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XPD Lys751Gln polymorphism and esophageal cancer risk: A meta-analysis involving 2288 cases and 4096 controls

World Journal of Gastroenterology 2011年第18期17卷 2343-2348页

作者： Ling Yuan Dan Cui er-jiang zhao Chen-Zhi Jia Li-Dong Wang Wei-Quan Lu Department of Gastroenterology The First Affiliated Hospital Zhengzhou University Zhengzhou 450052 HenanProvince China Department of Radiotherapy Henan Tumor Hospital and Institute Zhengzhou 450003 Henan Province China Department of Epidemiology HenanTumor Institute Zhengzhou 450003 Henan Province China Department of Epidemiology andBiostatistics College of Public Health Zhengzhou UniversityZhengzhou 450001 Henan Province China Department of Occupational and EnvironmentalHealth Sciences College of Public Health Zhengzhou Univer-sity Zhengzhou 450001 Henan Province China Henan Key Laboratory for Esophageal CancerResearch The First Affiliated Hospital College of Basic Medi-cine Zhengzhou University Zhengzhou 450052 Henan ProvinceChina

AIM: To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk. METHODS: We searched PubMed up to September 1, 2010 to identify eligible studies. A total of 10 casecontrol studies including 2288 cases and 4096 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 4.2. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the ***: The results suggested that there is no significant association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in the overall population. However, in subgroup analysis by histology type, a significant association was found between XPD Lys751Gln polymorphism and esophageal adenocarcinoma (for CC vs AA: OR = 1.25, 95% CI = 1.01-1.55, P = 0.05 for heterogeneity). CONCLUSION: Our meta-analysis suggested that XPD Lys751Gln polymorphism may be associated with increased risk of esophageal adenocarcinoma.

关键词： Xeroderma pigmentosum group D Polymorphism Esophageal cancer Mwta-analysis

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Glutathione S-transferase M1 polymorphism and esophagealcancer risk:An updated meta-analysis based on 37 studies

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World Journal of Gastroenterology 2016年第5期22卷 1911-1918页

作者： Quan-Jun Lu Ya-Cong Bo Yan zhao er-jiang zhao Wolde Bekalo Sapa Ming-Jie Yao Dan-Dan Duan Yi-Wei Zhu Wei-Quan Lu Ling Yuan Department of Nutrition and Food Hygiene College of Public HealthZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Affiliated Tumor Hospital of Zhengzhou University Henan Tumor HospitalZhengzhou 450003Henan ProvinceChina School of Basic Medical Sciences Peking UniversityBeijing 100191China Department of Radiotherapy Affiliated Tumor Hospital of Zhengzhou UniversityHenan Tumor HospitalZhengzhou 450003Henan ProvinceChina

AIM: To evaluate the relationship between glutathione S-transferase M1(GSTM1) polymorphism and susceptibility to esophageal cancer(EC).METHODS: A comprehensive search of the United States National Library of Medicine Pub Med database and the Elsevier, Springer, and China National Knowledge Infrastructure databases for all relevant studies was conducted using combinations of the following terms: "glutathione S-transferase M1", "GSTM1", "polymorphism", and "EC"(until November 1, 2014). The statistical analysis was performed using the SAS software(v.9.1.3; SAS Institute, Cary, NC, United States) and the Review Manager software(v.5.0; Oxford, England); crude odds ratios(ORs) with 95% confidence intervals(CIs) were used to assess the association between the GSTM1 null genotype and the risk of ***: A total of 37 studies involving 2236 EC cases and 3243 controls were included in this metaanalysis. We observed that the GSTM1 null genotype was a significant risk factor for EC in most populations(OR = 1.33, 95%CI: 1.12-1.57, P_(heterogeneity) erogeneity)erogeneity) = 0.97, and I2 = 0%).CONCLUSION: The GSTM1 null polymorphism may be associated with an increased risk for EC in Asian but not Caucasian populations.

