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炎症指标联合阴道分泌物预测宫颈环扎术后自发性早产的价值

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中国现代医生 2024年第7期62卷 5-8页

作者：史春波陈金亮陈安儿宁波市妇女儿童医院妇产科浙江宁波315010

目的探讨血清炎症指标联合阴道分泌物检查对宫颈环扎术后自发性早产(spontaneous premature birth,SPB)的预测价值。方法选取2018年1月至2022年12月于宁波市妇女儿童医院行孕期经阴道宫颈环扎的孕妇175例,根据其妊娠结局将其分为研究组(... 详细信息

目的探讨血清炎症指标联合阴道分泌物检查对宫颈环扎术后自发性早产(spontaneous premature birth,SPB)的预测价值。方法选取2018年1月至2022年12月于宁波市妇女儿童医院行孕期经阴道宫颈环扎的孕妇175例,根据其妊娠结局将其分为研究组(SPB,93例)和对照组(足月产,82例);比较两组孕妇的术后血常规、c反应蛋白(c-reaction protein,cRP)及阴道分泌物检查结果。采用多因素Logistic回归分析宫颈环扎术后SPB的独立危险因素,受试者操作特征曲线(receiver operating characteristic curve,ROc曲线)研究各指标单独或联合识别SPB的能力。结果研究组孕妇宫颈环扎术后的白细胞计数、cRP、支原体阳性率和细菌阳性率均显著高于对照组(Pc回归分析结果显示,宫颈环扎术后白细胞计数升高、cRP升高、阴道分泌物支原体培养阳性和细菌培养阳性均是SPB的独立危险因素(Pc曲线结果显示,上述指标单独及联合预测宫颈环扎术后SPB的曲线下面积分别为0.674、0.737、0.599、0.613、0.826,以四项指标联合的预测价值最大,敏感度79.6%,特异性79.3%。结论宫颈环扎术后白细胞计数、cRP检测联合阴道分泌物支原体、细菌培养对SPB有较好的预测价值。

关键词：宫颈环扎自发性早产预测价值

维普期刊数据库博看期刊

Formation and Structure of [Al_(13)(μ_3-OH)_6(μ_2-OH)_6(μ_2-OH)_(12)(H_2O)_(24)]cl_(15)·13H_2O

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chinese Journal of Structural chemistry 2006年第10期25卷 1217-1227页

作者： SUN Zhong ZHAO Hai-Dong TONG Hong-Ge-er WANG Rui-Fen ZHU Fan-Zhu college of chemistry and chemical Engineering Inner Mongolia University Hohhot 010021 China chemistry Department Yanbei Normal College Datong 037009 China Survey and Design Institute of Water Resources and Hydropower Inner Mongolia Autonomous Region Hohhot 010020 China

crystal structure of a novel hydrated tridecamer.c polyaluminium chloride, [Al13（μ3-OH）6（μ2-OH）6（μ2-OH）12（H2O）24] cl15·13H2O, has been determined by X-ray structure analysis, obtaining the detailed structural parameters and structure features. Moreover, the formation course was also discussed. The crystal belongs to monoclinic system, space group P21/c, with a = 1.3912（2）, b = 2.3529（3）, c = 2.2395（2） nm, β= 90.407（2）°, V = 7.3307（14） nm^3, Z = 4, Dc = 1.773 g/cm^3, F（000） = 4040, GOOF = 1.050,μ（MoKα）= 0.829 mm^-1, the final R = 0.0506 and wR = 0.1453 for 10553 observed reflections with I〉 2σ（I）. The structure of polycation of the title compound is different from either Keggin-type Al13 consisting of a central tetrahedral AlO4 core surrounded by twelve octahedral AlO6 units through corner-sharing or the ＂three hexamer.c rings juxtaposed＂ side by side predicted by ＂core-Links＂ model linked by thirteen octahedral AlO6 units through edge-sharing. It has a ＂tortoise-like＂ structure with turnup ＂forefeet＂ and ＂tail＂, that is, an octahedral AlO6 core is surrounded by a ＂hexamer.c ring＂ through edge-sharing, then six octahedral AlO6 units are suspended onto the periphery of the ring upper and lower alternately by sharing two neighboring corners with an average turn angle of 21° entad. This kind of hydrated tridecamer.c polyaluminium chloride with such form is very important to further understand the existing forms and transformation rules of aluminium ion in hydrolysis system of its salts, speculate the process and mechanism of various hydrolysis and polymerization forms from Al（H2O）6^3＋ to Al（OH）3, and establish the relationship between structure and properties.

