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Incidence and risk of herpes zoster in patients with ulcerative colitis and Crohn’s disease in the USA

Gastroenterology Report 2023年第1期11卷 271-281页

作者： david Singer Philippe Thompson-Leduc deepshekhar Gupta Wendy Y.Cheng Sara Poston Siyu Ma John E.Pawlowski Mei Sheng duh eric d.morris Francesca devine Francis A.Farraye US Health Outcomes and Epidemiology—Vaccines GSKPhiladelphiaPAUSA Health Economics and Outcomes Research Analysis GroupInc.MontrealQuebecCanada Health Economics and Outcomes Research Analysis GroupInc.Menlo ParkCAUSA Health Economics and Outcomes Research Analysis GroupInc.BostonMAUSA Tufts Medical Center BostonMAUSA Medical Affairs GSKPhiladelphiaPAUSA Health Economics and Outcomes Research Analysis GroupInc.New YorkNYUSA division of Gastroenterology and Hepatology Mayo ClinicJacksonvilleFLUSA

Background:Patients with inflammatory bowel disease(IBd)are at increased risk of herpes zoster(HZ).We evaluated the incidence of HZ in ulcerative colitis(UC)and Crohn’s disease(Cd)patients and compared this with HZ incidence in a non-IBd ***:We conducted a retrospective cohort study(GSK study identifier:VEO-000043)of adults aged18 years with UC and Cd and without IBd who were identified from claims recorded in a US healthcare database between October 2015 and February *** HZ incidence rates/1,000 person-years(PY)were calculated,and comparisons of HZ incidence rates between UC or Cd and non-IBd cohorts were made using adjusted generalized linear ***:The study population comprised a total of 29,928 UC,25,959 Cd,and 11,839,329 non-IBd *** overall HZ incidence rates were 13.64/1,000 PY(UC),15.94/1,000 PY(Cd),and 7.95/1,000 PY(non-IBd).UC and Cd patients had increased HZ incidence rates,with adjusted incidence rate ratios of 1.35(95%confidence interval[CI],1.26–1.44)and 1.66(95%CI,1.56–1.77),respectively,compared with non-IBd *** analysis indicated increased relative rates of HZ in progressively younger age strata in the UC and Cd patients compared with non-IBd *** incidence rates were higher in UC and Cd patients who had previously received thiopurines or methotrexate,TNF-inhibitors,or corticosteroids than in UC and Cd patients who did not take those ***:UC and Cd patients had increased HZ incidence rates compared with patients without IBd,demonstrating the importance of HZ prevention in IBd patients.

关键词： ulcerative colitis Crohn’s disease herpes zoster

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Fabrication of sub-20 nm MoS_(2) horizontal nanowire on silicon substrates by inclusion of precursors into polystyrene-bpolyethylene oxide nanopatterns: detailed structural investigation

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Nano Research 2024年第3期17卷 2145-2153页

作者： Tandra Ghoshal Michael A.morris School of Chemistry AMBER and CRANNTrinity College DublinDublinIrelandD02 AK60

Herein,we demonstrate the fabrication of sub-20 nm MoS_(2) horizontal nanowire arrays on silicon substrates using a self-assembled block copolymer assisted in situ inclusion *** separated long-range ordered polystyrene-b-polyethylene oxide(PS-b-PEO)block copolymer(BCP)line-space nanopatterns were achieved through thermo-solvent *** patterns produced had long-range order and domain sizes>1μ*** BCP structures were lightly etched and modified by anhydrous ethanol to facilitate insertion of molybdenum precursor within the film maintaining the parent BCP *** ordered molybdenum oxide nanowire arrays were then fabricated by ultraviolet(UV)/ozone treatment at room *** oxides were converted to sulphides by thermal evaporation at different temperatures in Ar/H_(2) environment.X-ray photoelectron spectroscopy revealed the composition and phases of the molybdenum oxide and sulphide *** mapping was performed to investigate the interfaces between the oxide and sulphide nanowires with the substrate *** formation and stability of the sulphide nanowires were studied at different *** photoluminescence and Raman properties were studied at different formation temperatures to investigate defects and estimate the number of layers.

关键词： MoS_(2) block copolymer nanowires inclusion X-ray photoelectron spectroscopy(XPS) mapping photoluminescence

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Raman spectroscopy monitors adverse bone sequelae of cancer radiotherapy

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Chinese Chemical Letters 2015年第4期26卷 401-406页

作者： Bo Gong Michael d.morris department of Chemistry College of LiteratureScience and the ArtsUniversity of Michigan

