检索结果-南通市图书馆

Pharmacological insights into autophagy modulation in autoimmune diseases

Acta Pharmaceutica Sinica B 2021年第11期11卷 3364-3378页

作者： Ming-Yue Wu er-jin wang Du Feng Min Li Richard D.Ye Jia-Hong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 9999078China Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory DiseaseCollege of Basic Medical ScienceGuangzhou Medical UniversityGuangzhou 510000China School of Pharmaceutical Sciences National and Local United Engineering Lab of Druggability and New Drugs EvaluationGuangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510000China Kobilka Institute of Innovative Drug Discovery School of Life and Health Sciencesthe Chinese University of Hong KongShenzhen 518000China

As a cellular bulk degradation and survival mechanism,autophagy is implicated in diverse biological ***-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus(SLE)and inflammatory bowel disease(IBD),indicating that autophagy dysregulation may be involved in the development of autoimmune diseases.A series of autophagy modulators have displayed protective effects on autoimmune disease models,highlighting the emerging role of autophagy modulators in treating autoimmune *** review explores the roles of autophagy in the autoimmune diseases,with emphasis on four major autoimmune diseases[SLE,rheumatoid arthritis(RA),IBD,and experimental autoimmune encephalomyelitis(EAE)].More importantly,the therapeutic potentials of small molecular autophagy modulators(including autophagy inducers and inhibitors)on autoimmune diseases are comprehensively analyzed.

关键词： Autophagy Autoimmune disease Systemic lupus erythematosus Inflammatory bowel disease Rheumatoid arthritis Experimental autoimmune encephalomyelitis Autophagy inducer Autophagy inhibitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease

引用

Burns & Trauma 2023年第1期11卷 245-257页

作者： er-jin wang Ming-Yue Wu Zheng-yu Ren Ying Zheng Richard D.Ye Chris Soon Heng TAN Yitao wang Jia-Hong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR999078China Center for Metabolic Liver Diseases and Center for Cholestatic Liver Diseases Department of GastroenterologyThe First Affiliated Hospital(Southwest Hospital)Third Military Medical University(Army Medical University)Chongqing400038China Kobilka Institute of Innovative Drug Discovery School of Life and Health SciencesThe Chinese University of Hong KongShenzhen518172China Department of Chemistry College of ScienceSouthern University of Science and TechnologyShenzhen518055China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research University of MacaoChina

Inflammatory bowel disease(IBD)is a chronic,non-specific,recurrent inflammatory disease,majorly affecting the gastrointestinal *** to its unclear pathogenesis,the current therapeutic strategy for IBD is focused on symptoms *** is a lysosome-mediated catabolic process for maintaining cellular ***-wide association studies and subsequent functional studies have highlighted the critical role of autophagy in IBD via a number of mechanisms,including modulating macrophage *** are the gatekeepers of intestinal immune homeostasis,especially involved in regulating inflammation remission and tissue ***,many autophagic proteins and IBD-related genes have been revealed to regulate macrophage function,suggesting that macrophage autophagy is a potentially important process implicated in IBD ***,we have summarized current understanding of macrophage autophagy function in pathogen and apoptotic cell clearance,inflammation remission and tissue repair regulation in IBD,and discuss how this knowledge can be used as a strategy for IBD treatment.

关键词： Autophagy Inflammatory bowel diseases Inflammation Tissue repair Efferocytosis Macrophage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

有机肥替代化肥氮对谷子氮素累积、产量及品质的影响

引用

作物学报 2025年第1期51卷 149-160页

作者：王媛许佳茵董二伟王劲松刘秋霞黄晓磊焦晓燕山西农业大学资源环境学院山西太原030031

有机肥部分替代化肥是一种实现化肥减量的可持续农业生产措施。本研究于2020和2021连续2年以“沁黄2号”为供试材料,设不施氮(CK)、常量化肥氮(NPK)、有机肥替代25%化肥氮(25%M)、有机肥替代50%化肥氮(50%M)、有机肥替代75%化肥氮(75%M... 详细信息

