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Clinical, cellular, microscopic, and ultrastructural studies of a case of fibrogenesis imperfecta ossium

Bone Research 2017年第2期5卷 123-136页

作者： Melissa L barron Mark S Rybchyn Sutharshani Ramesh Rebecca S Mason S Fiona Bonar Paul Stalley Sundeep Khosla Bernie Hudson Christopher Arthur Edward Kim Roderick j Clifton-Bligh Phillip B Clifton-Bligh Department of Physiology School of Medical Sciences Bosch Institute University of Sydney Sydney 2006 New South Wales Australia Douglas HanlyMoir Pathology Macquarie Park 2113 New South Wales Australia Department of Orthopaedics Royal Prince Alfred HospitalCamperdown 2050 New South Wales Australia Department of Endocrinology Mayo Clinic Rochester 55905 MN USA Department of Microbiology Royal North Shore Hospital St Leonards 2065 New South Wales Australia Department ofMicrobiology Royal North Shore Hospital St Leonards 2065 New South Wales Australia Department of Haematology Royal North Shore Hospital St Leonards 2065 New South Wales Australia Department of Endocrinology Royal North Shore Hospital St Leonards 2065 New SouthWales Australia and Faculty of Medicine University of Sydney Sydney 2006 New South Wales Australia

Fibrogenesis imperfecta ossium is a rare disorder of bone usually characterized by marked osteopenia and associated with variable osteoporosis and osteosclerosis, changing over time. Histological examination shows that newly formed collagen is abnormal, lacking birefringence when examined by polarized light. The case presented demonstrates these features and, in addition, a previously undocumented finding of a persistent marked reduction of the serum C3 and C4. Osteoblasts established in culture from a bone biopsy showed abnormal morphology on electron microscopy and increased proliferation when cultured with benzoylbenzoyl-ATP and 1,25-dihydroxyvitamin D, contrasting with findings in normal osteoblasts in culture. A gene microarray study showed marked upregulation of the messenger RNA(mRNA) for G-protein-coupled receptor 128(GPR 128), an orphan receptor of unknown function and also of osteoprotegerin in the patient's osteoblasts in culture. When normal osteoblasts were cultured with the patient's serum, there was marked upregulation of the mRNA for aquaporin 1. A single pathogenetic factor to account for the features of this disorder has not been defined, but the unique findings described here may facilitate more definitive investigation of the abnormal bone cell function.

关键词： ultrastructural cellular Clinical

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Numerical Simulation of a Batch-Type Reheating Furnace

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World journal of Engineering and Technology 2018年第4期6卷 713-722页

作者： Francisco j. Nava Miguel A. barron Dulce Y. Medina Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

A numerical analysis of a batch-type reheating furnace with and without thermal load was carried out using the Computational Fluid Dynamics technique. The furnace has two premixed burners and methane is used as fuel. Previous to the numerical experiments, a mesh convergence test was carried out and the average internal furnace temperature and the exhaust gases temperature were monitored as function of the number of cells in the discretized system. The influence of the Air/Fuel ratio, the position of the burners, and the thermal load on the average internal temperature, the exhaust gases temperature, and the molar fraction of methane and oxygen in the exhaust gases was numerically explored.

关键词： Air/Fuel Ratio CFD Simulation Exhaust Gas Numerical Simulation Premixed Burner Reheating Furnace Thermal Load

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Designing healthy communities： A walkability analysis of LEED-ND

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Frontiers of Architectural Research 2016年第4期5卷 433-452页

作者： Adriana A. Zuniga-Teran barron j. Orr Randy H. Gimblett Nader V. Chalfoun Scott B. Going David P. Guertin Stuart E. Marsh Udall Center for Studies in Public Policy University of Arizona Tucson AZ 85719 USA

Prevailing city design in many countries has created sedentary societies that depend on automobile use. Consequently, architects, urban designers, and land planners have developed new urban design theories, which have been incorporated into the Leadership in Energy and Environmental Design for Neighborhood Development （LEED-ND） certification system. The LEED- ND includes design elements that improve human well-being by facilitating walking and biking, a concept known as walkability. Despite these positive developments, relevant research findings from other fields of study have not been fully integrated into the LEED-ND. According to Zuniga-Teran （2015）, relevant walkability research findings from multiple disciplines were organized into a walkability framework （WF） that organizes design elements related to physical activity into nine categories, namely, connectivity, land use, density, traffic safety, surveil- lance, parking, experience, greenspace, and community. In this study, we analyze walkability in the LEED-ND through the lens of the nine WF categories. Through quantitative and qualitative analyses, we identify gaps and strengths in the LEED-ND and propose potential enhancements to this certification system that reflects what is known about enhancing walkability more comprehensively through neighborhood design analysis. This work seeks to facilitate the translation of research into practice, which can ultimately lead to more active and healthier societies.

关键词： Watkabitity LEED-ND Physical activity Urban design Well-being Built environment

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Designing healthy communities： Testing the walkability model

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Frontiers of Architectural Research 2017年第1期6卷 63-73页

作者： Adriana A. Zuniga-Teran barron j. Orr Randy H. Gimblett Nader V. Chalfoun Stuart E. Marsh David P. Guertin Scott B. Going Udall Center for Studies in Public Policy University of Arizona Tucson AZ 85719 USA

Research from multiple domains has provided insights into how neighborhood design can be improved to have a more favorable effect on physical activity, a concept known as walkability. The relevant research findings/hypotheses have been integrated into a Walkability Framework, which organizes the design elements into nine walkability categories. The purpose of this study was to test whether this conceptual framework can be used as a model to measure the interactions between the built environment and physical activity. We explored correlations between the walkability categories and physical activity reported through a survey of residents of Tucson, Arizona （n=486）. The results include significant correlations between the walkability categories and physical activity as well as between the walkabi[ity categories and the two motivations for walking （recreation and transportation）. To our knowledge, this is the first study that reports links between wa[kability and walking for recreation. Additionally, the use of the Walkability Framework allowed us to identify the walkability categories most strongly correlated with the two motivations for walking. The results of this study support the use of the Walkability Framework as a model to measure the built environment in relation to its ability to promote physical activity.