Raman spectroscopy provides information on bone chemical composition and structure via widely used metrics including mineral to matrix ratio, mineral crystallinity and carbonate content, collagen cross- linking ratio and depolarization ratios. These metrics are correlated with bone material properties, such as hardness, plasticity and Young＇s modulus. We review application of Raman spectroscopy to two important irradiated animal models： the mouse tibia, a model for damage to cortical bone sites including the rib （breast cancer） and to healthy tissue adjacent to extremity sarcomas, and the rat mandible, a model for radiation damage in head and neck cancer radiotherapy. Longitudinal studies of irradiated mouse tibia demonstrate that radiation-induced matrix abnormalities can persist even 26 weeks post- radiation. Polarized Raman spectroscopy shows formation of more ordered orientation of both mineral and collagen. At 8 weeks post-radiation, irradiated rat hemimandible exhibits transient hyperminer- alization, increased collagen cross-linking and decreased depolarization ratios of mineral and collagen. A standard radioprotectant, amifostine, mitigates rat mandible radiation damage, with none remaining detectable 18 weeks post-radiation. Already a powerful tool to monitor radiation damage, Raman spectroscopy may be important in development of new radiotherapy protocols and radioprotective agents. Further in vfvo studies of radiation effects on the rodent models are underway, as are development of methodologies for eventual use in human subjects.

关键词： BoneRaman spectroscopyCancer radiotherapy

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Multidimensional images and aberrations in STEM

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Chinese Physics B 2024年第9期33卷 68-74页

作者： eric R.Hoglund Andrew R.Lupini Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831United States

Recent advances in scanning transmission electron microscopy(STEM)have led to increased development of multidimensional STEM imaging modalities and novel image reconstruction *** interest arises because the main electron lens in a modern transmission electron microscope usually has a diffraction-space information limit that is significantly better than the real-space resolution of the same *** state-of-affairs is sometimes shared by other scattering methods in modern physics and contributes to a broader excitement surrounding multidimensional techniques that scan a probe while recording diffraction-space images,such as ptychography and scanning nano-beam ***,the contrasting resolution in the two spaces raises the question as to what is limiting their effective ***,we examine this paradox by considering the effects of aberrations in both image and diffraction planes,and likewise separate the contributions of pre-and post-sample *** consideration provides insight into aberration-measurement techniques and might also indicate improvements for super-resolution techniques.

关键词： scanning transmission electron microscopy (STEM) aberrations

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William morris,Establishing the Foundation for the Advancement of TCM in the US

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Chinese Medicine and Culture 2024年第1期7卷 29-40页

作者： Ioannis Solos Charles Buck William morris Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom AOMA Graduate School of Integrative Medicine Austin 78745the United States of America

The interview was conducted on March 2nd, 2023 by Ioannis Solos and Charles Buck. William morris has sustained practice since 1980. He has served on the California, Texas and Massachusetts Professional Associations, as well as the National Association. He has tendered 20 years of service to the field through academic medicine, earning a master’s degree in medical education to assist in developing Chinese medical doctoral programs and institutional review boards. He earned an OM.d. in 1988, a dAOM in 2002, and a Ph.d. focused on pulse diagnosis as clinical epistemology in 2009. He has published five books, including TCM Case Studies dermatology, Li Shi-zhen Pulse Studies: An Illustrated Guide, Neoclassical Pulse diagnosis, Cycles in Medical Astrology, and Transformation: Treating Trauma with Acupuncture and Herbs.

关键词： Acupuncture sustained diagnosis

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Larval development and voracity of Eupeodes americanus (diptera: Syrphidae): comparison of the focal prey Aphis gossypi (Hemiptera: Aphididae) and the banker prey Rhopalosiphum padi (Hemiptera: Aphididae)

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Insect Science 2024年第2期31卷 575-586页

作者： Arlette Fauteux Antonio Onofre Soares eric Lucas Laboratoire de lutte biologique Departement des sciences biologiquesUniversite du Quebec a Montreal(UQAM)MontrealQuebecCanada Faculty of Science and Technology Center for Ecology Evolution and Environmental ChangesAzorean Biodiversity Group(cE3c-ABG)&CHANGE-Global Change and Sustainability InstitutePonta DelgadaPortugal

Unlike European species,the potential of Nearctic syrphids as biological control agents is still poorly ***,the American hoverfly,Eupeodes americanus(Wiedemann),has recently demonstrated promising traits as a biocontrol agent,notably against the foxglove aphid,Aulacorthum solani Kaltenbach,on *** present study aims to extend our knowledge of the American hoverfly by evaluating its potential as a biocontrol agent in a banker plant system against the melon aphid,Aphis gossypi Glover,in a greenhouse cucumber *** preimaginal development and voracity of *** were compared when preying upon the focal prey/pest(***)or the banker prey(bird cherry-oat aphid,Rhopalosiphum padi L.)by daily observations of larvae from egg to *** development time,survival rate,and occurrence of deformation were similar on both prey *** weight of third instar and pupae,however,was higher for larvae that fed on the banker *** ad libitum voracity of the syrphid larvae was generally very high and did not significantly differ between prey species,except for the third-instar larvae which consumed more focal *** suggest that a banker plant system involving the bird cherry-oat aphid may be a promising tactic for utilizing *** for melon aphid biocontrol.

