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Role of surgery in colorectal cancer liver metastases

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World Journal of Gastroenterology 2014年第20期20卷 6113-6122页

作者： ?zgür Akgül erdin? ?etinkaya ?iyar Ers?z Mesut Tez Department of General Surgery Ankara Numune Education and Research Hospital 06100 Ankara Turkey

Colorectal carcinoma(CRC)is the third most common cancer,and approximately 35%-55%of patients with CRC will develop hepatic metastases during the course of their *** resection represents the only chance of long-term *** goal of surgery should be to resect all metastases with negative histological margins while preserving sufficient functional hepatic *** resection remains the only chance of long-term survival,management strategies should be tailored for each *** patients with extensive metastatic disease who would otherwise be unresectable,the combination of advances in medical therapy,such as systemic chemotherapy(CTX),and the improvement in surgical techniques for metastatic disease,have enhanced prognosis with prolongation of the median survival rate and *** use of portal vein embolization and preoperative CTX may also increase the number of patients suitable for surgical *** current treatment options,many patients still experience a recurrence after hepatic *** active systemic CTX agents are beingused increasingly as adjuvant therapy either before or after *** tumor ablative therapies,such as microwave coagulation therapy and radiofrequency ablation therapy,should be considered as an adjunct to hepatic resection,in which resection cannot deal with all of the tumor *** of an individualized plan,which combines surgery with systemic CTX,is a necessary task of the multidisciplinary *** aim of this paper is to discuss different approaches for patients that are treated due to CRC liver metastasis.

关键词： Colorectal cancer Metastasis Liver Prognosis

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas erdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

I_2-CONVERGENCE AND I_2-CAUCHY DOUBLE SEQUENCES

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Acta Mathematica Scientia 2014年第2期34卷 343-353页

作者： erdin DNDAR Bilal ALTAY Department of Mathematics Afyon Kocatepe University Department of Elementary Education nn University

In this article, we prove a decomposition theorem for L2-convergent double sequences and introduce the notions of L2-Cauchy and L2＊-Cauchy double sequence, and then study their certain properties. Finally, we introdu... 详细信息

关键词： Ideal double sequences L-convergence L-Cauchy.

Twin Earthquakes Devastate Southeast Türkiye and Syria:First Report from the Epicenters

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Journal of Earth Science 2023年第2期34卷 291-296页

作者： Timothy M.Kusky erdin Bozkurt Jiannan Meng Lu Wang Badong National Observatory and Research Station for Geohazards Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Department of Geological Engineering Middle East Technical University06800 AnkaraTürkiye

In early February,2023,southeastern Türkiye and northern Syria were hit by a series of deadly earthquakes(two of them above magnitude 7.5)that are proving to be one of the most significant earthquake disasters of this ***“twin quakes”caused a large number of casualties and property *** of press time,the death toll in Türkiye and Syria has surpassed 51000 and the number of injured has surpassed 120000,with the number affected>13.5 *** toll is constantly rising and the hope of finding more survivors has rapidly *** USGS PAGER(United States Geological Survey,Prompt Assessment of Global Earthquake for Response)service estimates economic losses of 10–100 billion US dollars.

关键词： Earthquake quake southeastern

Characterization of artificial spherical particles for DEM validation studies

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Particuology 2012年第2期10卷 209-220页

作者： Ignazio Cavarretta Catherine O'Sullivan erdin Ibraim Martin Lings Simon Hamlin David Muir Wood Division of Civil Chemical and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Department of Civil and Environmental Engineering Imperial College LondonLondon SW72AZUK Department of Civil Engineering University of BristolBristol BS81TRUK

This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method （DEM） simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were con- sidered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted.

关键词： Particle characterizationGlass beadsDEM

Partitioning Anatolian Kinematics into Tectonic Escape and Slab Rollback Dominated Domains

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Journal of Earth Science 2024年第3期35卷 758-768页

作者： Jiannan Meng Timothy M.Kusky erdin Bozkurt Hao Deng Ozan Sinoplu State Key Laboratory of Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan 430074China Department of Geological Engineering Middle East Technical University06800 AnkaraTurkey Department of Geosciences Auburn UniversityAuburn AL 36849USA

