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严重主动脉瓣狭窄病人无椭圆形收缩孔的融合主动脉瓣:心脏CT对区分有缝的二叶主动脉瓣与合缝处融合的三叶主动脉瓣有帮助

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国际医学放射学杂志 2015年第3期 306-306页

作者： S.H.Bak S.M.ko M.G.Song J.K.Shin H.K.Chee J.S.Kim 刘义涛 Department of Radiology Konkuk University Medical Center konkuk University School of Medicine 4-12 Hwayang-dongGwangjin-gu Seoul 143-729Korea konkuk University School of Medicine 4-12 Hwayang-dongGwangjin-gu Seoul 143-729Korea

目的确定心脏CT(CCT)能够区分伴有融合瓣尖和无椭圆形收缩孔的严重主动脉瓣狭窄(AS)病人的二叶主动脉瓣(BAV)与三叶主动脉瓣(TAV)的特征。方法回顾性

关键词：主动脉瓣狭窄 CT 病人三叶心脏

韩国抗大豆拟茎点种腐病(Phomopsis longicolla)的大豆品种评价

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大豆科技 2014年第5期 28-28页

作者： Suli Sun Kyujung Van Moon Young Kim Yeong-Ho Lee Jong-Min ko In-Youl Baek Yin-Won Lee Weixian Liu Suk-Ha Lee Baek Suk-Ha Lee 李雪光

大豆拟茎点种腐病（PSO），主要由Phomopsis longicolla引起的，是大豆重要种传病害之一，造成大豆产量严重损失。该研究评价了韩国主要大豆栽培品种对***的抗性，这些主栽品种主要用于亲本基因图谱绘制。2009--2010年间在韩国3个不同... 详细信息

大豆拟茎点种腐病（PSO），主要由Phomopsis longicolla引起的，是大豆重要种传病害之一，造成大豆产量严重损失。该研究评价了韩国主要大豆栽培品种对***的抗性，这些主栽品种主要用于亲本基因图谱绘制。2009--2010年间在韩国3个不同地点测定了田间自然发病条件下***和其他3种种传真菌的发病率。研究显示被测大豆品种对种传病害敏感性差异明显。品种Tae—kwangkong表现对***最大的抗性，平均发病率仅为0．33％，其他种传真菌平均发生率为6．17％。此外，在密阳（Milyang）和大邱（Daegu），品种Taekwangkong没有受到***0ngicolla的侵染。

关键词：大豆产量品种评价种腐病韩国茎种传病害种传真菌敏感性差异

前扣带皮层两种形式LTP的突触机制揭示焦虑和慢性疼痛相互作用

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科学新闻 2016年第1期 74-74页

作者： kohei koga Giannina Descalzi 陈涛 Hyoung-Gon ko Jinshan Lu Shermaine Li Junehee Son TaeHyun Kim Chuljung Kwak Richard L.Huganir 招明高 Bong-Kiun Kaang Graham L.Collingridge 卓敏日本Alima大学西安交通大学美国约翰·霍普金斯大学韩国国立大学英国布里斯托大学西安交通大学前沿科学技术研究院神经和疾病研究中心加拿大皇家科学院

文章简介慢性疼痛可导致焦虑,焦虑能增强痛觉。不幸的是,对这些现象的关联的基本神经机制了解很少。在这篇文章里,研究发现了和痛/焦虑相关的ACC有两种完全不同的长期可塑性(LTP):突触前和突触后。突触前LTP需要有腺苷酸环化酶和蛋白激... 详细信息

文章简介慢性疼痛可导致焦虑,焦虑能增强痛觉。不幸的是,对这些现象的关联的基本神经机制了解很少。在这篇文章里,研究发现了和痛/焦虑相关的ACC有两种完全不同的长期可塑性(LTP):突触前和突触后。突触前LTP需要有腺苷酸环化酶和蛋白激酶A的参与,而它的表达是通过一种机制涉及超极化激活环核苷酸门控通道(HCN)。有趣的是,慢性疼痛和焦虑都能选择性抑制突触前LTP。更重要的,将HCN的阻滞剂

