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Microstructure features of the BST/(Mg,ln)-ceramic

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Journal of Advanced Dielectrics 2022年第2期12卷 19-24页

作者： K.p.Andryushin A.V.Nagaenko S.V.Khasbulatov l.A.Shilkina E.V.Glazunova S.I.Dudkina I.N.Andryushina l.A.Reznichenko Research institute of physics Southern Federal University 194 Stachki Str.Rostov-on-Don 344090Russia institute of High Technology and piezo Technic Southern Federal University 10 MilchakovaRostov-on-Don 344090Russia Faculty of physics and Information-communication Technologies 32 Sheripova Str. Grozny 364024Russia

Solid solutions of the composition Ba_(1-x-y)(Mg,ln)_(x)SryTiO_(3)(x=0.01;0.025;0.04;y=0.20;0.50;0.80;ln=la,pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tu,Yb)were prepared by two-stage solid-phase synthesis followed by sintering using conventional ceramic *** influence of rare-earth elements on the microstructure of the prepared ceramic samples was *** was found that regardless of the type of modifiers introduced,the grain landscape of the studied solid solutions with different amounts of SrTiO_(3)is refined(in the initial system,the average grain size,d,at x=0.20 is 6μm;at x=0.50 is 4μm;at x=0.80 is 18μm)to crystallite sizes not exceeding(2-3)μm,and *** using of mechanical activation procedures leads to an even greater decrease in the size and an increase in the density of *** increasing in the concentration of modifiers in each group(within the considered range of dopant variation)against the background of such a fine-grained structure has little effect on the dynamics of changes in *** is concluded that it is advisable to use the data obtained in the development of functional materials based on BST/(Mg,ln)and devices with the participation of these compositions.

关键词： Ceramics BST microstructure rare-earth elements

Identifying High-Risk Medication prescriptions to prevent potentially Severe Adverse Drug Events in primary-Care patients with Chronic Multimorbidities:The polychrome Study

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Journal of pharmacy and pharmacology 2020年第2期8卷 35-43页

作者： pascal Clerc Virginie Boyer franÇoise Haramburu Annie Fourrier-Reglat Julien le Breton Inserm U955 Universite Paris Est Creteil(UPEC)Institut Mondor de Recherche Biomedicale(IMRB)equipe CEpiA(Clinical Epidemiology and Ageing)CreteilFrance Societe franÇaise de Medecine Generale SFMG141 avenue de VerdunIssy-Les-Moulineaux92130France Mutualite Sociale Agricole 13 Rue FerrereBordeaux cedex33052France Inserm U 657 Universite Bordeaux Segalen146 rue Leo SaignatBordeaux cedex33076France CIC-p 0005 CHU de BordeauxPlace Amelie Raba LeonBordeaux33000France departement universitaire de medecine generale Universite Paris Est Creteil8 avenue du General SarrailCreteil 94090France Centre de sante universitaire 2 mail de l'egaliteLa Courneuve 93120France

Background:The association between multimorbidities and polypharmacy among elderly individuals is well documented,and polypharmacy has been shown to increase the risk of adverse drug events(Ades).However,little information is available about the risks associated with the lifelong use of medications to treat chronic ***:To determine the prevalence and nature of high-risk prescriptions among primary-care patients with chronic ***:We studied a weighted stratified random sample of 105 prescriptions for different patients with chronic multimorbidities taken from the polychrome database established using information from the French primary-care record database(Observatoire de la Médecine Générale).A medication review was conducted to identify contra-indications and potential drug-drug interactions for each ***:Contra-indications were identified for 60(57.1%)prescriptions,potential drug-drug interactions for 70(66.7%),absolute contra-indications for 9(8.6%),and inadvisable drug combinations for 11(10.5%).In all,19(18.1%)different patients were at risk for major *** and nervous-system drugs contributed 66.2% of contra-indications and 69.3% of potential drug-drug ***:This exploratory study confirms the high prevalence and potential seriousness of prescriptions at risk for Ades in a population of primary-care patients with chronic *** high prevalence of interactions involving the cardiovascular and nervous systems indicates that efforts to improve prescription practices should target these two categories of conditions and drugs in patients with chronic multimorbidities.