Anatolia is the global archetype of tectonic escape,as witnessed by the devastating 2023 Kahramanmaraş Earthquake sequence,and the 2020 Samos Earthquake,which show different kinematics related to the framework of the escape *** Positioning System(GPS)motions of the wedge-shaped plate differ regionally from northwestwards to southwestwards(from east to west).Anatolia was extruded westward from the Arabian-Eurasian collision along the North and East Anatolian fault systems,rotating counterclockwise into the oceanic free-faces of the Mediterranean and Aegean,with dramatic extension of western Anatolia in traditional ***,which is the dominant mechanism for this change in kinematics,extrusion related to the Arabia/Eurasia collision or rollback of the African slab beneath western Anatolia is still *** assess the dominant driving mechanisms across Anatolia,we analyze recent GPS velocity datasets,and decomposed them into N-S and E-W components,revealing that westward motion is essentially constant across the whole plate and consistent with the slip rates of the North and East Anatolia fault zones,while southward components increase dramatically in the transition area between central and western Anatolia,where a slab tear is *** phenomenon is related to different tectonic driving *** ArabiaEurasia collision drives the Anatolian Plate uniformly westwards while western Anatolia is progressively more affected by the southward retreating African subducting slab west of the Aegean/Cypriot slab tear,which significantly increases the southward component of the velocity field and causes the apparent curve of the whole modern velocity *** 2020 and 2023 earthquake focal mechanisms also confirm that the northward colliding Arabian Plate forced Anatolia to the west,and the retreating African slab is pulling the upper plate of western Anatolian apart in *** propose that the Anatolian Plate is moving westwards as

关键词： tectonics neotectonics tectonic escape slab rollback Anatolian Plate GPS velocity field geodynamics.

Prevalence of refraction errors and color blindness in heavy vehicle drivers

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 319-322页

作者： Haydar Erdogan Levent zdemir Seher Arslan Ilhan etin Ayse Vural ze Selma etinkaya Haldun Sümer Department of Ophthalmology Faculty of MedicineCumhuriyet University Department of Public Health Faculty of MedicineCumhuriyet University Department of Medical Education Faculty of MedicineCumhuriyet University

AIM: To investigate the frequency of eye disorders in heavy vehicle ***: A cross-sectional type study was conducted between November 2004 and September 2006 in 200 driver and 200 non-driver persons.A complete ophthalmologic examination was performed,including visual acuity,and dilated examination of the posterior *** used the auto refractometer for determining refractive ***: According to eye examination results,the prevalence of the refractive error was 21.5% and 31.3% in study and control groups respectively (P <0.05).The most common type of refraction error in the study group was myopic astigmatism (8.3%) while in the control group simple myopia (12.8%).Prevalence of dyschromatopsia in the rivers,control group and total group was 2.2%,2.8% and 2.6% ***: A considerably high number of drivers are in lack of optimal visual *** errors in drivers may impair the traffic security.

关键词： refractive error myopia hypermetropia colour blindness

Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： erdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

Corneal properties in children with congenital isolated growth hormone deficiency

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 317-320页

作者： Pinar Nalcacioglu-Yuksekkaya Emine Sen Ufuk Elgin Mumin Hocaoglu Faruk Ozturk Sebahat Agladioglu Yilmaz Havva Nur Kendirci Semra etinkaya Zehra Aycan Department of Pediatric Ophthalmology Dr Sami Ulus Children's Health and Disease Training and Research Hospital Ulucanlar Eye Research Hospital Department of Pediatric Endocrinology Dr Sami Ulus Children's Health and Disease Training and Research Hospital

AIM:To compare the corneal parameters of children with congenital isolated growth hormone deficiency and healthy ***:In this cross-sectional,prospective study,50 cases with growth hormone(GH)deficiency treated with recombinant GH and 71 healthy children underwent a complete ophthalmic *** corneal hysteresis(CH),corneal resistance factor(CRF),Goldmann-correlated intraocular pressure(IOPg)and corneal-compensated intraocular pressure(IOPcc)were measured with the Ocular Response Analyzer(ORA).Central corneal thickness(CCT)was measured by a ultrasonic ***:The mean age was 13.0±3.0 years in the GH deficiency group consisting of 21 females and 29 males and 13.4±2.4 years in the healthy children group consisting of 41 females and 30 *** was no statistically significant difference between the groups for gender or age(Chi-square test,P=0.09;independent ttest,P=0.28,respectively).The mean duration of recombinant GH therapy was 3.8±2.4y in the study *** mean CH,CRF,IOPg and IOPcc values were 11.0±2.0,10.9±1.9,15.1±3.3,and 15.1±3.2 mm Hg respectively in the study *** same values were 10.7±1.7,10.5±1.7,15.2±3.3,and 15.3±3.4 mm Hg respectively in the control *** mean CCT values were 555.7±40.6,545.1±32.5μm in the study and control groups *** was no statistically significant difference between the two groups for CH,CRF,IOPg,IOPcc measurements or CCT values(independent t-test,P=0.315,0.286,0.145,0.747,0.13 respectively).CONCLUSION:Our study suggests that GH deficiency does not have an effect on the corneal parameters and CCT *** observation could be because of the duration between the beginning of disease and the diagnosis and beginning of GH therapy.

关键词： child corneal biomechanical parameters central corneal thickness growth hormone deficiency