关键词： hydrated tridecamer.c polyaluminium chloride crystal structure formation

Rhodium-catalyzed Asymmetric Ring Opening Reaction of Oxabenzo-norbornadiene with Substituted Phenolic Nucleophiles

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chinese chemical Letters 2006年第3期17卷 296-298页

作者： Ying Feng HAN Ding Qiao YANG er.chang LIU Jian Xia DONG college of chemistry and Environment South China Normal University Guangzhou 510006

We have developed an asymmetric ring opening reaction of oxabenzonorbornadienes with substituted phenolic nucleophiles. Under the reaction conditions （ [Rh（cOD）c1]2 （1 mol%）, （S）-（R）-PPF-P^Bu2 （2 mol%）, THF... 详细信息

关键词： Asymmetric ring opening rhodium-catalyzed oxabenzonorbornadienes.

Structure-based design of novel heter.cyclesubstituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4906-4917页

作者： Li-Min Zhao christophe Pannecouque erik De clerc Shuai Wang Fen-er.chen Key Laboratory of Natural Resources of changbai Mountain&Functional Molecules Ministry of EducationYanbian University College of PharmacyYanbian UniversityYanji 133002China Engineering center of catalysis and Synthesis for chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering center of Industrial Asymmetric catalysis for chiral Drugs Shanghai 200433China Rega Institute for Medical Research KU LeuvenLeuven B-3000Belgium

Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66(SI=2019.80,S=1.9μg/mL),a series of novel heter.cycle-substituted ATDP derivatives with significantly improved selectivity and solubility were identified by replacement of the biphenyl moiety of ZLM-66 with heter.cyclic group with lower ***,the representative analog 7w in this series exhibited dramatically enhanced selectivity and solubility(SI=12,497.73,S=4472μg/mL)in comparison with ZLM-66(SI=2019.80,S=1.9μg/mL).This new NNRTI conferred low nanomolar inhibition of wild-type HIV-1 strain and tested mutant strains(K103N,L1001,Y181c,E138K,and K103N+Y181c).The analog also demonstrated favorable safety and pharmacokinetic profiles,as evidenced by its insensitivity to cYP and herG,lack of mortality and pathological damage,and good oral bioavailability in rats(F=27.1%).Further development of 7w for HIV therapy will be facilitated by this valuable information.

关键词： HIV-1 RT NNRTIS ATDP Pyridone

出院后持续健康宣教对癫痫患者服药依从性及自测健康评分的影响

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黑龙江医学 2024年第4期48卷 466-468页

作者：李婷婷刘斯尔李莎莎刘艳德阳市人民医院神经内科四川德阳618000

目的:探讨出院后持续健康宣教对癫痫患者服药依从性及自测健康评分(SRHMS)的影响。方法:选取2017年1月—2018年12月德阳市人民医院神经内科收治的140例癫痫患者作为研究对象,按出院时间顺序将2017年1—12月出院患者为对照组(70例,行常... 详细信息

目的:探讨出院后持续健康宣教对癫痫患者服药依从性及自测健康评分(SRHMS)的影响。方法:选取2017年1月—2018年12月德阳市人民医院神经内科收治的140例癫痫患者作为研究对象,按出院时间顺序将2017年1—12月出院患者为对照组(70例,行常规出院指导),2018年1—12月出院患者作为观察组(70例,实施出院后持续健康宣教干预)。比较两组患者的临床疗效、用药依从率及不同时间点自测健康评定量表(SRHMS)评分情况。结果:干预后,观察组患者总有效率显著高于对照组,差异有统计学意义(χ^(2)=25.940,P0.05);出院后1个月、6个月、12个月,观察组患者SRHMS评分明显高于对照组,差异有统计学意义(t=7.507、27.570、8.199,P<0.05)。结论:出院后持续健康宣教用于癫痫患者,可有效提高其病情控制效果,改善其服药依从性和健康状态。

关键词：出院健康宣教癫痫依从性自测健康评分

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra c.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves S.camarero-Espinosa M.B.Baker L.Moroni Department of complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal IcVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKerBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymer.c surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PcL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PcL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PcL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMScs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density click chemistry Human

南阳古陶瓷发展及现状研究——基于周边博物馆与古窑址的考察

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中国陶瓷 2024年第9期60卷 62-69页

作者：丁二宝刘楠楠杨孟丽刘晓明杨静孙晓岗河南省中原古陶瓷研究重点实验室平顶山467000

以分析南阳古陶瓷发展与研究现状为目的,对南阳邓窑遗址古瓷片及附近制瓷原料进行采集,探究邓窑陶瓷器呈色与原料特征;对南阳博物馆与淅川博物馆陶瓷器分布地点进行统计分析,探究南阳古陶瓷发展与传播路径。结果表明:汉以前,陶器生产地... 详细信息

