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Nuclear Science and Techniques 2024年第5期35卷 154-172页

作者： Rui-Cong Xu Avadhesh Kumar Sharma erdal Ozdemir Shuichiro Miwa Shunichi Suzuki Department of Nuclear Engineering and Management The University of Tokyo7‑3‑1 HongoBunkyo‑KuTokyo 113‑8656Japan Nuclear Professional School The University of Tokyo2‑2

During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater *** the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting *** the cutting process,aerosol particles are expected to be generated at the submicron *** has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying ***,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water *** this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water *** experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water *** results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant.

关键词： Fukushima Daiichi decommissioning Aerosol scavenging Multiphase flow Spray system Aerosol-mist agglomeration

What Should Be Done if There Is Coronary Artery Disorder in Ruptured Abdominal Aortic Aneurysm?

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World Journal of Cardiovascular Surgery 2011年第1期1卷 1-4页

作者： erdal simsek Mehmet Bayraktaroglu Huseyin Bayram Sevket Atasoy Salih Fehmi Katircioglu 不详

Abdominal aortic aneurysm (AAA) is the most common type of aneurismal diseases. Generally, it is asymptomatic and when it is ruptured, it develops with high morbidity and mortality. Case report: A 62-years-old male patient consulted our emergency with a pain at his dorsum and lumbar part. Cardiologist with a suspicion of coronary artery disorder or dissection, coronary angiography was executed. Consecutive lesions of LAD artery (left anterior descending) 40% - 50% and 90%, CX artery (circumflex) 40% and 80% - 90%, and a lesion of RCA (right coronary artery) 20% - 30% were detected. With a suspicion of rupture, abdominal aneurysm tomography (CT) was demanded. In the tomography, a 7-cm-diameter ruptured abdominal aortic aneurysm was diagnosed. Levosimendan support was started. Under the support of levosimendan a Y graft operation was performed. The operation was ended up with levosimendan support considering that coronary bypass would increase mortality and morbidity. Discussion: Approximately 50% of the ruptured aneurysms are died before they reach hospital while the 30% - 70% operated ones are died within 30 days after operation. Early diagnosis and follow-up is extremely important to decrease morbidity and mortality. The patients consulting with rupture must be taken to the operation without delay. What should be done if coronary artery disorder is detected in the patient whose AAA is ruptured and if the bypass is necessary? In our opinion, a decision must be made according to the patient’s clinical condition. As a result of our case, we thought repairing the abdominal aortic aneurysm necessitates the other comorbidites must be treated medically. We aimed to decrease the cardiac oxygen requirement by starting levosimendan and decline afterload. If the patient, whose coronary artery disorder is detected, is under risk and his overall condition is bad, we think that coronary bypass operation can be delayed.

关键词： Abdominal Aortic Aneurysm Coronary Artery Disease Levosimendan

Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(P<0.001).The FIM scale includes both motor scores(P<0.05)and cognitive scores(P<0.001)and showed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

A New Hybrid Approach Using GWO and MFO Algorithms to Detect Network Attack

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1277-1314页

作者： Hasan Dalmaz erdal erdal Halil Muratünver Department of Computer Engineering Faculty of Engineering and ArchitectureKırıkkale UniversityKırıkkale71450Turkey

This paper addresses the urgent need to detect network security attacks,which have increased significantly in recent years,with high accuracy and avoid the adverse effects of these *** intrusion detection system should respond seamlessly to attack patterns and *** use of metaheuristic algorithms in attack detection can produce near-optimal solutions with low computational *** achieve better performance of these algorithms and further improve the results,hybridization of algorithms can be used,which leads to more successful ***,many studies are conducted on this *** this study,a new hybrid approach using Gray Wolf Optimizer(GWO)and Moth-Flame Optimization(MFO)algorithms was developed and applied to widely used data sets such as NSL-KDD,UNSW-NB15,and CIC IDS 2017,as well as various benchmark *** ease of hybridization of the GWO algorithm,its simplicity,its ability to perform global optimal search,and the success of the MFO algorithm in obtaining the best solution suggested that an effective solution would be obtained by combining these two *** these reasons,the developed hybrid algorithm aims to achieve better results by using the good aspects of both the GWO algorithm and the MFO *** reviewing the results,it was found that a high level of success was achieved in the benchmark *** achieved better results in 12 of the 13 benchmark functions *** addition,the success rates obtained according to the evaluation criteria in the different data sets are also *** the 97.4%,98.3%,and 99.2% classification accuracy results obtained in the NSL-KDD,UNSW-NB15,and CIC IDS 2017 data sets with the studies in the literature,they seem to be quite successful.