关键词：慢性疼痛突触前 LTP 两种

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慢性肾脏病伴高血压患者的强化血压控制

中华高血压杂志(中英文) 2010年第11期18卷 1005-1005页

作者：张玲玉叶鹏 Appel Lawrence J W Jackson TJr G Tom A Lawrence YA Brad CB George LC William HC Jeanne C Gabriel F Marquetta LG Francis BG Jennifer JH Lee AJ Kenneth ak Joel DK John WL James PL Janice PL Julia BL Michael SM Shaul GM Edgar RN Keith P Robert AP Velvie AR Otelio SR StephenG S Miroslaw JT Robert DW Xuelei

在观察性研究中发现,血压与终末期肾脏病(endstage renal disease,ESRD)直接相关,并且相互促进。非洲裔美国人中高血压相关的慢性肾脏病和ESRD的患病比例相当高,但极少有试验去检验对非洲裔美国人进行强化血压控制是否能够延缓其慢性肾... 详细信息

在观察性研究中发现,血压与终末期肾脏病(endstage renal disease,ESRD)直接相关,并且相互促进。非洲裔美国人中高血压相关的慢性肾脏病和ESRD的患病比例相当高,但极少有试验去检验对非洲裔美国人进行强化血压控制是否能够延缓其慢性肾脏病进展。方法:入选慢性肾脏病伴高血压的非洲裔美国人患者1094例作为研究对象,随机给予强化或者标准的血压控制治疗。[第一段]

关键词：慢性肾脏病高血压患者血压控制平均血压

强化与标准血压控制对痴呆的影响:随机临床试验

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中华高血压杂志 2019年第4期27卷 367-367页

作者：刘青叶鹏 Williamson JD Pajewski NM Auchus AP Bryan RN Chelune G Cheung ak Cleveland ML Coker LH Crowe MG Cushman WC Cutler JA Davatzikos C Desiderio L Erus G Fine LJ Gaussoin SA Harris D Hsieh MK Johnson KC Kimmel PL Tamura MK Launer LJ Lerner AJ Lewis CE Martindale-Adams J Moy CS Nasrallah IM Nichols LO Oparil S Ogrocki PK Rahman M Rapp SR Reboussin DM Rocco MV Sachs BC Sink KM Still CH Supiano MA Snyder JK Wadley VG Walker J Weiner DE Whelton PK Wilson VM Woolard N Wright JT Jr Wright CB SPRINT MIND investigators for theSPRINT research group

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开... 详细信息

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开始,于2015年8月20日提前停止,获得其主要观察指标(复合心血管事件)和全因死亡率的数据。认知观察指标随访的最后日期为2018年7月22日。

关键词：随机临床试验老年痴呆血压控制轻度认知障碍标准心血管事件治疗方法研究人员

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粤東沿海地區海豐、陸豐兩縣絲蟲病調查報告

微生物学报 1958年第3期 345-352页

作者：陳心陶徐秉錕蔡尚達陳維亮柯小麟蘇克勤何桂銘劉德山余炳楨容瓘勞綺雲鄺麗賢中山医学院寄生虫学教研组

海豐和陸豐是廣東的兩個沿海縣份,屬於亞熱帶氣候的沿海地區,日夜受海風的直接影響,空氣中的相對濕度很大,全年雨量平均在1300毫米以上。但在另一方面,佔兩縣很大一部分面積的海邊地帶,土地是比較瘦瘠,加上每年的風災、水災,農民生活本... 详细信息

海豐和陸豐是廣東的兩個沿海縣份,屬於亞熱帶氣候的沿海地區,日夜受海風的直接影響,空氣中的相對濕度很大,全年雨量平均在1300毫米以上。但在另一方面,佔兩縣很大一部分面積的海邊地帶,土地是比較瘦瘠,加上每年的風災、水災,農民生活本來就是比較貧困的;更由於這裏是老革命根據地,國民黨的破壞和掠奪特別殘酷,使得長期以來,田園荒芜,百業不振,農民生活十分困苦。解放之後,雖然根本改變了過去的面貌,但在我們

关键词：感染期银瓶山感染率库蚊库蚊属南塘蚊子胸肌代表性

Tolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders:A translational viewpoint