关键词： Meta-analysis glutathione S-transferaseM1 Polymorphism Esophageal cancer Deletions

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao Yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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外泌体miRNA治疗多发性骨髓瘤的作用与机制

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中国组织工程研究 2025年第31期29卷 6743-6752页

作者：赵艺涵孙旭杭赵琳蒋士卿河南中医药大学第一附属医院血液肿瘤科河南省郑州市450000 河南中医药大学第一临床医学院河南省郑州市450000 上海中医药大学附属曙光医院血液科上海市200000

背景:多发性骨髓瘤是最常见的血液恶性肿瘤之一,具有难治疗、易复发、易耐药的特点,至今仍无法治愈。外泌体的内源性转运系统通过影响细胞间功能成分的交换而发挥通讯作用,其中miRNA因尺寸微小更容易被包装在外泌体内,故影响细胞功能的... 详细信息

背景:多发性骨髓瘤是最常见的血液恶性肿瘤之一,具有难治疗、易复发、易耐药的特点,至今仍无法治愈。外泌体的内源性转运系统通过影响细胞间功能成分的交换而发挥通讯作用,其中miRNA因尺寸微小更容易被包装在外泌体内,故影响细胞功能的途径多、范围广。目的:归纳并总结多发性骨髓瘤中外泌体miRNA发挥作用的机制,提出潜在靶点。方法:以“multiple myeloma,bone marrow mesenchyml stem cell,fibroblasts,peripheral blood,complication,progression,drug resistance,exosomal miRNA”为英文关键检索词,检索PubMed数据库的相关文献。文献检索时限为数据库建库至2024年6月。通过阅读文题和摘要进行初筛,排除无关或内容重复或无参考意义的文献,最后纳入81篇文献进行综述。结果与结论:①多发性骨髓瘤细胞通过各种miRNA介导的外泌体调节成骨和破骨功能平衡参与多发性骨髓瘤骨病变、调控红细胞钙离子外排通道参与高钙血症的发生、促进肾上皮-间充质转化引发肾纤维化和肾功能不全、上调骨髓来源的单核抑制细胞促进免疫微环境的抑制;此外,多发性骨髓瘤细胞外泌体miRNA还参与了免疫治疗耐药的发生和发展以及血管生成、细胞增殖及细胞衰老等病理过程。②骨髓间充质干细胞和肿瘤相关成纤维细胞均可通过外泌体miRNA影响多发性骨髓瘤细胞的增殖、转移和凋亡,干预血管生成,调控化疗药物的耐药性。③外周血循环外泌体miRNA作为前沿的无创生物标志物,可发挥判断多发性骨髓瘤病程分期和进展,预测患者生存及预后,评估药物敏感性和耐药性等关键作用。④多发性骨髓瘤外泌体长链非编码RNA、环状RNA、miRNA及mRNA,靶基因多种研究因素可形成不同的组合,灵活地构建新型生物轴和生物分子网络,符合整体医学的发展理念。⑤外泌体miRNA作为预测生物标志物及新药研发的治疗靶点具有巨大的发展潜力,如何最大程度利用外泌体miRNA,如何加快相关科研结果的临床转化值得未来进一步研究。

关键词：多发性骨髓瘤进展耐药并发症骨髓间充质干细胞成纤维细胞外周血外泌体 miRNA

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Self-assembly Induced by Complexation of Diblock Copolyelectrolytes and Oppositely Charged Homopolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1321-1332,I0006页

作者： Ling zhao Zhi-Yuan Yin Jia-Di jiang er-Qiang Chen Shuang Yang Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Mater Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

We investigate the solution self-assembly of a mixture of positively charged homopolymers and AB diblock copolymers,in which the A blocks are negatively charged,and the B blocks are *** electrostatic complexation between oppositely charged polymers drives the formation of many ordered *** microstructures and phase diagrams are calculated using self-consistent field theory(SCFT)based on an ion-pair model with an equilibrium constant K to characterize the strength of binding between positively and negatively charged *** effects of the charge ratio,representing the ratio of charges from the homopolymer over all charges from polymers in the system,on the ordered structure are systematically studied,both for hydrophobic and hydrophilic A *** charge ratio plays an important role in determining the phase boundaries in the phase diagram of salt concentration versus polymer *** also provide information about the varying tendency of the domain spacing and core size of the spherical phase when the charge ratio is changed,and the results are in good agreement with *** studies provide a deep understanding of the self-assembled microstructures of oppositely charged diblock copolymer-homopolymer systems.