有机肥部分替代化肥是一种实现化肥减量的可持续农业生产措施。本研究于2020和2021连续2年以“沁黄2号”为供试材料,设不施氮(CK)、常量化肥氮(NPK)、有机肥替代25%化肥氮(25%M)、有机肥替代50%化肥氮(50%M)、有机肥替代75%化肥氮(75%M)和有机肥替代100%化肥氮(100%M) 6个处理,研究不同替代率对谷子产量构成和氮素吸收的影响,并分析氮素吸收调控小米米色、糊化特性和类胡萝卜素组分的效应,明确谷子生产中有机肥最佳替代率。结果表明,2年中较低的有机肥替代化肥氮率显著提高了谷子植株氮素累积,但随着替代率的持续增加,植株氮素累积量呈降低趋势,最终影响谷子产量和小米品质。2020年, 25%M处理显著提高了谷子地上部氮素累积量,较NPK处理提高9.6%;2021年,25%M处理谷子地上部氮素累积量、生物量、穗粒数和产量达到最高,较NPK处理分别提高6.1%、12.0%、15.4%和12.0%。50%M处理显著影响了小米的米色、糊化特征和类胡萝卜素含量,与NPK相比,小米籽粒红绿值、橘色值、支链淀粉含量、总淀粉含量、小米糊化最终黏度、叶黄素含量、玉米黄质含量和黄色素含量的增幅分别可达6.0%、6.0%、7.4%、4.3%、7.8%、20.7%、17.4%和2.8%。但有机肥完全替代化肥降低了谷子地上部氮素吸收、地上部生物量、穗粒数及谷子产量,也抑制了小米叶黄素和玉米黄质含量的提升。2年均表现出谷子地上部氮吸收量与小米单粒重、直链淀粉含量和小米糊化回升值呈显著的负相关。且2021年谷子地上部氮吸收量还与小米总淀粉含量、蛋白质含量、小米粉糊化峰值黏度和小米黄色素含量呈显著的负相关,与小米糊化峰谷黏度呈显著的正相关。综上,施氮总量120 kg hm^(–2)下,有机肥替代25%~50%化肥氮能通过促进植株氮素的吸收,实现产量、米色、蒸煮特性及类胡萝卜素的协同提升,为谷子化肥减量和提质增效生产提供技术支撑。

关键词：谷子有机肥替代化肥氮率氮素累积产量米色糊化特性类胡萝卜素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

First-principles Study of Adsorption and Dissociation of Methanol on the Pt（lO0） Surface

引用

Chinese Journal of Chemical Physics 2012年第2期25卷 199-203,I0004页

作者： Zhuo wang er-jun Kan jin-long Yang Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230025China Department of Applied Physics Nanjing University of Science and TechnologyNanjing 210037China

Using first-principles calculations, we studied the interaction of methanol with the Pt（100） surface based on generalized gradient approximation. We found that top sites of Pt（100） surface are the favored adsorptive positions in energy, and methanol molecule interacts with the Pt surface through oxygen atoms. Moreover, we also explored the possible dissociation pathways of methanol on the Pt surface, and suggested that the products of dissociation can be controlled by the external manipulation.

关键词： Methanol Pt(100) surface Adsorption Dissociation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of the Fabrication Processes of NC-Si:H Films on Their Mechanical Properties

引用

Chinese Journal of Aeronautics 2006年第B12期19卷 202-205页

作者： LIN jin-zhao wang jin-liang ZHOU Bo WU er-xing Department of Physics Beijing University of Aeronautics and Astronautics Beijing 100083 China

Studies of nanoindentation were performed on nc-Si：H films to evaluate the effects of the fabrication processes on their mechanical properties. It is observed that with the decrease of the SiH4 contents, the grain size of the films increases gradually, and as does the crystalline volume fraction. The smaller the grains become, the more homogeneous the films, and the more even the hardness as well as the modulus will be. The hardness and the modulus will increase with the substrate＇s temperature rising. The hardness and the modulus of the nc-Si：H films on the Si substrate prove to be higher than those on the glass substrate given the same technology parameters. How- ever, the films on the glass substrate appear to be more homogeneous.

关键词： nanoindentation hardness modulus plasma-enhanced chemical vapor deposition (PECVD) nc-Si:H

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Knockdown of specific cuticular proteins analogous to peritrophin 3 genes disrupt larval and ovarian development in Bactrocera dorsalis(Diptera:Tephritidae)

引用

Insect Science 2021年第5期28卷 1326-1337页

作者： Qiu-Li Hou er-Hu Chen Wei Dou jin-Jun wang Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqing 400715China College of Horticulture and Plant Protection Yangzhou UniversityYangzhouJiangsu 225009China

Cuticular proteins(CPs)are critical components of the insect cuticle and play important roles in maintaining normal insect development and defense against various environmental *** oriental fruit fly(Bactrocera dorsalis)is one of the most destructive pests worldwide,and its eight CPs analogous to peritrophin 3(BdCPAP3)family genes have been identified in our prev ious *** the present study,we further explored the possible roles of CPAP3 genes in *** *** sequence of BdCPAP3 genes contained three conserved ChtBD2(chitin-binding)*** and temporal expression patterns revealed that the four BdCPAP3 genes(BdCPAP3-AI,B,E,and E2)might play important roles in larval pupariation of ***,treatment with a juvenile hormone analog(methoprene)significantly restricted expression of these four CPAP3 genes,whereas treatment with 20-hydroxy-ecdysone induced *** RNA interference(RNAi)results revealed that down-regulated CPAP3 genes led to signif-icant delay of pupariation,and injection of dsBdCPAP3-E into 5-d-old *** larvae caused approximately 40%***,we also confirmed that BdCPAP3-D2 was involved in *** ovarian *** study showed that some specific CP4P3 genes had crucial roles in *** development,and these CP genes could be used as potential targets to control this pest via RNAi.