以分析南阳古陶瓷发展与研究现状为目的,对南阳邓窑遗址古瓷片及附近制瓷原料进行采集,探究邓窑陶瓷器呈色与原料特征;对南阳博物馆与淅川博物馆陶瓷器分布地点进行统计分析,探究南阳古陶瓷发展与传播路径。结果表明:汉以前,陶器生产地区主要以淅川为主,其他地区为辅,陶器类型由多元化特征向一元化特征变化;唐之后,陶瓷器制作主要以内乡邓窑为主,南召窑等其他窑口为辅,陶瓷器质量参差不齐,但种类丰富;采集的青釉瓷片a*值在4.85至-5.82间波动,b*值基本大于0,整体釉色偏黄;A、B、D类原料均属于低温熔剂类原料,其中D类原料可单独制备黑釉;c类原料富铁,可配合A、B类原料烧制青瓷;邓窑瓷器的运输路线主要有三条,分别为内乡汤堰河至丹江运输线、内乡汤堰河至刁河运输线、内乡至南召关路古道运输至鲁山、许昌及开封等运输线。

关键词：南阳古陶瓷邓窑陶瓷淅川古陶瓷运输路线

Transcriptome response of wheat Norin 10 to long-term elevated cO_2 under high yield field condition

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Journal of Integrative Agriculture 2016年第9期15卷 2142-2152页

作者： LIN Yue-bing SHEN cheng-guo LIN er-da HAO Xing-yu HAN Xue Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences/Key Laboratory of Agricultural Environment Ministry of Agriculture Bioinformatics Unit Source Bio Science college of Agronomy Shanxi Agricultural University

The increasing atmospher.c carbon dioxide concentration, caused by fossil fuel combustion and deforestation, plays an important role in plant growth and development. Wheat, as a major staple crop, adapts to climate change by tuning its inherent molecular mechanism, which is not well understood. The present study employed the RNA-Seq method to generate transcriptome profiles of the wheat Norin 10 in response to elevated cO_2 in comparison with ambient cO_2. The 10 895 787 high-quality clean reads of Norin 10 were assembled de novo using Trinity（without a reference genome） resulting in a total of 18 206 candidate transcripts with significant BLAST matches. GO enrichment analysis of Norin 10 at different cO_2 concentrations showed that some functional genes related to plastids, precursor metabolites, and energy, thylakoid and photosynthesis were apparently enriched at elevated cO_2（550 μmol mol^–1） in contrast to that at ambient cO_2（400 μmol mol^–1）; these findings were further.confirmed by RT-PcR analysis. The findings demonstrated the specific effects of elevated cO_2 during long-term period in free air cO_2 enrichment（FAcE） on transcriptome response of the high yielding wheat variety, Norin 10, which has a large spike.

关键词： Norin 10 transcriptome response wheat long term elevated carbon dioxide GO enrichment

Attenuation of Metal Bioavailability in Acidic Multi-Metal contaminated Soil Treated with Fly Ash and Steel Slag

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Pedosphere 2012年第4期22卷 544-553页

作者： QIU Hao GU Hai-Hong HE er-Kai WANG Shi-Zhong QIU Rong-Liang School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275(China) Guangdong Provincial Key Lab of Environmental Pollution control and Remediation Technology Guangzhou 510275(China)

A pot experiment was conducted with multi-metal （Pb, cd, cu, and Zn） contaminated acidic soil to investigate changes in available metal burden resulting from the application of industrial wastes （fly ash and steel slag）. The efficiency of amendments- induced metal stabilization was evaluated by diffusive gradients in thin films （DGT）, sequential extraction, and plant uptake. The stability of remediation was assessed by an acidification test and by chemical equilibrium modeling. Addition of fly ash （20 g kg-1） and steel slag （3 g kg-1） resulted in similar increase in soil pH. Both amendments significantly decreased the concentrations of metals measured with DGT （cDGT） and the metal uptake by Oryza sativa L. Significant correlations were found between cDGT and the concentration of a combination of metal fractions （exchangeable, bound to carbonates, and bound to Fe/Mn oxides）, unraveling the labile species that participate in the flux of metal resupply. The capability of metal resupply, as reflected by the R （ratio of cDGT to pore water metal concentration） values, significantly decreased in the amended soils. The cDGT correlated well with the plant uptake, suggesting that DGT is a good indicator for bioavailability. Acidification raised the extractable metal concentration in amended soil but the concentration did not return to the pre-amendment level. Equilibrium modeling indicated that the soil amendments induced the precipitation of several Fe, A1 and ca minerals, which may play a positive role in metal stabilization. chemical stabilization with alkaline amendments could be an effective and stable soil remediation strategy for attenuating metal bioavailability and reducing plant metal uptake.

关键词： acidification chemical stabilization diffusive gradients in thin films (DGT) heavy metal remediation