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Five years of fecal microbiota transplantation-an update of the Israeli experience

World Journal of Gastroenterology 2018年第47期24卷 5403-5414页

作者： Sharon A Greenberg Ilan Youngster Nathaniel A Cohen Dan M Livovsky Jacob Strahilevitz eran Israeli Ehud Melzer Kalman Paz Naomi Fliss-Isakov Nitsan Maharshak Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Centeraffiliated with the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 6423906Israel Bacteriotherapy Clinic Tel Aviv Sourasky Medical Centeraffiliated with the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 6423906Israel Assaf Harofe Medical Center Zerifin 70300Israel Digestive Diseases Institute Shaare Zedek Medical CenterJerusalem 91031Israel Department of Clinical Microbiology and Infectious Diseases Hadassah-Hebrew UniversityJerusalem 91120Israel Department of Gastroenterology and Liver Diseases Hadassah-Hebrew UniversityJerusalem 91120Israel Gastrointestinal and Liver Diseases Institute Kaplan Medical CenterRehovot 76100Israel

AIM To evaluate and describe the efficacy of fecal microbiota transplantation(FMT) for Clostridium difficile infection(CDI) in a national Israeli *** All patients who received FMT for recurrent(recurrence within 8 wk of the previous treatment) or refractory CDI from 2013 through 2017 in all the five medical centers in Israel currently performing FMT were included. Stool donors were screened according to the Israeli Ministry of Health guidelines. Clinical and laboratory data of patients were collected from patients' medical files, and they included indications for FMT, risk factors for CDI and disease severity. Primary outcome was FMT success(at least 2 mo free of CDI-related diarrhea post-FMT). Secondary outcomes included initial response to FMT(cessation of diarrhea within 7 d) and recurrence at 6 *** There were 111 FMTs for CDI, with a median age of 70 years [interquartile range(IQR): 53-82], and 42%(47) males. Fifty patients(45%) were treated via the lower gastrointestinal(LGI, represented only by colonoscopy) route, 37(33%) via capsules, and 24(22%) via the upper gastrointestinal(UGI) route. The overall success rate was 87.4%(97 patients), with no significant difference between routes of administration(P = 0.338). In the univariant analysis, FMT success correlated with milder disease(P = 0.01), ambulatory setting(P < 0.05) and lower Charlson comorbidity score(P < 0.05). In the multivariant analysis, only severe CDI [odd ratio(OR) = 0.14, P < 0.05] and inpatient FMT(OR = 0.19, P < 0.05) were each independently inversely related to FMT success. There were 35(32%) patients younger than 60 years of age, and 14(40%) of them had a background of inflammatory bowel *** FMT is a safe and effective treatment for CDI, with capsules emerging as a successful and well-tolerated route. Severe CDI is less likely to respond to FMT.

关键词： Clostridium difficile infection Capsules Israel Fecal microbiota transplantation

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The City Public Transport Overlooked: Analysis of Effective Distances

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Journal of Geographic Information System 2017年第6期9卷 663-684页

作者： Orit Rotem-Mindali eran Feitelson Yaron Michael Department of Geography and Environment Bar Ilan University Ramat Gan Israel Department of Geography The Hebrew University of Jerusalem Jerusalem Israel

Jerusalem is holy to the three main monotheistic religions. Hence Jerusalem is, from a touristic perspective, a world city. Jerusalem is also a highly segmented city. While Jerusalem may seem as an extreme case, it is not unique. Many cities attract large number of tourists to various widely renowned sites within them, in many cases with religious facets. Public transport systems are largely designed to address the demand of local residents. Yet, tourist flows often differ from the travel patterns of local residents, both temporally and spatially. This paper evaluates how Jerusalem’s public transport system serves the global tourist city. To this end, the study focuses on independent tourists, not package-tour tourists. Specifically, we analyze to what extent are the main tourist sites served by the public transportation system. To evaluate accessibility to tourist destinations we use GIS to conduct Least-Cost-Modeling. This methodology measures the effective, rather than the Euclidian distance to tourist destination. We find that the accessibility by public transportation to tourist destinations with high global importance, specifically Christian-religious sites is relatively low. In the final part of the paper we propose a number of explanations for that.