关键词： Self-assembly Polyelectrolyte complexation Self-consistent field theory Ion-pair

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Chemoselective photocatalytic sulfenylamination of alkenes with sulfenamides via energy transfer

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Chinese Chemical Letters 2024年第12期35卷 461-467页

作者： er-Meng Wang Ziyi Wang Xu Ban Xiaowei zhao Yanli Yin Zhiyong jiang Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University School of Chemistry and Chemical Engineering Henan Normal University College of Advanced Interdisciplinary Science and Technology Henan University of Technology

β-Amino sulfides hold significant biological importance,motivating the development of several methods for sulfenylamination of ***,these methods often involve a three-component system with limited alkene substrate *** this study,we present a pioneering two-component approach utilizing readily accessible sulfenamides as efficient difunctionalization *** to its success is the careful selection of a suitable photosensitizer,which enables precise modulation of sulfenamides by promoting unprecedented energy transfer rather than traditional single-electron *** novel strategy leads to the concurrent formation of N-and S-radical species,ensuring high regioselectivity for both electronneutral and electron-deficient *** a result,a wide range of valuable β-amino sulfides,including those with congested amine groups,can be readily *** findings highlight the potential of this method for the efficient synthesis of diverse functionalized β-amino sulfides.

关键词： Photocatalysis Energy transfer Sulfenamides Sulfenylamination Alkenes

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Oxidation behavior of multi-component Ta-W-Al-Ti alloy at 1173 K

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Rare Metals 2021年第7期40卷 1940-1948页

作者： Jia-Xin Li Yu-Hong Chen Zhang-Jun Bai Bao-Jun zhao Liang jiang Lan-er Wu School of Materials Science and Engineering North Minzu UniversityYinchuan 750021China CNMC Ningxia Orient Group Co.Ltd Shizuishan 753000China School of Chemical Engineering The University of QueenslandBrisbaneQLD 4072Australia

Ta-W alloys have unique properties but their applications at high temperatures are restricted due to their poor oxidation *** addition of Al and Ti decreases the oxidation rate of the alloy,as Al-contained protective oxide layer could be *** this study,ternary and quaternary Ta-W alloys containing Al and Ti were prepared by hot press *** microstructures and oxidation behaviors of the alloys were studied at1173 *** results show that the oxidation kinetics of all alloys follows a parabolic law at short oxidation *** cyclic oxidation,the kinetics of quaternary alloys still obeys the parabolic law but that of ternary alloy has been changed into linear law kinetics after 8-h *** ternary alloy,an outer layer with dense and continuous alumina was formed during the initial stage,and phase transformation caused the oxides to peel *** comparison,the quaternary alloys depicted continuously solid solution of the oxides ***,Al and Ti played key roles in oxidation degree and affected the oxidation kinetics of ternary and quaternary alloys.

关键词： Oxidation behavior Ta-W-based alloy Aluminum Titanium

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In Memory of Academician er-Mi zhao(1930-2016)

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Zoological Research 2017年第1期38卷 2-4页

作者： zhao er Mi Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Kunming Yunnan 650223 China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China

Academician er-Mi zhao,Professor of the Chengdu Institute of Biology,Chinese Academy of Sciences,and Sichuan University,passed away on 24 December,2016,to the great loss of both Chinese and world herpetology.

关键词： GF EM

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Sintering behavior and properties of SiC/Si_3N_4 composite

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Rare Metals 2015年第2期34卷 95-100页

作者： Yong jiang Lan-er Wu Wen-Zhou Sun School of Materials Science and Engineering Beifang University of Nationalities

SiC/Si_3N_4 composite was pressureless sintered using self-propagating high-temperature combustion synthesis a-Si_3N_4 powder and appropriate amount of b-SiC powder. Both of the sintering additive systems were used,which were YAN（Y_2O_3–Al_2O_3–AlN） and YN（Y_2O_3–AlN）.The influences of b-SiC content on sintering behavior of SiC/Si_3N_4 composite were investigated. The results show that the density, shrinkage, bending strength, hardness, and fracture toughness of the samples with two sintering additive systems increase first with the increase of the contents of b-SiC and then decrease even when b-SiC contents continually increase. The tendency of weight loss of the samples is opposite. The b-SiC content of the samples with the best mechanical properties is different in two systems. For YAN system, the best mechanical properties of the samples are gained when b-SiC content reaches 10 %, while as for YN system it is 5 %. The properties of YN samples are superior to YAN samples. J phase（2Y_2O_3 ·Si_2N_2O） forms in YN system easily. A small amount of M phase（Y_2O_3·Si_3N_4） is observed in YAN system.

关键词： SHS powder β-SIC SiC/Si_3N_4 composite Sintering behavior Properties

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