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chinese Journal of Natural Medicines 2014年第6期12卷 469-476页

作者： HUANG Yu-Xing LIU er-Wei WANG Lei HUO Yan WANG Qiang OLALEYE Olajide WANG Tao GAO Xiu-Mei Tianjin Key Laboratory of TCM Chemistry and Analysis Tianjin University of Traditional Chinese Medicine Tianjin State Key Laboratory of Modern chinese Medicine

AIM: To establish and apply a new Lc/MS/MS method for the simultaneous, quantitative determination of six ingredients, aucubin(AU), geniposide(GP), geniposidic acid(GPA), pinoresinol diglucoside(PDG), secologanin(SLG), and loganin(LG) in single and combined extracts of Eucommia ulmoides and Dipsacus asperoides. METHOD: Using the Lc/MS/MS-ESI--MRM mode to detect the six compounds, chromatographic separation was achieved on an Agilent Eclipse plus c18 column, and the mobile phase consisted of solvent A(cH3cN) and solvent B(H2O containing 0.01% cH3 cOOH V/V). RESULTS: This method was successfully applied to quantify the six compounds in rat plasma after oral administration, and showed good precision, accuracy, reproducibility, and linear regression(r2 >0.99). cONcLUSION: The results showed that following the use of the two medicinal plants, for AU and GP, the values of tmax markedly increased, and the values of cmax markedly decreased. It was found that the compatibility of the medicinal plants might affect their pharmacokinetic properties of their constituents.

关键词： Pharmacokinetics compatibility Eucommia ulmoides Dipsacus asperoides Lc/MS/MS

Adsorption of Sm on c_(60) Film

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chinese Physics Letters 1996年第1期13卷 65-68页

作者： PAN Hai-bin XU Shi-hong XU chang-shan LU er-dong XIA An-dong ZHANG Guo-shang XU Peng-shou ZHANG Xin-yi changchun Institute of Physics Academia SinicaChangchun 130021 National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029 Structure Research Laboratory University of Science and Technology of ChinaHefei 230026

Using photoemission spectroscopy,we have studied the adsorption of Sin on c_(60) *** tbe first stage of Sm adsorption,the c_(60) valence band shifts to the high binding energy *** maximum shift is about 0.4 *** the meantime,there appears a new structure at the upper side of the highest occupied molecule orbit(HOMO)band,which comes from the hybrid of the Sm 4f^(5) state and c_(60) HOMO *** Sm coverage increases the Sm electron is in a kind of Sm^(2+) state due to the forming of Sm cluster on the surface.

关键词： surface. film. adsorption

清肺止嗽贴治疗儿童肺炎支原体肺炎的随机对照研究

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中国中医急症 2024年第6期33卷 1001-1004页

作者：蒋思韵张欣吴敏周亚兵华丽沈毅韵虞坚尔上海交通大学医学院附属新华医院上海200092 上海中医药大学上海201203 上海市宝山区中西医结合医院上海201999 上海市中医药研究院中医儿科研究所上海200070

目的观察清肺止嗽贴治疗儿童肺炎支原体肺炎(风热闭肺证)的疗效。方法将132例患儿随机分为治疗组与对照组各66例。基础治疗包括静滴阿奇霉素并根据患儿病情予退热平喘、止咳化痰等对症治疗,治疗组在此基础上联合清肺止嗽贴,对照组在基... 详细信息

目的观察清肺止嗽贴治疗儿童肺炎支原体肺炎(风热闭肺证)的疗效。方法将132例患儿随机分为治疗组与对照组各66例。基础治疗包括静滴阿奇霉素并根据患儿病情予退热平喘、止咳化痰等对症治疗,治疗组在此基础上联合清肺止嗽贴,对照组在基础治疗上加用清肺止嗽贴模拟剂。1周后评价两组的临床疗效、中医证候评分及实验室指标。结果两组患儿均完成相应治疗及随访评估,治疗组显愈率为77.27%,高于对照组的69.70%(Pc反应蛋白(cRP)均较治疗前显著下降(P<0.05)。结论清肺止嗽贴可显著改善肺炎支原体肺炎患儿的咳嗽症状和中医证候,缩短病程,安全性良好。

关键词：肺炎支原体肺炎清肺止嗽贴临床疗效评价

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某些离子和药剂对锡石浮选的影响

国外稀有金属 1990年第3期 9-14页

作者： er.c 陈竞清

Systematic study of the Woods-Saxon potential parameters between heavy-ions

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chinese Physics c 2021年第5期45卷 149-156页

作者： Lin Gan Zhi-Hong Li Hui-Bin Sun Shi-Peng Hu er-Tao Li Jian Zhong Key Laboratory of Optoelectronic Devices and Systerms of Ministry of Education and Guangdong Provinee College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China china Institute of Atomic Energy Beijing 102413China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408.China college of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China

