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Morphological stability of worm-like vesicles consisting of amphiphilic diblock copolymer against external stress

第十九届世界儿童及青少年精神卫生与相关学科学术会议

作者： Arata Oiji Yukiko Morioka Madoka Sato Yume Nagata eri Sasaki Mayumi Oki Asami Sato Sumiko Naito Kitasato University Japan Taisho University Japan Japan Ground Self Defense Force Japan Sakuracho Hospital Japan Yamagata Prefecture Japan Nanakubo Shi-on-en Japan Kuzuha-no-mori Japan

＜正＞Background The number of child maltreatment cases filed by the child guidance centers had been increasing rapidly in these twenty years and reached 37 323 in 2006 in *** two thirds（63.4%in 2006） of maltreated children separated from their parents are placed in"Jido yougo shisetsu"（JYS）.J YS is a group foster care facility in *** may be similar to children’s homes in *** Ministry of Health,Labor and Welfare of Japan started financial support for JYS to introduce child psychotherapists in 1999 and family social workers in 2004 in order to facilitate therapeutic functions of *** aim of the present study is to explore important therapeutic

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Chemical Reports 2019年第2期1卷 102-107页

作者： eri Yoshida Department of Applied Chemistry and Life Science Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 Japan

The morphological stability of vesicles consisting of an amphiphilic poly(methacrylic acid)- block-poly(methyl methacrylate-random-methacrylic acid) diblock copolymer, PMAA-b-P(MMA-r-MAA), was investigated against the external stresses of pH, salt concentration and polyamine. The worm-like vesicles underwent a partial fusion at pH 12, however, they retained the worm-like shape at pH 13 due to electrostatic repulsion. On the other hand, the spherical vesicles were completely fused at pH 12, transformed into a sheet and did not retain their shape under the higher basic condition. Similarly, the worm-like vesicles retained their morphology in 0.1 mol% solutions of sodium chloride and sodium dodecyl sulfate, while the spherical vesicles caused division and fusion even at much lower concentrations. Poly(2-dimethylaminoethyl methacrylate)(PDMAEMA) transformed the worm-like vesicle into a cleavable sheet, while it changed the spherical vesicles into a sheet without a specific form. It was found that this transformation based on the acid-base interaction between the carboxylic acid of the MAA block and the amine of the PDMAEMA was dependent on the molecular weight of the PDMAEMA. The short PDMAEMA retarded the fusion of the vesicles.

关键词： morphological stability external stresses worm-like vesicles spherical vesicles amphiphilic diblock copolymer polyamine

LXR, PPAR<i>γ</i>, and PPAR<i>δ</i>Agonists Are Not Sufficient to Demonstrate Therapeutic Potential against Mouse Model of Systemic Lupus Erythematosus

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第2期7卷 128-136页

作者： Noriko Toyota Tatebe Katsue Sunahori Watanabe Sonia Zeggar Sumie Hiramatsu Minglu Yan Takayuki Katsuyama eri Katsuyama Haruki Watanabe Ken-ei Sada Jun Wada Department of Nephrology Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan

Aim: We aimed to investigate whether the agonists for liver X receptor (LXR) ameliorate lupus-like phenotypes in mice mediated by the clearance of apoptotic cells, and compare with peroxisome proliferator-activated receptor (PPAR) γ plus PPARδ agonists, which also facilitate the clearance of apoptotic cells and exert anti-inflammatory effects in systemic lupus erythematosus (SLE). Methods: We investigated the efficacy of LXR agonist (GW3965) or dual treatment of PPARγ (pioglitazone) and PPARδ (GW0742) agonists in SLE animal models, female MRL/MpJ-Fas/J mice and BALB/cAJcl mice treated with pristane. The data were analyzed with one-way analysis of variance and Tukey’s honestly significant difference tests. Results: The treatment with LXR or PPARγ/δ agonists did not significantly alter the swelling of lymph nodes, ds-DNA production, albuminuria, histological score of glomerular lesions, and mRNA expression of target genes including Abca1, C1qa, Icam1, Mertk and Tnf. Conclusion: LXR or PPARγ/δ agonists targeting the impaired clearance for apoptosis cells may not be efficient in the remission induction therapy in SLE.

