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Targeting innate sensing in the tumor microenvironment to improve immunotherapy

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Cellular & Molecular Immunology 2020年第1期17卷 13-26页

作者： Zhida liu Yang-Xin fu Department of Pathology UT Southwestern Medical CenterDallasTX 75235USA Department of Immunology UT Southwestern Medical CenterDallasTX 75235USA

The innate immune sensing pathways play critical roles in the defense against pathogen infection,but their roles in cancer immunosurveillance and cancer therapies are less *** propose that defective innate immune sensing inside the tumor microenvironment might limit T-cell responses to immunotherapy.A recent mechanistic understanding of conventional therapies revealed that both innate immune sensing and T-cell responses are essential for optimal antitumor efficacy.T-cell-based immunotherapy,particularly immune checkpoint blockade,has achieved great success in reactivating antitumor immune responses to lead to tumor regression,but only in a small fraction of ***,incorporating conventional therapy that can increase innate sensing and immunotherapy should lead to promising strategies for cancer ***,we review the innate sensing pathways related to cancer initiation/progression and therapies,summarize the recent key findings in innate immune sensing related to conventional therapies,evaluate current combination strategies,and highlight the potential issues of combinational therapies in terms of antitumor efficacy and toxicities.

关键词： Innate immune sensing Conventional therapy Immunotherapy

Distributed and recursive blind channel identification to sensor networks

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Control Theory and Technology 2017年第4期15卷 274-287页

作者： liu, Rui Chen, Han-fu Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing China

In this paper, the distributed and recursive blind channel identification algorithms are proposed for single-input multi-output （SIMO） systems of sensor networks （both time-invariant and time-varying networks）. At any time, each agent updates its estimate using the local observation and the information derived from its neighboring agents. The algorithms are based on the truncated stochastic approximation and their convergence is proved. A simulation example is presented and the computation results are shown to be consistent with theoretical analysis.

关键词： Blind channel identification distributed and recursive algorithm truncated stochastic approximation sensornetworks

Mechanical criterion for coal and gas outburst:a perspective from multiphysics coupling

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International Journal of Coal Science & Technology 2021年第6期8卷 1423-1435页

作者： Ting liu Baiquan Lin Xuehai fu Ang liu School of Safety Engineering China University of Mining&TechnologyXuzhou 221116China Key Laboratory of CBM Resources and Dynamic Accumulation Process China University of Mining&TechnologyXuzhou 221008China Department of Energy and Mineral Engineering G3 Center and EMS Energy InstituteThe Pennsylvania State UniversityUniversity ParkPAUSA

Although a series of hypotheses have been proposed,the mechanism underlying coal and gas outburst remains *** the low-index outbursts encountered in mining practice,we attempt to explore this mechanism using a multiphysics coupling model considering the effects of coal strength and gas mass transfer on *** on force analysis of coal ahead of the heading face,a risk identification index C_(m)and a critical criterion(C_(m)≥1)of coal instability are *** to this criterion,the driving force of an outburst consists of stress and gas pressure gradients along the heading direction of the roadway,whereas resistance depends on the shear and tensile strengths of the *** results show that outburst risk decreases slightly,followed by a rapid increase,with increasing vertical stress,whereas it decreases with increasing coal strength and increases with gas pressure *** the response surface method,a coupled multi-factor model for the risk identification index is *** results indicate strong interactions among the controlling ***,the critical values of the factors corresponding to outburst change depending on the environment of the coal seams,rather than being *** the buried depth of a coal seam increases,the critical values of gas pressure and coal strength decrease slightly,followed by a rapid *** to its controlling factors,outburst can be divided into stress-dominated,coal-strength-dominated,gas-pressure-dominated,and multi-factor compound *** on this classification,a classified control method is proposed to enable more targeted outburst prevention.

