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High-Order Low Dissipation Conforming Finite-Element Discretization of the Maxwell Equations

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Communications in Computational Physics 2012年第3期11卷 863-892页

作者： Sebastien Jund Stephanie Salmon eric Sonnendrucker IRMA UMR 7501 Universite de Strasbourg and CNRSand CALVI project-teamINRIA Nancy Grand Est7 rue Rene DescartesF-67084 STRASBOURG Cedex Laboratoire de Mathematiques EA 4535 Universite de ReimsU.F.R.Sciences Exactes et NaturellesMoulin de la Housse-BP 1039F-51687 REIMS cedex 2

In this paper,we study high order discretization methods for solving the Maxwell equations on hybrid triangle-quad *** have developed high order finite edge element methods coupled with different high order time schemes and we compare results and efficiency for several *** introduce in particular a class of simple high order low dissipation time schemes based on a modified Taylor expansion.

关键词： Maxwell’s equations edge finite element method mass lumping time discretization schemes

Celiac disease:a model disease for gene-environment interaction

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Cellular & Molecular Immunology 2011年第2期8卷 93-95页

作者： Raivo Uibo Zhigang Tian M eric Gershwin Immunology Group IGMPUniversity of TartuRavila 19TartuEstonia University of Science and Technology of China HefeiChina Division of Rheumatology Allergy and Clinical ImmunologyUniversity of California at Davis School of MedicineDavisCAUSA

Celiac sprue remains a model autoimmune disease for dissection of genetic and environmental influences on disease *** 2010 Congress of Autoimmunity included several key sessions devoted to genetics and *** papers from these symposia were selected for in-depth discussion and *** issue is devoted to this *** goal is not to discuss genetic and environmental interactions,but rather to focus on key elements of diagnosis,the inflammatory response and the mechanisms of autoimmunity.

关键词： environment andautoimmunity geoepidemiology autoimmunity

Comparison of Essential Oil Composition,Phenolic Compound and Biological Activities of Salvia microphylla and Teucrium polium(Lamiaceae)

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Journal of Renewable Materials 2022年第6期10卷 1607-1621页

作者： Ayda Khadhri Chedia Aouadhi eric Masson Antonio Pizzi Plant Soil and Environment Interactions LaboratoryFaculty of SciencesUniversity of El-Manar IITunisTunisia Bacteriology and Biotechnology Development Groups Epidemiology Laboratory and Veterinary MicrobiologyPasteur Institute of TunisUniversity of El-Manar IITunisTunisia CRITTBois EpinalFrance LERMAB University of LorraineEpinalFrance Department of Physics King Abdulaziz UniversityJeddahSaudi Arabia

Salvia microphylla and Teucrium polium are medicinal and aromatic plants with ethnobotanical *** present study was conducted to investigate the chemical composition of Salvia microphylla and Teucrium polium essential oils,the secondary metabolites,and the biological activities of their infusion and methanolic(MeOH)*** oils were extracted by hydrodistillation from shoots Salvia microphylla and Teucrium *** content,antioxidant and antimicrobial activities were *** chromatography-mass spectrometry(GCMS)results showed the presence of significant qualitative and quantitative variations for the composition of the both essential oils(EO).Salvia microphylla EO were most complex and present 70 compounds with the major components wereβ-caryophyllene(13.32%),1,8 cineole(11.25%),Cis p-Menthane-3-one(10.74%),andβ-Selinenol(9.71%).Where in the Teucrium polium EO,45 compounds were identified with the important components areβ-cadinene(10%),β-citronellol(8.5%),Carvacrol(7.63%),and Eugenol(7.15%).Obtained results showed that both plant are very rich in secondary *** isolated from Salvia microphylla presented the highest contents in the phenolic compound than extracted from Teucrium *** antioxidant activity data demonstrated that all extracts showed strong antioxidant and radical scavenging *** oil and methanol extracts presented a potential for antimicrobial activities against all tested *** obtained results highlight the potential use of Salvia microphylla and Teucrium polium as possible natural antioxidant substances and sources of bioactive molecules.