关键词： Nuclear Receptors Liver X Receptor (LXR) Peroxisome Proliferator-Activated Receptor (PPAR) Systemic Lupus Erythematosus (SLE)

A Case of Advanced Multiple Hepatocellular Carcinomas with Portal Vein Tumor Thrombosis Successfully Treated by Oral Tegafur/Uracil

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Journal of Cancer Therapy 2010年第3期1卷 160-164页

作者： Hiroto Tanaka Huuta Koga Masako hasegawa Hiroshi Takihara eri Kimura Tarou Inoue Chie Ueda Wataru Ono Seigou Takamatsu Yasushi Nakamura Hiroki Ueda 不详

A case of advanced multiple hepatocellular carcinomas (HCC) with portal vein tumor thrombosis successfully treated by oral tegafur/uracil is reported. A 69-year-old Japanese woman with advanced HCC with tumor thrombosis underwent transcatheter arterial infusion chemotherapy in April 2001. However, 1 year later, the patient experieced a recurrence with advanced multiple HCC with portal vein tumor thrombosis and ascites. Treatment with oral tegafur/uracil was started in May 2002 and resulted in the partial response of liver tumors and the complete improvement of ascites. She remained in good health for about 6 years. This case strongly suggests that oral tegafur/uracil is an effective treatment for some cases of advanced HCC with portal vein tumor thrombosis.

关键词： Advanced Hepatocellular Carcinoma Portal Vein Thrombosis Oral Tegafur/Uracil Chemotherapy

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禽流感病毒血凝素HA的可变性解析

病毒学报 2008年第1期24卷 34-40页

作者：修文琼中岛捷久信泽枝里福建省疾病预防控制中心病毒科福州350001 名古屋市立大学医学研究科日本

以重组的蒙古鸭H5N2禽流感病毒A/Duck/Mongolia/54/01的血凝素HA蛋白的cDNA为模板,进行PCR随机突变,表达只有单个氨基酸突变的H5HA基因共计38个。根据红细胞吸附反应,分析这些突变HA的功能,仍然具有红细胞吸附活性的单个氨基酸突变的HA... 详细信息

以重组的蒙古鸭H5N2禽流感病毒A/Duck/Mongolia/54/01的血凝素HA蛋白的cDNA为模板,进行PCR随机突变,表达只有单个氨基酸突变的H5HA基因共计38个。根据红细胞吸附反应,分析这些突变HA的功能,仍然具有红细胞吸附活性的单个氨基酸突变的HA约占89%,说明H5HA单个氨基酸突变的容许率是相当高的。HA1区突变数目大约是HA2区的两倍。对失去红细胞吸附功能和某些仍然拥有红细胞吸附功能的HA及单个氨基酸突变的位置与结构的关系进行探讨。有两个位点氨基酸突变了两次,但都不影响红细胞吸附功能,对红细胞吸附功能的影响,似乎主要由位置决定,而不是取决于取代的氨基酸的种类。位点179位和122位的突变是不允许的;位点179位于H5N1的受体结合区域RBD内,122位位于A抗原决定簇区附近,推测在H5HA三维结构上,这两个位点位于HA分子的内部,维持着H5HA的结构。HA1Cys位点4和HA2Cys位点148的突变是不允许的。这两个Cys正好形成HA1和HA2连接的桥梁,对维持H5HA结构也是相当重要的。本实验中HA先后失去了三个糖基化位点,但并不影响吸附红细胞的功能。总之,通过实验分析以研究某些氨基酸改变的效果,寻找关键位点是否突变,可以作为评估H5N1野毒株大流行潜力的分子标志。

关键词：禽流感病毒 H5N2 突变血凝素

竹轮理惠小姐向你传授专业技巧——成为化妆刷的高手！

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国际服装技术 2006年第3期 130-133页

作者： eri Nakao Gong Yunzhe（翻译） Kohshi Uchiyama（model）（摄影） Tatsuhiss Yogi（still）（摄影）