关键词： primary care General practice Chronic disease pharmacotherapy management Drug-drug interactions Medication review

Neurodegeneration and Mitochondria Organelle Transplantation: “A Technology That proof of principle Suggest Is Ready for prime Time”

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Neuroscience & Medicine 2020年第4期11卷 108-118页

作者： R. l. Elliott X. p. Jiang Elliott Mastology Center and Sallie Astor Burdine Breast Foundation Baton Rouge LA USA

It is known that mitochondrial dysfunction is associated with neurodegenerative diseases including amyotrophic lateral sclerosis (AlS). Researchers have tested the therapeutic efficacy of many mitochondrial targeted ... 详细信息

le="text-align:justify;"> It is known that mitochondrial dysfunction is associated with neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Researchers have tested the therapeutic efficacy of many mitochondrial targeted agents;however, results have been disappointing without significant impact on disease survival. Several groups have demonstrated that mitochondrial transfer of isolated normal healthy mitochondria to defective calls can restore functional recovery. Our experience with mitochondria organelle transplantation (MOT) in cancer cells led to investigating the technology for neurodegenerative diseases (NDs), especially ALS. The rationale was that if the uptake of normal mitochondria into cancer cells inhibited proliferation and glycolysis;then MOT might be a cell-based therapy for NDs. In this communication, we will present background research on MOT in vitro and in vivo cell culture and animal models respectively. This research evidence showed proof of principle of the technology. This fact led us to try the procedure on a desperate human AlS patient.pan>

关键词： Neurodegeneration Mitochondrial Organelle Transplantation Mitochondria AlS

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平台经济领域中算法协同行为的治理机制研究

经济问题 2022年第3期 38-45页

作者：剌森北京工商大学法学院北京100048

平台经济领域中的算法定价可能同时带来定价效率与共谋的风险,需要思考如何在反垄断法中构建算法协同行为的治理机制。首先,在认定算法协同行为时,需要考量意思联络、一致行为与经营者是否拥有合理解释等构成要件。算法的使用扩展了意... 详细信息

平台经济领域中的算法定价可能同时带来定价效率与共谋的风险,需要思考如何在反垄断法中构建算法协同行为的治理机制。首先,在认定算法协同行为时,需要考量意思联络、一致行为与经营者是否拥有合理解释等构成要件。算法的使用扩展了意思联络和一致行为的表现形式。其次,在算法协同行为的治理方面,有必要明确监管原则,加强平台自治和平台责任。将结构性监管与行为性执法相协调,一方面提高算法透明度,降低市场进入障碍;另一方面在执法中引入大数据技术进行价格监测并扩展执法机构的查阅、复制权。

关键词：算法协同行为垄断协议平台经济领域

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算法共谋中经营者责任的认定:基于意思联络的解读与分析

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现代财经（天津财经大学学报） 2022年第3期42卷 101-113页

作者：剌森北京工商大学法学院北京100048

在算法共谋中,意思联络达成与维持的方式发生了较大变化,因此经营者责任的认定面临着意思联络判定的困难。基于此,从意思联络视角讨论算法共谋场景下经营者责任认定问题具有一定的必要性。研究发现,算法便利了经营者实施间接意思联络,... 详细信息

在算法共谋中,意思联络达成与维持的方式发生了较大变化,因此经营者责任的认定面临着意思联络判定的困难。基于此,从意思联络视角讨论算法共谋场景下经营者责任认定问题具有一定的必要性。研究发现,算法便利了经营者实施间接意思联络,鉴于间接意思联络的特殊性,有必要扩展意思联络这一概念,知情默许与合理预见也应构成意思联络,并适当加强竞争者的背离义务。在算法共谋的场景下,对平行行为与协同行为进行划分仍然是具有意义的,但是需要依照意思联络表现形式的变化对两者的划分标准进行调整。算法共谋中经营者责任的认定受到算法工具性与自主性影响,当前反垄断法主要将算法视为工具,但随着自我学习算法的发展,算法的自主性也应当纳入考量。可以依据经营者对意思联络知情与否以及算法自主性程度作为分类标准对经营者责任进行分类讨论。

关键词：算法共谋经营者责任间接意思联络轴辐协议反垄断法

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Alteration of β-secretase traffic by the receptor tyrosine kinase signaling pathway- a new mechanism for regulating Alzheimer's β-amyloid production

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Cell Research 2007年第05期17卷 385-386页

作者： Yun-Wu Zhang Huaxi Xu, Center for Neuroscience and Aging, Burnham institute for Medical Research, 10901 N. Torrey pines Rd., la Jolla, CA 92037, USA. xuh@burnham. org CenterforNeuroscienceandAging BurnhamInstituteforMedicalResearch10901N.TorreyPinesRd.LaJollaCA92037USA

