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Image Quality Assessment Using NEMA Standards for Lu-177 Radionuclide

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2022年第3期11卷 125-134页

作者： Olivia Adu-Poku Bright Kwakye-Awuah eric kotei addison Stephen Inkoom Department of Physics Kwame Nkrumah University of Science and Technology Kumasi Ghana Komfo Anokye Teaching Hospital Oncology Directorate Department of Medical Physics Kumasi Ghana Department of Medical Physics Graduate School of Nuclear and Allied Sciences University of Ghana Accra Ghana Radiation Protection Institute Ghana Atomic Energy Commission Accra Ghana

A lutetium 177 (177Lu) radiopharmaceutical has been used as a theragnostic agent in molecular radiotherapies. This study aimed to produce images simulating those obtained in a total body imaging study with hot lesions to assess and investigate the image quality of the Hawkeye SPECT/CT images from Lu-177. The NEMA image quality phantom (PTW) with spheres (inner diameters of 10, 13, 17, 22, 28 and 37 mm) and lung insert was used. The measured volume in the background of the current phantom setting was 9482 mL. The five smaller spheres were filled with an activity concentration of 0.461 MBq/mL and the biggest sphere was filled with water. The phantom was placed on the couch and scanned at four hot sphere-to-background concentrations, which are no background, 16:1, 8:1 and 4:1. The images obtained from the scans were imported onto the OXIRIS image analysis tool. Regions of interest (ROIs) were drawn on each sphere of the reconstructed SPECT image. Image contrast and background variability ratios for hot spheres were used as measures of image quality. In addition, the accuracy of corrections were determined from the uniform background and cold lung insert regions. The 37 mm cold sphere had the highest percent contrast, whiles the 10 mm hot sphere had the least for the various hot sphere to background ratios. The background variability for each hot sphere was also determined. The average lung residual error was calculated to be 23.13% for the 16:1 and 22.57% for both the 8:1 and 4:1 hot sphere to background ratio. The results show that the scanner has very good overall performance.

关键词： Lutetium-177 Activity Concentration Dose Calibrator SPECT/CT

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Dosimetric Effects of Thermoplastic Immobilizing Devices on Surface Dose

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2022年第1期11卷 12-21页

作者： Olivia Adu-Poku eric kotei addison Cyril Schandorf Francis Hasford Stephen Inkoom Joseph Adom Akosah Kingsley Eunice Arthur Linus Owusu-Agyapong Department of Physics Kwame Nkrumah University of Science and Technology Kumasi Ghana Department of Medical Physics Komfo Anokye Teaching Hospital Oncology Directorate Kumasi Ghana Department of Medical Physics Graduate School of Nuclear and Allied Sciences University of Ghana Accra Ghana Radiation Protection Institute Ghana Atomic Energy Commission Accra Ghana

Thermoplastic immobilizing masks have dosimetric effects on the patient’s skin dose. The thermoplastic percentage depth dose (PDD), equivalent thickness of water for the masks and surface doses were determined. The surface dose factors due to the thermoplastic mask was found to be 1.7949, 1.9456, 2.0563, 2.1967, 2.3827, 2.5459 and 2.6565 for field sizes of 5 × 5, 8 × 8, 10 × 10, 12 × 12, 15 × 15, 18 × 18 and 20 × 20 cm2 respectively which shifted the percentage depth dose curve to lower values. The physical thermoplastic thickness was measured to be between 2.30 and 1.80 mm, and the equivalent thicknesses of water, de, were determined to be between 1.2 and 1.00 mm. This meant that, as the mask thickness decreased, its water equivalent thickness also decreased. The presence of the mask material increased the skin dose to a factor of 1%. The thermoplastic mask factor was also found to be 0.99.

关键词： Thermoplastic Mask Percentage Depth Dose Equivalent Thickness of Water Skin Dose

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Quality Assurance in SPECT/CT for Radionuclide Therapy with Lutetium-177

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2022年第1期11卷 60-76页

作者： Olivia Adu-Poku eric kotei addison Bright Kwakye-Awuah Stephen Inkoom Francis Hasford Cletus Ahadzie Joseph Adom Isaac Kojo Wilson Department of Physics Kwame Nkrumah University of Science and Technology Kumasi Ghana Komfo Anokye Teaching Hospital Oncology Directorate Department of Medical Physics Kumasi Ghana Department of Medical Physics Graduate School of Nuclear and Allied Sciences University of Ghana Accra Ghana Radiation Protection Institute Ghana Atomic Energy Commission Accra Ghana Nuclear Regulatory Authority Ghana Atomic Energy Commission Accra Ghana