最能够体现化妆水平是否接近专业的工具，正是化妆刷！从部件到挑选要点，还有简单操作的关键点，就让竹轮理惠小姐来一一传授！

关键词：专业技巧化妆刷竹轮理惠

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落压比对射流控制矢量喷管性能影响研究

弹箭与制导学报 2011年第6期31卷 126-128页

作者：张泽远郭颜红额日其太吴盟中国空空导弹研究院河南洛阳471009

文中利用数值模拟方法研究了落压比对射流控制矢量喷管流动和性能的影响,分析了喷管矢量角随落压比变化的机理。研究结果表明,随着落压比增大,矢量角减小;注气口下游分离区内的压力降低,上下壁面的压差减小,矢量角减小;喷管工作状态从... 详细信息

文中利用数值模拟方法研究了落压比对射流控制矢量喷管流动和性能的影响,分析了喷管矢量角随落压比变化的机理。研究结果表明,随着落压比增大,矢量角减小;注气口下游分离区内的压力降低,上下壁面的压差减小,矢量角减小;喷管工作状态从过膨胀状态向欠膨胀状态转变,压差产生的推力越来越大,喷管的矢量角和气流偏转角相差越来越大,矢量角越来越小。

关键词：射流控制矢量喷管落压比

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海人酸致鸡耳蜗传入神经元迟发性死亡

中国耳鼻咽喉颅底外科杂志 2003年第2期9卷 92-96,T002页

作者：孙虹 Richard.J.Salvi 丁大连 eri.hashino MarleneShero 郑向阳中南大学湘雅三医院耳鼻咽喉科湖南长沙410013 美国纽约州立大学(Buffalo)听力与耳聋研究中心美国纽约14214

目的观察不同剂量谷氨酸(Glu)类似物海人酸(kainic acid,KA)导致鸡基底乳头(以下称为叫“耳蜗”)传入神经元迟发性神经元死亡(delayed neuron death,DND)及相应的耳蜗电生理改变,探讨兴奋性神经元死亡的发生规律。方法 34只成年来亨鸡... 详细信息

目的观察不同剂量谷氨酸(Glu)类似物海人酸(kainic acid,KA)导致鸡基底乳头(以下称为叫“耳蜗”)传入神经元迟发性神经元死亡(delayed neuron death,DND)及相应的耳蜗电生理改变,探讨兴奋性神经元死亡的发生规律。方法 34只成年来亨鸡分3组。第一组经左耳蜗鼓阶灌注高剂量KA(5 mM,KA-H组)后测量不同时点的CAP、CM和DPOAE,并观察耳蜗显微和超微结构变化;第二组灌注低剂量KA(0.3mM,KA-L组)后只观察各时点耳蜗形态变化;第三组灌注Hank氏液(HBSS)作对照。结果 ①KA灌注后,KA-H和KA-L组高毛细胞(THC)下方的传入树突均迅速水肿,CAP振幅大幅下降;矮毛细胞(SHC)的形态不受影响。②KA灌注后,KA-H组大量传入神经元于2～4周后发生DND并有不可逆听力损伤,但THC长期存活;面KA-L组传入神经元数目无明显减少,且神经元和髓鞘病变在1周后开始恢复。结论 ①KA以剂量依赖性方式选择性损伤鸡耳蜗传入神经元;局部高浓度可造成DND,其发生的时间在KA处理2～4周后;②鸡耳蜗THC可在没有传入突触联系的情况下长期存活,这可能用作实验模型;③为推测人类耳蜗兴奋性损伤及其机理,有必要用生理性递质Glu对哺乳动物进行在体实验。

关键词：海人酸鸡耳蜗传入神经元迟发性死亡

不同土壤水分供应条件下,芽孢杆菌B006对茄子生长和发育的影响

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不同土壤水分供应条件下,芽孢杆菌B006对茄子生长和发育的影响