关键词： Coal and gas outburst Critical criterion Multiphysics coupling Response surface method

Conceptual understandings of the ecological engineering issues in China and abroad

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Journal of Environmental Sciences 2000年第2期12卷 78-83页

作者： Xu, fu-liu Tao, Shu Departemnt of Urban and Environemmal Sciences Peking University Beijing 100871 China

The research on ecological engineering has been lasting for more than four decades. As a new, cheaper, environmentally acceptable and alternative techniques, ecological engineering has been applied to many aspects, including ecoagricultural engineering, ecosystem restoration, environmental conservation, and pollution control. This paper presents a conceptual understanding on the issues of ecological engineering, including its origin, concepts, goals, principles and applications.

关键词： ecological engineering ecologist engineer CLC number: X171 4 Document code: A

豹纹鳃棘鲈生长差异分化相关lncRNA与mRNA加权基因共表达网络分析

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渔业科学进展 2025年第1期46卷 46-58页

作者：高进刘金叶陈傅晓王永波符书源海南省海洋与渔业科学院海南海口571126 海南热带海洋学院崖州湾创新研究院海南三亚572025 海南省热带海水养殖工程技术研究中心海南海口571126

为揭示豹纹鳃棘鲈(Plectropomus leopardus)生长差异分化的分子调控作用机制,该研究利用豹纹鳃棘鲈中间培育过程中不同生长阶段(42、70和91日龄)的18个幼鱼肌肉组织样本进行全转录组测序,获得lncRNA和mRNA基因表达谱数据,采用加权基因... 详细信息

为揭示豹纹鳃棘鲈(Plectropomus leopardus)生长差异分化的分子调控作用机制,该研究利用豹纹鳃棘鲈中间培育过程中不同生长阶段(42、70和91日龄)的18个幼鱼肌肉组织样本进行全转录组测序,获得lncRNA和mRNA基因表达谱数据,采用加权基因共表达网络分析(WGCNA)方法构建生长差异分化相关lncRNA和mRNA的共表达网络。通过特异性基因模块中差异表达基因的GO和KEGG富集对模块生物学功能进行分析,运用Cytoscape软件构建基因互作网络,挖掘豹纹鳃棘鲈生长差异分化相关的关键候选基因。结果显示,基因差异表达分析共筛选到6252个差异表达mRNA和367个差异表达lncRNA;共表达网络分析获得MEmagenta、MEgreenyellow和MEblack共3个生长差异分化特异性基因模块;GO和KEGG富集分析显示,特异性模块中差异表达基因显著富集于肌肉蛋白形成、横纹肌组织发育调控、主轴组织形成等生物学过程,参与了蛋白酶体、肌动蛋白细胞骨架调控及肌醇磷酸代谢等与生长差异分化相关的代谢通路;筛选3个特异性模块中权重和连通度高的lncRNA和mRNA构建基因互作网络,得到包括psmd6、nmt1、als2、brcc3、kank1、ada12、at131和hdac3等在内的生长差异分化关键基因和MSTRG.15660、MSTRG.8694、MSTRG.1896等20个lncRNA,为进一步解析豹纹鳃棘鲈生长差异分化的分子机制提供了新思路。

关键词：豹纹鳃棘鲈生长差异分化 WGCNA 共表达网络

Developments in metastatic pancreatic cancer:Is gemcitabine still the standard?

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World Journal of Gastroenterology 2012年第8期18卷 736-745页

作者： Jie-er Ying Li-Ming Zhu Bi-Xia liu Department of Medical Ontology Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina

In the past 15 years, we have seen few therapeutic advances for patients with pancreatic cancer, which is the fourth leading cause of cancer-related death in the United States. Currently, only about 6% of patients with advanced disease respond to standard gemcitabine therapy, and median survival is only about 6 mo. Moreover, phase Ⅲ trials have shown that adding various cytotoxic and targeted chemotherapeutic agents to gemcitabine has failed to improve overall survival, except in cases in which gemcitabine combined with erlotinib show minimal survival benefi t. Several metaanalyses have shown that the combination of gemcitabine with either a platinum analog or capecitabine may lead to clinically relevant survival prolongation, especially for patients with good performance status. Meanwhile, many studies have focused on the pharmacokinetic modulation of gemcitabine by fi xed-dose administration, and metabolic or transport enzymes related to the response and toxicity of gemcitabine. Strikingly, a phase Ⅲ trial in 2010 showed that, in comparison to gemcitabine alone, the FOLFIRINOX regimen in patients with advanced disease and good performance status, produced better median overall survival, median progression-free survival, and objective response rates. This regimen also resulted in greater, albeit manageable toxicity.