关键词： Bactrocera dorsalis CPAP3 family expression patterns larval-pupal tran-sition ovarian development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lateral strain tailoring in manganite homostructures assisted by atomic-flat freestanding membranes

引用

Nano Research 2023年第5期16卷 7829-7836页

作者： Yufei wang Yuchen Zhu Shengru Chen Dongke Rong Qiao jin er-Jia Guo College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Department of Physics&Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Complex oxide thin films exhibit intriguing phenomena due to the coupling between multiple degrees of freedom through interfacial structural *** tailoring of structural parameters determines unique band structure and phonon modes,regulating emergent magnetic and electrical properties of oxide ***,the construction of different strained and oriented domains in one intact oxide thin film is impossible using conventional *** we report the fabrication and quantitative structural analysis of La_(0.7)Sr_(0.3)MnO_(3)(LSMO)homostructures assisted by atomic-flat freestanding *** substrates and suspended membranes regulate the epitaxial strain and orientation of subsequently grown *** results demonstrate an ultrathin transition layer(~4 atomic layers)between freestanding membranes and LSMO films is formed due to the strain *** work offers a simple and scalable methodology for fabricating unprecedented innovative functional oxide homostructures through artificially controlled synthesis routes.

关键词： transmission electron microscopy oxide homostructure freestanding membranes manganites strain engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of Microstructure and Mechanical Properties of Ultrafine Grained Low Carbon Steel

引用

Journal of Wuhan University of Technology(Materials Science) 2016年第5期31卷 1099-1104页

作者：刘和平 SUN Feng'er SUN Hu'er LIU Bin wang Yi jin Xuejun School of Materials Science and Engineering North University of ChinaTaiyuan 030051China School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

A novel design scheme of hot stamping, quenching and partitioning process was conducted in a quenchable boron steel to obtain the nanometric duplex microstructure comprising ultrafine retained austenite and martensite. It is shown that the materials possess excellent mechanical properties and the ductility can be further improved without compromising the strength. The newly treated steel shows excellent mechanical properties and the total elongation of the steel increases from 6.6% to 14.8% compared with that of hot stamped and quenched steel. Therefore, this kind of steel has become another group of advanced high-strength steels. The microstructure which is mainly responsible for such excellent mechanical properties was investigated.

关键词： hot stamping quenching and partitioning(Q&P) retained austenite martensite grain refinement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sodium 4-phenylbutyrate Attenuates High-fat Diet-induced Impaired Spermatogenesis

引用

Biomedical and Environmental Sciences 2018年第12期31卷 876-882页

作者： wang er Hui YAO San Qiao TAO Ling XI jin Yan Department of Nutrition and Food Hygiene College of Public Health Xinxiang Medical University Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical University

Objective To determine the mitigating effects of sodium 4-phenylbutyrate(4-PBA) on high-fat diet(HFD)-induced spermatogenesis dysfunction. Methods Male rats(n = 30) were randomly divided into three groups: control, HFD, and 4-PBA(HFD +4-PBA). After 13 weeks, rats were euthanized. Testes and epididymis were harvested for further analysis. Sex hormones were detected, and hematoxylin and eosin staining was performed to examine the histological changes in the testes. Semen samples were collected to evaluate sperm quality. Spermatogenic cell apoptosis was detected by TUNEL assay. Results Compared with the control group, the final body weight and body weight gain were significantly higher in HFD-fed rats, while the testicle/body weight ratios were lower(P ere observed. Treatment with 4-PBA attenuated HFD-induced histological damage, ameliorated the HFD-induced decrease in serum testosterone(T), and reduced the rate of testicular cell apoptosis(P ers in HFD rats(P ermatogenesis, semen quality, serum T level, and testicular cell apoptosis in rats. Treatment with 4-PBA ameliorated HFD-induced impaired spermatogenesis via inhibition of apoptosis in rats. 4-PBA may have therapeutic value in the treatment of obesity-related impairment of spermatogenesis.

关键词： Male infertility Sodium 4-phenylbutyrate Obesity Spermatogenesis Semen Testis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure demonstration of perovskite oxide and its epitaxial thin films by second harmonic generation

引用

Science China(Technological Sciences) 2020年第5期63卷 874-876页

作者： wang JieSu GE Chen GUO er-Jia XU XiuLai wang Can jin KuiJuan Institute of Physics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

Perovskite oxide materials and their epitaxial thin films have attracted wide attention in various research fields,due to the new properties discovered at every *** the epitaxial perovskite oxide thin films,the interaction between the films and substrates could bring in some novel physical properties,such as two-dimensional electron gas[1],positive colossal magnetoresistance[2],polar metal state[3,4],interfacial enhancement effect[5–7].The(dis)appearance and regulation of these properties are usually accompanied with structural distortion changing of films,which may originate from the thickness variation,substrate replacement,or oxygen vacancies[8].Thus,it is crucial to define what structure it is and figure out how the structure evolves.

关键词： perovskite epitaxial harmonic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：