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基于改进CeiT的GTAW焊接熔透状态识别方法

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焊接学报 2024年第4期45卷 26-35,42,I0004,I0005页

作者：王颖高胜东北石油大学大庆163318

针对熔池信息与背景相似度高、噪声多、预测实时性差、识别精度低等问题,提出了基于改进CeiT网络模型的GTAW焊接熔透状态识别方法.首先通过MobileNetV3对Image-to-Tokens模块进行轻量化改进,提升预测的实时性能;其次设计DGCA模块改进LeF... 详细信息

针对熔池信息与背景相似度高、噪声多、预测实时性差、识别精度低等问题,提出了基于改进CeiT网络模型的GTAW焊接熔透状态识别方法.首先通过MobileNetV3对Image-to-Tokens模块进行轻量化改进,提升预测的实时性能;其次设计DGCA模块改进LeFF模块来增强特征间的远程依赖关系、丰富类标记中所包含的分类信息;最后将LeFF模块中的底层特征和高层语义特征进行融合,提高模型对熔池特征的表示能力.仿真结果表明,与MobileNetV3,ResNet50,ShuffleNetV2,DeiT和CeiT模型相比,所提出的模型获得了更高的准确率和较快的检测速度.

关键词：图像处理熔池熔透状态 CeiT网络熔化极气体保护焊

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不同特征未婚流动人口性相关行为的发生状况

生殖与避孕 2005年第12期25卷 738-744,F0003页

作者：楼超华沈燕高尔生涂晓雯上海市计划生育科学研究所上海200032

目的:了解流动人口中不同性别、年龄和职业的未婚青年性相关行为及其不良后果的发生比例及其影响因素。方法:采用结构式匿名问卷对上海市某区1 092名15-24周岁未婚流动人口的性与生殖健康知识、态度、行为和需求状况进行调查。结果:... 详细信息

目的:了解流动人口中不同性别、年龄和职业的未婚青年性相关行为及其不良后果的发生比例及其影响因素。方法:采用结构式匿名问卷对上海市某区1 092名15-24周岁未婚流动人口的性与生殖健康知识、态度、行为和需求状况进行调查。结果:有22．6％的对象自我报告有性经历(男:34．8％,女:12．7％)。分别有18．4％(男:26．3％,女:12．0％)和7．6％(男:11．8％,女:4．2％) 的对象已订婚和同居。有5．1％的对象报告有过商业性行为经历(男:7．9％,女:2．8％)。有2．8％的对象在过去的一年内有2个及以上的性伴(男:4．5％,女:1．5％)。9．4％的对象曾经怀孕或使其性伴怀孕(男:13．7％,女:6．0％)。过去一年内有过生殖道感染／性病的人数比例为11．5％(男:14．9％, 女:8．7％)。分性别的多因素分析结果表明,年龄大、看过色情录像及受同伴的影响和压力较大的男女对象发生婚前性行为的可能性较大。此外,问过父母性相关问题的男性及从事服务行业工作、外出打工时间较长和对婚前性行为持开放态度的女性发生婚前性行为的可能性较大。结论:未婚流动人口中婚前性行为较为普遍,尤其男性和服务行业女性的性相关行为的发生比例较高,他们面临着未婚妊娠、人工流产、生殖道感染／性病等生殖健康问题的危险。

关键词：流动人口未婚青年性相关行为不良结局发生比例

Delivering Microrobots in the Musculoskeletal System

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Nano-Micro Letters 2024年第11期16卷 585-617页

作者： Mumin Cao Renwang sheng Yimin Sun Ying Cao Hao Wang Ming Zhang Yunmeng Pu Yucheng gao Yuanwei Zhang Panpan Lu gaojun Teng Qianqian Wang Yunfeng Rui Department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuPeople’s Republic of China School of Medicine Southeast UniversityNanjing 210009People’s Republic of China Orthopaedic Trauma Institute(OTI) Southeast UniversityNanjing 210009People’s Republic of China Jiangsu Key Laboratory for Design and Manufacture of Micro‑Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing 210009People’s Republic of China Center of Interventional Radiology and Vascular Surgery Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009People’s Republic of China

Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited *** often suffer chronic pain and might eventually have to undergo end-stage ***,future treatments should focus on early detection and intervention of regional *** have been gradually used in organisms due to their advantages of intelligent,precise and minimally invasive targeted *** the combination of control and imaging systems,microrobots with good biosafety can be delivered to the desired area for *** the musculoskeletal system,microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the *** to traditional biomaterial and tissue engineering strategies,active motion improves the efficiency and penetration of local targeting of cells/*** review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal *** summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.

关键词： Microrobot Musculoskeletal system Targeted delivery Microrobotic systems Magnetic actuation

pH-controlled reversible sol-gel inversion by cerous phosphate nanofibers for hemostasis

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Rare Metals 2024年第10期43卷 5141-5151页

作者： Tuo Su Jun-Chen Xu Wei Yu Dan Su Di-er Shi Yi-Chao Pang Yao Ying Wang-Chang Li Juan Li Jing-Wu Zheng Liang Qiao sheng-Lei Che Jing Yu Research Center of Magnetic and Electronic Materials College of Materials Science and EngineeringZhejiang University of Technology State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang University Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province Department of Clinical MedicineHangzhou Medical College Department of Chemistry Zhejiang University Clinical Medical College Yangzhou University

Developing biomimetic soft materials that display stimuli responsiveness using solely inorganic materials has been regarded as a challenge owing to that such materials?properties typically vary from those of living ***,biomimetic soft materials have been developed using organic materials or inorganic materials modified with organic small *** this study,we prepared cerium phosphate nanofibers （CePO4NFs） by using inorganic agents only without further *** CePO4NFs demonstrate sol-ge switching properties in response to pH value,allowing them to form a gel under high hydroxide ion （OH-） concentrations and turn back into sol under low *** formation of gel could be ascribed to the physical cross-linking of the nanofibers induced by the attractive electrostatic force of OH-and surface Ce3+.As a result,CePO4NFs are able to form a gel when in contac with blood of high pH value for *** specific clotting mechanism makes them better candidates for hemostasis of heavy bleeding.

关键词： Cerium phosphate nanofibers Hemostasis pH-responsive Reversible Sol-gel switching

SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4164-4173页

作者： Kaixiang Zhu Lili Song Linyue Wang Lei Hua Ziyu Luo Tongyun Wang Bo Qin Shuofeng Yuan Xiaopan gao Wenyi Mi sheng Cui NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College) Ministry of EducationBeijing 100730China The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)Tianjin Medical University General HospitalDepartment of ImmunologyTianjin Medical UniversityTianjin 300070China Medical School Yan’an UniversityShaanxi ProvinceYan’an 716000China State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina Department of Microbiology Li Ka ShingFaculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina

Viruses often manipulate ubiquitination pathways to facilitate their replication and ***2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase,is bound by SARS-CoV-2 ORF10 to increase its E3 ligase activity,leading to degradation of IFT46,a protein component of the intraflagellar transport(IFT)complex *** results in dysfunctional cilia,which explains certain symptoms that are specific to ***,the precise molecular mechanism of how ORF10 recognizes CUL2ZYG11B remains ***,we determined the crystal structure of CUL2ZYG11B complexed with the N-terminal extension(NTE)of SARS-CoV-2 ORF10(2.9 A°).The structure reveals that the ORF10 N-terminal heptapeptide(NTH)mimics the Gly/N-degron to bind *** studies identified key residues within ORF10 that are key players in its interaction with CUL2ZYG11B both in ITC assay and in vivo *** addition,we prove that enhancement of CUL2ZYG11B activity for IFT46 degradation by which ORF10-mediated correlates with the binding affinity between ORF10 and ***,we used a Global Protein Stability system to show that the NTH of ORF10 mimics the Gly/N-degron motif,thereby binding competitively to CUL2ZYG11B and inhibiting the degradation of target substrates bearing the Gly/N-degron ***,this study sheds light on how SARS-CoV-2 ORF10 exploits the ubiquitination machinery for proteasomal degradation,and offers valuable insights for optimizing PROTAC-based drug design based on NTH CUL2ZYG11B interaction,while pinpointing a promising target for the development of treatments for COVID-19.

