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Neural Regeneration Research 2021年第1期16卷 115-116页

作者： Topaz Altman eran perlson Department of Physiology and Pharmacology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael Sagol School of Neuroscience Tel-Aviv UniversityTel-AvivIsrael

Motor neurons are highly polarized cells,with long axons that extend to more than 1 m in the adult human.The axons further arborize into a specialized synaptic compartment,the motor unit,containing up to 2000 neuromuscular junctions(NMJs).While the size of other neuronal synapses can be up to 1μm,the NMJ is much larger and can reach 10–30μm(Jones et al.,2017).The vast size of the motor unit requires motor neurons to evolutionally adapt and supply this distal portion with a sufficient amount of ATP,as well as to replenish the axonal protein pool in order to maintain their synapses.

关键词： specialized maintain sword

Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases

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Neural Regeneration Research 2017年第4期12卷 534-537页

作者： Shiran Naftelberg Gil Ast eran perlson Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel Department of Physiology and Pharmacology Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

Familial dysautonomia （FD） is a rare children neurodegenerative disease caused due to a point mutation in the IKBKAP gene that results in decreased IKK complex-associated protein （IKAP） protein production. The disease affects mostly the dorsal root ganglion （DRG） and the sympathetic ganglion. Recently, we found that the molecular mechanisms underlying neurodegeneration in FD patients are defects in axonal transport of nerve growth factors and microtubule stability in the DRG. Neurons are highly polarized cells with very long axons. In order to survive and maintain proper function, neurons depend on transport of proteins and other cellular components from the neuronal body along the axons. We further demonstrated that IKAP is necessary for axon maintenance and showed that phosphatidylserine acts as an HDAC6 inhib- itor to rescue neuronal function in FD cells. In this review, we will highlight our latest research findings.

关键词： axonaI transport neurodegeneration microtubule familial dysautonomia phosphatidylserine HDAC6

Muscle secretion of toxic factors,regulated by miR126-5p,facilitates motor neuron degeneration in amyotrophic lateral sclerosis

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Neural Regeneration Research 2019年第6期14卷 969-970页

作者： Roy Maimon eran perlson Department of Physiology and Pharmacology Sackler Faculty of MedicineTel Aviv University

Amyotrophic lateral sclerosis(ALS)is a lethal neurodegenerative disease characterized by neuromuscular junction(NMJ)disruption,motor neuron(MN)axon degeneration,and neuronal death.Unfortunately,there is currently no effective treatment available for ALS and consequently,most patients die several years post diagnosis.The neurodegeneration that occurs in ALS is considered to be a non-cell autonomous process involving interactions between the motor neuron and its diverse extracellular microenvironments via an unknown mechanism.Distal Axonopathy is one of the early disease signs;however,the involvement and contribution of neighboring tissues and specifically,the muscle environment to the disease pathology remain controversial.Few works have concluded that muscles play a minor role or none at all in ALS pathology.

关键词： Muscle secretion toxic factors facilitates motor

Receptor-mediated increase in rabies virus axonal transport

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Neural Regeneration Research 2015年第6期10卷 883-884页

作者： Shani Gluska Stefan Finke eran perlson Department of Physiology and Pharmacology Sackler Faculty of Medicineand the Sagol School of NeuroscienceTel Aviv University Friedrich-Loeffler-Institut Federal Research Institute for Animal HealthInstitute of Molecular Virology and Cell Biology

Rabies virus （RABV） of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease, and is still a major risk mostly in developing countries. A key step in the RABV infection process is its arrival into the central nervous system （CNS）, for which it uses the cellular transport machinery. Neurons are irregular cells with a specialized anatomy, and often extend lengthy axons that may span over a meter long. In infected organisms, RABV virions enter the neuron periphery at the area of a bite and must overcome great distances in order to reach the peripheral neuron＇s cell body and from there,

关键词： NCAM Receptor-mediated increase in rabies virus axonal transport NGF GDNF