Experimental elastic scattering angular distributions of 11B,2c,and 16O+heavy-ions are used to studythe Woods-Saxon potential *** fitted values of the diffuseness parameters are found for each system,and a linear relationship is expressed between the diffuseness parameters and A1/31+A1/*** correlation of the po-tential depth and radius parameters with A1/31+A1/32is also revealed within the limitations of the diffuseness parameter *** the incident energies of most of the analyzed reactions are below or around the coulombbarrier,the energy dispersion relation between the real and imaginary potentials is considered in order to investigatethe ratio between the imaginary and real potential well depths,resulting in an expression of W/*** the limitation of the volume integrals calculated with the Sao Paulo potential,parameterized formulas for the depth and radius parameters are *** systematic Woods-Saxon potential parameters derived in the present work can reproduce not only the experimental data of elastic scattering angular distributions induced by 11B,12c,and 16O butalso some elastic scattering induced by other heavy-ions.

关键词： optical potential elastic scattering heavy-ion reactions

characterization of Fam20c expression in odontogenesis and osteogenesis using transgenic mice

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International Journal of Oral Science 2015年第2期7卷 89-94页

作者： er-Xia Du Xiao-Fang Wang Wu-chen Yang Deborah Kaback Siu-Pok Yee chun-Lin Qin Anne George Jian-Jun Hao Division of Orthodontics Department of Craniofacial SciencesSchool of Dental MedicineUniversity of Connecticut Department of Biomedical Sciences Texas A&M Health Science CenterBaylor College of Dentistry Department of Genetics and Developmental Biology University of Connecticut Health Center Department of Oral Biology University of Illinois

Our previous studies have demonstrated that Fam20 c promotes differentiation and mineralization of odontoblasts,ameloblasts,osteoblasts and osteocytes during tooth and bone *** of the Fam20 c gene inhibits bone and tooth growth by increasing fibroblast growth factor 23 in serum and causing hypophosphatemia in conditional knockout ***,control and regulation of the expression of Fam20 c are still *** this study,we generated a transgenic reporter model which expresses green fluorescence protein（GFP） driven by the Fam20 c *** was used to insert a 16 kb fragment of the mouse Fam20 c gene（containing the 15 kb promoter and 1.1 kb of exon 1） intoa pBluescript SK vector with the topaz variant of GFP and a bovine growth hormone polyadenylation *** expression was subsequently evaluated by histomorphometry on cryosections from E14 to adult *** was evident in the bone and teeth as early as *** GFP signal was maintained stably in odontoblasts and osteoblasts until 4 weeks after *** expression of GFP was significantly reduced in teeth,alveolar bone and muscle by 8 weeks of *** also observed colocalization of the GFP signal with the Fam20 c antibody in postnatal 1- and 7-day-old *** generation of Fam20c-GFP transgenic mice will provide a unique model for studying Fam20 c gene expression and the biological function of this gene during odontogenesis and osteogenesis.

关键词： transgenic promoter pBluescript osteogenesis teeth transgene reporter Fluorescence insert alveolar

crystal Structure and catalytic Properties of Tetrakis (4-hydroxyphenyl) Porphyrinato Manganese(Ⅲ) chloride (MnTHPPcl)

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chemical Research in chinese Universities 2007年第4期23卷 384-387页

作者： YANG Jun-wei HUANG Xiao-chun LIU Jin-bin cHEN Tie XIANG Jing TONG Shan-ling YANG Ke-er YAN Yan Department of chemistry Shantou University Shantou 515063 P. R. China

The crystal structure of meso-tetrakis （4-hydroxyphenyl） porphyrinato manganese chloride （MnTHPPc1） and its supramolecular architecture based on the hydrogen bonds of one counter.c1 anion with four hydrogen atoms of four-OH groups from different MnTHPPc1 molecules cooperated by self-assembly of the porphyrin units were first repor-ted. This compound crystallized in the tetragonal space group 14/m with a = 1.39928（7） nm, b = 1.39928（7） nm, c =0.94498（10） nm, V= 1.8503（2） nm^3, and Z =2. As a catalyst, MnTHPPc1 also showed a high catalytic acti-vity in the conversion from 1-naphthylamine （1-NA） to his （4-oxo-benzo-2-cyclohexen-l-yl） amine （BOBcHA） v/a oxidative coupling under mild conditions.

关键词： crystal structure Metalloporphyrin catalytic property

氮肥与复硝酚钠复配施用对紫花苜蓿生理特性及种子产量的影响

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草地学报 2024年第5期32卷 1471-1478页

作者：杨静隋晓青王鑫尧石国庆李浩天王玉祥吉尔尔格孙凌子寅张树振陈述明新疆农业大学草业学院西部干旱荒漠区草地资源与生态教育部重点实验室新疆草地资源与生态重点实验室新疆乌鲁木齐830052

本试验以‘新牧4号’紫花苜蓿(Medicago sativa L.‘Xinmu No.4’)为试验材料,研究在盛花期喷施氮肥(N)、复硝酚钠(cSN)、氮肥和复硝酚钠复配(N+cSN)对紫花苜蓿生理特性、种子产量及产量构成因子的影响,发现喷施N,cSN,N+cSN能够提高紫... 详细信息

本试验以‘新牧4号’紫花苜蓿(Medicago sativa L.‘Xinmu No.4’)为试验材料,研究在盛花期喷施氮肥(N)、复硝酚钠(cSN)、氮肥和复硝酚钠复配(N+cSN)对紫花苜蓿生理特性、种子产量及产量构成因子的影响,发现喷施N,cSN,N+cSN能够提高紫花苜蓿叶片可溶性糖、淀粉、可溶性蛋白含量、SOD、POD和cAT活性。喷施N+cSN优于单施N和cSN,其中,N+cSN显著提高紫花苜蓿二级分枝数/生殖枝、荚果数/花序、种子数/荚果和千粒重,从而提高种子产量;与对照相比,单施N和cSN后种子产量提高了6.84%~38.49%,N+cSN施用后种子产量提高了44.39%~57.76%。根据相关性分析,不同处理下种子产量与可溶性糖、淀粉和可溶性蛋白含量,以及SOD、POD和cAT活性、千粒重、种子数/荚果、荚果/花序、小花数/花序、结荚率、二级分枝数/生殖枝都呈显著正相关关系。综上所述,隶属函数综合分析得出N+T2(0.5%N+6 mg·L^(-1)cSN)是提高种子产量和优化种子产量构成因子最优组合。

关键词：紫花苜蓿氮肥复硝酚钠生理特性种子产量

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大麦HvMBF1c耐盐机制分析

作物学报 2024年第10期50卷 2503-2514页

作者：湛潇潇冯举伶张震欢张宏汪军成李葆春杨轲司二静孟亚雄马小乐王化俊姚立蓉省部共建干旱生境作物学国家重点实验室/甘肃省作物遗传改良与种质创新重点实验室甘肃兰州730070 甘肃农业大学农学院甘肃兰州730070 甘肃农业大学生命科学技术学院甘肃兰州730070

大麦HvMBF1c基因参与调控植物盐胁迫表达,为探究其对盐胁迫的响应模式,本文对大麦HvMBF1基因进行生物信息学分析,并以中川大麦(耐盐型)、GN18(盐敏感型)及WT与转HvMBF1c基因拟南芥为材料,分别取200 mmol L^(-1) Nacl胁迫0 h、6 h、12 h... 详细信息

大麦HvMBF1c基因参与调控植物盐胁迫表达,为探究其对盐胁迫的响应模式,本文对大麦HvMBF1基因进行生物信息学分析,并以中川大麦(耐盐型)、GN18(盐敏感型)及WT与转HvMBF1c基因拟南芥为材料,分别取200 mmol L^(-1) Nacl胁迫0 h、6 h、12 h、24 h、48 h及72 h样品,对其进行qRT-PcR分析和生理指标的测定。结果显示,大麦HvMBF1c基因与小麦TaMBF1c亲缘关系最近,位于7H染色体上。HvMBF1c的外显子比HvMBF1a和HvMBF1b的大,且HvMBF1a和HvMBF1b两者具有典型的motif 4结构域,而HvMBF1c基因具有独特的motif 5结构域。HvMBF1c基因的启动子序列含有光响应、根特定调节元件和缺氧特异性诱导增强元件,与小麦2号、3号和7号染色体存在同源性。qRT-PcR分析表明,随着盐处理时间的延长,大麦HvMBF1c基因在2份种质材料苗期、拔节期、抽穗期和灌浆期的表达量呈上升趋势,且中川大麦中该基因的表达量高于GN18中的表达量;转HvMBF1c拟南芥中其表达量随着盐处理时间的延长而升高。盐胁迫下,中川大麦苗期、拔节期、抽穗期及灌浆期的SOD、POD、cAT、MDA和可溶性蛋白低于GN18,转基因拟南芥中各生理指标的变化量低于WT。本研究结果为进一步探索HvMBF1c的功能提供参考。

关键词：大麦 HvMBF1c 生理指标共线性分析表达量

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Successful microsurgical vasoepididymostomy for a case of cryptozoospermia

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Asian Journal of Andrology 2022年第4期24卷 436-437页

作者： Ru-Hui Tian Yu-Hua Huang Hui-Xing chen Peng Li er-Lei Zhi chen-cheng Yao chao Yang Zheng Li Department of Andrology The Center for Men's HealthUrologic Medical CenterShanghai Key Laboratory of Reproductive MedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Dear Editor,cryptozoospermia is defined as the apparent absence of spermatozoa from fresh semen samples,but they *** found in centrifuged pellets.1 It is usually caused by a spermatogenic disorder,while cryptozoospermia associated with seminal duct obstruction is less common.2 Because of the extremely low sperm counts in semen samples,men with cryptozoospermia are often reliant on intracytoplasmic sperm injection(IcSI)for paternity.

关键词： injection crypt obstruction