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Neuroprotection 2024年第3期2卷 228-242页

作者： Svea-Solveig Mennen Maren Franta Martin Begemann Justus B.H.Wilke Roman Schroder Umer Javed Butt Jonathan-Alexis Cortés-Silva Umut Cakir Marie Gura Markus de Marees Vinicius Daguano Gastaldi Johannes Burtscher Julie Schanz Matthias Bohn Martin Burtscher Andreas Fischer Luise Poustka Peter Hammermann Markus Stadler Fred Luhder Manvendra Singh Klaus-Armin Nave Kamilla Woznica Miskowiak Hannelore Ehrenreich Clinical Neuroscience Max Planck Institute for Multidisciplinary SciencesCity CampusGottingenGermany Georg-August-University GottingenGermany Department of Sports Medicine Ruhr UniversityBochumGermany Institute of Sports Science University of LausanneLausanneSwitzerland Department of Clinical Chemistry and Interdisciplinary UMG Laboratory University Medical Center GottingenGottingenGermany Clinical Pharmacy Georg-August-UniversityGottingenGermany Faculty of Sports Science University of InnsbruckInnsbruckAustria Department of Child and Adolescent Psychiatry&Psychotherapy Center for Psychosocial MedicineUniversity Hospital HeidelbergHeidelbergGermany HBL Investmentpartners GmbH München-FrankfurtGermany Datico Sport&Health GmbH BurghausenGermany Institute for Neuroimmunology and Multiple Sclerosis Research University Medical Center GottingenGottingenGermany Department of Neurogenetics Max Planck Institute for Multidisciplinary SciencesCity CampusGottingenGermany Frederiksberg Hospital and Department of Psychology Neurocognition and Emotion in Affective Disorders(NEAD)CentreCopenhagen Affective Disorder Research CentrePsychiatric Centre CopenhagenUniversity of CopenhagenCopenhagenDenmark Experimental Medicine Department of Psychiatry and PsychotherapyCentral Institute of Mental HealthMedical Faculty MannheimHeidelberg UniversityMannheimGermany

Hypoxia is more and more perceived as pivotal physiological driving force,allowing cells in the brain and elsewhere to acclimate to lowered oxygen(O_(2)),and abridged *** mediating transcription program is induced by inspiratory hypoxia but also by intensive motor-cognitive tasks,provoking a relative decrease in O_(2) in relation to the acutely augmented *** termed this fundamental,demand-dependent drop in O_(2) availability"functional hypoxia."Major players in the hypoxia response are hypoxia-inducible factors(HIFs)and associated *** are transcription factors,stabilized by low O_(2) accessibility,and control expression of a multitude of *** in oxygen,however,can also be sensed via other pathways,among them the thiol-oxidase(2-aminoethanethiol)*** the far-reaching biological response to hypoxia,hitherto mostly observed in rodents,we initiated a translational project,combining mild to moderate inspiratory with functional *** had identified this combination earlier to benefit motor-cognitive attainment in mice.A total of 20 subjects were included:13 healthy individuals and 7 patients with depression and/or autism spectrum ***,we show that motor-cognitive training under inspiratory hypoxia(12%O_(2))for 3.5 h daily over 3 weeks is optimally *** present first signals of beneficial effects on general well-being,cognitive performance,physical fitness and *** in serum increases under hypoxia and flow cytometry analysis of blood reveals several immune cell types to be mildly modulated by *** obtain reliable information regarding the"add-on"value of inspiratory on top of functional hypoxia,induced by motor-cognitive training,a single-blind study—with versus without inspiratory hypoxia—is essential and outlined here.

关键词： brain cognition erythropoietin functional hypoxia high-parameter flow cytometry immune cells oxygen saturation physical fitness plasticity

Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury D.Cinabro L.Corona L.M.Cremaldi S.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De Nardo M.De Nuccio G.De Pietro R.de Sangro M.Destefanis S.Dey A.De Yta-Hernandez F.Di Capua S.Di Carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek S.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang H.B.Jeon S.Jia Y.Jin C.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.kodyš T.koga I.komarov T.konno S.korpar D.kotchetkov N.kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise