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Variability of anti-human transglutaminase testing in celiac disease across Mediterranean countries

World Journal of Gastroenterology 2017年第24期23卷 4437-4443页

作者： Andrea Smarrazzo Giuseppe Magazzù Mongi Ben-Hariz Maria Legarda Tamara Virtut Velmishi Elefhteria Roma Aydan Kansu Dusanka Micetic-Turk enzo Bravi Pio Stellato Carmela Arcidiaco Luigi Greco Department of Translational Medical Sciences School of MedicineSection of PediatricsUniversity of Naples“Federico II” European Laboratory for Food Induced Diseases Celiac Regional Centre Pediatric Gastroenterology and Cystic Fibrosis UnitUniversity of Messina Pediatric Unit Mongi SLIM’s Hospital of Tunis Paediatric Gastroenterology Unit Cruces University Hospital Service of Pediatric Gastroenterology"Mother Teresa"Hospital First Department of Pediatrics University of Athens Department of Pediatric Gastroenterology School of MedicineAnkara University University Medical Centre Paediatric Department Eurospital SpA

To verify the precision and accuracy of transglutaminase antibodies (TGA) assays across Mediterranean countries. METHODSThis study involved 8 referral centres for celiac disease (CD) in 7 Mediterranean countries. A central laboratory prepared 8 kits of 7 blinded and randomized serum samples, with a titrated amount of Human TGA IgA. Each sample was analysed three times on three different days, with each centre running a total of 21 tests. The results were included in a blindly coded report form, which was sent to the coordinator centre. The coordinator estimated the mean coefficient of Variation (CoVar = σ/μ), the mean accuracy (Accur = Vobserved - Vreal) and the mean percent variation (Var% = [(Vobserved - Vreal)/Vreal] × 100). RESULTSThe analysis showed that 79.17% of the mean variation fell between -25% and +25% of the expected value, with the accuracy and precision progressively increasing with higher titres of TGA. From values 1.25 times greater than the normal cut-off, the measurements were highly reliable. CONCLUSIONTGA estimation is a crucial step for the diagnosis of CD; given its accuracy and precision, clinicians could be confident in establishing a diagnosis.

关键词： Coeliac disease Gluten Transglutaminase Non-invasive testing Accuracy Precision

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Possible Location of the Next Major Earthquakes in the Northern Apennines: Present Key Role of the Romagna-Marche-Umbria Wedge

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International Journal of Geosciences 2017年第11期8卷 1301-1314页

作者： enzo Mantovani Marcello Viti Daniele Babbucci Caterina Tamburelli Nicola Cenni Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università degli Studi di Siena Siena Italy Dipartimento di Fisica e Astronomia Università degli Studi di Bologna Bologna Italy Dipartimento di Ingegneria Civile Chimica Ambientale e Meccanica Università degli Studi di Bologna Bologna Italy Abstract

It is argued that in some zones of the Northern Apennines, in particular the Rimini-Ancona thrust system, the Romagna Apennines and the Alta Valtiberina trough, the probability of major earthquakes is now higher than in other Apennine zones. This hypothesis is suggested by the comparison of the present short-term kinematics of the Romagna-Marche-Umbria wedge in the Northern Apennines, deduced by the distribution of major shocks in the last tens of years, with the previous repeated behavior of the same wedge, evidenced by the distribution of major earthquakes in the last seven centuries. The seismotectonics of the Apennine region here considered is closely connected with the larger context that involves the progressive migration (from south to north) of seismicity along the peri-Adriatic zones. The information provided by this study can be used to better manage the resources for prevention in Italy.

关键词： Peri-Adriatic Seismicity Northern Apennines Romagna-Marche-Umbria Seismotectonics

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签名

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网球大师 2007年第7期 68-75页

作者： enzo

签名,是一件很拉风的事情,但是,假设有一天回过头来看你签的名字连起来都能绕赤道一周的时候,也许在你意识到这一点之前,你就已经厌倦了签名。在时候,我们可以很容易就体量到,这些球星在签名时的感受,实在和上小学时因为写错了字被老师... 详细信息

签名,是一件很拉风的事情,但是,假设有一天回过头来看你签的名字连起来都能绕赤道一周的时候,也许在你意识到这一点之前,你就已经厌倦了签名。在时候,我们可以很容易就体量到,这些球星在签名时的感受,实在和上小学时因为写错了字被老师罚抄一百遍还要郁闷,毕竟罚抄的时候你可以名正言顺地郁闷,而球星们还得显得很开心,当然,他们也是人,偶尔也会在心里哼唱"一百遍啊一百遍"!

关键词：签名球星赤道名字厌倦哼唱意识实在写错学时

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浮生半日闲

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网球大师 2008年第Z1期 56-63页

作者： enzo

每个时代,最多一个能在自己的领域中被尊奉为"神"。通常,他依靠超越这项运动的某种天赋和能力,获得俯视众生的地位。而久居其位的索然和可能失去它的恐惧,让舒马赫拂衣而去,让伍兹日感孤独,也让费德勒心生倦意。然而,仅仅是一丝倦意而... 详细信息

每个时代,最多一个能在自己的领域中被尊奉为"神"。通常,他依靠超越这项运动的某种天赋和能力,获得俯视众生的地位。而久居其位的索然和可能失去它的恐惧,让舒马赫拂衣而去,让伍兹日感孤独,也让费德勒心生倦意。然而,仅仅是一丝倦意而已。或许,只需要半日之闲,王者恃天地雄心,仍可风云再起。

关键词：超越时代运动能力俯视领域地位孤独恐惧马赫

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加州风情

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网球大师 2008年第4期 66-73页

作者： enzo

3月15日,印第安维尔斯网球公园,加利福尼亚州。来此间参加太平洋寿险杯的一群网坛名将成了时尚品牌Trina Turk的代言人。

关键词：以色列加利福尼亚州双打印第安太平洋加州代言人网球寿险拉姆

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May the assessment of baseline mucosal molecular pattern predict the development of gluten related disorders among microscopic enteritis?

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World Journal of Gastroenterology 2016年第35期22卷 8017-8025页

作者： Giuseppe Losurdo Floriana Giorgio Domenico Piscitelli Lucia Montenegro Claudia Covelli Maria Grazia Fiore Antonio Giangaspero Andrea Iannone Mariabeatrice Principi Annacinzia Amoruso Michele Barone Alfredo Di Leo enzo Ierardi Section of Gastroenterology Department of Emergency and Organ Transplantation University of Bari Section of Pathology Department of Emergency and Organ Transplantation University of Bari

AIM To evaluate mucosal baseline m RNA expression of tissue transglutaminase 2(t TG2), interferon gamma(IFNγ), toll-like receptor 2(TLR2) and Myeloid Differentiation factor 88(MyD 88) in patients with microscopic enteritis(ME).METHODS We retrospectively enrolled 89 patients with ME of different etiology, which was defined within a 2-year mean period of follow-up. Baseline histological examination was performed on Hematoxylin-Eosin stained sections and CD3 lymphocyte immunohistochemistry was used for intraepithelial lymphocyte count(IELs). ME was defined according to the criteria of Bucharest Consensus Conference. For each patient, formalin embedded biopsy samples of the duodenum referred to the period of ME diagnosis were retrieved. Real-time polymerase chain reaction(RT-PCR) was used to detect the amount of mR NA coding for tT G2, IFNγ, TLR2 and My D88, and the quantity was expressed as fold change compared to controls. Control group was represented by duodenal normal specimens from 15 healthy subjects undergoing endoscopy for functional symptoms. Comparisons among continuous variables were performed by One way analysis of variance(ANOVA) and Bonferroni’s test. The χ~2 test was used for categorical variables. Pearson’s test was used to evaluate correlations. Receiver operating curves were drawn for all four markers to estimate sensitivity and specificity in discriminating the development of CD and *** After a period of follow up of 21.7 ± 11.7 mo, the following diagnoses were achieved: gluten related disorders in 48 subjects(31 CD; 17 GS) and non-gluten related ones in 41(29 Irritable Bowel Syndrome- IBS; 12 Others). CD patients had the highest tT G2 levels(8.3 ± 4.5). The ANOVA plus Bonferroni analysis showed that CD > Other ME > GS = IBS > negative controls. A cut off value of 2.258 was able to discriminate between CD and GS with a sensitivity of 52.94% and a specificity of 87.1%. Additionally, CD patients had the highest IFNγ levels(8.5 ± 4.1). ANOVA plus

关键词： Celiac disease MyD 88 Microscopic enteritis Gluten sensitivity Tissue transglutaminase Interferon gamma Toll-like receptor 2

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2007“影像”年终版进化

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网球大师 2007年第8期 52-61页

作者： enzo

2007年,网球将令人震撼、或令人平静的美继续呈现予世人,继续创造历史。但是,我们仍注意到这是与往常经验有着不同的一年。正如费德勒也应能感觉到的,经过今年,他已经非常接近史上最伟大的称号,他有可能成为地平线上的第一个人,但是,这... 详细信息