关键词： Network attack detection hybrid GWO MFO

A fixed point theorem for Proinov mappings with a contractive iterate

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Applied Mathematics(A Journal of Chinese Universities) 2023年第3期38卷 403-412页

作者： erdal Karapnar Andreea Fulga Department of Medical Research China Medical UniversityTaichungTaiwanChina Department of Mathematics Cankaya University06790EtimesgutAnkaraTurkey Department of Mathematics and Computer Science Transilvania University of BrasovBrasovRo-mania.

In this paper,we consider the fixed point theorem for Proinov mappings with a contractive iterate at a *** other words,we combine and unify the basic approaches of Proinov and Sehgal in the framework of the complete m... 详细信息

关键词： contractive iterate at a point Proinov mappings fixed point theorems

Optimization of Electrical Conductivity of SA-graphene Nanocomposites Using Response Surface Methodology

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Chemical Research in Chinese Universities 2022年第2期38卷 596-602页

作者： HakanŞAHAL Gülben TORĞUT erdal CANPOLAT Vocational School of Tunceli Department of Food ProcessingMunzur UniversityTunceli 62000Turkey Vocational School of Tunceli Department of Chemistry and Chemical ProcessesMunzur UniversityTunceli 62000Turkey Department of Elementary Science Education Faculty of EducationFirat UniversityElazig 23119Turkey

Synthesis and characterization of 4-{(E)-[(5-bromo-2-hydroxyphenyl)methylidene]amino}-N-carbamimidoylbenzene-1-sulfonamide(SA) and its composites with graphene(SA-GF) were performed. Compound SA and SA-GF were characterized by FTIR and 1H NMR. The GF dispersion in the composites was analyzed by means of scanning electron microscopy(SEM) for morphology. Thermal properties of SA and nanocomposites were investigated using differential thermal analysis(DTA) and thermogravimetric analysis(TGA). The optimum electrical conductivity of the new sulfonamide-based Schiff base was determined to be 1.78×10–5 S/cm at a frequency of 9923 Hz, an applied voltage of –19 V, a mass fraction of 9.38% for graphene loading using a central composite design in the response surface methodology. The significance of the selected parameters(frequency, voltage and GF amount) in the model was determined by the analysis of variance(ANOVA). The results showed that frequency and graphene loading represent important model terms and have considerable effects on the conductivity of SA.

关键词： Schiff base Sulfonamide Graphene Conductivity Nanocomposite

Commentary on"Primary orbital monophasic synovial sarcoma with calcification:A case report"

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World Journal of Clinical Cases 2022年第22期10卷 8054-8056页

作者： Oguzhan Tokur Sonay Aydın erdal Karavas Department of Radiology Ankara Training and Research HospitalAnkara 06230Turkey Department of Radiology Erzincan UniversityErzincan 24100Turkey

The present letter to the editor is related to the study titled“Primary orbital monophasic synovial sarcoma with calcification:A case report”.Orbital synovial sarcoma is one of the rare intraorbital masses seen in adult and pediatric *** case reports in the literature revealed that synovial sarcoma may contain ***,it is important to make differential diagnosis among calcified orbital masses in childhood.

关键词： Orbital tumor Synovial sarcoma Calcification Children Histopathology Radiology

Imaging of acute appendicitis: Advances

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World Journal of Gastrointestinal Surgery 2022年第4期14卷 370-373页

作者： Sonay Aydın erdal Karavas Duzgun Can Senbil Department of Radiology Erzincan Binali Yıldırım University Faculty of MedicineErzincan 24100Turkey

We read with interest the review by Teng et al,who summarized the current approach to the diagnosis and treatment of acute appendicitis(AA).Also,the article summarizes the clinical scoring systems very *** one of the previous studies conducted by our research group,we showed that the use of the Alvarado score,ultrasound and C-reactive protein values in combination provides a safe confirmation or exclusion of the diagnosis of *** tomography is particularly sensitive in detecting periappendiceal abscess,peritonitis and gangrenous *** tomography is not a good diagnostic tool in pediatric patients because of the ionizing radiation it *** is a valuable diagnostic tool to differentiate AA from lymphoid *** of fluid collection in the periappendiceal and lamina propria thickness less than 1 mm are the most effective parameters in differentiating appendicitis from lymphoid *** AA is the most common cause of surgical acute abdomen,it remains an important diagnostic and clinical *** combining clinical scoring systems,laboratory data and appropriate imaging methods,diagnostic accuracy and adherence to treatment can be *** hyperplasia and perforated appendicitis present significant diagnostic challenges in *** ultrasound findings are increasingly defined to differentiate AA from these conditions.

关键词： Acute appendicitis Inflammation Acute abdomen Perforation