关键词： Salvia microphylla Teucrium polium phenolic compounds antioxidant antimicrobial activity essential oil

Emerging roles for insulin-like growth factor binding protein like protein 1

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Neural Regeneration Research 2019年第2期14卷 258-259页

作者： Yingqian Li eric Zhao Dong Feng Chen Schepens Eye Research Institute of Massachusetts Eye and Ear Department of Ophthalmology Harvard Medical School

Insulin-like growth factors (IGFs) mediate diverse cellular processesin various tissues, including the central nervous system (CNS)and thus require robust and delicate regulatory mechanisms. Itis now known that IGF signaling is regulated by a superfamily ofIGF binding proteins (IGFBPs) which share significant sequencehomology and are secreted to the extracellular environment tobind IGF (Nguyen et al., 2013). Currently, there are 6 known IGFBPsand 10 IGFBP related proteins. A new member of the IGFBPsuperfamily, IGFBP like protein 1 (IGFBPL1), was then identifiedand shown to have tumor suppressor like properties (Smith et al.,2007). Since then, little has been reported about the physiologicalroles of IGFBPL1. Recently, IGFBPL1 was found to be criticallyinvolved in mediating IGF-1 signaling to control CNS axon growthand regeneration (Guo et al., 2018). The study has uncovered a newsignaling loop in the regulation of the pleiotropic functions of IGF-1 and presents a possible novel pharmacological manipulation forpromoting nerve regeneration and repair.

关键词： et al IGFBPL CNS

Targeting and utilizing primary tumors as live vaccines:changing strategies

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Cellular & Molecular Immunology 2012年第1期9卷 20-26页

作者： Xuanming Yang eric D Mortenson Yang-Xin Fu Department of Pathology and Committee on Immunology University of ChicagoChicagoILUSA

Tumor metastases and relapse are the major causes of morbidity and mortality in *** surgery,chemotherapy and/or radiation therapy can typically control primary tumor growth,metastatic and relapsing tumors are often inaccessible or resistant to these *** adaptive immune response can be generated during these conventional treatments of the primary tumor,and presumably both the primary tumor and secondary metastases share many of the same or similar antigenic characteristics recognized by the immune ***,when established,this response should be able to control metastatic growth and tumor *** review summarizes the mechanisms by which antitumor immune responses are generated,and recent findings supporting the hypothesis that many therapies targeting primary tumors can generate antitumor adaptive immune responses to prevent metastases and tumor relapse.

关键词： chemotherapy immunotherapy metastasis radiotherapy tumor vaccine

Germinal center-dependent and-independent immune responses of tumor-infiltrating B cells in human cancers

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Cellular & Molecular Immunology 2023年第9期20卷 1040-1050页

作者： Eve Playoust Romain Remark eric Vivier Pierre Milpied Marseille Université CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance Innate Pharma MarseilleFrance

B cells play essential roles in immunity,mainly through the production of high affinity plasma cells(PCs)and memory B(Bmem)*** affinity maturation and differentiation of B cells rely on the integration of B-cell receptor(BCR)intrinsic and extrinsic signals provided by antigen binding and the microenvironment,*** recent years,tumor infiltrating B(TIL-B)cells and PCs(TIL-PCs)have been revealed as important players in antitumor responses in human cancers,but their interplay and dynamics remain largely *** lymphoid organs,B-cell responses involve both germinal center(GC)-dependent and GC-independent pathways for Bmem cell and PC *** maturation of BCR repertoires occurs in GC reactions with specific spatiotemporal dynamics of signal integration by B *** general,the reactivation of high-affinity Bmem cells by antigens triggers GC-independent production of large numbers of PC without BCR *** B-cell dynamics in immune responses requires the integration of multiple tools and readouts such as single-cell phenotyping and RNA-seq,in situ analyses,BCR repertoire analysis,BCR specificity and affinity assays,and functional ***,we review how those tools have recently been applied to study TIL-B cells and TIL-PC in different types of solid *** assessed the published evidence for different models of TIL-B-cell dynamics involving GC-dependent or GC-independent local responses and the resulting production of antigen-specific ***,we highlight the need for more integrative B-cell immunology studies to rationally investigate TIL-B cells as a leverage for antitumor therapies.

