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journal of Innovative Optical Health Sciences 2020年第2期13卷 70-80页

作者： joanne Li Madison N.Wilson Andrew j.Bower Marina Marjanovic eric j.chaney Ronit Barkalifa Stephen A.Boppart Department of Bioengineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana ILU.S.A Carle Illinois College of Medicine University of Illinois at Urbana-Champaign Urbana ILU.S.A

To date,numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases,but few have attempted to characterize these cellular events under conditions similar to the native *** address this challenge,a three-dimensional(3D)multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin,which was then utilized to process in vivo wound healing data to demonstrate its *** attention is focused on in vivo biological parameters that are difficult to study with ex vivo analysis,including 3D cell tracking and techniques to connect biological information obtained from different imaging *** results here open new possibilities for evaluating 3D cellular dynamics in vivo,and can potentially provide new tools for characterizing the skin microenvironment and pathologies in the future.

关键词： Cellular dynamics multimodal imaging multiphoton microscopy

SEGMENTATION AND CORRELATION OF OPTICAL COHERENCE TOMOGRAPHY AND X-RAY IMAGES FOR BREAST CANCER DIAGNOSTICS

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journal of Innovative Optical Health Sciences 2013年第2期6卷 71-81页

作者： jONATHAN G.SUN STEVEN G.ADIE eric j.chaney STEPHEN A.BOPPART Beckman Institute for Advanced Science and Technology 405 North Mathews Avenue UrbanaIllinois 61801USA Department of Bioengineering Beckman Institute for Advanced Science and Technology 405 North Mathews Avenue UrbanaIllinois 61801USA Departments of Electrical and Computer Engineering and Internal Medicine University of Illinois at Urbana-Champaign UrbanaIllinoisUSA

Pre-operative X ray mammography and int raoperative X-ray specimen radiography are routinely used to identify breast cancer *** advances in optical coherence tomography(OCT)have enabled its 1use for the intraoperative assessment of surgical margins during breast cancer *** each modality offers distinct contrast of normal and pathological features,there is an essential need to correlate image based features between the two modalities to take adv antage of the diagnostic capabilities of each *** compare OCT to X-ray images of resected human breast tissue and correlate different tissue features between modalities for future use in real-tine intraoperative OCT imaging.X ray imaging(specimen radiography)is currently used during surgical breast cancer procedures to verify tumor margins,but cannot image tissue in *** has the potential to solve this problem by providing intrao-perative imaging of the resected specimen as well as the in situ tumor *** and micro-CT(X-ray)images are automatically segmented using different computational approaches,and quantitatively compared to determine the ability of these algorithms to automat ically differentiate regions of adipose tissue from ***,two-dimensional(2D)and three-dimensional(3D)results are *** correlations,combined with real-time intraoperative OCT,have the potential to identify possible regions of tumor within breast tissue which correlate to tumor regions identified previously on X-ray imaging(mammography or specimen radiography).

关键词： Optical imaging mammography specimen radiography segmentation breast cancer intraoperative imaging

FC-DIRECTED ANTIBODY CONjUGATION OF MAGNETIC NANOPARTICLES FOR ENHANCED MOLECULAR TARGETING

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journal of Innovative Optical Health Sciences 2009年第4期2卷 387-396页

作者： ROBABEH REZAEIPOOR RENU jOHN STEVEN G.ADIE eric j.chaney MARINA MARjANOVIC AMY L.OLDENBURG STEPHANIE A.RINNE STEPHEN A.BOPPART Biophotonics Imaging Laboratory Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaILUSA Departments of Electrical and Computer Engineering Bioengineeringand Internal Medicine University of Illinois at Urbana-Champaign UrbanaILUSA

In this study, we report the fabrication of engineered iron oxide magnetic nanoparticles (MNPs)functionalized with anti-human epidermal growth factor receptor type 2 (HER2) antibody totarget the tumor antigen HER2. The Fc-directed conjugation of antibodies to the MNPs aidstheir efficient immunospecific targeting through free Fab portions. The directional specificity ofconjugation was verified on a macrophage cell line. Immunofluorescence studies on macrophagestreated with functionalized MNPs and free anti-HER2 antibody revealed that the antibodymolecules bind to the MNPs predominantly through their Fc portion. Different cell lines with different HER2 expression levels were used to test the specificity of our functionalized nanoprobe formolecular targeting applications. The results of cell line targeting demonstrate that these engineered MNPs are able to differentiate between cell lines with different levels of HER2 expression.