The receptor tyrosine kinases (RTKs) are a family of cellsurface proteins with diverse functions in proliferation, dif-ferentiation or cell-cell communication. When a specific li-gand binds to its cognate receptor, a conformational changeof this receptor due to the ligand-receptor interaction willlead to activation of the intrinsic tyrosine kinase residing inthe intracellular domain of the receptor. The activation ofthis tyrosine kinase is essential for transducing the signals toa cascade of its downstream molecules that eventually causerelated physiological responses [1]. For example, binding ofnerve growth factor (NGF) to its receptor TrkA is essentialfor the proper development, patterning, and maintenanceof the mammalian nervous system. This ligand and recep-tor interaction will lead to the formation of a crab-shapedhomodimeric TrkA structure [2], and the subsequent activa-tion of its intrinsic RTK will cause auto-phosphorylationof its own intracellular tyrosine residues. phosphorylatedTrkA receptors recruit and increase the phosphorylationof plC-γ and Shc, which leads to activation of either thepI3K/Akt pathway or Ras/raf/ERK pathway. In the brainOf Alzheimer's disease (AD) patients, alterations of nervegrowth factor (NGF) and its receptor TrkA have beenreported to associate with AD pathogenesis [3]. However,the underlying mechanisms remain elusive.

关键词： BACE amyloid production NGF Alteration of a new mechanism for regulating Alzheimer’s secretase traffic by the receptor tyrosine kinase signaling pathway TrkA RTK

神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用并有助于移植细胞与宿主胶质细胞间缝隙连接的建立

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神经损伤与功能重建 2014年第2期9卷 F0003-F0003页

作者： Rocío Talaverón Esperanza R.Matarredona Rosa R.de la Cruz David Macías Victoria Gálvez and Angel M. Pastor Departamento de Fisiología Facultad de Biología Universidad de Sevilla Avenida Reina Mercedes

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经... 详细信息

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经元的电活动及突触联系,并可增加神经营养因子的释放。本研究拟观察移植的神经干/祖细胞与宿主胶质细胞间的解剖关系,以探讨神经干/祖细胞移植的神经保护作用的可能机制。从新生大鼠的脑室下区提取神经干/祖细胞移植到内侧纵束横断伤模型大鼠脑内。移植后8周取脑进行相关检测。免疫组化检测结果显示,与未移植神经干/祖细胞的大鼠相比,移植了神经干/祖细胞的大鼠脑内更多的小胶质细胞被激活。移植的神经干/祖细胞聚集在激活的小胶质细胞和星形胶质细胞附近。缝隙连接蛋白CX-43表达在损伤部位的神经干/祖细胞和胶质细胞上,且较多的存在于移植细胞和胶质细胞相连接的部位。移植的神经干/祖细胞和宿主胶质细胞及宿主小胶质细胞间均形成了缝隙连接,但移植的神经干/祖细胞和宿主胶质细胞间的缝隙连接较多。本研究结果显示,神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用,并可能通过在移植细胞和宿主细胞间建立缝隙连接来调节细胞间的通讯,这可能是细胞移植的神经保护作用的机制之一。

关键词：星形胶质细胞轴索断裂缝隙连接蛋白-43 小胶质细胞脑室下区

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孔子学院:提升文化软实力还是加强文化交流 ——德克萨斯大学圣安东尼奥分校的案例研究

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孔子学院:提升文化软实力还是加强文化交流 ——德克萨斯大学圣安...

作者： deSTINEE QUI-la lING HARTMAN 浙江大学

学位级别：硕士

If we were to ask the average American what they know about China,they might say:it's a country in Asia and they have great ***,what do we really know about China?Do we have an understanding about the language,culture,and or the people that populate 1/7 of the word?I would say most Americans know about China,but they don't have an understanding of *** this being said,in the past years China has worked very hard to convey language and culture *** of the most prevalent means is through the Confucius ***'s means of cultural communication through this institute has been a very interesting topic in the United *** say its just one way to share their culture with the world,but others say it's to push their ideas and spread soft *** paper will take a look at both theories soft power and cultural communication and connect it to the Confucius ***,we selected a specific CI location in the state of Texas at one of the local universities to conduct our *** questions yet to be answered is what is China' s goal?Where should there be improvement?China and the US have always had a unique *** you think of the West you think America and when you think of the East you think *** these countries need each other.

关键词： China Confucius institute cultural communication soft power UTSA

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lE BIEN ET lE MAl

法国研究 1985年第4期 26-30页

作者： par Wang Tai lai-la modernitéchez Victor Hugo…

Au cours de mis au point de ma présente étude,j′ai change de titrequi était deCOUVERTE *** hésitation peut s′expli-quer par le fait que ma communication a été préparée à partir de deuxséries d′interrogati... 详细信息

关键词：责任编辑