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Role of surgery in colorectal cancer liver metastases

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World Journal of Gastroenterology 2014年第20期20卷 6113-6122页

作者： ?zgür Akgül erdin? ?etinkaya ?iyar Ers?z Mesut Tez Department of General Surgery Ankara Numune Education and Research Hospital 06100 Ankara Turkey

Colorectal carcinoma(CRC)is the third most common cancer,and approximately 35%-55%of patients with CRC will develop hepatic metastases during the course of their *** resection represents the only chance of long-term *** goal of surgery should be to resect all metastases with negative histological margins while preserving sufficient functional hepatic *** resection remains the only chance of long-term survival,management strategies should be tailored for each *** patients with extensive metastatic disease who would otherwise be unresectable,the combination of advances in medical therapy,such as systemic chemotherapy(CTX),and the improvement in surgical techniques for metastatic disease,have enhanced prognosis with prolongation of the median survival rate and *** use of portal vein embolization and preoperative CTX may also increase the number of patients suitable for surgical *** current treatment options,many patients still experience a recurrence after hepatic *** active systemic CTX agents are beingused increasingly as adjuvant therapy either before or after *** tumor ablative therapies,such as microwave coagulation therapy and radiofrequency ablation therapy,should be considered as an adjunct to hepatic resection,in which resection cannot deal with all of the tumor *** of an individualized plan,which combines surgery with systemic CTX,is a necessary task of the multidisciplinary *** aim of this paper is to discuss different approaches for patients that are treated due to CRC liver metastasis.

关键词： Colorectal cancer Metastasis Liver Prognosis

Partitioning Anatolian Kinematics into Tectonic Escape and Slab Rollback Dominated Domains

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Journal of Earth Science 2024年第3期35卷 758-768页

作者： Jiannan Meng Timothy M.Kusky erdin Bozkurt Hao Deng Ozan Sinoplu State Key Laboratory of Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan 430074China Department of Geological Engineering Middle East Technical University06800 AnkaraTurkey Department of Geosciences Auburn UniversityAuburn AL 36849USA

Anatolia is the global archetype of tectonic escape,as witnessed by the devastating 2023 Kahramanmaraş Earthquake sequence,and the 2020 Samos Earthquake,which show different kinematics related to the framework of the escape *** Positioning System(GPS)motions of the wedge-shaped plate differ regionally from northwestwards to southwestwards(from east to west).Anatolia was extruded westward from the Arabian-Eurasian collision along the North and East Anatolian fault systems,rotating counterclockwise into the oceanic free-faces of the Mediterranean and Aegean,with dramatic extension of western Anatolia in traditional ***,which is the dominant mechanism for this change in kinematics,extrusion related to the Arabia/Eurasia collision or rollback of the African slab beneath western Anatolia is still *** assess the dominant driving mechanisms across Anatolia,we analyze recent GPS velocity datasets,and decomposed them into N-S and E-W components,revealing that westward motion is essentially constant across the whole plate and consistent with the slip rates of the North and East Anatolia fault zones,while southward components increase dramatically in the transition area between central and western Anatolia,where a slab tear is *** phenomenon is related to different tectonic driving *** ArabiaEurasia collision drives the Anatolian Plate uniformly westwards while western Anatolia is progressively more affected by the southward retreating African subducting slab west of the Aegean/Cypriot slab tear,which significantly increases the southward component of the velocity field and causes the apparent curve of the whole modern velocity *** 2020 and 2023 earthquake focal mechanisms also confirm that the northward colliding Arabian Plate forced Anatolia to the west,and the retreating African slab is pulling the upper plate of western Anatolian apart in *** propose that the Anatolian Plate is moving westwards as

关键词： tectonics neotectonics tectonic escape slab rollback Anatolian Plate GPS velocity field geodynamics.

Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： erdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas erdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas erdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(P<0.001).The FIM scale includes both motor scores(P<0.05)and cognitive scores(P<0.001)and showed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

Surgical treatment of a rare brachial artery aneurysm postarteriovenous fistula closure after kidney transplant:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4755-4761页

作者： Nahit Arda Demirkan Yasemin Keskin Hakan Sevinç Ömer Arda Çetinkaya Department of General Surgery Ankara University School of MedicineAnkara 06100Türkiye Department of General Surgery Dr.Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalAnkara 06100Türkiye

BACKGROUND Brachial artery aneurysms are defined as dilations greater than 50%of the normal diameter,which are rare among all peripheral arterial *** they are often present as pseudoaneurysms,true brachial artery aneurysms are also detected *** this case report,the surgical repair method of true brachial artery aneurysms,which is a rare condition,is *** SUMMARY Herein,we present a 61-year-old male patient with complaints of swelling and pain in the right arm antecubital region that had been progressing over 6 *** the diagnosis of a true brachial artery aneurysm associated with arteriovenous fistula,the aneurysm was surgically repaired with an autologous saphenous vein *** patient was discharged without any neurovascular complications *** True brachial artery aneurysms are rare and there are not any recommendations for their management in the current *** though the treatment of true aneurysms in this artery is primarily based on a surgical treatment,endovascular repair also might be an option.

关键词： Brachial artery aneurysm Arteriovenous fistula Kidney transplantation Surgical repair Autologous vein interposition Case report

I_2-CONVERGENCE AND I_2-CAUCHY DOUBLE SEQUENCES

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Acta Mathematica Scientia 2014年第2期34卷 343-353页

作者： erdin DNDAR Bilal ALTAY Department of Mathematics Afyon Kocatepe University Department of Elementary Education nn University

In this article, we prove a decomposition theorem for L2-convergent double sequences and introduce the notions of L2-Cauchy and L2＊-Cauchy double sequence, and then study their certain properties. Finally, we introdu... 详细信息

关键词： Ideal double sequences L-convergence L-Cauchy.

Twin Earthquakes Devastate Southeast Türkiye and Syria:First Report from the Epicenters

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Journal of Earth Science 2023年第2期34卷 291-296页

作者： Timothy M.Kusky erdin Bozkurt Jiannan Meng Lu Wang Badong National Observatory and Research Station for Geohazards Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Department of Geological Engineering Middle East Technical University06800 AnkaraTürkiye

In early February,2023,southeastern Türkiye and northern Syria were hit by a series of deadly earthquakes(two of them above magnitude 7.5)that are proving to be one of the most significant earthquake disasters of this ***“twin quakes”caused a large number of casualties and property *** of press time,the death toll in Türkiye and Syria has surpassed 51000 and the number of injured has surpassed 120000,with the number affected>13.5 *** toll is constantly rising and the hope of finding more survivors has rapidly *** USGS PAGER(United States Geological Survey,Prompt Assessment of Global Earthquake for Response)service estimates economic losses of 10–100 billion US dollars.

关键词： Earthquake quake southeastern

Characterization of artificial spherical particles for DEM validation studies

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Particuology 2012年第2期10卷 209-220页

作者： Ignazio Cavarretta Catherine O'Sullivan erdin Ibraim Martin Lings Simon Hamlin David Muir Wood Division of Civil Chemical and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Department of Civil and Environmental Engineering Imperial College LondonLondon SW72AZUK Department of Civil Engineering University of BristolBristol BS81TRUK

This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method （DEM） simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were con- sidered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted.

关键词： Particle characterizationGlass beadsDEM