关键词： Nanoprobe molecular imaging cancer

Gαq takes centre stage in multiple sclerosis pathogenesis

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Cellular & Molecular Immunology 2017年第5期14卷 401-402页

作者： eric j Downer School of Medicine Discipline of PhysiologyTrinity Biomedical Sciences Institute Trinity Col-lege Dublin Dublin 2 Ireland

There is no cure for multiple sclerosis （MS）; however, a number of strategies exist for disease management, including medications that reduce the frequency of relapses and long-term accrual of disability.1 However, the fact that MS therapies can be partially effective and have the risk of side effects, in addition to the observation that disability often continues to worsen despite immunotherapy, has highlighted the need for novel therapeutic targets in the disease.

关键词： Gαq centre stage multiple sclerosis

Chromate and selenate hydrocalumite solid solutions and their applications in waste treatment

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Science China(Life Sciences) 2005年第z1期48卷 165-173页

作者： eric j. Reardon Department of Earth Sciences University of Waterloo Waterloo Ontario Canada N2L 3G1

Hydrocalumite, a calcium aluminate hydrate phase, consists of positively-charged structure units, and is therefore an ideal candidate for accommodating anionic contaminants. In this study, a series of batch experiments was carried out to examine the uptake of chromate and selenate by hydrocalumite. To determine the uptake capacity and long-term stability, hydrocalumite solid solutions between chromate/selenate and hydroxyl were synthesized over a reaction time of more than one year. At a ratio of water to initial solids added (CaAl2O4+CaO) of 75: 1, the maximum uptake capacities were over 77 and 114 g/kg for Cr and Se, *** values are very close to the theoretical uptake capacities of chromate and selenate hydrocalumite end-members (81 and 118 g/kg, respectively). The oxyanion removal efficiency from solution was above 95%. Due to the high uptake capacity and anion removal efficiency of hydrocalumites, their application in wastewater treatment is promising. Hydrocalumites are also important hydration products of cementitious materials and the long-term stability of these phases is of significance for application in solidification/stabilization technology.

关键词： chromate, selenate, hydrocalumite, uptake capacity, stability.

Microstructural evolution of a heat-treated H23 tool steel

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International journal of Minerals,Metallurgy and Materials 2015年第3期22卷 272-284页

作者： Meilinda Nurbanasari Panos Tsakiropoulos eric j.Palmiere Department of Mechanical Engineering Institut Teknologi Nasional Department of Materials Science and Engineering The University of Sheffield

The microstructure and the stability of carbides after heat treatments in an H23 tool steel were investigated. The heat treatments consisted of austenization at two different austenizing temperatures （1100℃ and 1250℃）, followed by water quenching and double-aging at 650℃, 750℃, and 800℃with air cooling between the first and second aging treatments. Martensite did not form in the as-quenched micro- structures, which consisted of a ferrite matrix, M6C, M7C3, and MC carbides. The double-aged microstructures consisted of a ferrite matrix and MC, M6C, M7C3, and M23C6 carbides. Secondary hardening as a consequence of secondary precipitation of fine M2C carbides did not occur. There was disagreement between the experimental microstructure and the results of thermodynamic calculations. The highest double-aged hardness of the H23 tool steel was 448 HV after austenization at 1250℃ and double-aging at 650℃, which suggested that this tool steel should be used at temperatures below 650℃.

关键词： tool steel microstruc^ral evolution heat treatment carbides stability hardness

Effects of pH on rheological characteristics and stability of petroleum coke water slurry

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Petroleum Science 2016年第4期13卷 782-787页

作者： Fu-Yan Gao eric-j.Hu Ningbo Institute of Technology Zhejiang University School of Mechanical Engineering University of Adelaide

In this study, the effects of pH on slurrying properties of petroleum coke water slurry（PCWS） were investigated. The slurrying concentration, rheological characteristics and stability of PCWS were studied with four different types of additives at pH varying from 5 to *** results showed that the slurrying concentration, rheological characteristics and stability of PCWS all increased at first and then decreased with increasing pH from 5 to 11,and a pH of around 9 was found to be the most favorable acid–alkali environment to all these three slurrying properties. It was also indicated that only in a moderate alkaline environment can the additives be active enough to react with particle surfaces sufficiently to obtain good slurrying concentration and form a stable three-dimensional network structure, which can support strong pseudoplastic characteristics and good stability. An acid environment was a very unfavorable factor to the slurrying properties of PCWS.

