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Single Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population

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Chinese Medical Journal 2016年第7期129卷 854-859页

作者： Fang Qin Hu Wang Lei Song Xi-Li Lu Li-Rui Yang er-peng liang Wei Wang Yu-Bao Zou Jin Bian Hai-Ying Wu Xian-liang Zhou Ru-Tai Hui H ui--Min Zhang Xiong-Jing Jiang Hypertension Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Background： Takayasu arteritis （TA） is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods： Four single nucleotide polymorphisms （SNPs） those locate in the IL12B region （rs56167332）, the MLX region （rs665268）, the FCGR2A/FCGR3A locus （rsi0919543）, and the HLA-B/M1CA locus （rs12524487）, associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results： Among the four SNPs, rs 10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor （odds ratio [OR] = 6.532, 95% confidence interval [C1] = 2.402 - 17.763, P 〈 0.001 ） for TA. Among TA patients, the level of eosinophil granulocytes （Eos） in the peripheral blood was observed to be higher in the GG group of rs 10919543 （n = 23, Eos = 0. I 1 [0.08, 0.17] x 109/L） than the GA ＋ AA group （n = 100, Eos = 0.08 [0.05, 0.13] 10/L, P = 0.028）. No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions： Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.

关键词： FCGR2A, FCGR3A Single Nucleotide Polymorphisms Takayasu Arteritis

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浅论露天采矿技术及采矿设备的发展趋势

世界有色金属 2018年第6期43卷 82-83页

作者：杨二鹏朱少亮陕西有色冶金矿业集团有限责任公司陕西西安710500

在我国的社会经济发展中,矿产行业有着举足轻重的地位,所以国家对于矿产行业也较为重视。比如煤矿的生产,受到空间的限制作用,只有特定的卡un国产设备才能进行煤矿产品的生产。但是矿产行业中的露天采矿则不用考虑空间因素的限制,矿产... 详细信息

在我国的社会经济发展中,矿产行业有着举足轻重的地位,所以国家对于矿产行业也较为重视。比如煤矿的生产,受到空间的限制作用,只有特定的卡un国产设备才能进行煤矿产品的生产。但是矿产行业中的露天采矿则不用考虑空间因素的限制,矿产品生产效率高且安全系数较高。且在露天采矿中,各企业越来越重视采矿技术的提升以及采矿设备的完善和优化。本文通过想深入分析露天采矿设备和采矿技术的关系,以及露天采矿技术和采矿设备的发展趋势,为业界人士提供参考依据。

关键词：露天采矿技术采矿设备发展趋势

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian peng liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei peng Xiaoyan Zhou Lixia Qin Lingyan liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Synthesis of rac-α-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

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Chinese Chemical Letters 2022年第2期33卷 830-834页

作者： peng Gao Miaolin Ke Tong Ru Guanfeng liang Fen-er Chen Department of Chemistry Sichuan UniversityChengdu 610064China Department of Chemistry Fudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Fudan UniversityShanghai 200433China

This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes,providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield(up to 97%) and branched-regioselectivity(up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

关键词： Aryl propionaldehydes Hydroformylation Water-soluble PNP ligands Regioselectivity Rhodium

Clinical Application of Vibration Controlled Transient Elastography in Patients with Chronic Hepatitis B

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Journal of Clinical and Translational Hepatology 2017年第4期5卷 368-375页

作者： Xie-er liang Yong-peng Chen State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis Research Department of Infectious Diseases and Hepatology Unit Nanfang Hospital Southern Medical University Guangzhou China

Evaluation of the extent and progression of liver fibrosis and cirrhosis is of critical importance in the management and prognosis of patients with chronic hepatitis *** to the limitation of liver biopsy,non-invasive methods,especially liver stiffness measurement (LSM) by vibration controlled transient elastography,have been developed and widely applied for liver fibrosis *** aims to reduce,but not to substitute,the need for liver biopsy for fibrosis/cirrhosis *** LSM may have potential utility in monitoring treatment response,its applications in prediction of liver complications in terms of portal hypertension and esophageal varices,as well as disease prognosis,have been gradually ***,we review the latest clinical applications of LSM in patients with chronic hepatitis B.

关键词： Hepatitis B Liver fibrosis Liver stiffness Transient elastography

Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao XIA Jianing liang Yuhao JIANG Zhiyang peng Jiaxu LI Chen XIAO Renyou XU Wenwen WANG Xiantao SHANG Shiyang LU Dapeng ZHU Hong-Xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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Characteristics of American Scholars’Research on Chinese Medical Classics and Their Contributions

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Chinese Journal of Integrative Medicine 2020年第8期26卷 629-632页

作者： WANG er-liang CHEN Xiao School of Basic Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China

Chinese medical classics are important carriers for the inheritance,innovation and development of academic thoughts of Chinese medicine(CM),containing rich thoughts on diagnosis and treatment as well as therapeutic principles of *** international exchange of CM has a very long *** the development of society,Western scholars in modern times are deepening their researches on Chinese medical *** would provide a new way for promoting CM in Western countries to investigate researches made by famed American scholars and their academic viewpoints.

关键词： Chinese medicine classics international exchange American scholar

Seminal plasma miR-192a： a biomarker predicting successful resolution of nonobstructive azoospermia following varicocele repair

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Asian Journal of Andrology 2018年第4期20卷 396-399页

作者： er-Lei Zhi Guo-Qing liang peng Li Hui-Xing Chen Ru-Hui Tian peng Xu Zheng Li Department of Andrology Center for Men's Health Department of ART Institute of Urologic Medical Center Shanghai General Hospital Shanghai Key Lab of Reproductive Medicine Shanghai Jiao Tong University 100 Haining Road Shanghai 200080 China Department of Andrology Seventh People's Hospital of Shangha University of TCM Shanghai 200000 China Oriental Jinghua Hospital of Shenyang Department of ART 156 Nanjing Road Shenyang 110005 China

This study was performed to investigate a potential marker for the presence of spermatozoa in the ejaculate following varicocelectomy in Chinese men with nonobstructive azoospermia and varicoceles. The micro-RNA （miR）-192a levels in seminal plasma and testicular tissue were evaluated by quantitative real-time polymerase chain reaction from 60 men with nonobstructive azoospermia and varicoceles （Group A： 27 men with spermatozoa found in the ejaculate after surgery; Group B： 33 men without spermatozoa found in the ejaculate after surgery） and 30 controls. The seminal plasma and testicular tissue miR-192a levels were higher in Group B than in Group A and the controls （P〈 0.001）, and there was no significant difference between Group A and the controls （P〉 0.05）. Apoptosis and proliferation assays with miR mimics and inhibitors showed that miR-192a induced GC-2 cell apoptosis through the activation of Caspase-3 protein. Thus, seminal plasma miR-192a appears to be a potential marker for successfully indicating spermatozoa in the ejaculate following microsurgical varicocelectomy in men with nonobstructive azoospermia and varicoceles. Seminal plasma miR-192a may be a useful clinical marker for prescreening to determine which patients with nonobstructive azoospermia and varicoceles would benefit from varicocelectomy.

关键词： miR-192a nonobstructive azoospermia seminal plasma varicocelectomy