2007年,网球将令人震撼、或令人平静的美继续呈现予世人,继续创造历史。但是,我们仍注意到这是与往常经验有着不同的一年。正如费德勒也应能感觉到的,经过今年,他已经非常接近史上最伟大的称号,他有可能成为地平线上的第一个人,但是,这‘切发生的同时,也是他内心最为艰难的时刻,比过去任何时候都要艰难。这是进化中的一步。对于人类而言,进化还有着精神上的动力:每个人,都希望自己生活在最伟大的时代。

关键词：进化创造历史影像艰难地平线网球年终大师时代背景后期制作

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莎娃日程

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网球大师 2008年第2期 54-61页

作者： enzo

除了网球场上那一声声亘古不变的吼叫,莎拉波娃无疑是热衷于制造新鲜感的美女。去年年末至今,大约半个多月时间,她训练,比赛,出席发布会,做秀,逛街,开PARTY,她从马德里到新加坡到香港到墨尔本,她很少穿相同的衣服。

关键词：网球场新鲜感发布会新加坡马德里莎拉训练比赛墨尔本制造

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ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells

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Genes & Diseases 2020年第4期7卷 620-635页

作者： Luca Tirinato Francesca Pagliari Simone Di Franco Elisa Sogne Maria Grazia Marafioti Jeanette Jansen Andrea Falqui Matilde Todaro Patrizio Candeloro Carlo Liberale Joao Seco Giorgio Stassi enzo Di Fabrizio Biomedical Physics in Radiation Oncology DKFZ(German Cancer Research Center)69120 HeidelbergGermany Physical Science and Engineering(PSE)Division King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia Department of Experimental and Clinical Medicine University“Magna Graecia”of Catanzaro88100 Loc.GermanetoCatanzaroItaly Biological and Environmental Sciences and Engineering(BESE)Division King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Cellular and Molecular Pathophysiology Laboratory Department of SurgicalOncological and Stomatological SciencesUniversity of PalermoPalermoItaly Ruprecht Karls University Heidelberg Department of Physics69120 HeidelbergGermany Department of Health Promotion Mother and Child CareInternal Medicine and Medical Specialties(PROMISE)University of PalermoPalermoItaly

Lipid Droplets(LDs)are emerging as crucial players in colon cancer development and *** expression has been associated with high tumorigenicity in Cancer Stem Cells(CSCs),so that they have been proposed as a new functional marker in Colorectal Cancer Stem Cells(CR-CSCs).They are also indirectly involved in the modulation of the tumor microenvironment through the production of pro-inflammatory *** is growing evidence that a possible connection between metabolic alterations and malignant transformation exists,although the effects of nutrients,primarily glucose,on the CSC behavior are still mostly *** is an essential fuel for cancer cells,and the connections with LDs in the healthy and CSC populations merit to be more deeply ***,we showed that a high glucose concentration activated the PI3K/AKT pathway and increased the expression of CD133 and CD44v6 CSC ***,glucose was responsible for the increased amount of Reactive Oxygen Species(ROS)and LDs in both healthy and CR-CSC *** also investigated the gene modulations following the HG treatment and found out that the healthy cell gene profile was the most ***,Atorvastatin,a lipidlowering drug,induced the highest mortality on CR-CSCs without affecting the healthy counterpart.

关键词： Cholesterol metabolism Colorectal cancer stem cells Fatty acid

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Design and Maintenance of Valves on a H_2 Reciprocating Compressor

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International Journal of Plant Engineering and Management 2010年第2期15卷 103-106页

作者： GU Hong-mei WANG Qi ZHANG Xiao-hua enzo Giacomelli Daqing Refining & Chemical Company China National Petroleum Company(CNPC) Daqing 163411 P.R. China Dott. Ing. Mario Cozzani Srl Italy 10921

Cylinder valves are the most important parts of a reciprocating compressor; their working condition affects the safety and operation of the reciprocating compressor directly. In initial design, it is dedicated to simulate the behaviour of a reciprocating compressor and peorformance of cylinder valves. For hydrogen application, it is considering carefully the real operating conditions both from the dynamic point of view and taking care of the effective condi- tions of the gas purity. The dynamic aspects of the design are related to the mechanical behaviour and to the conse- quent fatigue. The mathematical models are able to determine the ring displacement and the flow and pressure drop of the gas. Instruments are available for on-line monitoring of the reciprocating compressor. The various parts have to be repaired in time in case they have abrupt problems during the operating period. By detail design and maintenance, saving the quantities of spare parts, the reciprocating compressor of the plant can be running smoothly. Actually, the cylinder valves can be used nearly three years.

关键词： compressor valve design maintenance

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