关键词： Petroleum coke Petroleum coke water slurry pH Slurrying concentration Rheological characteristics Stability

Inherent relations between yield stress and stability of bubble petroleum coke water slurry

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Petroleum Science 2018年第1期15卷 157-163页

作者： Fu-Yan Gao eric j.Hu Ningbo Institute of Technology Zhejiang University School of Mechanical Engineering The University of Adelaide

The stability of petroleum coke water slurry（PCWS） is currently a hot topic. The inherent relationship between yield stress and stability of bubble-PCWS was studied through orthogonal experiments and range analysis in this work. The results showed that the stability of bubble-PCWS was positively related to the yield stress and that the yield stress could be greatly impacted by the operation conditions during preparation of bubble-PCWS. The main factors affecting the yield stress of bubble-PCWS were solid concentration, aeration time and dosage of frother. However, the effects of aperture size of air distribution plates and type of frother on the yield stress were slight within the experimental range. The optimal conditions for the greatest yield stress were as follows： aeration time of 30 min, solid concentration of 65 wt%, frother dosage of0.030 wt% of the air-dried pulverized petroleum coke, aperture size of air distribution plate of 2-5 lm and AOS *** yield stress and the pour rate of bubble-PCWS under this optimum operation condition could reach maxima of more than 0.4 Pa and 96%, respectively.

关键词： Petroleum coke Petroleum coke water slurry (PCWS) Stability Yield stress Orthogonal experiment

An ensemble method for gene discovery based on DNA microarray data

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Science China(Life Sciences) 2004年第5期47卷 396-405页

作者： Kathy L. MOSER eric j. TOPOL Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technology has offered the promise of casting new insights onto deciphering secrets of life by monitoring activities of thousands of genes simulta-neously. Current analyses of microarray data focus on precise classification of biological types, for example, tumor versus normal tissues. A further scientific challenging task is to extract dis-ease-relevant genes from the bewildering amounts of raw data, which is one of the most critical themes in the post-genomic era, but it is generally ignored due to lack of an efficient approach. In this paper, we present a novel ensemble method for gene extraction that can be tailored to fulfill multiple biological tasks including (i) precise classification of biological types; (ii) disease gene mining; and (iii) target-driven gene networking. We also give a numerical application for (i) and (ii) using a public microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensemble decision,recursive partition tree,feature gene selection.

Diffusion weighted imaging in the liver

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World journal of Gastroenterology 2010年第13期16卷 1567-1576页

作者： Petra G Kele eric j van der jagt Department of Radiology University Medical Center Groningen University of Groningen

Diffusion weighted magnetic resonance imaging (DWI) is an imaging technique which provides tissue contrast by the measurement of diffusion properties of water molecules within tissues. Diffusion is expressed in an apparent diffusion coefficient (ADC), which reflects the diffusion properties unique to each type of tissue. DWI has been originally used in neuroradiology. More recently, DWI has increasingly been used in addition to conventional unenhanced and enhanced magnetic resonance imaging (MRI) in other parts of the body. The reason for this delay was a number of technical problems inherent to the technique, making DWI very sensitive to artifacts, which had to be overcome. With assessment of ADC values, DWI proved to be helpful in characterization of focal liver lesions. However, DWI should always be used in conjunction to conventional MRI since there is considerable overlap between ADC values of benign and malignant lesions. DWI is useful in the detection of hepatocellular carcinoma in the cirrhotic liver and detection of liver metastases in oncological patients. In addition, DWI is a promising tool in the prediction of tumor responsiveness to chemotherapy and the follow-up of oncological patients after treatment, as DWI may be capable of detecting recurrent disease earlier than conventional *** review focuses on the most common applications of DWI in the liver.

关键词： Diffusion Magnetic resonance imaging Diffusion weighted imaging Benign neoplasms Liver neoplasms