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Reproduction of <i>Atherina lagunae</i>from the Tunis North Lake

Journal of Water Resource and Protection 2012年第9期4卷 779-782页

作者： Nedia Ayed eric faure Jean-Pierre Quignard Monia Trabelsi Laboratory of Analysis Topology and Probability 7353 Aix-Marseille Universités Marseille France Laboratory of Ichthyology University of Montpellier II Montpellier France Unit of Marine Biology Faculty of Sciences University Campus Tunis El Manar Tunisia

In this study, the reproduction of the sand smelt, Atherina lagunae, from the Tunis North Lake is investigated. The smallest mature female was 39 mm total length (TL). Fifty percent of the females were mature at 58 mm (TL). The yearly and monthly average gonadosomatic indexes (GSI) are presented. The average value of GSI for the 12-month period was respectively 3.02%, 2.57% and 2.8% for females, males and both sexes. The GSI began to increase in March (2.37% for females and 2.12% for males). The maximum GSI was recorded in May, 11.29% for females and 10.03% for males. The highest values were recorded between March and July, indicating the reproduction period of Atherina lagunae in the Tunis North Lake. Similar GSI values were recorded in sand smelt males from brackish lagoons of southern France.

关键词： Atherina lagunae Tunis North Lake Tunisia Reproduction GSI

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Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer

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World Journal of Gastroenterology 2012年第12期18卷 1357-1364页

作者： Romain Altwegg Marc Ychou Vanessa Guillaumon Simon Thezenas Pierre Senesse Nicolas Flori Thibault Mazard Ludovic Caillo Stéphanie faure Emmanuelle Samalin eric Assenat the Oncology and Digestive Endoscopy Department of the CRLC Val d'Aurelle 34000 MontpellierFrance

AIM： To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastat- ic pancreatic cancer [（frequency, response, outcome, course of carbohydrate antigen 19-9 （CA 19-9）].METHODS： This retrospective study included all patients with advanced or metastatic pancreatic cancer （adenocarcinoma or carcinoma） treated with secondline chemotherapy in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine, and prior surgery or radiotherapy was permitted. We analyzed each chemotherapy protocol for second-line treatment, the number of cycles and the type of combination used. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, response rate, grade 3-4 toxicity, dosage modifications and CA 19-9 course.a second-line therapy among 206 patients who had initially received first-line treatment with a gemcitabi- ne-based regimen. Median number of cycles was 4 （range： 1-12） and the median duration of treatment was 2.6 mo （range： 0.3-7.4）. The overall disease control rate was 40.0%. The median overall survival and progression-free survival from the start of second-line therapy were 5.8 （95% CI： 4.1-6.6） and 3.4 mo （95% CI： 2.4-4.2）, respectively. Toxicity was generally acceptable. Median overall survival of patients with a CA 19-9 level declining by more than 20% was 10.3 mo （95% CI： 4.5-11.6） vs 5.2 mo （95% CI： 4.0-6.4） for others （P = 0.008）.CONCLUSION： A large proportion of patients could benefit from second-line therapy, and CA 19-9 allows efficient treatment monitoring both in first and secondline chemotherapy.

关键词： Second-line Chemotherapy Pancreatic can-cer Gemcitabine Carbohydrate antigen 19-9

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