关键词： Watkability Physical activity Buitt environment LEED-ND Neighborhood design

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Electrocardiographic interference and conductance volume measurements

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journal of Biomedical Science and Engineering 2009年第7期2卷 491-498页

作者： Simon P. McGuirk Dan Ewert David j. barron john H. Coote 不详

The conductance catheter technique enables continuous ventricular volume measurements based on the electrical conductance of blood within the ventricular cavity. However, ventricular excitation also produces a measurable electrical signal within the ventricular cavity. This study was undertaken to investigate the relationship between the ventricular electrogram and conductance volume measurements in a physical model of the left ventricle without parallel conductance. The ventricular electrogram was simulated with an ECG signal, ECGinput connected to two ring electrodes within the model ventricle. Conductance volume measurements were made with and without ECGinput. The difference between these measurements, GECG(t), represented the conductance volume due to ECGinput. GECG(t) varied as a function of the first-derivative of ECGinput with respect to time (r2=0.92, Perror varied widely between –12% and +9%. As a re-sult, end-diastole could not be reliably identified on the pressure-volume loop. The accuracy of conduc-tance volume measurements during late diastole and early isovolumic contraction are substantially affected by the ventricular electrogram. This may result in a significant error in end-diastolic volume estimates, which has important implications for the quantitative assessment of ventricular function including, in particular, the assessment of chamber compliance.

关键词： Volume Measurement Conductance Catheter Electrocardiogram Ventricular Electrogram

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作者： j.·巴伦(j. barron)

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作者： j.·巴伦(j. barron)

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克格勃的秘密

克格勃的秘密

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作者： j.·巴伦(j. barron)原

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Endocrine correlates of mate choice and promiscuity in females of a socially monogamous avian mating system with alternative male reproductive phenotypes

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Current Zoology 2014年第6期60卷 804-815页

作者： Hubert SCHWABL Willow R. LINDSAY Douglas G. barron Michael S. WEBSTer School of Biological Sciences and Center for Reproductive Biology Washington State University Pullman WA 99164-4236 USA Department of Department of Biological and Environmental Sciences Goteborg University Box 463405 30 Goteborg Sweden Department of Psychology University of South Florida Tampa FL 33620-7200 USA Department of Neurobiology and Behavior and Comell Laboratory for Ornithology Comell University Ithaca NY 14850 USA

While our understanding of male reproductive strategies is informed by extensive investigations into endocrine mechanisms, the proximate mechanisms by which females compete for mates and adjust reproduction to social environment remains enigmatic. We set out to uncover endocrine correlates of mate choice, social environment, and reproductive investment in female red-backed fairy-wrens Malurus melanocephalus. In this socially monogamous, yet highly sexually promiscuous species, females experience discrete variation in the phenotype of their mates, which vary in both plumage signals and level of paternal care, and in the composition of their breeding groups, which consist of either the pair alone or with an additional cooperative auxiliary; fe- male investment varies according to these social parameters. We found that androgen, estrogen, and glucorticoid levels varied with reproductive stage, with highest androgen and estrogen concentrations during nest construction and highest corticosterone concentrations during the pre-breeding stage. These stage-dependent patterns did not vary with male phenotype or auxiliary presence, though androgen levels during pre-breeding mate selection were lower in females obtaining red/black mates than those obtaining brown mates. We found no evidence that androgen, estrogen, or corticosterone levels during the fertile period were re- lated to extra-pair young （EPY） frequency. This study demonstrates clear changes in steroid levels with reproductive stage, though it found little support for variation with social environment. We suggest hormonal responsiveness to social factors may be physiologically constrained in ways that are bypassed through exogenous hormone manipulations.

关键词： Androgen Estrogen Glucocorticoid Mate choice Promiscuity Alternative phenotypes

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克格勃苏联秘密警察全貌 1版

克格勃苏联秘密警察全貌

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1985年

作者：（美）巴伦（barron j.）沈思清译

KGBTHESECRETWORKOFSOVIETSECRETAGENTSBYjOHNbarronREADer'***1974书中较为详细地介绍了苏联特务机关“国家安全委员会”即克格勃的历史改革、组织机构和任务作用，具体描述了它的某些重要活动，对于了解苏联领导集团对内实行控制、在... 详细信息

ISBN: (纸本)3090·742

KGBTHESECRETWORKOFSOVIETSECRETAGENTSBYjOHNbarronREADer'***1974书中较为详细地介绍了苏联特务机关“国家安全委员会”即克格勃的历史改革、组织机构和任务作用，具体描述了它的某些重要活动，对于了解苏联领导集团对内实行控制、在国外窃取情报和资产阶级的所谓自由，攻击无产阶级革命导师列宁，并严重歪曲了列宁、斯大林的论述。这些充分暴露了作者的资产阶级立场。原书由美国《读者文摘》社1974年出版。原书正文后所附“在海外从事秘密活动的苏联公民”、“材料来源、事例索引”、“参考书目”以及“谢辞”略去。

关键词：政治、法律各国政治欧洲政治

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