关键词： SARS-CoV-2 ORF10 Crystal structure cullin-2 RING E3 ligase Drug design

Psychological Status and Warfarin Therapy in Patients after Valve Replacement during the COVID-19 Pandemic:A Cross-sectional Study

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Current Medical Science 2024年第4期44卷 686-691页

作者： Xiao-yan CHEN sheng HE Zhen TAN Feng gao Hui JIANG Lu CHEN Li YANG Yu-shan LIU Si-yi HE Department of Cardiovascular Surgery The General Hospital of Western Theater CommandChengdu610083China Department of Digestive Medicine The General Hospital of Western Theater CommandChengdu610083China Department of General Surgery The General Hospital of Western Theater CommandChengdu610083China

Objective The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve *** present study explored the possible risk factors for anxiety and depression during the coronavirus disease 2019(COVID-19)pandemic and analyzed the influence of psychological state on medication *** Eligible patients received a web-based questionnaire survey via the Wenjuanxing platform during outpatient *** was evaluated by the Self-Rating Depression Scale(SDS).Anxiety was evaluated by the Self-Rating Anxiety Scale(SAS).Medication adherence was evaluated by the Morisky *** A total of 309 patients(aged 52.2±11.4 years)were included in the present *** SDS score of all included patients was 36.9±9.4 points,of which 11(3.6%)patients were diagnosed as having *** SAS score of all included patients was 43.1±9.3 points,of which 71(23%)patients were diagnosed as having *** patients(2.3%)had both anxiety and *** regression analysis revealed that only monthly income was an independent influencing factor for *** anxiety,patients who underwent repeated operations had a 2.264-fold greater risk,and patients who received combination medication had a 2.140-fold greater *** bleeding events and coagulation disorders could be observed in patients with anxiety,depression or *** anxiety occurred,patients showed worse medication ***,depression had no significant effect on medication *** During the COVID-19 pandemic,the detection rate of mental illnesses such as anxiety and depression was high,which seriously affected the medication safety of *** of its influencing factors will provide a reference for further standardized regulation of warfarin anticoagulant therapy after valve replacement.

关键词： Warfarin COVID-19 valve replacement depression anxiety

Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor

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Rare Metals 2024年第9期43卷 4286-4301页

作者： Li Song Xiao-Hong Zhong Fang-Lin Wang Zhi-Hui Huang Zhe Hong Yun-Fang gao Hai-Dong Wang Jian-Wei Ren sheng-Jie Peng Lei Li College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Research and Development Department Jiangxi Ganfeng LiEnergy Technology Co.Ltd.Xinyu 338000China Department of Mechanical Engineering Science University of JohannesburgAuckland ParkJohannesburg 2092South Africa

The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is ***,the carbon nanotubes(CNTs)coupled with lowcrystalline sulfur and nitrogen co-doped Ni Co-LDH(denoted as SN-Ni Co-LDH)nanosheets array are grown on Ni Co foam(NCF)substrate by two convenient steps of metal induced self-assembly and corrosion engineering,which present the advantages of operating at roomtemperature and low preparation *** from the S–N co-doping and low-crystallinity of Ni Co-LDH,the prepared SN-Ni Co-LDH@CNTs@NCF electrode presents a topping charge capacity of 2470 C·g^(-1)(4.94 C·cm^(-2))at 5 m A·cm^(-2).Furthermore,the fabricated asymmetry supercapacitor(ASC)achieves an extraordinary energy density of 77 Wh·kg^(-1)(0.617 m Wh·cm^(-2))at a power density of 438 W·kg^(-1)(3.5 m W·cm^(-2))and outstanding stability(91%capacity retention after 5000 cycles at20 m A·cm^(-2)).Impressively,the structure evolution of Ni Co-LDH during the charge/discharge processes has been thoroughly elucidated by in-situ Raman ***,this work verifies a powerful strategy and practical value for preparing composite electrodes with high supercapacitance performance,and also provides guidance for the rational design of the smart electrodes.

