 receptor(P2X4)is an ATP-gated cation channel that is highly permeable to Ca2+and widely expressed in neuronal and glial cell types throughout the central nervous system(CNS).A growing body of evidence indicates that P2X4 plays key roles in numerous central disorders.P2X4 trafficking is highly regulated and consequently in normal situations,P2X4 is present on the plasma membrane at low density and found mostly within intracellular endosomal/lysosomal *** increase in the de novo expression and/or surface density of P2X4 has been observed in microglia and/or neurons during pathological *** review aims to summarize knowledge on P2X4 functions in CNS disorders and provide some insights into the relative contributions of neuronal and glial P2X4 in pathological ***,determination of the cell-specific functions of P2X4 along with its intracellular and cell surface roles remain to be elucidated before its potential as a therapeutic target in multiple disorders can be defined.

关键词： Purinergic signaling P2X ATP Ligandgated ion channels Chronic pain Brain trauma Ischemia Neurodegenerative diseases Alcohol Neuropsychiatric disorders

Precision medicine in inflammatory bowel disease:Individualizing the use of biologics and small molecule therapies

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World Journal of Gastroenterology 2023年第10期29卷 1539-1550页

作者： eric Cheah James Guoxian Huang Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital MelbourneParkvilleVIC 3052Australia Department of Paediatrics Khoo Teck Puat-National University Children's Medical InstituteNational University Health SystemSingapore 119228Singapore Department of Paediatrics Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

The advent of biologics and small molecules in inflammatory bowel disease(IBD)has marked a significant turning point in the prognosis of IBD,decreasing the rates of corticosteroid dependence,hospitalizations and improving overall quality of *** introduction of biosimilars has also increased affordability and enhanced access to these otherwise costly targeted *** do not yet represent a complete panacea:A subset of patients do not respond to first-line anti-tumor necrosis factor(TNF)-alpha agents or may subsequently demonstrate a secondary loss of *** who fail to respond to anti-TNF agents typically have a poorer response rate to second-line *** is uncertain which patient would benefit from a different sequencing of biologics or even a combination of biologic *** introduction of newer classes of biologics and small molecules may provide alternative therapeutic targets for patients with refractory *** review examines the therapeutic ceiling in current treatment strategies of IBD and the potential paradigm shifts in the future.

关键词： Precision medicine Therapeutic ceiling Inflammatory bowel disease Biologics Small molecules

Patent foramen ovale and cryptogenic stroke:diagnosis and updates in secondary stroke prevention

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Stroke & Vascular Neurology 2018年第2期3卷 84-91页

作者： Kristy Yuan Scott eric Kasner Department of Neurology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

The patent foramen ovale(PFO),given its high prevalence in the general population and especially in patients with cryptogenic stroke,has long generated investigation and debate on its propensity for stroke by paradoxical embolism and its management for stroke *** pendulum has swung for percutaneous PFO closure for secondary stroke prevention in cryptogenic *** on a review of current evidence,the benefit from PFO closure relies on careful patient selection:those under the age of 60 years with few to no vascular risk factors and embolic-appearing stroke deemed cryptogenic after thorough *** these data look towards influencing guideline statements and device approvals in the future,patient selection remains the crucial ingredient for clinical decision making and future trials.

关键词： prevention diagnosis closure

Migrants Spilling over Borders:The Long View

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Fudan Journal of the Humanities and Social Sciences 2019年第1期12卷 27-44页

作者： eric Richards Flinders University AdelaideAustralia

Today one of the most polarising problems across the developed world,the first world,is the movement of apparently uncontrollable millions of people over *** fears that these torrents of people induce are profound and now invade virtually all political agendas in Europe,America and *** movement of relatively poor people towards the affluent countries is a universal phenomenon,the source of anxiety and radical policies to stop up the *** migration is not new一the long history of Europe is one of the waves of invading populations,partly colonising,partly conquering,partly displacing― ver many *** was mainly intra-continental migration though some of it echoed later *** the early nineteenth century,there was a vital change in scale,reach and velocity of this migratory *** migration out of Western Europe rose rapidly after 1820 and became mass international *** was a prototype of modem mass migration,and it originated in the British Isles,the source and dynamic of the socalled *** process then appeared to replicate across Europe in the following 80 *** was also the model for the same process across the world during the next century and its present day *** paper explores some of the origins of mass international migration and its repercussions.

关键词： International Migration History Origins Mechanisms Repercussions

The Historic Urban Landscape and the Metropolis

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Built Heritage 2018年第4期2卷 20-30页

作者： eric Huybrechts Institut d'aménagement et d'urbanisme d'Ile-de-France(IAU-IdF) ParisFrance

The Historic Urban Landscape(HUL)recommendation adopted by UNESCO in 2011 provides a holistic approach based on landscape planning *** is in line with the International Guidelines for Urban and Territorial Planning adopted by UN-Habitat in 2015(UN-Habitat 2015).HUL concerns the integration of culture in territorial planning processes and the historical urban centre inside their urban or city *** cities are becoming the dominant pattern of the human settlements *** are the main engine of economic development,attracting people for jobs,creating the highest values and are the main support for the globalisation *** 21^(st) century is the era of the metropolis,with a large increase of cities of more than 500,000 *** heritage of the 21^(st) century will be building through the *** can consider the metropolis as an artefact of the *** produces large urban-rural systems supported by large infrastructures,iconic buildings and specific *** upgrading of the main characteristics of the metropolis adds value in cities for the quality of life,creating new heritage at a scale greater than the existing world heritage *** could be extended as a relevant approach to be applied on the metropolitan scale.

关键词： Historic Urban Landscape metropolis heritage territorial planning

SERVICE CREDIT UNION HEADQUARTERS CASE STUDY

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Journal of Green Building 2014年第1期9卷 23-39页

作者： eric Svahn AIA LEED AP BD+C

Creating a new headquarters is a unique opportunity to celebrate mission,optimize operations,and invest in the future of an *** article describes the process of conceptualizing,designing,and constructing a new world headquarters for Service Credit Union in Portsmouth,NH,that achieved LEED Gold *** the headquarters to a not-for-profit institution,the project needed to embody Service Credit Union’s core mission of service to its *** the beginning,sustainable design was embraced as a methodology to increase employee retention and productivity,lead to more self-sufficient operations,and ultimately provide value and benefit to all its *** new world headquarters for Service Credit Union takes advantage of smart design strategies,green materials and technologies,while planning for the *** creates an iconic corporate image for the forward-thinking credit union with quality and integrity as standout characteristics of the building design.

关键词： smart design strategies for a new corporate headquarters healthy and productive workspaces site rehabilitation LEED-ND renewable energy sources