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Honey prevents hepatic damage induced by obstruction of the common bile duct

World Journal of Gastroenterology 2008年第23期14卷 3729-3732页

作者： B Imge Erguder Sibel S Kilicoglu Mehmet Namuslu Bulent Kilicoglu erdinc devrim Kemal Kismet Ilker Durak Department of Biochemistry Ankara University Faculty of MedicineAnkara 06100Turkey Department of Histology and Embriology Ufuk University Faculty of MedicineAnkara 06800Turkey Ankara Research and Training Hospital Clinics of General SurgeryAnkara 06100Turkey

AIM:To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. METHODS:The study was performed with 30 male rats divided into three groups:a sham group,an obstructive jaundice group,and an obstructive jaundice plus honey group. At the end of the study period,the animals were sacrificed,and levels of nitric oxide(NO) ,and NO synthase(NOS) activities were measured in liver tissues,and levels of adenosine deaminase(ADA) and alanine transaminase(ALT) activities were measured in serum. RESULTS:Blood ALT and ADA activities were significantly elevated in the jaundice group as compared to those of the sham group. In the obstructive jaundice plus honey group,blood ALT and ADA activities were significantly decreased as compared to those of the jaundice group. In erythrocytes and liver tissues,NO levels were found to be significantly higher in the obstructive jaundice plus honey group compared to those of the sham group. Additionally,NO levels were found to be significantly higher in liver tissues from the animals in the obstructive jaundice plus honey group than those of the jaundice group.CONCLUSION:Honey was found to be beneficial in the prevention of hepatic damage due to obstruction of the common bile duct.

关键词：肝损伤黄疸阻塞治疗方法蜂蜜腺苷脱氧酶

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