关键词： Supercapacitor NiCo-LDH Carbon nanotubes Sulfur and nitrogen co-doped Convenient synthesis

育龄妇女婚前及婚后药物流产的利用及并发症情况的分析

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生殖与避孕 2008年第11期28卷 673-676页

作者：苗茂华高尔生陈爱民袁伟上海计划生育科学研究所上海200032

目的:了解育龄妇女婚前、婚后对药物流产的利用情况及其并发症发生情况。方法:对北京、上海、成都3个中心因怀孕而在妇产科门诊就诊的妇女进行调查,内容包括一般人口学特征、药物流产史、药物流产相关健康结局等,共获得有1次药物流产史... 详细信息

目的:了解育龄妇女婚前、婚后对药物流产的利用情况及其并发症发生情况。方法:对北京、上海、成都3个中心因怀孕而在妇产科门诊就诊的妇女进行调查,内容包括一般人口学特征、药物流产史、药物流产相关健康结局等,共获得有1次药物流产史的妇女4931名。结果:婚前、婚后进行药物流产的对象比例分别为44.76%和55.24%,婚前药流者具有年龄较轻、文化程度偏低、选择在私人诊所进行药流的比例较高、孕周在7周以上者较多等特点。在调整了流产时的年龄、受教育程度、药流地点、流产时的孕周等因素后,婚前、婚后药物流产者流产后刮宫率、并发症发生率差异无统计学意义,OR值分别为0.94(0.81-1.08)和0.94(0.78-1.13)。结论:婚前药物流产者在年龄、药流地点、药流时孕周等方面具有一些与不良结局相关的特征,但未观察到婚姻状况与药物流产相关并发症的发生有关。

关键词：药物流产婚姻并发症

Association of Sexual Intercourse with Psychological Suppression and Copying Modes for Vocational School Students

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Journal of Reproduction and Contraception 2009年第2期20卷 101-112页

作者： Li WANG Xiao-jin WANG Xiao-wen TU Chao-hua LOU er-shenggao School of Public Health Fudan university Shanghai 200032 China Department of Epidemiology and Social Science Research on Reproductive Health Shanghai Institute ofPlanned Parenthood Research Shanghai 200032 China Department of Biostatistics Shanghai Jiaotong University School of Medicine Shanghai 200025 China

Objective To evaluate the association of sex behavior with sexual related psychological suppression and coping modes among students in three vocational schools in Shanghai. Methods A cross-sectional survey was conducted among 1 368 grade one students from three vocational schools in a district of Shanghai, with Computer Assisted Self- Interview （CASI）. The field work began in the April 2003 for a baseline survey, and completed in the December, 2003. Data on students＇ sexual intercourse, sexual related psychological suppression and psychological coping modes, and communication with parents were collected and analyzed. Binary logistic regression was used to adjust the potential confounding factors. Results After controlling for demographic factors, adolescents with middle or high scores of active psychological coping strategies on sexual related events were less likely to have sexual intercourse （ORadj=0.48, 95%CI=0.30-0. 77 and ORadj=0.49, 95%CI=0.30-0.83, respectively）, while association between psychological suppression on sex related events and sexual intercourse was not statistically significant （ORadj= 0.93, 95%CI=0.63-1.37）; sexual related psychological suppression and active coping modes were positively associated with adolescents＇ communicating with parents for 2-7 h/week about school things, but negatively associated with parents＇ open attitudes towards heterosexual contacts and talking sex related things with others. Conclusion Vocational school students with active psychological coping strategies on sexual related events were less likely to engage in sexual intercourse, so interventions focus on reducing unprotected sexual behaviors should target on psychological coping modes skills training.

关键词： psychological suppression psychological coping modes sexual intercourse