关键词： Accessibility Cities Spatial Planning GIS Urban Transportation

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Genetic analysis of four consanguineous multiplex families with inflammatory bowel disease

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Gastroenterology Report 2021年第6期9卷 521-532页

作者： Noam Ben-Yosef Matthew Frampton Elena RSchiff Saleh Daher Fadi Abu Baker Rifaat Safadi eran Israeli Anthony W.Segal Adam P.Levine Centre for Molecular Medicine Division of MedicineUniversity College LondonLondonUK Institute of Gastroenterology and Liver disease Hadassah Medical CenterJerusalemIsrael Institute of Ophthalmology Moorfields Eye HospitalUniversity College LondonLondonUK Institue of Gastroenterology and Hepatology Hillel Yaffe Medical CenterHaderaIsrael Institute of Gastroenterology and Liver disease E.Wolfson Medical CenterHolonIsrael Department of Pathology University College LondonLondonUK

Background:Family studies support a genetic predisposition to inflammatory bowel diseases(IBD),but known genetic variants only partially explain the disease *** withmultiple affected individuals potentially harbour rare and highimpact causal *** regions of homozygosity due to recent inbreedingmay increase the risk of individuals bearing homozygous loss-of-function *** study aimed to identify rare and homozygous genetic variants contributing to ***:Four families with known consanguinity and multiple cases of IBD were *** a family-specific analysis,we utilised homozygosity mapping complemented by whole-exome ***:We detected a single region of homozygosity shared by Crohn’s disease cases from a family of Druze ancestry,spanning 2.6Mb containing the NOD2 ***-exome sequencing did not identify any potentially damaging variants within the region,suggesting that non-coding variation may be *** addition,affected individuals in the families harboured several rare and potentially damaging homozygous variants in genes with a role in autophagy and innate immunity including LRRK1,WHAMM,DENND3,and ***:This study examined the potential contribution of rare,high-impact homozygous variants in consanguineous families with *** the analysis was not designed to achieve statistical significance,our findings highlight genes or loci that warrant further ***-coding variants affecting NOD2 may be of importance in Druze patients with Crohn’s disease.

关键词： inflammatory bowel disease family study genetics homozygosity

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螺纹铣削——“螺纹加工”将来式

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工具技术 2017年第2期51卷 I0008-I0009页

作者： Andrei Petrilin eran Panko 伊斯卡可转位铣刀螺纹铣刀

机床技术的持续进步使得螺纹铣削在世界各地金属切削制造领域的应用越来越普及。今天，数控机床可通过螺旋插补铣实现高效切削，这一优势确保了铣螺纹工序这种螺纹生成方式呈增长趋势。尽管大多数内螺纹的生成采用传统的螺纹攻丝方式，... 详细信息

机床技术的持续进步使得螺纹铣削在世界各地金属切削制造领域的应用越来越普及。今天，数控机床可通过螺旋插补铣实现高效切削，这一优势确保了铣螺纹工序这种螺纹生成方式呈增长趋势。尽管大多数内螺纹的生成采用传统的螺纹攻丝方式，但在’直径相对较小的螺纹孔加工中．更高效的螺纹铣削技术终结了攻丝加工的绝对主导地位，导致其不再是最主要的螺纹加工方式。

关键词：螺纹加工螺纹铣削螺纹孔加工制造领域金属切削机床技术高效切削螺旋插补

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Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey

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World Journal of Gastroenterology 2019年第30期25卷 4246-4260页

作者： Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein eran Israeli Institute of Gastroenterology and Liver Diseases Hadassah-Hebrew University Medical CenterJerusalem 91120Israel Department of Gastroenterology Galilee Medical CenterFaculty of Medicine in the GalileeBar-Ilan UniversityNahariya 22100Israel IBD Clinical and Research Centre University of ManitobaWinnipegMB R3E3P4Canada Research Branch IDF Medical CorpsTel-HashomerRamat Gan 52630Israel Institute of Gastroenterology Meir Medical CenterKfar-saba 4428164Israel Sackler School of Medicine Tel-Aviv UniversityTel-Aviv 6997801Israel Institute of Gastroenterology Sheba Medical CenterRamat-Gan 52630Israel Institute of Gastroenterology Rabin Medical CenterPetach-Tikva 49100Israel

BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on *** informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their *** large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and *** hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the *** To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information *** We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current *** performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study *** Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six *** responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients w

关键词： Inflammatory bowel diseases Information needs Patient education Knowledge resources Patient profiles

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Inflammatory bowel disease among first generation immigrants in Israel:A nationwide epi-Israeli Inflammatory Bowel Disease Research Nucleus study

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World Journal of Methodology 2023年第5期13卷 475-483页

作者： Mira Stulman Gili Focht Yiska Loewenberg Weisband Shira Greenfeld Amir Ben Tov Natan Ledderman eran Matz Ora Paltiel Shmuel Odes Iris Dotan Eric Ian Benchimol Dan Turner The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical CenterFaculty of MedicineThe Hebrew University of JerusalemJerusalem 9103102Israel Braun School of Public Health and Community Medicine Hadassah Medical OrganizationFaculty of MedicineHebrew University of JerusalemJerusalem 9574869Israel Clalit Research Institute Tel Aviv 6209804Israel Maccabi Health Services and the Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6801296Israel Meuhedet Health Services Tel Aviv 6203854Israel Leumit Health Services Tel Aviv 6473704Israel Faculty of Health Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Gastroenterology Rabin Medical CenterPetah Tikva 49100Israel Department of Paediatrics and Institute of Health Policy Management and EvaluationThe Hospital for Sick ChildrenUniversity of TorontoToronto M5G 1X8ONCanada SickKids Inflammatory Bowel Disease Centre Division of GastroenterologyHepatology and NutritionChild Health Evaluative SciencesThe Hospital for Sick Children and the SickKids Research InstituteToronto M5G 1X8Canada ICES Toronto M4N 3M5Canada

BACKGROUND Israel has a high rate of Jewish immigration and a high prevalence of inflammatory bowel disease(IBD).AIM To compare IBD prevalence in first-generation immigrants vs Israel-born *** Patients with a diagnosis of IBD as of June 2020 were included from the validated epi-IIRN(Israeli IBD Research Nucleus)cohort that includes 98%of the Israeli *** stratified the immigration cohort by IBD risk according to country of origin,time period of immigration,and age group as of June *** A total of 33544 patients were ascertained,of whom 18524(55%)had Crohn’s disease(CD)and 15020(45%)had ulcerative colitis(UC);28394(85%)were Israel-born and 5150(15%)were *** was more prevalent in immigrants(2717;53%)than in non-immigrants(12303,43%,P<0.001),especially in the<1990 immigration *** adjusting for age,longer duration in Israel was associated with a higher point prevalence rate in June 2020(high-risk origin:Immigration<1990:645.9/100000,≥1990:613.2/100000,P=0.043;intermediate/low-risk origin:<1990:540.5/100000,≥1990:192.0/100000,P<0.001).The prevalence was higher in patients immigrating from countries with high risk for IBD(561.4/100000)than those originating from intermediate-/low-risk countries(514.3/100000;P<0.001);non-immigrant prevalence was 528.9/*** Lending support to the environmental effect on IBD etiology,we found that among immigrants to Israel,the prevalence of IBD increased with longer time since immigration,and was related to the risk of IBD in the country of *** UC rate was higher than that of CD only in those immigrating in earlier time periods.

关键词： Epidemiology Inflammatory bowel disease Immigration Environment

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Pattern of respiratory-induced changes in fingertip blood volume measured by light transmission

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Journal of Biomedical Science and Engineering 2011年第8期4卷 529-534页

作者： Meir Nitzan Daniel Dayan eran Shalom Yuval Slovik Alan Murray 不详

Respiratory-induced fluctuations in heart rate and arterial blood pressure have been intensively investigated, but there is little information on the effect of respiration on peripheral blood volume. In the current study, blood volume changes in the finger, obtained by light transmission measurements, were measured during regular breathing (6 s periods) and long breathing (12 s periods). Respiratory chest-circumference changes were simultaneously measured in order to associate the pattern of tissue blood volume change with the respiratory cycle. Sixteen subjects were studied, and in fourteen finger blood vol ume increased during inspiration and decreased during expiration in the long-breathing periods. In all 14 subjects the start of blood volume decrease was significantly delayed from the start of expiration by mean ± SD 1.00 ± 0.65 s (p < 0.001, range 0 - 2.3 s). The start of blood volume increase was significantly delayed from the end of expiration by 3.45 ± 1.76 s (p < 0.005). In eight, finger blood volume started to increase more than 2 s before the start of inspiration. For the 6 s breathing period, blood volume decreased during inspiration in five examinations, and increased in seven. The increase in peripheral blood volume during inspiration could be attributed to the higher abdominal pressure during inspiration, and to the decrease in sympathetic activity during inspiration and the subsequent vasodilatation. The decrease in peripheral blood volume during inspiration is probably due to the negative thoracic pressure during inspiration and its mechanical effect on thoracic vessels.