This study was done to quality assure the Hawkeye SPECT/CT at the St. Olav’s hospital and create a clinical method for doing individual dosimetry with 177Lu-octreotate in targeted radionuclide therapy for neuroendocrine tumors. Various quality control parameters were performed on Infinia Hawkeye SPECT/CT. A calibration dose of 160% ± 2% MBq was ordered and first calibrated for all the dose calibrators. The uniformity test was obtained using a 40 MBq Tc-99m point source positioned 2.5 m away from the two detectors. A 200 MBq Tc-99m was diluted in 70 ml of water, dispersed in six syringes for the registration test. A Lu-177 point source was placed in front of the detectors, one at a time, to check the energy peaks. The Jaczczak phantom with a hollow sphere set (volumes: 0.5, 1, 2, 4, 8, and 16) ml with an additional 60 ml sphere was used for the 3D sensitivity and recovery with Lu-177. Total activity of 945.3 MBq was added to 160 ml of water yielding an activity concentration of 5.908 MBq/ml in the spheres. The phantom was then scanned at various time intervals. A cylindrical phantom with a volume of 6283 ml was also used to obtain the cross-calibration measurement (cps/MBq). Total activity of 995.6 MBq was added and the phantom was scanned at days 0, 6, 13 and 23. The dose calibration factor was changed from 762 to 760 to achieve correct doses. The 2D mean sensitivity factor was 5.56 cps/MBq. Uniformities for both detectors were approved after iteration calibration of the PM tubes. The X-ray to SPECT registration was found to be accurate and within specifications. The energy peak test revealed off-centered 208 keV energy peaks for the two detectors. Quality assurance of imaging devices using radiation is essential for radiation protection and ensures a high-quality image.

关键词： Lutetium-177 Activity Concentration Dose Calibrator SPECT/CT

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Image Quality Assessment Using NEMA Standards for Lu-177 Radionuclide

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2022年第3期

作者： olivia adu-poku bright kwakye-awuah eric kotei addison stephen inkoom

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Social media growth of orthopaedic surgery residency programs in response to the COVID-19 pandemic

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World Journal of Orthopedics 2022年第8期13卷 693-702页

作者： Joseph S Geller Dustin H Massel Michael G Rizzo Ean Schwartz Jacob eric Milner Chester J Donnally III Department of Orthopaedic Surgery University of Miami Miller School of MedicineMiamiFL 33136United States Department of Orthopedics University of Miami Miller School of MedicineMiamiFL 33136United States University of Miami Leonard M.Miller School of Medicine University of Miami Miller School of MedicineMiamiFL 33136United States Miller School of Medicine University of MiamiMiamiFL 33136United States Texas Spine Consultants Texas Spine ConsultantsAddisonTX 75001United States

BACKGROUND In the Spring of 2020,residency programs across the country experienced rapid and drastic changes to their application process as a result of the coronavirus disease 2019(COVID-19)*** response,residency programs shifted to virtual events and began harnessing social media to communicate with *** To analyze the changes in social media usage by orthopaedic surgery programs in response to the COVID-19 *** Based on the 2019 residency and fellowship electronic database,accredited US orthopaedic surgery programs were reviewed for social media presence on Instagram and *** 47000 tweets from 2011-2021 were extracted through the Twitter application programming *** extracted:Total number of followers,accounts following,tweets,likes,date of account creation,hashtags,and *** language processing was utilized for tweet sentiment analysis and classified as positive,neutral,or *** data was collected and deemed current as of August 11,*** account foundation date analysis was based on the date recognized as the start of the COVID-19 outbreak in the United States,before or after March 1,*** A total of 85(42.3%)orthopaedic surgery residency program Twitter handles were ***-five(41.2%)programs joined Twitter in the nine months after the 2020 covid *** 2020,there was a 126.6%increase in volume of tweets by orthopaedic surgery residency accounts as compared to *** median number of followers was 474.5(interquartile range 205.0-796.5).The account with the highest number of tweets was Hospital for Special Surgery(@HSpecialSurgery)with 13776 tweets followed by University of Virginia(@UVA_Ortho)with 5063 and Yale(@OrthoAtYale)with *** analysis before 2020 revealed 30.4%positive,60.8%neutral,and 8.8%negative sentiments across ***,the positive sentiment percentage increased in 2020 from 30.4%to 34.5%.Of the 201 ACGME-accredited ortho

关键词： Social media COVID-19 Orthopaedic surgery Residency

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