关键词： Chemotherapy Palliative therapy Metasta-sis Biomarkers Pancreatic neoplasms

A Low-Profile Cylindrical Dielectric Resonator Antenna with Bandwidth-Enhancement Under Triple-Mode Resonance

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Journal of Communications and Information Networks 2020年第4期5卷 447-456页

作者： Sen Gao Nengwu liu Guang fu 不详 State Key Laboratory of Millimeter Waves Nanjing 210096China

A low-profile cylindrical dielectric resonator antenna(CDRA)with enhanced impedance bandwidth is proposed via sharing a single triple-mode dielectric ***,the resonant frequencies of TM01d and TM02d modes of a conventional CDRA are maintained far away from each other under central probe ***,a circular disk with an annular ring is loaded around the conventional CDRA,aiming to excite an additional mode between these dual *** electric fields demon-strate that the previous TM_(02δ) mode is transformed into the TM03d mode for the modified CDRA,and an additional TM_(02δ) mode is successfully excited between the TM_(01δ) and TM_(03δ) *** a result,the resonant frequencies of these three radiative modes are reallocated in proximity to each other,thus achieving the desired bandwidth *** addition,considering the small input impedance of the CDRA,a microstrip feeding line is introduced underneath the central probe for good impedance *** these arrangements,the resultant antenna can generate an extended bandwidth under simultaneous radiation of TM_(01δ),TM_(02δ),and TM_(03δ) ***,the proposed CDRA is designed,fabricated,and measured to validate the predicted *** simulated and measured results show that the impedance bandwidth(|S11|erty of about 0.15 free space wavelength is achieved as well.

关键词： dielectric resonator antenna triple-mode resonance wide impedance bandwidth low profile

Analysis of Microstructure and Mechanical Properties of Ultrafine Grained Low Carbon Steel

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Journal of Wuhan University of Technology(Materials Science) 2016年第5期31卷 1099-1104页

作者：刘和平 SUN Feng'er SUN Hu'er liu Bin WANG Yi JIN Xuejun School of Materials Science and Engineering North University of ChinaTaiyuan 030051China School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

A novel design scheme of hot stamping, quenching and partitioning process was conducted in a quenchable boron steel to obtain the nanometric duplex microstructure comprising ultrafine retained austenite and martensite. It is shown that the materials possess excellent mechanical properties and the ductility can be further improved without compromising the strength. The newly treated steel shows excellent mechanical properties and the total elongation of the steel increases from 6.6% to 14.8% compared with that of hot stamped and quenched steel. Therefore, this kind of steel has become another group of advanced high-strength steels. The microstructure which is mainly responsible for such excellent mechanical properties was investigated.

关键词： hot stamping quenching and partitioning(Q&P) retained austenite martensite grain refinement

Indirect Flow Injection Chemiluminescence Method for the Determination of Tetracyclines Using Cu(Ⅱ) as a Probe Ion

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Chinese Chemical Letters 2005年第8期16卷 1067-1070页

作者： Su Qin HAN er Bao liu Hua LI Institute of Analytical Science Northwest University Xi＇an 710069 School of Chemistry and Material Science Shanxi Normal University Linfen 041004 College of Chemistry and Life Science Tianjin Normal University Tianjin 300074

This paper reported an indirect flow injection chemiluminescence （FI-CL） method for the determination of the drugs tetracycline （TC）, chlortetracycline （CTC） and oxytetracycline（OTC） using Cu（ Ⅱ ） as a probe ion. The CL reaction was induced on-line and after injection of the sample the negative peaks appeared as a result of complexation. The method was applied to the determination of TCs in pharmaceuticals and human urine with recoveries in the range95-105%.

关键词： Cu(Ⅱ) probe ion inhibitory chemiluminescence tetracyclines.