关键词： american hoverfly banker plant system biological control bird cherry-oat aphid greenhouse cucumber melon aphid

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Foam rolling and stretching do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第4期13卷 509-520页

作者： Konstantin Warneke Gerit Plöschberger Lars H.Lohmann eric Lichtenstein daniel Jochum Stanislav d.Siegel Astrid Zech david G.Behm Institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria department of Human Motion Science and Exercise Physiology Friedrich Schiller UniversityJena 07749Germany department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland department of Health Sciences and Technology ETH ZurichZurich 8092Switzerland School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is a widely reported effect of stretching and foam rolling,which is commonly explained by changes in pain threshold and/or musculotendinous ***,these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle ***,we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching or foam rolling that promote an increase in muscle ***:After a systematic search in PubMed,Web of Science,and SPORTdiscus databases,38 studies comparing the effects of stretching and foam rolling with several other interventions on ROM and passive properties were *** studies had 1134 participants in total,and the data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using robust variance estimation model with ***:Study quality of the included studies was classified as fair(PEdro score=4.58)with low to moderate certainty of *** showed no significant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching or foam rolling and the other identified *** plots revealed no publication ***:Based on current literature,our results challenge the established view on stretching and foam rolling as a recommended component of warm-up *** lack of significant difference between interventions suggests there is no need to emphasize stretching or foam rolling to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Range of motion Passive properties Muscletendon unit Muscle tissue

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Parallelization of frequency domain quantum gates:manipulation and distribution of frequency-entangled photon pairs generated by a 21 GHz silicon microresonator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： Antoine Henry dario A.Fioretto Lorenzo M.Procopio Stéphane Monfray Frédéric Boeuf Laurent Vivien eric Cassan Carlos Alonzo-Ramos Kamel Bencheikh Isabelle Zaquine Nadia Belabas Institut Polytechnique de Paris LTCITélécom ParisPalaiseauFrance Université Paris-Saclay CNRSCentre for Nanosciences and NanotechnologyUMR 9001PalaiseauFrance Weizmann Institute of Science RehovotIsrael STMicroelectronics SAS CrollesFrance

Harnessing the frequency dimension in integrated photonics offers key advantages in terms of scalability,noise resilience,parallelization,and compatibility with telecom multiplexing *** ring resonators have been used to generate frequency-entangled states through spontaneous four-wave ***,state-of-the-art integrated resonators are limited by trade-offs among size,spectral separation,and efficient photon pair *** have developed silicon ring resonators with a footprint below 0.05 mm^(2)providing more than 70 frequency channels separated by 21 *** exploit the narrow frequency separation to parallelize and independently control 34 single qubit-gates with a single set of three off-the-shelf electro-optic *** fully characterize 17 frequency-bin maximally entangled qubit pairs by performing quantum state *** demonstrate for the first time,we believe,a fully connected five-user quantum network in the frequency *** results are a step towards a generation of quantum circuits implemented with scalable silicon photonics technology,for applications in quantum computing and secure communications.

关键词： integrated photonics frequency domain quantum gates quantum networks

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Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

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World Journal of diabetes 2024年第7期15卷 1448-1460页

作者： eric d Tenda Joshua Henrina Jin H Cha Muhammad R Triono Ersananda A Putri dahliana J Aristy dicky L Tahapary division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia Head of Research Group Artificial Intelligence and digital Health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2dM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2dM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

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Quantifying the Role of the Eddy Transfer Coefficient in Simulating the Response of the Southern Ocean Meridional Overturning Circulation to Enhanced Westerlies in a Coarse-resolution Model

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Advances in Atmospheric Sciences 2024年第9期41卷 1853-1867页

作者： Yiwen LI Hailong LIU Pengfei LIN eric PCHASSIGNET Zipeng YU Fanghua WU School of Ocean Sciences China University of GeosciencesBeijing 100083China Laoshan Laboratory Qingdao 266237China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Center for Ocean-Atmospheric Prediction Studies Florida State UniversityTallahassee 32306FloridaUSA China Meteorological Administration Beijing 100081China

This study assesses the capability of a coarse-resolution ocean model to replicate the response of the Southern Ocean Meridional Overturning Circulation(MOC) to intensified westerlies,focusing on the role of the eddy transfer coefficient(κ).κ is a parameter commonly used to represent the velocities induced by unresolved *** findings reveal that a stratification-dependent κ,incorporating spatiotemporal variability,leads to the most robust eddy-induced MOC response,capturing 82% of the reference eddy-resolving *** the eddy-induced velocity into its vertical variation(VV) and spatial structure(SS) components unveils that the enhanced eddy compensation response primarily stems from an augmented SS term,while the introduced VV term weakens the ***,the temporal variability of the stratification-dependent κ emerges as a key factor in enhancing the eddy compensation response to intensified *** experiment with stratification-dependent κ exhibits a more potent eddy compensation response compared to the constant κ,attributed to the structure of κ and the vertical variation of the density *** results underscore the critical role of accurately representing κ in capturing the response of the Southern Ocean MOC and emphasize the significance of the isopycnal slope in modulating the eddy compensation mechanism.

关键词： eddy transfer coefficient mesoscale eddy parameterization enhanced westerlies Southern Ocean Meridional Overturning Circulation ocean model

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