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Nowhere-zero 15-Flow in 3-Edge-connected Bidirected Graphs

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Acta Mathematica Sinica,English Series 2014年第4期30卷 649-660页

作者： er ling wei Wen Liang TANG Dong YE Department of Mathematics Renmin University of China Department of Mathematics West Virginia University Department of Mathematical Sciences Middle Tennessee State University

It was conjectured by Bouchet that every bidirected graph which admits a nowhere-zero κ flow will admit a nowhere-zero 6-flow. He proved that the conjecture is true when 6 is replaced by 216. Zyka improved the result with 6 replaced by 30. Xu and Zhang showed that the conjecture is true for 6-edge-connected graphs. And for 4-edge-connected graphs, Raspaud and Zhu proved it is true with 6 replaced by 4. In this paper, we show that Bouchet＇s conjecture is true with 6 replaced by 15 for 3-edge-connected graphs.

关键词： Bidirected graph integer flow signed graph

The Characterization of p-factor-critical Graphs

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Acta Mathematicae Applicatae Sinica 2022年第1期38卷 154-158页

作者： Shao-hui ZHAI er-ling wei Fu-ji ZHANG School of Applied Mathematics Xiamen University of TechnologyXiamen 361024China School of Mathematics Renmin University of ChinaBeijing 100872China School of Mathematical Sciences Xiamen UniversityXiamen 361005China

A graph G is said to be p-factor-critical if G-u1-u2-···-up has a perfect matching for any u1,u2,···,up∈V(G).The concept of p-factor-critical is a generalization of the concepts of factor-critical and bicritical for p=1 and p=2,*** Zhang and Fuji Zhang[Construction for bicritical graphs and k-extendable bipartite graphs,Discrete Math.,306(2006)1415–1423]gave a concise structure characterization of bicritical *** this paper,we present the characterizations of p-factor-critical graphs and minimal p-factorcritical graphs for p≥*** an application,we also obtain a class of graphs which are minimal p-factor-critical for p≥1.

关键词： perfect matching,p-factor-critical graph transversal

The genus distributions for a certain type of permutation graphs in orientable surfaces

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Science China Mathematics 2007年第12期50卷 1748-1754页

作者： Rong-xia HAO~(1+) wei-li HE~1 Yan-pei LIU~1 er-ling wei~2 ~1 Department of Mathematics,Beijing Jiaotong University,Beijing 100044,China ~2 School of Information,Renmin University of China,Beijing 100872,China Department of Mathematics Beijing Jiaotong University Beijing 100044 China School of Information Renmin University of China Beijing 100872 China

A circuit is a connected nontrivial 2-regular graph. A graph G is a permutation graph over a circuit C, if G can be obtained from two copies of C by joining these two copies with a perfect matching. In this paper, based on the joint tree method introduced by Liu, the genus polynomials for a certain type of permutation graphs in orientable surfaces are given.

关键词： graph, genus distribution, genus, surfaces

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极大外平面图的不可定向强最大亏格

数学学报（中文版） 2007年第3期50卷 527-534页

作者：魏二玲刘彦佩中国人民大学数学系北京100872 北京交通大学数学系北京100044

强嵌入猜想称:任意2-连通图都可以强嵌入到某一曲面上．本文通过分析极大外平面图的结构以及强嵌入的特征,讨论了该图类的不可定向强最大亏格,并给出了一个复杂度为O(nlogn)的算法．其中部分图类的强最大亏格嵌入提供该图的一个少双圈... 详细信息

强嵌入猜想称:任意2-连通图都可以强嵌入到某一曲面上．本文通过分析极大外平面图的结构以及强嵌入的特征,讨论了该图类的不可定向强最大亏格,并给出了一个复杂度为O(nlogn)的算法．其中部分图类的强最大亏格嵌入提供该图的一个少双圈覆盖．

关键词：图强嵌入双圈覆盖亏格

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael QJiang ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

FFConvNeXt3D:提取中大规模目标特征的大卷积核网络

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郑州大学学报(理学版) 2025年第2期57卷 37-43页

作者：黄乾坤黄蔚凌兴宏苏州大学计算机科学与技术学院苏州大学东吴学院计算机系苏州城市学院计算科学与人工智能学院吉林大学符号计算与知识工程教育部重点实验室

目前大卷积核模型在图像领域已经证明其有效性，但是在视频领域还没有优秀的3D大卷积核模型。此外，之前的工作中忽视了时空行为检测任务主体是人的特点，其中的骨干网络只针对通用目标提取特征。针对上述原因，提出了一种含有特征融合... 详细信息

目前大卷积核模型在图像领域已经证明其有效性，但是在视频领域还没有优秀的3D大卷积核模型。此外，之前的工作中忽视了时空行为检测任务主体是人的特点，其中的骨干网络只针对通用目标提取特征。针对上述原因，提出了一种含有特征融合结构的3D大卷积核神经网络(FFConvNeXt3D)。首先，将成熟的ConvNeXt网络膨胀成用于视频领域的ConvNeXt3D网络，其中，预训练权重也进行处理用于膨胀后的网络。其次，研究了卷积核时间维度大小和位置对模型性能的影响。最后，提出了一个特征融合结构，着重提高骨干网络提取人物大小目标特征的能力。在UCF101-24数据集上进行了消融实验和对比实验，实验结果验证了特征融合结构的有效性，并且该模型性能优于其他方法。

关键词：大卷积核目标检测时空行为检测行为识别特征融合

siRNA therapeutics:a clinical reality

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Science China(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei er Saw er-wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)*** its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of *** years after the discovery of RNAi,siRNA therapeutics finally charts its way into *** we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease ***,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical ***,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics.

关键词： siRNA therapeutic disease treatment systemic siRNA delivery clinical application

Phage display screening of therapeutic peptide for cancer targeting and therapy

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Protein & Cell 2019年第11期10卷 787-807页

作者： Phei er Saw er-wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage display technology has been announced as the recipient of Nobel Prize in Chemistry *** display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and *** this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening *** will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display *** will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics.

关键词： phage display tumor targeting peptide,tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor

Kinetic Studies on Interactions of Ferreous-porphyrins with Hydrogen Peroxide

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Chemical Research in Chinese Universities 2004年第5期20卷 594-597页

作者： YANYan JIANWen-ping GUOHong-wei YANGKe-er TongShan-ling FANGChi-guang LIQing CHANGXin XIAOFeng-shou DepartmentofChemistry ShantouUniversityShantou515063P.R.China CollegeofChemistry JilinUniversityChangchun130023P.R.China TheSanitationCenterofInspection＆TestofJilinProvince Changchun130012P.R.China

In an alkali-methanol solution, both 1- and 2-naphthol can be converted into 2-hydroxy-1,4-naphthoquinone(HNQ) with selectivity more than 95% by H_2O_2 over metalloporphyrin catalyst. The UV-Vis spectra indicate that a high valence oxygen-ferreous porphyrin intermediate has been produced by addition of an aqueous solution of H_2O_2 into the catalytic system. This intermediate formation rate is influenced by the concentrations of low valence ferrous porphyrin, H_2O_2, and NaOH existing in the system. With the aid of the UV-Vis spectrum varieties, the rate equations and formation rate constants of the intermediate at different temperatures can be determined by changing the original concentration of each reactant. The formation activation energy of this intermediate was also determined by changing temperature.

关键词： Ferrous porphyrin catalyst Intermediate Kinetics