关键词： antibody tertiary lymphoid structure plasma cell germinal center cancer

Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal

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Journal of Molecular Cell Biology 2018年第6期10卷 494-502页

作者： Benjamin Ravaux Sophie Favier eric Perez and Christine Gourier Laboratoire de Physique Statistique Ecole Normale Superieure/PSL Research UniversityUPMC Univ Paris 06Universite Paris DiderotCNRS75005 ParisFrance

Mammalian fertilization involves membrane events-adhesion,fusion,sperm engulfment,membrane block to polyspermy-whose causes remain largely ***,specific oscillations of the sperm in contact with the egg were shown to be necessary for *** a microfluidic chip to impose the venue for the encounter of two gametes allowed real-time observation of the membrane remodelling occurring at the sperm/egg *** spatiotemporal mapping of egg CD9 revealed that this protein concentrates at the egg/sperm interface as a result of sperm oscillations,until a CDg-rich platform is nucleated on which fusion immediately takes *** 2-5 min after fusion,most of the CD9 leaves the egg for the external aqueous *** an egg membrane wave engulfs the sperm head in^25 *** results show that sperm oscillations initiate the CD9 recruitment that causes gamete fusion after which CD9 and associated proteins leave the membrane in a process likely to contribute to block *** highlight that the gamete fusion story in mammals is an unexpected interplay between mechanical constraints and proteins.

关键词： mammalian fertilization membrane dynamics real-time imaging CDg sperm oscillations gamete fusion

APPROXIMATION OF COMMON FIXED POINT OF FAMILIES OF NONLINEAR MAPPINGS WITH APPLICATIONS

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Acta Mathematica Scientia 2015年第5期35卷 1225-1240页

作者： eric U.OFOEDU Charles E.ONYI Department of Mathematics Nnamdi Azikiwe University

It is our purpose in this paper to show that some results obtained in uniformly convex real Banach space with uniformly Gateaux differentiable norm are extendable to more general reflexive and strictly convex real Banach space with uniformly G＆teaux differentiable norm. Demicompactness condition imposed in such results is dispensed with. Furthermore, Applications of our theorems to approximation of common fixed point of countable infinite family of continuous pseudocontractive mappings and approximation of common solution of countable infinite family of generalized mixed equilibrium problems are also discussed. Our theorems improve, generalize, unify and extend several recently announced results.

关键词： nonexpansive mappings, reflexive real Banach spaces fixed point uniformly Aateaux differentiable norm

A Megatheropod Tooth from the Early Cretaceous of Fusui, Guangxi, Southern China

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Acta Geologica Sinica(English Edition) 2014年第1期88卷 6-12页

作者： MO Jinyou HUANG Chaolin XIE Shaowen Buffetaut eric Natural History Museum of Guangxi CNRS UMR 8538 Laboratoire de Geologie de l'Ecole Normale Superieure

A nearly complete right maxillary or left dentary tooth（NHMG 10858） from the Lower Cretaceous Xinlong Formation of the Napai Basin, Fusui County, Guangxi, southern China, is described. The tooth is large in size, with a CBL of 37 mm. Given the geological age and its crown morphology, including the size, it is most likely that the tooth belongs to a carcharodontosaurid. The recovered specimen represents one of the largest theropod teeth hitherto reported from the Early Cretaceous of Asia.

关键词： Tooth Theropoda Xinlong Formation Early Cretaceous Napai Basin Guangxi