关键词： Light Absorption Deep Breathing Sympathetic Nervous system Tissue Blood Volume

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Multi-parametric MRI of the prostate:Factors predicting extracapsular extension at the time of radical prostatectomy

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Asian Journal of Urology 2017年第1期4卷 31-36页

作者： Geoffrey S.Gaunay Vinay Patel Paras Shah Daniel Moreira Ardeshir R.Rastinehad eran Ben-Levi Robert Villani Manish A.Vira The Smith Institute for Urology Hofstra Northwell School of MedicineNew Hyde ParkNYUSA Department of Urology Mayo ClinicRochesterMNUSA Department of Urology Icahn School of Medicine at Mount SinaiNew YorkNYUSA Department of Radiology Hofstra Northwell School of MedicineNew Hyde ParkNYUSA

Objective:Extracapsular extension(ECE)of prostate cancer is a poor prognostic factor associated with progression,recurrence after treatment,and increased prostate cancer-related *** staging prior to radical prostatectomy is crucial in avoidance of positive margins and when planning nerve-sparing ***-parametric magnetic resonance imaging(mpMRI)of the prostate has shown promise in this regard,but is hampered by poor *** sought to identify additional clinical variables associated with pathologic ECE and determine our institutional accuracy in the detection of ECE amongst patients who went on to radical ***:mpMRI studies performed between the years 2012 and 2014 were cross-referenced with radical prostatectomy *** properties of ECE as well as additional clinical and biochemical variables to identify pathology-proven prostate cancer ECE were ***:The prevalence of ECE was 32.4%,and the overall accuracy of mpMRI for ECE was 84.1%.Overall mpMRI sensitivity,specificity,positive predictive value,and negative predictive value for detection of ECE were 58.3%,97.8%,93.3%,and 81.5%,*** mpMRI characteristics predictive of pathologic ECE included primary lesion size((20.73±9.09)mm,mean±SD,p<0.001),T2 PIRADS score(p=0.009),overall primary lesion score(p<0.001),overall study suspicion score(p=0.003),and MRI evidence of seminal vesicle invasion(SVI)(p=0.001).

关键词： Prostate cancer Magnetic resonance imaging Staging Prostatectomy Extracapsular extension

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DSP的独特价值及陷阱

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电子设计应用 2009年第5期7卷 27-29页

作者： eran Briman CEVA公司

本文涵盖了关于DSP的各种问题,包括DSP如何定义、为何需要DSP、如何实现DSP功能等,并介绍了一些认知上的陷阱。

关键词： DSP MCU SoC

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MVME2100掀起以单片计算机为代表的工业趋势

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电子产品世界 2000年第2期7卷 64-65页

作者： eran Strod Motorola公司

VMEbus历史回顾纵观历史发展的进程,人们可以很好地理解计算机向VMEbus单片计算机(Single Chip Computer)演变的原因.七十年代后期,工程师们便提议应开发出一种基于VERSAbus和Eurocard标准的板级产品.几年以后,这种提议就促成了VMEBus标... 详细信息

VMEbus历史回顾纵观历史发展的进程,人们可以很好地理解计算机向VMEbus单片计算机(Single Chip Computer)演变的原因.七十年代后期,工程师们便提议应开发出一种基于VERSAbus和Eurocard标准的板级产品.几年以后,这种提议就促成了VMEBus标准,并在1981年10月慕尼黑举行的System 81年会上公布.最初展示的三种样板向业界提出了VERSAbus Eurocard设计的概念,这三种样板是68000 CPU板、动态内存板和静态内存板.

关键词：单片机微机 MVME2100

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